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Soleus affiliates report 5.2% stake in Prelude Therapeutics (NASDAQ: PRLD)

Filing Impact
(Neutral)
Filing Sentiment
(Neutral)
Form Type
SCHEDULE 13G

Rhea-AI Filing Summary

Prelude Therapeutics Inc disclosure: multiple Soleus-related entities and Guy Levy report aggregated ownership stakes in Prelude Therapeutics common stock. The filing lists 3,378,378 shares tied to Soleus Capital Management, L.P. and Soleus GP, LLC (each) representing 5.2% of the class, and 2,702,702 shares held by the Soleus Capital Master Fund, L.P. (representing 4.2%). The filing states 64,914,770 shares outstanding as of April 27, 2026 and includes footnotes where the reporting persons disclaim beneficial ownership of the shares held by the funds except for Section 13(d) purposes. The report is signed by Guy Levy on 07/08/2026.

Positive

  • None.

Negative

  • None.
Shares outstanding 64,914,770 shares as of April 27, 2026
Soleus Capital Management holdings 3,378,378 shares reported beneficially owned; labeled 5.2% of class
Soleus GP / Guy Levy holdings 3,378,378 shares reported aggregate for Soleus GP, LLC and Guy Levy (5.2%)
Master Fund holdings 2,702,702 shares Soleus Capital Master Fund, L.P.; labeled 4.2% of class
Soleus Private Equity Fund III holdings 675,676 shares reported beneficially owned; labeled 1.0% of class
Schedule 13G regulatory
"Item 1. | (a) | Name of issuer: Prelude Therapeutics Inc"
A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.
shared dispositive power financial
"Shared Dispositive Power 3,378,378.00"
beneficial ownership regulatory
"Each of ... disclaims beneficial ownership of these shares held by Soleus PE"
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
Section 13(d) regulatory
"disclaims beneficial ownership ... other than for the purpose of determining their obligations under Section 13(d)"
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FAQ

What stake does Soleus hold in Prelude Therapeutics (PRLD)?

Soleus-related entities report holdings including 3,378,378 shares (5.2%) for Soleus Capital Management and Soleus GP, LLC, and 2,702,702 shares (4.2%) for Soleus Capital Master Fund, L.P., as stated in the filing.

How many Prelude Therapeutics shares were outstanding when the percentages were calculated?

The filing cites 64,914,770 shares outstanding as of April 27, 2026, which the filing uses to compute the reported ownership percentages for the Soleus entities.

Does Guy Levy personally claim beneficial ownership of the reported shares?

Guy Levy is listed with an aggregate position of 3,378,378 shares (5.2%), but footnotes state that the reporting persons disclaim beneficial ownership of the shares held by the funds except for Section 13(d) purposes.

Which entities signed the Schedule 13G for Prelude Therapeutics?

The Schedule 13G was filed jointly by Soleus Private Equity Fund III, L.P.; Soleus Capital Master Fund, L.P.; affiliated Soleus entities; and is signed by Guy Levy as managing member on 07/08/2026.

How is voting and dispositive power reported for these holdings?

The filing reports 0 sole voting and dispositive power and lists the shared voting and shared dispositive powers tied to each entity (for example, 3,378,378 shared votes for Soleus Capital Management, L.P.).





74065P101

(CUSIP Number)
04/21/2026

(Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)




schemaVersion:


SCHEDULE 13G




Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Soleus Private Equity Fund III, L.P. ("Soleus PE"). Soleus Private Equity GP III, LLC ("Soleus PE GP") is the sole general partner of Soleus PE, Soleus PE GP III, LLC is the sole manager of Soleus PE GP, Soleus Capital Management, L.P. ("SCM ") is the investment manager for Soleus PE and for Soleus Capital Master Fund, L.P. ("Master Fund"), and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP III, LLC and of Soleus GP, LLC. Each of Mr. Levy, Soleus PE GP III, LLC, Soleus PE GP, SCM and Soleus GP, LLC disclaims beneficial ownership of these shares held by Soleus PE other than for the purpose of determining their obligations under Section 13(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage set forth in row 11 is calculated based upon 64,914,770 shares of voting common stock of Prelude Therapeutics Incorporated (the "Issuer") outstanding as of April 27, 2026, as reported in the proxy statement that was filed by the Issuer with the Securities and Exchange Commission on April 29, 2026 (the "Proxy").


SCHEDULE 13G




Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Soleus PE. Soleus PE GP is the sole general partner of Soleus PE, Soleus PE GP III, LLC is the sole manager of Soleus PE GP, SCM is the investment manager for Soleus PE and for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP III, LLC and of Soleus GP, LLC. Each of Mr. Levy, Soleus PE GP III, LLC, Soleus PE GP, SCM and Soleus GP, LLC disclaims beneficial ownership of these shares held by Soleus PE other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage set forth in row 11 is calculated based upon 64,914,770 shares of voting common stock of the Issuer outstanding as of April 27, 2026, as set forth in the Proxy.


