Personalis Q3 2026 net loss widens to $33.8M
Clinical test volume was 13,157, and Personalis said its merger agreement with Tempus means it will no longer provide guidance or hold quarterly earnings calls.
Sentiment and the balance of points
Rhea-AI Sentiment reads the wording of the document, how positive or negative its language is on a 1 to 5 scale. The balance of points shown with the takes weighs what the document actually discloses, so the two can disagree, for example when a trial that missed its main goal is described in upbeat language.
Rhea-AI Filing Summary
Personalis, Inc. (PSNL) reported third-quarter 2026 revenue of $25.6 million, compared with $14.5 million a year earlier. Clinical test revenue was $4.4 million versus $0.4 million, and clinical test volume was 13,157 versus 4,388. The company said revenue reflected growth in clinical testing, increased population sequencing and higher pharma testing services; population sequencing revenue was $4.0 million versus $0.2 million.
Net loss was $33.8 million, compared with $21.7 million. Personalis ended September 30, 2026 with approximately $190.6 million in cash, cash equivalents and short-term investments. It commercially launched optional Real-Time Variant Tracker supplemental results for its NeXT Personal test. In pre-interim results from its B-STRONGER-1 study in triple-negative breast cancer, Personalis reported a 96% baseline ctDNA detection rate, 83.3% of positive detections at T1 in the ultrasensitive range below 100 PPM, and an 82% ctDNA clearance rate following two cycles of neoadjuvant therapy. Following its July 20, 2026 announcement that it entered into an Agreement and Plan of Merger with Tempus AI, Personalis said it will no longer provide financial guidance or conduct quarterly earnings calls.
How this balance works
Rhea-AI gives every point it takes from this document a weight. Minor counts 1, Moderate 3 and Major 9, so one Major point outweighs several Minor ones. The bar adds up the weights on each side, and when neither side holds more than 65% of the total the balance reads Mixed.
It reads the document as published, with the same rules for every company, and it does not look at what the market expected or at how the stock traded, so a point can be objectively good on a day the stock falls.
Rhea-AI Sentiment measures something else, the tone of the wording.
Positive
- Moderate pointQuarterly revenue was $25.6 million, versus $14.5 million a year earlier.
Negative
- Moderate pointQuarterly net loss was $33.8 million, versus $21.7 million a year earlier.
Filing Explained
At
8-K Event Classification
Key Figures
Key Terms
molecular residual disease (MRD) medical
ctDNA medical
neoadjuvant therapy (NAT) medical
ultrasensitive range technical
Earnings Snapshot
Personalis said it will no longer provide financial guidance or conduct a quarterly earnings conference call following its July 20, 2026 announcement that it entered into an Agreement and Plan of Merger with Tempus AI, Inc.
FAQ
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What was PSNL's revenue in the third quarter of 2026?
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AI-generated analysis. How Rhea-AI works. Not financial advice.
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported):
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Registrant’s Telephone Number, Including Area Code
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(Former Name or Former Address, if Changed Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instructions A.2. below):
Securities registered pursuant to Section 12(b) of the Act:
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Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item 2.02 Results of Operations and Financial Condition.
On November 4, 2026, Personalis, Inc. issued a press release announcing its financial results for the quarter ended September 30, 2026. The full text of the press release is furnished as Exhibit 99.1 to this report on Form 8-K and is incorporated herein by reference.
The information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed to be “filed” for purposes of Section 18 of the Securities Exchange Act of 1934 (the “Exchange Act”), or otherwise subject to the liability of that section, and shall not be incorporated by reference into any registration statement or other document filed under the Securities Act of 1933 or the Exchange Act, except as shall be expressly set forth by specific reference in such filing.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits
Exhibit Number |
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Description |
99.1 |
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Press release of Personalis, Inc., dated November 4, 2026. |
104 |
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Cover Page Interactive Data File (embedded within the inline XBRL document). |
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
Date: November 4, 2026 |
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Personalis, Inc. |
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By: |
/s/ Aaron Tachibana |
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Aaron Tachibana |
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Chief Financial Officer and Chief Operating Officer |
Exhibit 99.1
Personalis Reports Third Quarter Results
Reports Q3 clinical test volume of 13,157, clinical revenue of $4.4 million and overall revenue of $25.6 million
FREMONT, Calif. – November 4, 2026 – Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for precision oncology, today reported financial and operational results for the third quarter ended September 30, 2026.
Recent Strategic and Operational Highlights
Third Quarter 2026 Financial Results Compared with Third Quarter 2025
1
CEO Commentary
"These results reflect the strength of our team’s execution and commitment to helping transform the active management of cancer through more informed care," said Chris Hall, Chief Executive Officer of Personalis. “Combining with Tempus gives us the scale, complementary capabilities and resources to accelerate innovation and deliver even greater value to patients, clinicians, and biopharma partners.”
