Welcome to our dedicated page for Mesoblast SEC filings (Ticker: MESO), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
Parsing a Mesoblast filing can feel like navigating a clinical protocol: pages of stem-cell science, FDA dialogues, and cash runway tables. If you are hunting for pipeline milestones, manufacturing risk factors, or the latest Ryoncil trial data, the company’s disclosures are uniquely dense. Stock Titan streamlines that complexity—our AI breaks down each Mesoblast SEC filing so you can focus on whether the next catalyst really moves MESO.
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Mesoblast Limited Schedule 13G/A filed for ordinary shares/ADRs reports that Gregory George, his sons James and Grant George, and G to the Fourth Investments, LLC collectively hold substantial positions as of September 11, 2025. Gregory George is reported as beneficial owner of 275,851,734 shares in the aggregate (21.59% of the 1,277,782,187 outstanding shares), including 137,123,887 shares he solely owns and discretionary voting or dispositive authority over additional shares held by G to the Fourth Investments and by his sons. G to the Fourth Investments, LLC holds 126,727,847 shares (9.92%). James George and Grant George each report 6,000,000 shares (0.47% each). The filing states the holdings were not acquired to change or influence control.
Mesoblast is a commercial-stage biotech focused on allogeneic mesenchymal lineage cell therapies. The company received FDA approval in December 2024 for remestemcel-L (Ryoncil®) to treat steroid-refractory acute graft-versus-host disease in pediatric patients and launched the product in March 2025. Since launch through June 30, 2025, Mesoblast reported net product sales of $11.3 million.
The company reported a net loss of $102.1 million for the year ended June 30, 2025 and cumulative losses of $1,010.9 million since inception. At June 30, 2025 Mesoblast held $161.6 million in cash and reported net cash usage from operations of $50.0 million for the year. Management states current cash plus forecasted Ryoncil® revenue are sufficient to meet operating cash needs for the next 12 months, and they expect to refinance existing borrowings within that period. The company remains dependent on third-party manufacturers, certain single-source suppliers and successful commercialization, and highlights multiple operational, regulatory and market risks that could affect future results.