Welcome to our dedicated page for OnKure Therapeutics SEC filings (Ticker: OKUR), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
The SEC filings page for OnKure Therapeutics, Inc. (OKUR) provides access to the company’s official regulatory disclosures as a clinical-stage biopharmaceutical issuer listed on the Nasdaq Global Market. These documents offer detailed information about its precision oncology programs, financial condition, and capital markets activities, complementing the high-level descriptions found in press releases.
Through its periodic reports on Forms 10-K and 10-Q, OnKure describes its focus on discovering and developing precision medicines that target biologically validated drivers of cancers underserved by current therapies. These filings expand on the company’s strategy around PI3Kα-targeted programs, including its lead candidate OKI-219 and its PI3Kα pan-mutant and other discovery-stage efforts, and include sections such as “Risk Factors” that outline scientific, clinical, regulatory, and financial risks.
Current reports on Form 8-K capture material events between periodic filings. For example, OnKure has filed 8-Ks to report quarterly financial results and to disclose entry into a sales agreement with Leerink Partners LLC for an at-the-market offering program of its Class A common stock. That agreement allows the company, subject to specified parameters and an effective shelf registration statement on Form S-3, to sell shares through Leerink Partners acting as sales agent, with compensation based on a percentage of gross proceeds.
On this page, users can review new and historical SEC filings, including 10-K annual reports, 10-Q quarterly reports, 8-K current reports, and registration statements such as Form S-3 referenced in the at-the-market program. Stock Titan’s tools apply AI-powered summaries to help explain the contents of lengthy filings, highlight key items like clinical development updates, capital raising arrangements, and risk disclosures, and make it easier to track how OnKure’s regulatory narrative evolves over time.
OnKure Therapeutics reports beneficial ownership disclosures by ADAR1-related holders. ADAR1 Capital Management, LLC is reported to beneficially own 1,014,158 shares of Class A common stock, representing 7.9% of the class, based on 12,861,672 shares outstanding as of November 5, 2025. The holdings include 793,602 shares held by ADAR1 Partners, LP, 119,064 shares held by Spearhead Insurance Solutions IDF, LLC and 101,492 shares held by separately managed accounts, all reported as of December 31, 2025.
ADAR1 Capital Management GP, LLC is shown with 793,602 shares (6.2%) and Daniel Schneeberger is reported to indirectly beneficially own 1,014,158 shares (7.9%) through his managerial roles. The filing is a joint Schedule 13G with a joint filing agreement and signatures dated 02/17/2026.
Citadel-affiliated investment entities and Kenneth Griffin report a passive minority stake in OnKure Therapeutics, Inc. They may be deemed to beneficially own 223,125 Class A common shares, representing 1.7% of the company’s outstanding stock based on 12,861,672 shares outstanding as of November 18, 2025.
Citadel Advisors LLC, Citadel Advisors Holdings LP and Citadel GP LLC each may be deemed to beneficially own 48,957 shares, while Citadel Securities LLC, Citadel Securities Group LP and Citadel Securities GP LLC each may be deemed to beneficially own 174,168 shares. The reporting group certifies the holdings are not for the purpose of changing or influencing control of OnKure.
OnKure Therapeutics, Inc. received an updated ownership report from Highbridge Capital Management, LLC, filed as Amendment No. 1 to a Schedule 13G. Highbridge, a Delaware investment adviser, reports beneficial ownership of 542,361 shares of OnKure’s Class A common stock.
This stake represents 4.2% of the outstanding Class A common stock, based on 12,861,672 shares outstanding as of November 5, 2025 as disclosed in OnKure’s Form 10-Q for the quarter ended September 30, 2025. Highbridge has sole voting and dispositive power over these shares and certifies they are held in the ordinary course of business, not to change or influence control of the company.
OnKure Therapeutics Inc received an updated institutional ownership report from The Vanguard Group, which beneficially owns 626,593 shares of OnKure common stock, representing 4.87% of the class as of the reported date. Vanguard reports no sole voting or dispositive power, but shared voting power over 44,116 shares and shared dispositive power over all 626,593 shares.
