Welcome to our dedicated page for Intellia Therape SEC filings (Ticker: NTLA), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
The Intellia Therapeutics, Inc. (NASDAQ: NTLA) SEC filings page on Stock Titan provides access to the company’s regulatory disclosures, including Current Reports on Form 8-K that detail material events in its clinical and corporate development. As a clinical-stage gene editing company, Intellia uses SEC filings to report key information about its CRISPR-based programs, financial results and significant regulatory interactions.
Recent 8-K filings furnished by Intellia describe positive Phase 1 and Phase 1/2 data for its investigational in vivo CRISPR therapies, nexiguran ziclumeran (nex-z) for transthyretin (ATTR) amyloidosis and lonvoguran ziclumeran (lonvo-z) for hereditary angioedema (HAE). These filings summarize trial designs, patient numbers, biomarker reductions, clinical outcome measures and safety observations over multi-year follow-up. Other 8-Ks discuss the initiation and status of global Phase 3 trials such as MAGNITUDE, MAGNITUDE-2 and HAELO, as well as the FDA’s clinical hold on the MAGNITUDE programs for nex-z.
Intellia also uses Form 8-K to furnish quarterly financial results, including collaboration revenue, research and development expenses, general and administrative expenses and cash, cash equivalents and marketable securities. Additional filings report equity inducement grants made under the company’s 2024 Inducement Plan pursuant to Nasdaq Listing Rule 5635(c)(4), and changes involving senior executives.
On Stock Titan, these SEC filings are updated in near real time from EDGAR and can be paired with AI-powered summaries that highlight the most important points in dense regulatory documents. Users can quickly understand the implications of Intellia’s 8-K disclosures, track the evolution of its nex-z and lonvo-z programs, and monitor material events that may affect NTLA’s risk profile and development timeline.
Intellia Therapeutics (NTLA) reported an FDA clinical hold on the Investigational New Drug applications for its MAGNITUDE and MAGNITUDE‑2 Phase 3 trials of nexiguran ziclumeran (nex‑z). The company was verbally informed on October 29, 2025, and the FDA indicated it will issue a formal Clinical Hold Letter within 30 calendar days.
The hold follows a previously disclosed patient case with Grade 4 liver transaminases and increased total bilirubin in the MAGNITUDE trial. On October 27, 2025, Intellia had already paused dosing and screening in both Phase 3 studies under the trial’s protocol‑defined pausing criteria. Intellia stated it intends to work with the FDA to address the hold as expeditiously as possible.
Intellia Therapeutics temporarily paused dosing and screening in its Phase 3 MAGNITUDE (ATTR-CM) and MAGNITUDE-2 (ATTRv-PN) trials of nexiguran ziclumeran (nex-z) after a safety event met protocol-defined pausing criteria.
The action follows an October 24 report of Grade 4 liver transaminases and increased total bilirubin in a patient dosed on September 30 in MAGNITUDE. More than 650 patients with ATTR-CM are enrolled in MAGNITUDE and 47 patients with ATTR-PN are enrolled in MAGNITUDE-2; over 450 patients are estimated to have been dosed with nex-z. The company furnished a press release as Exhibit 99.1 and included standard forward-looking statements regarding the ability to resume and complete these studies.
Intellia Therapeutics (NTLA) reported an insider transaction by its EVP and Chief Scientific Officer. On October 1, 2025, the officer executed a mandatory sell-to-cover of 31 shares of common stock at $17.38 to satisfy tax withholding upon RSU vesting, which the filing notes was not a voluntary trade.
Following the transaction, the officer directly beneficially owned 105,184 shares of Intellia common stock.
Michael P. Dube, Vice President and Chief Accounting Officer of Intellia Therapeutics, Inc. (NTLA), reported a Form 4 disclosing a mandatory tax-withholding sale related to RSU vesting. On 10/01/2025 the reporting person had 1,871 shares sold (transaction code S(1)) at $17.38 per share to satisfy tax withholding obligations arising from RSU vesting. After the sale, the reporting person beneficially owned 55,266 shares. The Form 4 was signed by an attorney-in-fact and dated 10/03/2025. The filing describes the sale as non-volitional and linked solely to tax withholding.
Intellia Therapeutics reported interim clinical data for its in vivo CRISPR gene editing therapy "nex-z" (NTLA-2001) in hereditary transthyretin (ATTR) amyloidosis with polyneuropathy. In an open-label Phase 1 study, a one-time dose at or above 0.3 mg/kg (n=33) produced a mean serum TTR reduction of 92% at 24 months, corresponding to a mean absolute TTR level of 17.3 µg/mL (95% CI 12.5–22.2). Among 12 patients followed to 36 months, mean reduction was 90% with a mean absolute level of 20 µg/mL (95% CI 11.2–28.8).
Clinical measures such as quality-of-life for diabetic neuropathy (QoL-DN) and neurofilament light chain (NfL) trended toward improvement, and 89% of patients showed improvement or stability in PND scores through 24 months versus baseline. The filing also reiterates standard development and collaboration risks, including regulatory and development uncertainties and reliance on partners.
William J. Chase, a director of Intellia Therapeutics, Inc. (NTLA), reported an open-market purchase of 100,000 shares of the issuer's common stock on 08/20/2025. The shares were bought in accordance with the company's trading policies at a weighted average price of $10.03, with transaction prices ranging from $9.97 to $10.04. Following the purchase, the reporting person beneficially owned 134,693 shares. The Form 4 was filed as a single-person report and signed by attorney-in-fact James Basta on 08/22/2025.
Intellia Therapeutics (NTLA) filed an 8-K current report dated 7 Aug 2025 covering two disclosure items.
- Item 2.02 – Results of Operations: The company furnished a press release (Ex. 99.1) announcing Q2 2025 financial results and business updates for the period ended 30 Jun 2025. Specific revenue, EPS or guidance figures are not included in the filing; the information is furnished, not filed, and may be incorporated into future SEC filings only if explicitly referenced.
- Item 5.02 – Executive Change: Executive Vice President & Chief Medical Officer Dr. David Lebwohl, M.D. will retire effective 7 Aug 2026. He will remain CMO until a successor is appointed and stay employed through the retirement date. Upon departure, his equity awards will follow the terms of the company’s Amended & Restated Retirement Policy (filed as Ex. 10.30 to the 2022 10-K).
No other material events, financial tables, or strategic transactions are disclosed in this report.