| UNITED STATES |
| SECURITIES AND EXCHANGE COMMISSION |
| Washington, D.C. 20549 |
| Notice of Effectiveness |
| Effectiveness Date: |
November 18,
2025 |
| Accession Number: |
0001193125-25-270150 |
| Submission Type: |
POS AM |
| CIK: |
0001637715 |
| Company Name: |
OnKure Therapeutics, Inc. |
| File Number: |
333-282792 |
|
