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ProQR Therapeutics (PRQR) boosts Q2 revenue and extends cash runway to 2028

(Neutral)
(Neutral)
Form Type
6-K

Rhea-AI Filing Summary

ProQR Therapeutics reported second-quarter 2026 results and highlighted clinical validation of its Axiomer™ RNA editing platform. Phase 1 data for AX-0810 in healthy volunteers showed up to 8‑fold increases in total serum bile acids at 6 mg/kg, exceeding the predefined 2‑fold threshold for meaningful NTCP modulation, with a favorable safety profile and an estimated eight-week half-life. A Phase 1 trial of next-generation NTCP candidate AX-0811 is planned pending CTA authorization, with initial data expected by year-end 2026, and multiple additional programs (biliary atresia IIT, AX-0422, AX-2911) targeted to read out in 2027.

Financially, second-quarter 2026 revenue was €8.8 million, up from €3.8 million a year earlier, and net loss narrowed to €8.7 million from €12.2 million. Cash and cash equivalents increased to €117.1 million at June 30, 2026 from €92.4 million at year-end 2025, supported by a $59.2 million equity financing with public investors and Eli Lilly. Equity rose to €79.5 million, and management states this funding provides cash runway into mid‑2028.

Positive

  • Revenue grew to €8.8 million from €3.8 million year over year in Q2 2026, while net loss narrowed to €8.7 million from €12.2 million, indicating materially improved operating performance.
  • Cash and cash equivalents rose to €117.1 million after a $59.2 million equity financing, and management reports this provides funding runway into mid‑2028, supporting the multi-program Axiomer pipeline.

Negative

  • None.

Filing Explained

The completed June financing issued ordinary shares, increasing the share count and reducing existing holders’ percentage ownership absent offsetting changes.

Form 6-K is a foreign private issuer’s interim report for furnishing material home-market information; here, ProQR furnishes its August 13, 2026 results release.

The completed June financing issued 27,624,310 ordinary shares in an underwritten registered direct offering and 5,100,780 shares in a concurrent private placement; issuing these shares increases the total share count and reduces existing holders’ percentage ownership absent offsetting changes.

The supplied definitions describe a registered direct as a negotiated sale of registered securities to selected investors and a private placement as a sale to selected investors outside a public offering.

The interim statement reports 143,466,309 ordinary shares at June 30, 2026, versus 107,710,916 at January 1, 2026. It also reports €12.3 million of net cash used in operating activities during the quarter ended June 30, 2026.

Q2 2026 Revenue €8,759 thousand Three month period ended June 30, 2026
Q2 2025 Revenue €3,817 thousand Three month period ended June 30, 2025
Q2 2026 Net loss €8,728 thousand Three month period ended June 30, 2026
Cash and cash equivalents €117,125 thousand Balance at June 30, 2026
Total equity €79,477 thousand Balance at June 30, 2026
Equity financing proceeds $59.2 million Underwritten registered direct offering and concurrent private placement closed in June 2026
AX-0810 bile acid increase Up to 8-fold Total serum bile acids at 6 mg/kg in Phase 1 healthy volunteers
AX-0810 half-life Eight weeks Pharmacokinetic findings supporting sustained target engagement
Axiomer™ medical
"pioneering a next-generation RNA base editing technology called Axiomer™"
Editing Oligonucleotides medical
"Axiomer™ “Editing Oligonucleotides”, or EONs, mediate single nucleotide changes"
Clinical Trial Application (CTA) regulatory
"submitted a Clinical Trial Application (CTA) to the European Medicines Agency"
A clinical trial application (CTA) is the formal request a company files with health regulators asking permission to begin testing a new drug or medical device in people. It matters to investors because approval is a key development milestone—like getting a building permit to start construction—signaling reduced regulatory risk, unlocking the next phase of data generation and timelines for potential commercial value, while rejection or delay can push back prospects and increase costs.
investigator-initiated trial (IIT) medical
"preparations for an investigator-initiated trial (IIT) in pediatric biliary atresia"
An investigator-initiated trial (IIT) is a clinical study designed and run by an independent researcher or academic group rather than by a company that makes the drug or device. It matters to investors because IITs can provide independent safety and effectiveness data, uncover new uses, or validate early results without the sponsor bearing full trial costs—like an outside chef testing a recipe that, if successful, can boost confidence and commercial prospects for the product.
cholestatic diseases medical
"targeting NTCP for the treatment of cholestatic diseases"
MPS I Hurler syndrome medical
"AX-0422 (IDUA) patient data in MPS I Hurler syndrome"

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FAQ

How did ProQR (PRQR) perform financially in the second quarter of 2026?

