Opko Health director buys 10,000 shares

Opko Health director John A. Paganelli bought 10,000 shares of common stock in an open-market purchase at $1.135 per share.

Accepted by SEC EDGAR 03/20/2026 - 04:25 PM EDT Learn about SEC filing dates

Rhea-AI Filing Summary

Opko Health director John A. Paganelli bought 10,000 shares of common stock in an open-market purchase at $1.135 per share. After this transaction, he directly holds 394,340 shares. An additional 9,175 shares are owned by his spouse, for which he disclaims beneficial ownership except for any pecuniary interest.

Insider Trade Summary

Net Buyer: 10,000 shares

Net Buy 1 txn

Insider PAGANELLI JOHN A

Role Director

Bought 10,000 shs ($11K)

Increase in Position 2.6%

Type	Security	Shares	Price	Value
Purchase	Common Stock	10,000	$1.135	$11K
Holding	Common Stock	--	--	--

Holdings After Transaction: Common Stock — 394,340 shares (Direct); Common Stock — 9,175 shares (Indirect, See Footnote)

Holdings Before and After: Common Stock, 384,340 to 394,340 shares (Direct)

Footnotes (1)

1. F1. These securities are owned by Mr. Paganelli's spouse. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purposes.

FAQ

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What insider transaction did Opko Health (OPK) director John A. Paganelli report?

John A. Paganelli reported buying 10,000 Opko Health common shares in the open market. The shares were purchased at $1.135 each, increasing his direct holdings to 394,340 shares according to the Form 4 insider trading report.

At what price did John A. Paganelli purchase Opko Health (OPK) shares?

Paganelli purchased 10,000 Opko Health common shares at $1.135 per share. This open-market transaction on the reported date reflects an insider buy, as disclosed in the Form 4 filing with the updated post-transaction share ownership.

How many Opko Health (OPK) shares does John A. Paganelli own after this Form 4?

After the purchase, Paganelli directly owns 394,340 Opko Health common shares. The Form 4 also notes 9,175 additional shares held by his spouse, for which he disclaims beneficial ownership except for any pecuniary interest.

Are there any indirect Opko Health (OPK) holdings reported for John A. Paganelli?

Yes, 9,175 Opko Health shares are reported as indirectly owned through his spouse. The filing states Paganelli disclaims beneficial ownership of these shares, except to the extent of any pecuniary interest, which is a standard Section 16 disclosure.

Was John A. Paganelli’s Opko Health (OPK) transaction a buy or a sell?

The Form 4 shows a buy transaction by John A. Paganelli. He executed an open-market purchase of 10,000 Opko Health common shares, with no reported sales, resulting in a net-buy position in this filing.

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SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

PAGANELLI JOHN A

(Last) (First) (Middle)

OPKO HEALTH, INC.

4400 BISCAYNE BLVD.

(Street)

MIAMI FLORIDA 33137

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
OPKO HEALTH, INC. [ OPK ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
03/20/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	03/20/2026		P		10,000	A	$1.135	394,340	D
Common Stock								9,175	I	See Footnote(1)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. These securities are owned by Mr. Paganelli's spouse. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of the securities for purposes of Section 16 or for any other purposes.

	Steven D. Rubin, Attorney-in-Fact	03/20/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)