Maze Therapeutics CEO reports 31,908-share trust sale

Both trust sales were made under a Rule 10b5-1 plan adopted by CEO Jason V. Coloma on February 6, 2026.

Rhea-AI Filing Summary

Maze Therapeutics, Inc. CEO and director Jason V. Coloma reported sales of 2,593 shares held by The Coloma 2021 Irrevocable Trust at a weighted average price of $27.0241 per share and 31,908 shares held by Coloma Family Trust at a weighted average price of $27.0210 per share on October 1, 2026. Both sales were made under a Rule 10b5-1 trading plan adopted by Coloma on February 6, 2026. After the transactions, the trusts held 15,558 and 191,447 shares, respectively. A separate direct holding entry lists 27,362 shares.

Insider Trade Summary 10b5-1

Net Seller: 34,501 shares

Net Sell 3 txns

Insider Coloma Jason V

Role Chief Executive Officer

Sold 34,501 shs ($932K)

Type	Security	Shares	Price	Value
Sale	Common Stock F1, F2, F3	2,593	$27.0241	$70K
Sale	Common Stock F1, F4, F5	31,908	$27.021	$862K
holding	Common Stock	--	--	--

Holdings After Transaction: Common Stock — 15,558 shares (Indirect, The Coloma 2021 Irrevocable Trust); Common Stock — 191,447 shares (Indirect, Coloma Family Trust); Common Stock — 27,362 shares (Direct)

Footnotes (5)

1. F1. This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.
2. F2. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.645 to $27.46 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 4 of this Form 4.
3. F3. These securities are directly held by The Coloma 2021 Irrevocable Trust, for which the reporting person and his spouse serve as co-trustees.
4. F4. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.585 to $27.47 per share, inclusive.
5. F5. These securities are directly held by the Coloma Family Trust, for which the reporting person and his spouse serve as co-trustees.

Key Figures

Shares sold by The Coloma 2021 Irrevocable Trust: 2,593 shares Weighted average sale price: $27.0241 per share Shares held after transaction: 15,558 shares +4 more

7 metrics

Shares sold by The Coloma 2021 Irrevocable Trust 2,593 shares October 1, 2026

Weighted average sale price $27.0241 per share The Coloma 2021 Irrevocable Trust sale on October 1, 2026

Shares held after transaction 15,558 shares The Coloma 2021 Irrevocable Trust

Shares sold by Coloma Family Trust 31,908 shares October 1, 2026

Weighted average sale price $27.0210 per share Coloma Family Trust sale on October 1, 2026

Shares held after transaction 191,447 shares Coloma Family Trust

Direct shares held 27,362 shares October 1, 2026

Key Terms

Rule 10b5-1 trading plan, weighted average price, co-trustees

3 terms

Rule 10b5-1 trading plan regulatory

"effected pursuant to a Rule 10b5-1 trading plan"

A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.

weighted average price financial

"The reported price in Column 4 is a weighted average price."

Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.

co-trustees regulatory

"serve as co-trustees"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What shares did MAZE CEO Jason V. Coloma report selling?

On October 1, 2026, The Coloma 2021 Irrevocable Trust sold 2,593 shares at a weighted average price of $27.0241 per share, and Coloma Family Trust sold 31,908 shares at a weighted average price of $27.0210. Both sales were made under a Rule 10b5-1 plan adopted February 6, 2026.

What price ranges were reported for the MAZE trust sales?

The Coloma 2021 Irrevocable Trust's shares were sold at prices ranging from $26.645 to $27.46 per share, inclusive. Coloma Family Trust's shares were sold at prices ranging from $26.585 to $27.47 per share, inclusive.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 10/02/2026 - 04:12 PM Accepted by SEC EDGAR 10/02/2026 - 04:12 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Coloma Jason V

(Last) (First) (Middle)

C/O MAZE THERAPEUTICS, INC.

171 OYSTER POINT BOULEVARD, SUITE 300

(Street)

SOUTH SAN FRANCISCO CALIFORNIA 94080

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Maze Therapeutics, Inc. [ MAZE ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Executive Officer

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
10/01/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	10/01/2026		S(1)		2,593	D	$27.0241(2)	15,558	I	The Coloma 2021 Irrevocable Trust(3)
Common Stock	10/01/2026		S(1)		31,908	D	$27.021(4)	191,447	I	Coloma Family Trust(5)
Common Stock								27,362	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 6, 2026.

2. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.645 to $27.46 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnote 4 of this Form 4.

3. These securities are directly held by The Coloma 2021 Irrevocable Trust, for which the reporting person and his spouse serve as co-trustees.

4. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.585 to $27.47 per share, inclusive.

5. These securities are directly held by the Coloma Family Trust, for which the reporting person and his spouse serve as co-trustees.

	/s/ Courtney Phillips, as attorney-in-fact	10/02/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)