Welcome to our dedicated page for Nuvalent SEC filings (Ticker: NUVL), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
Nuvalent, Inc. filings document a clinical-stage oncology company developing small-molecule inhibitors for clinically proven kinase targets. Its Form 8-K reports disclose operating and financial results, pipeline and clinical-trial updates for zidesamtinib and neladalkib, FDA submission events, material-event disclosures, and royalty or revenue-share arrangements for its investigational product candidates.
Proxy materials cover annual meeting governance, executive compensation, equity awards, and shareholder voting matters. Other disclosures describe Nuvalent's Class A common stock, capital-structure matters, research and development spending, cash resources, and regulatory considerations associated with advancing ROS1-, ALK-, and HER2-directed cancer programs.
Nuvalent, Inc. filed a current report describing a key regulatory milestone for its lead oncology program. On September 22, 2025, the company completed submission of a New Drug Application to the U.S. Food and Drug Administration for zidesamtinib as a treatment for tyrosine kinase inhibitor pre-treated patients with advanced ROS1-positive non-small cell lung cancer. This step means Nuvalent has finished providing the clinical and other data the agency needs to begin its formal review of the drug candidate for this specific patient group.
Nuvalent, Inc. filed a current report describing a key regulatory milestone for its lead oncology program. On September 22, 2025, the company completed submission of a New Drug Application to the U.S. Food and Drug Administration for zidesamtinib as a treatment for tyrosine kinase inhibitor pre-treated patients with advanced ROS1-positive non-small cell lung cancer. This step means Nuvalent has finished providing the clinical and other data the agency needs to begin its formal review of the drug candidate for this specific patient group.
Nuvalent, Inc. (NUVL) insider Form 4: James R. Porter, President and CEO and a director, reported transactions on 09/15/2025 effected under a Rule 10b5-1 trading plan. He acquired a stock option for 27,000 shares at an exercise price of $18.93 and simultaneously sold 27,000 shares in three tranches: 8,823 shares at a weighted average price of $78.42, 16,080 shares at $79.30, and 2,097 shares at $80.12. After these transactions the reporting person beneficially owned 249,062 shares of Class A common stock and held options covering 27,000 shares (report shows 249,400 derivative securities beneficially owned following the transactions). The filing was signed by attorney-in-fact Nathan McConarty on 09/17/2025.
Nuvalent, Inc. (NUVL) insider Form 4: James R. Porter, President and CEO and a director, reported transactions on 09/15/2025 effected under a Rule 10b5-1 trading plan. He acquired a stock option for 27,000 shares at an exercise price of $18.93 and simultaneously sold 27,000 shares in three tranches: 8,823 shares at a weighted average price of $78.42, 16,080 shares at $79.30, and 2,097 shares at $80.12. After these transactions the reporting person beneficially owned 249,062 shares of Class A common stock and held options covering 27,000 shares (report shows 249,400 derivative securities beneficially owned following the transactions). The filing was signed by attorney-in-fact Nathan McConarty on 09/17/2025.
Form 144 notice shows an insider sale filing for Nuvalent, Inc. (NUVL). The filer intends to sell 6,158 common shares through Morgan Stanley Smith Barney on the NASDAQ with an aggregate market value of $484,819.34. Those 6,158 shares were acquired the same day (09/10/2025) by exercising stock options and paid for in cash. The filing reports that 23,945 shares were sold over the prior three months under a mix of 10b5-1 plans and direct sales, generating total gross proceeds of $1,888,286.34. The seller identified in the filing is Henry E. Pelish. The form includes the standard signature representation that the seller is not aware of any undisclosed material adverse information.
Nuvalent, Inc. (NUVL) Form 4: Henry E. Pelish, the company’s Chief Scientific Officer, reported transactions dated 08/29/2025 that increased his direct holdings. The filing shows two non-derivative additions of 2,007 and 3,000 shares of Class A common stock at reported prices of $0.87 and $1.08, raising his beneficial ownership from 62,963 to 65,963 shares. Corresponding derivative entries show stock options for 2,007 shares exercisable through 12/15/2030 and 3,000 shares exercisable through 02/16/2031. The filer discloses the underlying option shares are fully vested. The submission is signed via attorney-in-fact Nathan N. McConarty on 09/03/2025.
Nuvalent insider transactions by Chief Development Officer Darlene Noci: The filing shows an option exercise and contemporaneous open-market sales done under a Rule 10b5-1 plan. The reporting person exercised a stock option to acquire 4,000 shares at $27.85 on 08/25/2025. On the same date she sold a total of 4,000 Class A shares in multiple transactions at weighted-average prices of $73.96, $74.93, and $75.63, reducing her direct Class A holdings from 52,034 to 48,034 shares. The Form 4 notes the 10b5-1 trading plan was adopted on November 18, 2024, and the reporting person will provide transaction-level sale prices on request.
James R. Porter, President and CEO and a director of Nuvalent, Inc. (NUVL), reported multiple transactions on 08/15/2025 under a pre-existing Rule 10b5-1 trading plan adopted April 2, 2024. He acquired 27,000 shares by exercising stock options at an $18.93 exercise price and simultaneously sold 27,000 shares across three blocks (20,035; 6,865; 100) at weighted average prices of approximately $75.22, $75.98, and $76.90, respectively.
Following these transactions his beneficial ownership of Class A common stock decreased from 276,062 to 249,062 shares. The option underlying the 27,000 shares vests per the grant schedule with an expiration date of 01/04/2032. The filing was signed by an attorney-in-fact on 08/19/2025.
Nuvalent insider activity: option exercises and a planned sale under a 10b5-1 plan. Henry E. Pelish, Nuvalent's Chief Scientific Officer, acquired shares through option exercises and sold shares pursuant to a pre-established trading plan. On 08/07/2025 Pelish exercised options to acquire 731 shares at $18.93, 877 shares at $27.85 and 3,892 shares at $29.33, and sold 5,500 shares at $74.85. After these transactions his reported direct beneficial ownership is 60,956 shares. The filing notes the trades were effected under a Rule 10b5-1 plan adopted November 1, 2024, and includes vesting schedules for the options.