ProQR reported Q2 2026 revenue of €8.8 million, up from €3.8 million in Q2 2025, and a net loss of €8.7 million, improved from a €12.2 million loss a year earlier, reflecting higher collaboration revenue and lower losses.

What is ProQR’s (PRQR) cash position and runway after the latest quarter?

At June 30, 2026, ProQR held €117.1 million in cash and cash equivalents, up from €92.4 million at December 31, 2025. Following a $59.2 million equity financing, management states this cash is expected to fund operations into mid‑2028.

What key clinical results did ProQR (PRQR) report for AX-0810 in Q2 2026?

ProQR reported positive Phase 1 target engagement data for AX-0810, with up to an 8‑fold increase in total serum bile acids at 6 mg/kg, above the 2‑fold target for NTCP modulation, and an estimated eight-week half-life with favorable safety and tolerability.

What are the main upcoming milestones for ProQR’s (PRQR) NTCP franchise?

Planned milestones include full AX-0810 Phase 1 data by year-end 2026, initial AX-0811 healthy volunteer data by year-end 2026 pending CTA authorization, initial data from a pediatric biliary atresia IIT in China in H1 2027, and a potentially registration-enabling Phase 2 program starting mid‑2027.

Which additional pipeline programs is ProQR (PRQR) advancing beyond NTCP?

Beyond NTCP, ProQR is progressing AX-0422 for MPS I Hurler syndrome with a CTA filing for a first-in-patient study anticipated in early 2027 and initial data in H1 2027, and AX-2911 targeting PNPLA3 for MASH with a first-in-human IIT in China expected in H1 2027.

How did ProQR’s (PRQR) operating expenses and cash burn trend in Q2 2026?

In Q2 2026, R&D costs were €12.7 million versus €11.4 million a year earlier, and G&A was €4.9 million versus €4.8 million. Net cash used in operating activities was €12.3 million, slightly higher than €11.4 million in Q2 2025.

 

 

UNITED STATES 

SECURITIES AND EXCHANGE COMMISSION 

Washington, D.C. 20549

 

FORM 6-K

 

Report of Foreign Private Issuer 

Pursuant to Rule 13a-16 or 15d-16 of 

the Securities Exchange Act of 1934

 

For the month of August 2026

 

Commission File Number: 001-36622

 

PROQR THERAPEUTICS N.V.

 

Zernikedreef 9 

2333 CK Leiden 

The Netherlands 

Tel: +31 88 166 7000 

(Address, Including Zip Code, and Telephone Number,
Including Area Code, of Registrant’s Principal Executive Offices)

 

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

 

Form 20-F  x  Form 40-F  ¨

 

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):  ¨

 

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):  ¨

 

 

 

 

 

Furnished as Exhibit 99.1 to this Report on Form 6-K is a press release of ProQR Therapeutics N.V. (the “Company”) dated August 13, 2026, announcing the Company’s results for the three month period ended June 30, 2026.

 

On August 13, 2026 the Company issued a press release titled, “ProQR Announces Second Quarter 2026 Operating and Financial Results,” announcing the Company’s results for the three month period ended June 30, 2026 and providing a business update. A copy of this press release is attached hereto as Exhibit 99.1 and is incorporated herein by reference

 

 

 

 

INDEX TO EXHIBITS

 

Number   Description
     
99.1 Press Release of ProQR Therapeutics N.V. dated August 13, 2026, announcing the Company's results for the three month period ended June 30, 2026.