Full Year 2026 Outlook
As a result of the announcement on July 20, 2026, that Personalis and Tempus AI, Inc. have entered into an Agreement and Plan of Merger, Personalis will no longer provide financial guidance or conduct a quarterly earnings conference call.
About Personalis, Inc.
At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care throughout the patient journey. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable the selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California. To learn more, visit www.personalis.com and connect with us on LinkedIn and X (Twitter).
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include all statements that are not historical facts and can generally be identified by terms such as “anticipate,” “estimate,” “expect,” “if,” “may,” “future,” “will” or similar expressions. These statements include statements relating to: the attributes, advantages, capabilities, sensitivity, availability and clinical relevance of the NeXT Personal test and the potential impact or expected benefits of the Personalis’ published data and presentations and statements regarding the proposed transaction between Personalis and Tempus AI, Inc. (Tempus) and the benefits of such transaction. Such forward-looking statements involve known and unknown risks and uncertainties and other factors that may cause actual results to differ materially from any anticipated results or expectations expressed or implied by such statements, including the risks, uncertainties and other factors that relate to the pending acquisition by Tempus, including the occurrence of any event, change or other circumstances that could give rise to the termination of the Agreement and Plan of Merger (the Agreement), the possibility that Personalis shareholders may not adopt the Agreement, the risk that the parties may not be able to satisfy the conditions to the proposed transaction in a timely manner or at all, risks related to disruption of management time from ongoing business operations due to the proposed transaction, the risk that any announcements relating to the proposed transaction could have adverse effects on the market price of Personalis’ common stock or Tempus’ common stock, the risk of any litigation relating to the proposed transaction, the risk that the proposed transaction and its announcement could have an adverse effect on the ability of Personalis and/or Tempus to retain and hire key personnel; the timing and pace of new orders from customers, including from ModernaTX, Inc., Merck Sharp & Dohme LLC and other biopharma customers, and the VA MVP; the success of Personalis’ and Tempus’ respective sales and marketing efforts; the timing of tissue, blood, and other specimen sample receipts from customers, which can materially impact revenue quarter-over-quarter and year-over-year; Personalis’ ability to demonstrate attributes, advantages or clinical validity of the NeXT platform; future clinical data differing from the clinical data previously presented or expected results; Personalis’ ability to obtain Medicare coverage and reimbursement in additional indications and the timing thereof; the impact of competition and macroeconomic factors on Personalis’ business; the partnering and/or collaboration arrangements that Personalis has
2
entered into or may enter into in the future may not be successful, or may terminate, which could adversely impact Personalis’ business or affect its ability to develop and commercialize its services and products; having a limited number of suppliers; and customer concentration. These and other potential risks and uncertainties that could cause actual results to differ materially from the results predicted in these forward-looking statements are described under the captions “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” in Personalis’ Quarterly Report on Form 10-Q for the quarter ended June 30, 2026, filed with the Securities and Exchange Commission (SEC) on August 4, 2026 and Quarterly Report on Form 10-Q for the quarter ended September 30, 2026, to be filed with the SEC on November 4, 2026. All information provided in this release is as of the date of this press release, and any forward-looking statements contained herein are based on assumptions that we believe to be reasonable as of this date. Undue reliance should not be placed on the forward-looking statements in this press release, which are based on information available to us on the date hereof. Personalis undertakes no duty to update this information unless required by law.
Contacts:
Investor Relations:
Caroline Corner
investors@personalis.com
646-277-1279
Media:
pr@personalis.com
3
PERSONALIS, INC.
CONSOLIDATED STATEMENTS OF OPERATIONS (Unaudited)
(In thousands, except share and per share data)
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Three Months Ended September 30, |
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Nine Months Ended September 30, |
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2026 |
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2025 |
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2026 |
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2025 |
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Consolidated Statements of Operations: |
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Revenue (1) |
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$ |
25,596 |
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$ |
14,495 |
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$ |
63,425 |
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$ |
52,303 |
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Costs and expenses |
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Cost of revenue |
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19,026 |
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12,581 |
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51,831 |
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38,426 |
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Research and development |
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16,074 |
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12,171 |
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46,949 |
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37,192 |
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Selling, general and administrative (2) |
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26,014 |
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13,034 |
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65,915 |
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39,476 |
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Total costs and expenses |
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61,114 |
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37,786 |
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164,695 |
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115,094 |
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Loss from operations |
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(35,518 |
) |
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(23,291 |
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(101,270 |
) |
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(62,791 |
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Interest income |
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1,760 |
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1,680 |
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5,898 |
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5,585 |
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Interest expense |
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(36 |
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(64 |
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(120 |
) |
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(140 |
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Other income (expense), net |
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(4 |
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26 |
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— |
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(100 |
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Loss before income taxes |
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(33,798 |
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(21,649 |
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(95,492 |
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(57,446 |
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Provision for income taxes |
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3 |
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3 |
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24 |
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12 |
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Net loss |
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$ |
(33,801 |
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$ |
(21,652 |
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$ |
(95,516 |
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$ |
(57,458 |
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Net loss per share, basic and diluted |
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$ |
(0.32 |
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$ |
(0.24 |
) |
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$ |
(0.90 |
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$ |
(0.65 |
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Weighted-average shares outstanding, basic and diluted |
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107,206,827 |
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88,699,131 |
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105,607,799 |
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88,226,838 |
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(1) Includes related party revenue of $5.9 million and $1.1 million for the three months ended September 30, 2026 and 2025, respectively, and $17.4 million and $3.5 million for the nine months ended September 30, 2026 and 2025, respectively.
