Adage Capital Management, L.P., together with Robert Atchinson and Phillip Gross, reports beneficial ownership of Monopar Therapeutics Inc. common stock. The group reports 324,195 shares of common stock, including 115,000 shares issuable upon exercise of warrants, with no sole voting or dispositive power and full holdings under shared voting and shared dispositive power.
Based on 6,699,062 shares outstanding as of April 30, 2026, the reporting persons state their beneficial ownership represents 4.76% of Monopar’s common stock, indicating ownership of 5 percent or less of the class. The securities are held through Adage Capital Partners, L.P., for which Adage Capital Management, L.P. acts as investment manager.
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Key Figures
Beneficial ownership shares:324,195 sharesOwnership percentage:4.76%Shares outstanding:6,699,062 shares+3 more
6 metrics
Beneficial ownership shares324,195 sharesShares of Monopar common stock beneficially owned by the reporting persons
Ownership percentage4.76%Percentage of Monopar common stock class beneficially owned by the reporting persons
Shares outstanding6,699,062 sharesMonopar common stock outstanding as of April 30, 2026, used for the ownership calculation
Warrant shares included115,000 sharesShares of common stock issuable upon exercise of warrants held by Adage Capital Partners, L.P.
Shared voting power324,195 sharesShares over which the reporting persons have shared voting power
Shared dispositive power324,195 sharesShares over which the reporting persons have shared dispositive power
"The filing of this statement should not be construed in and of itself as an admission by any Reporting Person as to beneficial ownership"
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
shared voting powerfinancial
"6 | Shared Voting Power 324,195.00 7 | Sole Dispositive Power 0.00 8 | Shared Dispositive Power 324,195.00"
Shared voting power occurs when two or more parties jointly have the right to vote or decide how a block of company shares is cast, like co-owners who must agree before moving a piece of furniture. Investors care because who controls voting rights affects board elections, major corporate decisions and takeover outcomes, and shared control can alter regulatory disclosures and the practical influence any holder has over a company’s direction and value.
shared dispositive powerfinancial
"6 | Shared Voting Power 324,195.00 7 | Sole Dispositive Power 0.00 8 | Shared Dispositive Power 324,195.00"
warrantsfinancial
"Includes 115,000 shares of Common Stock issuable upon exercise of warrants directly held by ACP"
Warrants are special documents that give you the right to buy a company's stock at a set price before a certain date. They are often used as a way for companies to attract investors or raise money, and their value can increase if the company's stock price goes up.
investment managerfinancial
"Adage Capital Management, L.P., a Delaware limited partnership, as the investment manager of Adage Capital Partners, L.P."
FAQ
What percentage of Monopar Therapeutics (MNPR) does Adage Capital report owning?
Adage Capital and related reporting persons report beneficial ownership of 4.76% of Monopar Therapeutics’ common stock. This percentage is based on 6,699,062 shares outstanding as of April 30, 2026, as cited from the company’s Form 10-Q.
How many Monopar (MNPR) shares are reported as beneficially owned by Adage Capital?
The reporting persons state beneficial ownership of 324,195 shares of Monopar common stock. This total includes both currently outstanding shares and 115,000 shares issuable upon exercise of warrants held by Adage Capital Partners, L.P.
How many Monopar (MNPR) shares in Adage Capital’s position come from warrants?
The position includes 115,000 shares of Monopar common stock issuable upon exercise of warrants. These warrant shares are part of the total 324,195 shares of beneficial ownership reported by the Adage-related reporting persons.
What voting and dispositive powers do the Adage reporting persons have over Monopar (MNPR) shares?
The reporting persons disclose 0 shares with sole voting or dispositive power and 324,195 shares with shared voting and shared dispositive power. All reported Monopar shares are therefore controlled on a shared, not sole, basis.
On what share count is Adage Capital’s 4.76% Monopar (MNPR) ownership based?
The stated 4.76% ownership is calculated using 6,699,062 shares of common stock outstanding as of April 30, 2026. This outstanding share figure is referenced from Monopar’s Form 10-Q for the quarter ended March 31, 2026.
Who are the reporting persons in the Monopar (MNPR) Schedule 13G/A filing?
The filing identifies Adage Capital Management, L.P., Robert Atchinson, and Phillip Gross as the reporting persons. Adage Capital Partners, L.P. directly holds the Monopar securities, with Adage Capital Management acting as its investment manager.