 

 

 

 

SIGNATURES

 

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

 

  PROQR THERAPEUTICS N.V.
   
Date: August 13, 2026 By: /s/ Dennis Hom
    Dennis Hom
    Chief Financial Officer

 

 

 

 

Exhibit 99.1 

 

ProQR Announces Second Quarter 2026 Operating and Financial Results

 

·First clinical validation of Axiomer™ RNA editing established through NTCP modulation with positive AX-0810 clinical target engagement data; full Phase 1 dataset to be presented at a medical or scientific conference later this year
·Multiple clinical milestones, including initial AX-0811 Phase 1 data expected by year-end 2026, followed in H1 2027 by:
·biliary atresia IIT initiation and initial data,
·initial AX-0422 (IDUA) patient data in MPS I Hurler syndrome, and
·advancement of AX-2911 (PNPLA3) to the clinic
·Strengthened balance sheet through $59.2 million financing during the quarter; ended Q2 2026 with € 117.1 million cash and cash equivalents, supporting runway through mid-2028

 

LEIDEN, Netherlands & CAMBRIDGE, Mass., August 13, 2026 – ProQR Therapeutics N.V. (Nasdaq: PRQR) (ProQR), a clinical-stage company dedicated to changing lives through transformative RNA therapies based on its proprietary Axiomer™ RNA editing technology platform, today reported its financial and operating results for the second quarter ended June 30, 2026, and provided a business update.

 

“The second quarter marked an important inflection point for ProQR as we established the first clinical validation of our Axiomer RNA editing platform by modulating NTCP with AX-0810,” said Daniel A. de Boer, Founder and Chief Executive Officer of ProQR. “We believe these data, together with the significant unmet need that remains in cholestatic liver diseases, including biliary atresia, support the continued advancement of our NTCP franchise. Combined with our recent financing, we are well positioned to deliver a series of important clinical milestones, including presentation of the full AX-0810 Phase 1 dataset later this year, initial Phase 1 data from AX-0811 by year end, initiation of our biliary atresia clinical program and initial data in the first half of 2027, and continued advancement of our MPS I Hurler syndrome and MASH programs. Together, these milestones reflect ProQR’s evolution into a multi-program clinical-stage RNA editing company, strengthen the growing body of evidence supporting the broader potential of our Axiomer platform, and bring us closer to delivering transformative RNA editing therapies for patients.”

 

 

Recent Progress and Anticipated Upcoming Events

 

First Clinical Validation of Axiomer and Next Milestones with NTCP Franchise

 

ProQR’s NTCP RNA editing approach is designed to modulate NTCP and reduce bile acid uptake directly in hepatocytes, with the goal of reducing intrahepatic cholestasis.

 

In June, ProQR announced positive AX-0810 Phase 1 target engagement data from healthy volunteers, establishing the first clinical validation of the Company’s proprietary Axiomer RNA editing platform. Key findings included:

 

·Up to 8-fold increase in total serum bile acids (6 mg/kg) exceeding the Company’s pre-defined 2-fold threshold for meaningful NTCP modulation;
·Dose-dependent changes in conjugated bile acids, together with concordant changes in total serum bile acids and TUDCA, supporting the therapeutic rationale that modulating NTCP reduces the accumulation of toxic bile acids in the liver;
·Favorable safety and tolerability profile observed with AX-0810 to date, with no serious adverse events or pruritus reported; pharmacokinetic findings to date support sustained target engagement, including a half-life of eight weeks; and
·Data supporting advancement into patient study.

 

ProQR plans to present the full dataset from the Phase 1 study of AX-0810, including Cohort 3, at a medical or scientific conference later this year.

 

In July, the Company submitted a Clinical Trial Application (CTA) to the European Medicines Agency (EMA) to initiate a Phase 1 clinical trial of AX-0811, its next-generation editing oligonucleotide (EON) targeting NTCP for the treatment of cholestatic diseases. AX-0811 is generated by ProQR’s AI-enabled discovery engine and demonstrated higher potency and longer durability than AX-0810 preclinically, which will lead to lower dose levels and less frequent dosing in the clinic. Pending CTA authorization, initial data with AX-0811 is anticipated by year end 2026.

