[SCHEDULE 13D/A] PRECIGEN, INC. SEC Filing

Rhea-AI Filing Summary

Randal J. Kirk and related entities updated their Schedule 13D/A for Precigen, Inc. (PGEN). The filing discloses that on September 17, 2025 the R.J. Kirk Declaration of Trust converted 25,000 shares of 8.00% Series A Convertible Perpetual Preferred Stock into 17,385,257 shares of Common Stock. Between September 18–19, 2025, Kapital Joe, LLC (under common control) sold 5,000,252 shares in open-market transactions for approximately $18,648,905.62. The cover-page holdings show Mr. Kirk with beneficial ownership of 146,295,359 shares (39.4%), RJ DOT 98,831,434 shares (26.6%), Sunset 2020 LLC 16,406,828 shares (4.4%), and Third Security, LLC 27,454,284 shares (7.4%). The filing also notes exercisable warrants (16,666,667) and options (906,512) included in Mr. Kirk's beneficial ownership calculation and incorporates prior amendments.

Positive

• Conversion transparency: The filing clearly discloses conversion of Preferred Stock into 17,385,257 shares by RJ DOT.
• Full disclosure of sales: Kapital Joe's open-market sales of 5,000,252 shares for ~$18.65M are explicitly reported.
• Comprehensive ownership detail: Reporting pages disclose aggregate beneficial ownership and include exercisable warrants and options in calculations.

Negative

• Share dilution: The conversion and the filing note an increase in shares outstanding used for percentage calculations (company reported conversion of 54,937,411 shares overall), which dilutes existing holders.
• Affiliate sell-down: Kapital Joe's sale of 5.0M shares represents near-term monetization by a Kirk-controlled entity, reducing that affiliate's stake.

Insights

Financial Analyst

TL;DR: Kirk significantly increased reported common shares via conversion while a related entity sold 5.0M shares, modestly monetizing holdings.

The conversion of Preferred Stock into 17.4 million common shares materially increases Kirk-affiliated common shares outstanding and is disclosed as an investment action by RJ DOT. The near-term sale of 5.0 million shares by Kapital Joe generated about $18.65 million of proceeds, reducing that affiliate's stake. Beneficial ownership percentages reported reflect inclusion of convertible securities and exercisable warrants/options, which could further affect dilution if exercised. The filing is a standard 13D/A amendment providing transparency on ownership and recent transactions.

Corporate Governance Expert

TL;DR: The amendment transparently updates conversions and market sales but signals active disposition and potential future dilution from exercisable securities.

The Schedule 13D/A documents a conversion event and subsequent open-market sales by an affiliate under common control. Inclusion of 16,666,667 exercisable warrants and 906,512 options in the ownership calculation is notable for governance because exercise or conversion would change voting power and economic interest. The joint filing agreement and repeated amendments reflect ongoing reporting compliance by the Reporting Persons.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13D

Under the Securities Exchange Act of 1934

(Amendment No. 20)

PRECIGEN, INC.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

46122T102

(CUSIP Number)

Third Security, LLC
1881 Grove Avenue, Attention: April D. Jones
Radford, VA, 24141
5406337900

John Owen Gwathmey, Esq.
Troutman Pepper Locke Building, 1001 Haxall Point
Richmond, VA, 23219
8046971239

David I. Meyers, Esq.
Troutman Pepper Locke Building, 1001 Haxall Point
Richmond, VA, 23219
8046971239

Troutman Pepper Locke, LLP
Troutman Pepper Locke Building, 1001 Haxall Point
Richmond, VA, 23219
8046971239

(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)

09/17/2025

(Date of Event Which Requires Filing of This Statement)

If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

SCHEDULE 13D

CUSIP No. 46122T102

1

Name of reporting person

RANDAL J. KIRK

2

Check the appropriate box if a member of a Group (See Instructions)

(a)
(b)

3

SEC use only

4

Source of funds (See Instructions)