The filing notes that, following an internal realignment on January 12, 2026, certain Vanguard subsidiaries or divisions are expected to report beneficial ownership separately while pursuing the same investment strategies. Vanguard states the securities are held in the ordinary course of business for its clients and not to change or influence control of OnKure.
OnKure Therapeutics, Inc. is registering 1,507,685 shares of its Class A common stock for resale by investors who bought these shares in an October 4, 2024 private PIPE financing. This is a secondary offering only, so all sale proceeds will go to the selling securityholders, while OnKure will cover registration and listing expenses.
The shares may be sold from time to time by the selling securityholders using various methods, including market and privately negotiated transactions, at market or negotiated prices. OnKure’s Class A common stock trades on Nasdaq under the symbol “OKUR,” and the last reported sale price on November 20, 2025 was $2.62.
As context, there were 12,861,672 shares of Class A common stock and 686,527 shares of non-voting Class B common stock outstanding as of September 30, 2025. Class B shares are convertible into Class A shares subject to a beneficial ownership cap that initially limits holders to 9.9% of outstanding Class A shares.
OnKure Therapeutics, Inc. (OKUR) filed Post‑Effective Amendment No. 2 converting its prior S‑1 to Form S‑3 and registering the resale of 1,507,685 shares of Class A common stock. These shares were issued in an October 4, 2024 private placement (PIPE) and are being registered to satisfy previously granted registration rights.
The company will not receive proceeds from sales by the selling securityholders; it will bear customary registration expenses. The selling securityholders may sell from time to time using various methods and prices as described under “Plan of Distribution.” Shares outstanding were 12,861,672 Class A and 686,527 Class B as of September 30, 2025. On Nasdaq, OKUR last quoted a sale price of $3.00 on November 5, 2025. No additional securities are being registered, and prior filing fees cover this amendment.
OnKure Therapeutics (OKUR) filed an S-3 shelf to offer up to $200,000,000 of securities and established an at‑the‑market program for up to $15,986,792 of Class A Common Stock, to be sold from time to time after effectiveness.
The ATM is included within the $200,000,000 shelf and may be executed through Leerink Partners as sales agent or principal, with compensation of up to 3% of gross proceeds. Sales may occur on Nasdaq or other permitted markets using methods defined as an “at the market offering” under Rule 415(a)(4). OnKure’s Class A Common Stock trades on the Nasdaq Global Market under “OKUR.”
Under General Instruction I.B.6, the company states it will not sell more than one‑third of the aggregate market value of non‑affiliate common stock in any 12‑month period while public float is below $75,000,000, and notes no I.B.6 sales in the prior 12 months. The base prospectus covers multiple securities (common, preferred, debt, depositary shares, warrants, subscription rights, purchase contracts, and units), with specific terms and use of proceeds to be set in future supplements.
OnKure Therapeutics, Inc. filed a prospectus supplement registering the resale of 2,938,005 shares of Class A Common Stock previously issued in a PIPE financing. The supplement updates the prospectus dated March 21, 2025 and must be read together with it. The prospectus also covers any additional securities issuable due to stock splits, stock dividends, or similar events.
The company attached its latest Quarterly Report on Form 10-Q and a Current Report on Form 8-K. As of November 5, 2025, shares outstanding were 12,861,672 for Class A common stock and 686,527 for Class B common stock. For the quarter ended September 30, 2025, cash and cash equivalents were $70.3 million, and net loss was $14.7 million, reflecting continued R&D investment as OKI-219 advances in a first-in-human Phase 1a/1b trial. Management states cash resources are sufficient to fund the current operating plan for at least the next 12 months from the financial statement issuance date.
OnKure Therapeutics (OKUR) entered a Sales Agreement with Leerink Partners to sell Class A common stock from time to time through an at‑the‑market offering. The company will direct sale parameters, and Leerink Partners will act as sales agent.
Leerink Partners will receive up to 3.0% of gross proceeds from shares sold under the program. OnKure has no obligation to sell and may suspend sales at any time. Either party may terminate the agreement on 10 days’ notice, with additional immediate termination rights under certain conditions. Sales will be made under a Form S‑3 shelf and its prospectus supplement and no sales may occur until the registration statement becomes effective.