 

ProQR continues preparations for an investigator-initiated trial (IIT) in pediatric biliary atresia in China, with initial clinical data expected in the first half of 2027.

 

Strengthened Financial Position

 

In June, ProQR closed an underwritten registered direct offering of $50.0 million, alongside a concurrent private placement to an existing shareholder and strategic partner Eli Lilly and Company (Lilly) of $9.2 million, for total gross proceeds of approximately $59.2 million. The financing further strengthened the Company’s balance sheet providing runway into mid-2028, and is expected to support the continued advancement of its wholly owned Axiomer RNA editing pipeline, including multiple anticipated clinical milestones.

 

 

Platform and Research Progress

 

ProQR continues to strengthen the scientific foundation of its Axiomer RNA editing platform through ongoing research and publication of preclinical findings. During the quarter, the Company’s preclinical research describing RNA editing of B4GALT1 was published online as a peer-reviewed Journal Pre-proof in Molecular Therapy – Nucleic Acids. The publication further expands the body of evidence supporting the breadth and versatility of the Axiomer platform beyond the Company’s clinical pipeline.

 

Upcoming anticipated milestones

 

NTCP franchise

 

·AX-0810 data from the 9 mg/kg cohort and 12-week follow up from the ongoing Phase 1 study expected by year-end 2026
·AX-0811 initial data in healthy volunteers expected by year-end 2026, pending CTA authorization
·IIT in pediatric biliary atresia in China, with initial data targeted for first half of 2027
·Potentially registration-enabling Phase 2 program, subject to regulatory interactions, expected to start in mid-2027 with first interim analysis data expected by mid-2028

 

Other pipeline candidates

 

·AX-0422 for MPS I Hurler Syndrome (IDUA) CTA filing for a first-in-patient study anticipated in early 2027 and initial data expected in the first half of 2027
·AX-2911(PNPLA3) FIH IIT in China expected in the first half of 2027

 

Partnership

 

·Continue to execute on Lilly collaboration, with potential data updates and milestone payments

 

Financial Highlights

 

At June 30, 2026, ProQR held cash and cash equivalents of approximately € 117.1 million, compared to € 92.4 million at December 31, 2025. In June 2026, the Company closed an underwritten registered direct offering of 27,624,310 ordinary shares and a concurrent private placement of 5,100,780 ordinary shares with Lilly for gross proceeds totaling approximately $59.2 million.

 

Net cash used in operating activities during the second quarter ended June 30, 2026 was € 12.3 million, compared to € 11.4 million used for the same period in 2025.

 

Research and development (R&D) costs for the quarter ended June 30, 2026 were € 12.7 million, compared to € 11.4 million for the same period last year.

 

 

General and administrative costs for the quarter ended June 30, 2026 were € 4.9 million, compared to € 4.8 million for the same period in 2025.

 

Net loss for the quarter ended June 30, 2026 was € 8.7 million, or € 0.08 per diluted share, compared to € 12.2 million, or € 0.12 per diluted share, for the same period in 2025.

 

For further financial information for the period ended June 30, 2026, please refer to our Q2 financial report filing available on our website, www.proqr.com under Financials and Filings.

 

About Axiomer

 

ProQR is pioneering a next-generation RNA base editing technology called Axiomer, which could potentially yield a new class of medicines for diverse types of diseases. Axiomer “Editing Oligonucleotides”, or EONs, mediate single nucleotide changes to RNA in a highly specific and targeted way using molecular machinery that is present in human cells called ADAR (Adenosine Deaminase Acting on RNA). Axiomer EONs are designed to recruit and direct endogenously expressed ADARs to change an Adenosine (A) to an Inosine (I) in the RNA – an Inosine is translated as a Guanosine (G) – correcting an RNA with a disease-causing mutation back to a normal (wild type) RNA, modulating protein expression, or altering a protein so that it will have a new function that helps prevent or treat disease.

