OPKO Health (NASDAQ: OPK) director reports initial common stock holdings

Rhea-AI Filing Summary

OPKO HEALTH, INC. director Dr. Uppaluri Subbarao V filed an initial Form 3 reporting his ownership of the company’s common stock. He reports direct ownership of 622,817 shares and several indirect interests through family-related entities and trusts.

One indirect position is held by Uppaluri Investments, LLC, which is owned equally by the Uppaluri 2012 Family Trust and the Ajay Uppaluri 2020 Gift Trust. Additional indirect holdings are reported through the 2020 Trust and shares owned by his spouse. For each of these indirect positions, Dr. Uppaluri disclaims beneficial ownership except to the extent of his pecuniary interest.

Insider Trade Summary

4 transactions reported

Mixed 4 txns

Insider UPPALURI SUBBARAO V

Role Director

Type	Security	Shares	Price	Value
holding	Common Stock	--	--	--
holding	Common Stock	--	--	--
holding	Common Stock	--	--	--
holding	Common Stock	--	--	--

Holdings After Transaction: Common Stock — 622,817 shares (Direct); Common Stock — 2,000,000 shares (Indirect, See Footnote)

Footnotes (1)

1. Uppaluri Investments, LLC ("Uppaluri Investments"), owns these shares. Dr. Uppaluri is the Manager of Uppaluri Investments. Each of the Uppaluri 2012 Family Trust ("2012 Trust") and the Ajay Uppaluri 2020 Gift Trust ("2020 Trust") owns 50% of Uppaluri Investments. The 2012 Trust is for the benefit of Dr. Uppaluri's spouse, Anita Uppaluri, and she is the trustee. The 2020 Trust is for the benefit of Dr. Uppaluri's son, Ajay Uppaluri, and Dr. Uppaluri and his spouse are co-trustees. Dr. Uppaluri disclaims beneficial ownership of the shares held by Uppaluri Investments except to the extent of his pecuniary interest therein. The shares are owned by the 2020 Trust, which is for the benefit of Ajay Uppaluri. Dr. Uppaluri and his spouse are co-trustees. Dr. Uppaluri disclaims beneficial ownership of the shares held by the 2020 Trust, except to the extent of his pecuniary interest therein. The shares are owned by Dr. Uppaluri's spouse. Dr. Uppaluri disclaims beneficial ownership of the shares held by his spouse, except to the extent of his pecuniary interest therein.

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SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0104
Estimated average burden
hours per response:			0.5

1. Name and Address of Reporting Person^*

UPPALURI SUBBARAO V

(Last) (First) (Middle)

OPKO HEALTH, INC.

4400 BISCAYNE BLVD.

(Street)

MIAMI FLORIDA 33137

(City) (State) (Zip)

UNITED STATES

(Country)

2. Date of Event Requiring Statement (Month/Day/Year)
03/18/2026

3. Issuer Name and Ticker or Trading Symbol
OPKO HEALTH, INC. [ OPK ]

3a. Foreign Trading Symbol

5. If Amendment, Date of Original Filed (Month/Day/Year)

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	622,817	D
Common Stock	2,000,000	I	See Footnote(1)
Common Stock	500,000	I	See Footnore(2)
Common Stock	36,000	I	See Footnote(3)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Uppaluri Investments, LLC ("Uppaluri Investments"), owns these shares. Dr. Uppaluri is the Manager of Uppaluri Investments. Each of the Uppaluri 2012 Family Trust ("2012 Trust") and the Ajay Uppaluri 2020 Gift Trust ("2020 Trust") owns 50% of Uppaluri Investments. The 2012 Trust is for the benefit of Dr. Uppaluri's spouse, Anita Uppaluri, and she is the trustee. The 2020 Trust is for the benefit of Dr. Uppaluri's son, Ajay Uppaluri, and Dr. Uppaluri and his spouse are co-trustees. Dr. Uppaluri disclaims beneficial ownership of the shares held by Uppaluri Investments except to the extent of his pecuniary interest therein.

2. The shares are owned by the 2020 Trust, which is for the benefit of Ajay Uppaluri. Dr. Uppaluri and his spouse are co-trustees. Dr. Uppaluri disclaims beneficial ownership of the shares held by the 2020 Trust, except to the extent of his pecuniary interest therein.

3. The shares are owned by Dr. Uppaluri's spouse. Dr. Uppaluri disclaims beneficial ownership of the shares held by his spouse, except to the extent of his pecuniary interest therein.

	/s/ Subbarao V. Uppaluri	03/20/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 3: SEC 1473 (03-26)

FAQ

What does OPKO Health (OPK) director Uppaluri Subbarao report on his Form 3?

He reports initial ownership of OPKO Health common stock, including 622,817 shares held directly and additional indirect holdings through family-related entities and trusts. The filing establishes his baseline ownership position as a director as of the reported date.

How many OPKO Health (OPK) shares does Dr. Uppaluri hold directly versus indirectly?

Dr. Uppaluri reports 622,817 OPKO Health common shares held directly. He also reports indirect positions through Uppaluri Investments, LLC, the Ajay Uppaluri 2020 Gift Trust, and shares owned by his spouse, while disclaiming beneficial ownership of those indirect holdings except for his pecuniary interest.

What is Uppaluri Investments, LLC in relation to OPKO Health (OPK) shares?

Uppaluri Investments, LLC holds OPKO Health common shares and is managed by Dr. Uppaluri. It is owned 50% by the Uppaluri 2012 Family Trust and 50% by the Ajay Uppaluri 2020 Gift Trust, both family trusts that ultimately benefit his spouse and son.

How does the Ajay Uppaluri 2020 Gift Trust relate to OPKO Health (OPK) stock?

The Ajay Uppaluri 2020 Gift Trust holds OPKO Health shares directly and also owns half of Uppaluri Investments, LLC. The trust is for the benefit of Ajay Uppaluri, with Dr. Uppaluri and his spouse serving as co-trustees, and Dr. Uppaluri disclaiming beneficial ownership except for his pecuniary interest.

Does Dr. Uppaluri fully own all indirectly reported OPKO Health (OPK) shares?

No. For shares held by Uppaluri Investments, LLC, the Ajay Uppaluri 2020 Gift Trust, and his spouse, Dr. Uppaluri disclaims beneficial ownership except to the extent of his pecuniary interest. This means his economic interest is limited and he does not claim full beneficial ownership.

Does this OPKO Health (OPK) Form 3 show any insider buying or selling?

No transaction codes or share amounts are reported as purchases or sales. The Form 3 serves as an initial statement of beneficial ownership, listing direct and indirect positions but not reporting new buy or sell transactions on the filing date.