PF

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

6

Citizenship or place of organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 146,295,359.00
8	Shared Voting Power 0.00
9	Sole Dispositive Power 146,295,359.00
10	Shared Dispositive Power 0.00

11

Aggregate amount beneficially owned by each reporting person

146,295,359.00

12

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

13

Percent of class represented by amount in Row (11)

39.4 %

14

Type of Reporting Person (See Instructions)

IN

Comment for Type of Reporting Person:

The indicated amount of Common Stock beneficially owned by Mr. Kirk assumes the full conversion of (i) 25,000 shares of Preferred Stock, as that term is defined herein (ii) 906,512 Options to Purchase Common Stock, which are fully vested and exercisable at the discretion of Mr. Kirk, and (iii) 16,666,667 Warrants to Purchase Common Stock, which are fully vested and exercisable at the discretion of Mr. Kirk.

SCHEDULE 13D

CUSIP No. 46122T102

1

Name of reporting person

R.J. KIRK DECLARATION OF TRUST

2

Check the appropriate box if a member of a Group (See Instructions)

(a)
(b)

3

SEC use only

4

Source of funds (See Instructions)

PF

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

6

Citizenship or place of organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 98,831,434.00
8	Shared Voting Power 0.00
9	Sole Dispositive Power 98,831,434.00
10	Shared Dispositive Power 0.00

11

Aggregate amount beneficially owned by each reporting person

98,831,434.00

12

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

13

Percent of class represented by amount in Row (11)

26.6 %

14

Type of Reporting Person (See Instructions)

OO

Comment for Type of Reporting Person:

OO - trust; The indicated amount of Common Stock beneficially owned by RJ DOT assumes the full conversion of (i) 25,000 shares of Preferred Stock, as that term is defined herein and (ii) 16,666,667 Warrants to Purchase Common Stock, which are fully vested and exercisable at the discretion of Mr. Kirk.

SCHEDULE 13D

CUSIP No. 46122T102

1

Name of reporting person

SUNSET 2020 LLC

2

Check the appropriate box if a member of a Group (See Instructions)

(a)
(b)

3

SEC use only

4

Source of funds (See Instructions)

WC

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

6

Citizenship or place of organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 16,406,828.00
8	Shared Voting Power 0.00
9	Sole Dispositive Power 16,406,828.00
10	Shared Dispositive Power 0.00

11

Aggregate amount beneficially owned by each reporting person

16,406,828.00

12

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

13

Percent of class represented by amount in Row (11)

4.4 %

14

Type of Reporting Person (See Instructions)

OO

Comment for Type of Reporting Person:

OO - limited liability company

SCHEDULE 13D

CUSIP No. 46122T102

1

Name of reporting person

THIRD SECURITY, LLC

2

Check the appropriate box if a member of a Group (See Instructions)

(a)
(b)

3

SEC use only

4

Source of funds (See Instructions)

WC

5

Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

6

Citizenship or place of organization

VIRGINIA

Number of Shares Beneficially Owned by Each Reporting Person With:

7	Sole Voting Power 27,454,284.00
8	Shared Voting Power 0.00
9	Sole Dispositive Power 27,454,284.00
10	Shared Dispositive Power 0.00

11

Aggregate amount beneficially owned by each reporting person

27,454,284.00

12

Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

13

Percent of class represented by amount in Row (11)

7.4 %

14

Type of Reporting Person (See Instructions)

OO

Comment for Type of Reporting Person:

OO - limited liability company

SCHEDULE 13D

Item 1.	Security and Issuer
(a)	Title of Class of Securities: Common Stock
(b)	Name of Issuer: PRECIGEN, INC.
(c)	Address of Issuer's Principal Executive Offices: 20374 Seneca Meadows Parkway, Germantown, MARYLAND , 20876.
Item 1 Comment: This Amendment No. 20 (the "Amendment") amends and supplements the Statement on Schedule 13D, dated March 27, 2014 and filed on April 7, 2014, as amended by Amendment No. 1 dated December 31, 2014 and filed on January 5, 2015, by Amendment No. 2 dated May 31, 2016 and filed June 2, 2016, by Amendment No. 3 dated July 24, 2017 and filed July 26, 2017, by Amendment No. 4 dated October 16, 2017 and filed October 23, 2017, by Amendment No. 5 dated December 29, 2017 and filed on January 2, 2018, by Amendment No. 6 dated January 19, 2018 and filed January 22, 2018, by Amendment No. 7 dated July 3, 2018 and filed July 6, 2018, by Amendment No. 8 dated May 13, 2019 and filed May 15, 2019, by Amendment No. 9 dated May 24, 2019 and filed on May 24, 2019, by Amendment No. 10 dated June 6, 2019 and filed on June 10, 2019, by Amendment No. 11 dated January 1, 2020 and filed on January 6, 2020, by Amendment No. 12 dated January 31, 2020 and filed on February 4, 2020, by Amendment No. 13 dated August 11, 2020 and filed on August 13, 2020, by Amendment No. 14 dated December 17, 2020 and filed on December 21, 2020, by Amendment No. 15 dated October 6, 2022 and filed on October 7, 2022, by Amendment No. 16 dated January 27, 2023 and filed on January 31, 2023, by Amendment No. 17 dated May 2, 2024 and filed on May 3, 2024, by Amendment No. 18 dated August 9, 2024 and filed on August 13, 2024, and by Amendment No. 19 dated and filed on December 30, 2024 (the "Original Schedule 13D"), relating to the Common Stock, no par value per share (the "Common Stock"), of Precigen, Inc., formerly known as Intrexon Corporation, a Virginia corporation (the "Company"). Mr. Randal J. Kirk ("Mr. Kirk"), the R.J. Kirk Declaration of Trust, a revocable trust established by Mr. Kirk ("RJ DOT"), Third Security, LLC, a Virginia limited liability company that is controlled by Mr. Kirk ("Third Security"), and Sunset 2020 LLC, a Delaware limited liability company that is controlled by Mr. Kirk ("Sunset 2020" and, together with Mr. Kirk, the RJ DOT, and Third Security, the "Reporting Persons") are filing this Amendment to disclose (i) the receipt on September 17, 2025 of 17,385,257 shares of Common Stock by RJ DOT following the election to convert 25,000 shares of 8.00% Series A Convertible Perpetual Preferred Stock ("Preferred Stock"), which Preferred Stock was issued to RJ DOT pursuant to a Securities Purchase Agreement entered into by and between the Company and certain existing and new investors in a private placement transaction that closed on December 30, 2024 (the "Offering") and (ii) the sale of an aggregate of 5,000,252 shares of Common Stock by Kapital Joe, LLC, a Virginia limited liability company under the common control of Mr. Kirk ("Kapital Joe"), in open market transactions between September 18, 2025 and September 19, 2025.
Item 2.	Identity and Background
(a)	See Original Schedule 13D
(b)	See Original Schedule 13D
(c)	See Original Schedule 13D
(d)	See Original Schedule 13D
(e)	See Original Schedule 13D
(f)	See Original Schedule 13D
Item 4.	Purpose of Transaction
	Item 4 of the Original Schedule 13D is hereby amended and supplemented as follows: The information set forth in Items 3 and 6 is incorporated herein by reference. In the Offering, the Company issued 79,000 shares of Preferred Stock of the Company to certain new and existing investors, including RJ DOT, on the terms and conditions set forth in that certain Securities Purchase Agreement, filed as Exhibit 10.1 to the Company's Current Report on Form 8-K dated December 27, 2024 and filed on December 30, 2024. The Preferred Stock was convertible into shares of common stock of the Company (i) at the option of the holder at any time on or after the later of the six-month anniversary of the issue date and the date on which the issuer has, among other things, obtained shareholder approval, which requisite shareholder approval was obtained on June 26, 2025 and (ii) at an initial conversion price of approximately $1.125 per share, which conversion price was subject to upward adjustment based on the valuation of the common stock from time to time. On September 17, 2025, RJ DOT received 17,385,257 shares of Common Stock following its election to convert 25,000 shares of Preferred Stock. RJ DOT acquired these shares for investment purposes. Kapital Joe sold a total of 5,000,252 shares of Common Stock in open market transactions between September 18, 2025 and September 19, 2025, for aggregate net proceeds of approximately $18,648,905.62.
Item 5.	Interest in Securities of the Issuer
(a)	The responses to Items 11 and 13 of the cover pages, as well as the applicable comments thereto, to this Amendment No. 20 are incorporated herein. The percentage ownership is calculated based on 297,972,920 shares of Common Stock issued and outstanding as of August 8, 2025, as disclosed in the Company's Form S-3 Registration Statement dated and filed on August 19, 2025, increased by (i) 54,937,411 shares of Common Stock issued by the Company pursuant to the conversion of the Preferred Stock, as disclosed by the Company on its Form 8-K filed on September 17, 2025, of which Mr. Kirk received 17,385,257 shares of Common Stock issued to RJ DOT (ii) 16,666,667 shares of Common Stock issuable to Mr. Kirk upon exercise of Warrants to Purchase Common Stock, which are exercisable within sixty (60) days; (iii) 906,512 shares of Common Stock issuable to Mr. Kirk upon exercise of Options to Purchase Common Stock, which are exercisable within sixty (60) days, and (iv) 1,154,000 shares of Common Stock issued on September 12, 2025 to certain executive officers of the Company pursuant to vested Performance Stock Units, as reported by the Company in Forms 4 filed on September 16, 2025.
(b)	The responses to Items 7, 8, 9 and 10 of the cover pages to this Amendment No. 20 are incorporated herein.
(c)	Except as disclosed in the Original Schedule 13D and this Amendment No. 20, the Reporting Persons have not engaged in any transactions within the previous sixty (60) days.
(d)	Not applicable
(e)	Not applicable
Item 6.	Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer
	Item 6 of the Original Schedule 13D is hereby amended and supplemented to include the responses in Item 4 above.
Item 7.	Material to be Filed as Exhibits.
	Exhibit 1 Joint Filing Agreement, dated as of September 19, 2025, by and among Randal J. Kirk, R.J. Kirk Declaration of Trust, Sunset 2020 LLC, and Third Security, LLC.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