 

About ProQR

 

ProQR Therapeutics is a clinical-stage company dedicated to changing lives through the creation of transformative RNA therapies. ProQR is pioneering a next-generation RNA technology called Axiomer, which uses a cell’s own editing machinery called ADAR to make specific single nucleotide edits in RNA to reverse a mutation or modulate protein expression and could potentially yield a new class of medicines for both rare and prevalent diseases with unmet need. Based on our unique proprietary RNA repair platform technologies we are growing our pipeline with patients and loved ones in mind.

 

Learn more about ProQR at www.proqr.com.

 

 

Forward Looking Statements

 

This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “continue,” "anticipate," "believe," "could," "estimate," "expect," "goal," "intend," "look forward to", "may," "plan," "potential," "predict," "project," "should," "will," "would" and similar expressions. Such forward-looking statements include, but are not limited to, statements regarding our business, technology, strategy, preclinical and clinical model data; our initial pipeline targets and the upcoming strategic priorities and milestones related thereto; the continued advancement of our lead development pipeline programs, including ongoing and planned clinical trials; the ongoing Phase 1 clinical study of AX-0810 in NTCP for cholestatic diseases, including the timing and presentation of the full Phase 1 dataset, including Cohort 3 and 12-week follow-up data, and the potential advancement into patient studies; our expectations regarding the safety, tolerability, target engagement and potential therapeutic benefits of AX-0810; our ability to collaborate with investigators to initiate, conduct and recruit for an IIT of our NTCP program in China in pediatric participants with biliary atresia and to generate meaningful data therefrom, including the anticipated timing of initial data readout in H1 2027; the anticipated initiation of our registration-enabling Phase 2 program in mid-2027 with first interim analysis data expected by mid-2028, subject to regulatory interactions; our pipeline targets, including the planned Phase 1 clinical trial of AX-0811 in healthy volunteers; our ability to obtain authorization for, initiate, enroll, and complete a Phase 1 clinical trial for AX-0811 and the anticipated timing of initial data readout by year end 2026, pending CTA authorization; the anticipated first-in-human study of AX-0422 targeting IDUA for MPS I Hurler syndrome, with a CTA filing expected in early 2027 and anticipated initial clinical data readout in H1 2027; the anticipated IIT in China of AX-2911 targeting PNPLA3 for MASH in H1 2027; our expectations regarding clinical updates across multiple programs in 2026 and 2027; the potential design, initiation and timing of a potentially registration-enabling Phase 2 program for the NTCP franchise, subject to regulatory interactions; the therapeutic potential and development timeline regarding AX-0810, AX-0811, AX-0422, and AX-2911;our participation at upcoming scientific conferences; the continued development and advancement of our Axiomer platform; the therapeutic potential of our Axiomer RNA editing oligonucleotides and product candidates; the timing, progress and results of our preclinical studies and other development and pipeline activities, including the release of data related thereto; our patent estate, including our anticipated strength and our continued investment in it, as well as the timing of our clinical development; the potential of our technologies and product candidates; the collaboration with Lilly and the intended benefits thereof, including timing for data updates, and potential milestones; our ability to selectively form new partnerships and enter into future collaborations; our financial position and expected cash-runway to fund our operations through mid 2028. Forward-looking statements are based on management's beliefs and assumptions and on information available to management only as of the date of this press release. Our actual results could differ materially from those expressed or implied by these forward-looking statements for many reasons, including, without limitation, the risks, uncertainties and other factors in our filings made with the Securities and Exchange Commission, including certain sections of our most recent annual report filed on Form 20-F. These risks and uncertainties include, among others, risks and uncertainties associated with conducting IITs in China, including evolving regulatory requirements, the cost, timing and results of preclinical studies and clinical trials and other development activities by us and our collaborative partners whose operations and activities may be slowed or halted due to shortage and pressure on supply chains and logistics in the global market, economic sanctions and international tariffs; the likelihood of our preclinical and clinical programs being initiated and executed on timelines provided and our reliance on our contract research organizations and predictability of timely enrollment of subjects and patients to advance our clinical trials and maintain their own operations; our reliance on contract manufacturers to supply materials for research and development and the risk of supply interruption from a contract manufacturer; the potential for future data to alter initial and preliminary results of early-stage clinical trials; the unpredictability of the duration and results of the regulatory review of applications or clearances that are necessary to initiate and continue to advance and progress our clinical programs; the ability to secure, maintain and realize the intended benefits of collaborations with partners, including the collaboration with Lilly; the possible impairment of, inability to obtain, and costs to obtain intellectual property rights; possible safety or efficacy concerns that could emerge as new data are generated in research and development; general business, operational, financial and accounting risks, and risks related to litigation and disputes with third parties; and risks related to macroeconomic conditions and market volatility resulting from global economic developments, geopolitical events and conflicts, inflationary pressures, fluctuating interest rates, tariffs and potential for significant changes in U.S. policies and regulatory environment. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.