SCHEDULE 13G




Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Soleus PE. Soleus PE GP is the sole general partner of Soleus PE, Soleus PE GP III, LLC is the sole manager of Soleus PE GP, SCM is the investment manager for Soleus PE and for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP III, LLC and of Soleus GP, LLC. Each of Mr. Levy, Soleus PE GP III, LLC, Soleus PE GP, SCM and Soleus GP, LLC disclaims beneficial ownership of these shares held by Soleus PE other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage set forth in row 11 is calculated based upon 64,914,770 shares of voting common stock of the Issuer outstanding as of April 27, 2026, as set forth in the Proxy.


SCHEDULE 13G




Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Master Fund. Soleus Capital, LLC is the sole general partner of Master Fund, Soleus Capital Group, LLC ("SCG") is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for Soleus PE and for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of SCG and of Soleus GP, LLC. Each of SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage set forth in row 11 is calculated based upon 64,914,770 shares of voting common stock of the Issuer outstanding as of April 27, 2026, as set forth in the Proxy.


SCHEDULE 13G




Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Master Fund. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for Soleus PE and for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of SCG and of Soleus GP, LLC. Each of SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage set forth in row 11 is calculated based upon 64,914,770 shares of voting common stock of the Issuer outstanding as of April 27, 2026, as set forth in the Proxy.


SCHEDULE 13G




Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Master Fund. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for Soleus PE and for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of SCG and of Soleus GP, LLC. Each of SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage set forth in row 11 is calculated based upon 64,914,770 shares of voting common stock of the Issuer outstanding as of April 27, 2026, as set forth in the Proxy.


SCHEDULE 13G




Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Soleus PE and by Master Fund. Soleus PE GP is the sole general partner of Soleus PE, Soleus PE GP III, LLC is the sole manager of Soleus PE GP, SCM is the investment manager for Soleus PE, and Soleus GP, LLC is the sole general partner of SCM. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP III, LLC, SCG and Soleus GP, LLC. Each of Soleus PE GP, Soleus PE GP III, LLC, Soleus Capital, LLC, SCG, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held directly by Soleus PE and Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage set forth in row 11 is calculated based upon 64,914,770 shares of voting common stock of the Issuer outstanding as of April 27, 2026, as set forth in the Proxy.


SCHEDULE 13G




Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Soleus PE and by Master Fund. Soleus PE GP is the sole general partner of Soleus PE, Soleus PE GP III, LLC is the sole manager of Soleus PE GP, SCM is the investment manager for Soleus PE, and Soleus GP, LLC is the sole general partner of SCM. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP III, LLC, SCG and Soleus GP, LLC. Each of Soleus PE GP, Soleus PE GP III, LLC, Soleus Capital, LLC, SCG, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held directly by Soleus PE and Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage set forth in row 11 is calculated based upon 64,914,770 shares of voting common stock of the Issuer outstanding as of April 27, 2026, as set forth in the Proxy.


SCHEDULE 13G




Comment for Type of Reporting Person: (1) The shares reported in the table above are held directly by Soleus PE and by Master Fund. Soleus PE GP is the sole general partner of Soleus PE, Soleus PE GP II, LLC is the sole manager of Soleus PE GP, SCM is the investment manager for Soleus PE, and Soleus GP, LLC is the sole general partner of SCM. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for Master Fund, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP II, LLC, SCG and Soleus GP, LLC. Each of Soleus PE GP, Soleus PE GP II, LLC, Soleus Capital, LLC, SCG, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held directly by Soleus PE and Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage set forth in row 11 is calculated based upon 64,914,770 shares of voting common stock of the Issuer outstanding as of April 27, 2026, as set forth in the Proxy.


SCHEDULE 13G



Soleus Private Equity Fund III, L.P.
Signature:/s/ Guy Levy
Name/Title:Guy Levy, Managing Member of the Sole Manager of the General Partner of Soleus Private Equity Fund III, L.P.
Date:07/08/2026
Soleus Private Equity GP III, LLC
Signature:/s/ Guy Levy
Name/Title:Guy Levy, Managing Member of the Sole Manager of Soleus Private Equity GP III, LLC
Date:07/08/2026
Soleus PE GP III, LLC
Signature:/s/ Guy Levy
Name/Title:Guy Levy, Managing Member
Date:07/08/2026
Soleus Capital Master Fund, L.P.
Signature:/s/ Guy Levy
Name/Title:Guy Levy, Managing Member of the Managing Member of the General Partner of Soleus Capital Master Fund, L.P.
Date:07/08/2026
Soleus Capital, LLC
Signature:/s/ Guy Levy
Name/Title:Guy Levy, Managing Member of the Managing Member of Soleus Capital, LLC
Date:07/08/2026
Soleus Capital Group, LLC
Signature:/s/ Guy Levy
Name/Title:Guy Levy, Managing Member
Date:07/08/2026
Soleus Capital Management, L.P.
Signature:/s/ Guy Levy
Name/Title:Guy Levy, Managing Member of the General Partner of Soleus Capital Management, L.P.
Date:07/08/2026
Soleus GP, LLC
Signature:/s/ Guy Levy
Name/Title:Guy Levy, Managing Member
Date:07/08/2026
Levy Guy
Signature:/s/ Guy Levy
Name/Title:Guy Levy
Date:07/08/2026

Comments accompanying signature: Exhibit 99.A - Joint Filing Agreement