PRAXIS PRECISION MEDICINES INC. ownership disclosure: FMR LLC reports beneficial ownership of 2,156,343.22 shares of common stock, representing 7.7% of the class as of 03/31/2026. The filing states these shares are held on behalf of others and that no single other person holds more than 5% of the class.
Positive
None.
Negative
None.
Insights
FMR LLC holds a 7.7% stake in PRAXIS as of 03/31/2026.
FMR LLC reports beneficial ownership of 2,156,343.22 shares, a sizable passive stake for an investment-manager disclosure under Schedule 13G/A. The filing identifies holdings as being held on behalf of other persons, consistent with pooled investment vehicles.
Watch subsequent filings for any shift to an active 13D status or changes in percent held; timing not specified further in the excerpt.
Filing follows Schedule 13G/A disclosure conventions and includes a power-of-attorney signature.
The amendment includes a reference to an Exhibit 99 agreement and a power of attorney effective April 13, 2026, incorporated by reference. Signatures are dated 05/05/2026, showing timely amendment procedures.
Compliance considerations: confirm Exhibit 24 cross-reference and the 13d-1(k)(1) agreement in Exhibit 99 are on file for full attribution details.
Key Figures
Shares beneficially owned:2,156,343.22 sharesPercent of class:7.7%Sole dispositive power:2,156,343.22 shares
3 metrics
Shares beneficially owned2,156,343.22 sharesBeneficial ownership reported as of 03/31/2026
Percent of class7.7%Percent of common stock class as reported
Sole dispositive power2,156,343.22 sharesDispositive power reported on cover responses
Key Terms
Schedule 13G/A, beneficially owned, 13d-1(k)(1) agreement, power of attorney
4 terms
Schedule 13G/Aregulatory
"Amendment No. 1 PRAXIS PRECISION MEDICINES INC. COMMON STOCK"
A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.
Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.
13d-1(k)(1) agreementregulatory
"Please see Exhibit 99 for 13d-1(k) (1) agreement."
power of attorneylegal
"Duly authorized under Power of Attorney effective as of April 13, 2026"
A power of attorney is a legal document that allows one person to make decisions and act on behalf of another person, often in financial or legal matters. It’s like giving someone a trusted helper or agent the authority to handle important tasks if you are unable to do so yourself. This matters to investors because it can impact how their assets are managed or transferred if they become unable to oversee their affairs.
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 1)
PRAXIS PRECISION MEDICINES INC.
(Name of Issuer)
COMMON STOCK
(Title of Class of Securities)
74006W207
(CUSIP Number)
03/31/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
74006W207
1
Names of Reporting Persons
FMR LLC
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
2,152,365.75
6
Shared Voting Power
0.00
7
Sole Dispositive Power
2,156,343.22
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
2,156,343.22
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
7.7 %
12
Type of Reporting Person (See Instructions)
HC
SCHEDULE 13G
CUSIP Number(s):
74006W207
1
Names of Reporting Persons
Abigail P. Johnson
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
0.00
7
Sole Dispositive Power
2,156,343.22
8
Shared Dispositive Power
0.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
2,156,343.22
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
7.7 %
12
Type of Reporting Person (See Instructions)
IN
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
PRAXIS PRECISION MEDICINES INC.
(b)
Address of issuer's principal executive offices:
99 HIGH STREET, 30TH FLOOR,BOSTON,MA,USA,02110
Item 2.
(a)
Name of person filing:
FMR LLC
(b)
Address or principal business office or, if none, residence:
245 Summer Street, Boston, Massachusetts 02210
(c)
Citizenship:
Not applicable
(d)
Title of class of securities:
COMMON STOCK
(e)
CUSIP No.:
74006W207
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
2156343.22
(b)
Percent of class:
7.7 %
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
Please see the responses to Items 5 and 6 on the cover page.
(ii) Shared power to vote or to direct the vote:
0.00
(iii) Sole power to dispose or to direct the disposition of:
2156343.22
(iv) Shared power to dispose or to direct the disposition of:
0.00
Item 5.
Ownership of 5 Percent or Less of a Class.
Not Applicable
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
One or more other persons are known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the COMMON STOCK of PRAXIS PRECISION MEDICINES INC.. No one other person's interest in the COMMON STOCK of PRAXIS PRECISION MEDICINES INC. is more than five percent of the total outstanding COMMON STOCK.
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary.
See attached Exhibit 99.
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
FMR LLC
Signature:
Richard Bourgelas
Name/Title:
Duly authorized under Power of Attorney effective as of April 13, 2026, by and on behalf of FMR LLC and its direct and indirect subsidiaries*
Date:
05/05/2026
Abigail P. Johnson
Signature:
Richard Bourgelas
Name/Title:
Duly authorized under Power of Attorney effective as of April 13, 2026, by and on behalf of Abigail P. Johnson*
Date:
05/05/2026
Comments accompanying signature: *This power of attorney is incorporated herein by reference to Exhibit 24 to the Schedule 13G filed by FMR LLC on April 29,2026, accession number: 0000315066-26-000738.
FMR LLC reports beneficial ownership of 2,156,343.22 shares, equal to 7.7% of PRAX common stock as of 03/31/2026. The filing is an amended Schedule 13G/A reflecting that position.
Is FMR LLC acting on behalf of others in the PRAX filing?
Yes. The filing states the shares are held on behalf of other persons and lists beneficiaries implicitly; no single other person holds more than 5% of the class per the disclosure.
What documents are referenced in the Schedule 13G/A amendment?
The amendment references a power of attorney effective 04/13/2026 and an Exhibit 99 13d-1(k)(1) agreement; signatures are dated 05/05/2026, incorporated by reference.
Does the filing indicate FMR LLC has voting or dispositive power?
The cover-page entries show FMR LLC with 2,152,365.75 shares sole voting power and 2,156,343.22 shares sole dispositive power, according to the disclosed Item 5/6 responses.
When is the ownership position reported as of?
The ownership figures are reported with an as of date of 03/31/2026 at the top of the excerpt, per the disclosure.