 

 

ProQR Therapeutics N.V.

 

Investor and media contact:
Sarah Kiely
ProQR Therapeutics N.V.
T: +1 617 599 6228
skiely@proqr.com
or
Investor contact:
Peter Kelleher
LifeSci Advisors
T: +1 617 430 7579
pkelleher@lifesciadvisors.com

 

 

PROQR THERAPEUTICS N.V.
Unaudited Interim Condensed Consolidated Statement of Financial Position

 

   June 30,   December 31, 
   2026   2025 
   €1,000   €1,000 
Assets          
Property, plant and equipment   11,923    12,630 
Investments in financial assets        
Non-current assets   11,923    12,630 
           
Cash and cash equivalents   117,125    92,413 
Trade and other receivables   3,908    6,800 
Other taxes   597    913 
Current assets   121,630    100,126 
Total assets   133,553    112,756 
           
Equity and liabilities          
Equity          
Equity attributable to owners of the Company   79,477    49,374 
Total equity   79,477    49,374 
           
Liabilities          
Borrowings        
Lease liabilities   8,692    9,547 
Deferred income   10,510    21,394 
Non-current liabilities   19,202    30,941 
           
Borrowings   5,017    4,872 
Lease liabilities   1,603    1,545 
Derivative financial instruments   213    234 
Trade payables       298 
Social securities and other taxes   214     
Deferred income   17,644    17,552 
Other current liabilities   10,183    7,940 
Current liabilities   34,874    32,441 
Total liabilities   54,076    63,382 
           
Total equity and liabilities   133,553    112,756 

 

 

PROQR THERAPEUTICS N.V.
Unaudited Interim Condensed Consolidated Statement of Profit or Loss and Other Comprehensive Income
 

(€ in thousands, except share and per share data)

 

   Three month period   Six month period 
   ended June 30,   ended June 30, 
   2026   2025   2026   2025 
   €1,000   €1,000   €1,000   €1,000 
Revenue   8,759    3,817    10,792    8,336 
                     
Other income       158        380 
                     
Research and development costs   (12,667)   (11,408)   (24,497)   (23,731)
General and administrative costs   (4,914)   (4,816)   (8,766)   (8,050)
Total operating costs   (17,581)   (16,224)   (33,263)   (31,781)
                     
Operating result   (8,822)   (12,249)   (22,471)   (23,065)
Finance income and expense   152    192    364    647 
Results related to financial liabilities measured at fair value through profit or loss   (33)   (104)   21    178 
                     
Result before corporate income taxes   (8,703)   (12,161)   (22,086)   (22,240)
Income taxes   (25)   (18)   (25)   (18)
                     
Result for the period   (8,728)   (12,179)   (22,111)   (22,258)
Other comprehensive income (foreign exchange differences on foreign operation)   48    (682)   227    (1,053)
                     
Total comprehensive income   (8,680)   (12,861)   (21,884)   (23,311)
                     
Result attributable to                    
Owners of the Company   (8,728)   (12,179)   (22,111)   (22,258)
                     
Total comprehensive income attributable to                    
Owners of the Company   (8,680)   (12,861)   (21,884)   (23,311)
                     
Share information                    
Weighted average number of shares outstanding1   109,958,613    105,343,897    107,673,118    105,320,495 
                     
Earnings per share attributable to owners of the Company (Euro per share)                    
Basic loss per share1   (0.08)   (0.12)   (0.21)   (0.21)
Diluted loss per share1   (0.08)   (0.12)   (0.21)   (0.21)

 

1.For these periods the potential exercise of share options is not included in the diluted earnings per share as the Company was loss-making. Due to the anti-dilutive nature of the outstanding options, basic and diluted earnings per share are equal.