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 2)
Monopar Therapeutics Inc.
(Name of Issuer)
Common Stock, par value $0.001 per share
(Title of Class of Securities)
61023L207
(CUSIP Number)
06/30/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
61023L207
1
Names of Reporting Persons
Adage Capital Management, L.P.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
324,195.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
324,195.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
324,195.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
4.76 %
12
Type of Reporting Person (See Instructions)
IA, PN
Comment for Type of Reporting Person: Includes 115,000 shares of Common Stock (as defined in Item 2(a)) issuable upon exercise of warrants.
SCHEDULE 13G
CUSIP Number(s):
61023L207
1
Names of Reporting Persons
Robert Atchinson
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
324,195.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
324,195.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
324,195.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
4.76 %
12
Type of Reporting Person (See Instructions)
HC, IN
Comment for Type of Reporting Person: Includes 115,000 shares of Common Stock issuable upon exercise of warrants.
SCHEDULE 13G
CUSIP Number(s):
61023L207
1
Names of Reporting Persons
Phillip Gross
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
324,195.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
324,195.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
324,195.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
4.76 %
12
Type of Reporting Person (See Instructions)
HC, IN
Comment for Type of Reporting Person: Includes 115,000 shares of Common Stock issuable upon exercise of warrants.
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
Monopar Therapeutics Inc.
(b)
Address of issuer's principal executive offices:
1000 Skokie Blvd., Suite 350, Wilmette, IL 60091
Item 2.
(a)
Name of person filing:
This statement is filed by:
(i) Adage Capital Management, L.P., a Delaware limited partnership ("ACM"), as the investment manager of Adage Capital Partners, L.P., a Delaware limited partnership ("ACP"), with respect to the shares of common stock, par value $0.001 per share ("Common Stock"), of Monopar Therapeutics Inc., a Delaware corporation (the "Company"), and shares of Common Stock issuable upon exercise of warrants directly held by ACP;
(ii) Robert Atchinson ("Mr. Atchinson"), as (1) managing member of Adage Capital Advisors, L.L.C., a limited liability company organized under the laws of the State of Delaware ("ACA"), managing member of Adage Capital Partners GP, L.L.C., a limited liability company organized under the laws of the State of Delaware ("ACPGP"), general partner of ACP and (2) managing member of Adage Capital Partners LLC, a Delaware limited liability company ("ACPLLC"), general partner of ACM, with respect to the shares of Common Stock and shares of Common Stock issuable upon exercise of warrants directly held by ACP; and
(iii) Phillip Gross ("Mr. Gross"), as (1) managing member of ACA, managing member of ACPGP and (2) managing member of ACPLLC, general partner of ACM, with respect to the shares of Common Stock and shares of Common Stock issuable upon exercise of warrants directly held by ACP.
The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." Any disclosures herein with respect to persons other than the Reporting Persons are made on information and belief after making inquiry to the appropriate party.
The filing of this statement should not be construed in and of itself as an admission by any Reporting Person as to beneficial ownership of the securities reported herein.
(b)
Address or principal business office or, if none, residence:
The address of the business office of each of the Reporting Persons is 200 Clarendon Street, 52nd Floor, Boston, Massachusetts 02116.
(c)
Citizenship:
ACM is a limited partnership organized under the laws of the State of Delaware. Messrs. Gross and Atchinson are citizens of the United States.
(d)
Title of class of securities:
Common Stock, par value $0.001 per share
(e)
CUSIP No.:
61023L207
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference.
The percentage set forth in this Schedule 13G is calculated based upon an aggregate of 6,699,062 shares of Common Stock outstanding as of April 30, 2026, as reported in the Company's Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2026, filed with the Securities and Exchange Commission on May 14, 2026, and assumes the exercise of the warrants held by ACP.
(b)
Percent of class:
4.76%
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference.
(ii) Shared power to vote or to direct the vote:
The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference.
(iii) Sole power to dispose or to direct the disposition of:
The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference.
(iv) Shared power to dispose or to direct the disposition of:
The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference.
Item 5.
Ownership of 5 Percent or Less of a Class.
Ownership of 5 percent or less of a class
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
See Item 2(a).
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
Not Applicable
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Adage Capital Management, L.P.
Signature:
/s/ Robert Atchinson
Name/Title:
By: Adage Capital Partners LLC, its General Partner, By: Robert Atchinson, its Managing Member