RANDAL J. KIRK

Signature:	/s/ Randal J. Kirk
Name/Title:	Randal J. Kirk
Date:	09/19/2025

R.J. KIRK DECLARATION OF TRUST

Signature:	/s/ Randal J. Kirk
Name/Title:	Randal J. Kirk Trustee
Date:	09/19/2025

SUNSET 2020 LLC

Signature:	/s/ Randal J. Kirk
Name/Title:	Randal J. Kirk Manager
Date:	09/19/2025

THIRD SECURITY, LLC

Signature:	/s/ Randal J. Kirk
Name/Title:	Randal J. Kirk Managing Member
Date:	09/19/2025

FAQ

What did Randal J. Kirk disclose in the PGEN Schedule 13D/A?

The filing discloses that RJ DOT converted 25,000 shares of Preferred Stock into 17,385,257 shares of Common Stock and that Kapital Joe sold 5,000,252 shares in the open market for approximately $18,648,905.62.

How much of Precigen (PGEN) does Mr. Kirk beneficially own after the amendment?

The cover page reports Mr. Kirk's beneficial ownership as 146,295,359 shares, representing 39.4% of the class based on the filing's calculation.

Are there additional convertible or exercisable securities disclosed for PGEN?

Yes. The filing includes 16,666,667 warrants and 906,512 options exercisable within 60 days that are included in Mr. Kirk's beneficial ownership calculation.

When were the conversion and the sales reported?

The conversion to RJ DOT occurred on September 17, 2025. Kapital Joe's open-market sales occurred between September 18 and September 19, 2025.

How were the proceeds from the Kapital Joe sales reported?

Kapital Joe sold 5,000,252 shares for aggregate net proceeds of approximately $18,648,905.62.