 

 

PROQR THERAPEUTICS N.V.
Unaudited Interim Condensed Consolidated Statement of Changes in Equity

 

   Attributable to owners of the Company 
   Number
of shares
   Share
Capital
   Share
Premium
   Equity settled
Employee
Benefit
Reserve
   Translation
Reserve
   Accumulated
Deficit
   Total
Equity
 
       €1,000   €1,000   €1,000   €1,000   €1,000   €1,000 
Balance at January 1, 2025  107,710,916   4,308   483,812   26,248   1,350   (427,158)  88,560 
Result for the period                 (22,258)  (22,258)
Other comprehensive income              (1,053)     (1,053)
Recognition of share-based payments           1,667         1,667 
Treasury shares transferred  (131,525)                  
Share options lapsed           (1,462)     1,462    
Share options exercised / RSUs vested  131,525      67   (181)     181   67 
                             
Balance at June 30, 2025  107,710,916   4,308   483,879   26,272   297   (447,773)  66,983 
                             
Balance at January 1, 2026  107,710,916   4,308   483,881   28,426   265   (467,506)  49,374 
Result for the period                 (22,111)  (22,111)
Other comprehensive income              227      227 
Recognition of share-based payments           2,786         2,786 
Issuance of ordinary shares  35,755,393   1,430   47,771            49,201 
Treasury shares transferred  (4,623)                  
Share options lapsed           (2,199)     2,199    
Share options exercised / RSUs vested  4,623         (6)     6    
                             
Balance at June 30, 2026  143,466,309   5,738   531,652   29,007   492   (487,412)  79,477 

 

 

PROQR THERAPEUTICS N.V.
Unaudited Interim Condensed Consolidated Statement of Cash Flows

 

   Three month period   Six month period 
   ended June 30,   ended June 30, 
   2026   2025   2026   2025 
   €1,000   €1,000   €1,000   €1,000 
Cash flows from operating activities                    
Net result   (8,728)   (12,179)   (22,111)   (22,258)
Adjustments for:                    
— Other income       (158)       (380)
— Depreciation   707    675    1,401    1,353 
— Share-based compensation   1,358    909    2,786    1,667 
— Financial income and expenses   (110)   (139)   (369)   (647)
— Results related to financial liabilities measured at fair value through profit or loss   33    104    (21)   (178)
— Income tax expenses   25    18    25    18 
                     
Changes in working capital   (5,754)   (1,178)   (5,645)   (7,900)
Cash used in operations   (12,469)   (11,948)   (23,934)   (28,325)
                     
Corporate income tax (paid)/received   (25)   (18)   (25)   (18)
Interest received   359    617    726    1,405 
Interest paid   (135)   (52)   (182)   (261)
                     
Net cash used in operating activities   (12,270)   (11,401)   (23,415)   (27,199)
                     
Cash flow from investing activities                    
Purchases of property, plant and equipment   (291)   (101)   (455)   (325)
                     
Net cash used in investing activities   (291)   (101)   (455)   (325)
                     
Cash flows from financing activities                    
Proceeds from issuance of shares, net   49,201        49,201     
Proceeds from exercise of share options               67 
Repayment of lease liability   (621)   (293)   (925)   (860)
                     
Net cash generated by / (used in) financing activities   48,580    (293)   48,276    (793)
                     
Net increase / (decrease) in cash and cash equivalents   36,019    (11,795)   24,406    (28,317)
                     
Currency effect cash and cash equivalents   18    (854)   306    (1,326)
Cash and cash equivalents, at beginning of the period   81,088    132,414    92,413    149,408 
                     
Cash and cash equivalents at the end of the period   117,125    119,765    117,125    119,765 

 

 

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