(2) Includes related party sales and marketing expenses of $4.8 million and $1.2 million for the three months ended September 30, 2026 and 2025, respectively, and $11.5 million and $2.7 million for the nine months ended September 30, 2026 and 2025, respectively.
4
PERSONALIS, INC. SUPPLEMENTAL REVENUE INFORMATION (Unaudited) |
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(In thousands) |
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Three Months Ended September 30, |
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Nine Months Ended September 30, |
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2026 |
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2025 |
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2026 |
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2025 |
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Pharma testing services (1) |
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$ |
17,114 |
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$ |
13,137 |
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$ |
44,627 |
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$ |
37,754 |
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Enterprise sales |
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8 |
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650 |
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401 |
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5,430 |
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Population sequencing |
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4,067 |
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234 |
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9,567 |
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7,755 |
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Clinical diagnostic |
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4,374 |
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384 |
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8,346 |
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1,161 |
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Other |
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33 |
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90 |
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484 |
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203 |
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Total revenue |
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$ |
25,596 |
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$ |
14,495 |
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$ |
63,425 |
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$ |
52,303 |
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(1) Includes related party revenue of $5.9 million and $1.1 million for the three months ended September 30, 2026 and 2025, respectively, and $17.4 million and $3.5 million for the nine months ended September 30, 2026 and 2025, respectively.
5
PERSONALIS, INC.
CONSOLIDATED BALANCE SHEETS (Unaudited)
(In thousands, except share and par value data)
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September 30, 2026 |
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December 31, 2025 |
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Assets |
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Current assets |
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Cash and cash equivalents |
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$ |
98,271 |
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$ |
124,245 |
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Short-term investments |
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92,331 |
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115,708 |
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Accounts receivable, net (1) |
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18,035 |
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16,203 |
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Inventory and other deferred costs |
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7,384 |
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6,144 |
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Prepaid expenses and other current assets |
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7,029 |
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5,651 |
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Total current assets |
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223,050 |
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267,951 |
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Property and equipment, net |
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50,316 |
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44,815 |
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Operating lease right-of-use assets |
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14,763 |
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15,118 |
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Other long-term assets |
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3,471 |
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6,280 |
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Total assets |
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$ |
291,600 |
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$ |
334,164 |
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Liabilities and Stockholders’ Equity |
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Current liabilities |
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Accounts payable (2) |
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$ |
14,488 |
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$ |
12,989 |
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Accrued and other current liabilities (2) |
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33,139 |
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25,079 |
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Contract liabilities |
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1,647 |
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1,562 |
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Total current liabilities |
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49,274 |
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39,630 |
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Long-term operating lease liabilities |
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29,296 |
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31,866 |
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Other long-term liabilities |
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360 |
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1,483 |
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Total liabilities |
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78,930 |
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72,979 |
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Commitments and contingencies |
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||||||
Stockholders’ equity |
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||||||
Preferred stock, $0.0001 par value — 10,000,000 shares authorized; none issued |
|
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— |
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— |
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||||
Common stock, $0.0001 par value — 200,000,000 shares authorized; 108,378,087 and 102,475,891 shares issued and outstanding, respectively |
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10 |
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10 |
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||||
Additional paid-in capital |
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939,603 |
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892,331 |
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Accumulated other comprehensive income (loss) |
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|
(167 |
) |
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104 |
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||||
Accumulated deficit |
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(726,776 |
) |
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(631,260 |
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Total stockholders’ equity |
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212,670 |
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|
261,185 |
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Total liabilities and stockholders’ equity |
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$ |
291,600 |
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|
$ |
334,164 |
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(1) Includes related party accounts receivable of $4.2 million and $2.5 million as of September 30, 2026 and December 31, 2025, respectively.
(2) Includes related party liabilities of $5.0 million and $5.7 million as of September 30, 2026 and December 31, 2025, respectively.
6