| Item 1. | Security and Issuer |
| (a) | Title of Class of Securities:
Common Stock, par value $0.0001 per share |
| (b) | Name of Issuer:
Personalis, Inc. |
| (c) | Address of Issuer's Principal Executive Offices:
6600 Dumbarton Circle, Fremont,
CALIFORNIA
, 94555. |
Item 1 Comment:
This Amendment No. 3 (this "Amendment No. 3" or this "Schedule 13D/A") amends and supplements the statement on Schedule 13D originally filed with the Securities and Exchange Commission (the "SEC") on August 24, 2020, and amended on March 7, 2022 and June 28, 2024 (as amended, the "Statement") by Lightspeed Venture Partners VIII, L.P. ("Lightspeed VIII"), Lightspeed General Partner VIII, L.P. ("LGP VIII"), Lightspeed Ultimate General Partner VIII, Ltd. ("LUGP VIII"), Lightspeed Venture Partners Select, L.P. ("Lightspeed Select"), Lightspeed General Partner Select, L.P. ("LGP Select"), Lightspeed Ultimate General Partner Select, Ltd. ("LUGP Select"), Lightspeed Venture Partners Select IV, L.P. ("Lightspeed Select IV"), Lightspeed General Partner Select IV, L.P. ("LGP Select IV"), Lightspeed Ultimate General Partner Select IV, L.L.C. ("LUGP Select IV"), LSVP VIII Trust ("Lightspeed VIII Trust"), Lightspeed Trustee VIII, LLC ("Lightspeed VIII Trustee"), Barry Eggers, Ravi Mhatre, Peter Y. Nieh and Arif Janmohamed. Unless otherwise defined herein, capitalized terms used in this Amendment No. 3 shall have the meanings ascribed to them in the Statement. Unless amended or supplemented below, the information in the Statement remains unchanged. |
| Item 2. | Identity and Background |
|
| (a) | This Schedule 13D/A is being filed on behalf of Lightspeed Select IV, LGP Select IV, LUGP Select IV, Lightspeed Select, LGP Select, LUGP Select, Lightspeed VIII, LGP VIII, LUGP VIII, Lightspeed VIII Trust, and Lightspeed VIII Trustee. The foregoing entities are collectively referred to herein as the "Reporting Persons." The agreement among the Reporting Persons to file this Schedule 13D jointly in accordance with Rule 13d-1(k) of the Securities Exchange Act of 1934, as amended, (the "Act") is attached hereto as Exhibit 99.1. |
| (b) | The address of the principal business office of each of the Reporting Persons is 2200 Sand Hill Road, Menlo Park, CA 94025. To the knowledge of the Reporting Persons, the name, business address, citizenship, and principal occupation or employment of each director and officer of each of the Reporting Persons, and any other information concerning the Reporting Persons and other persons and entities as to which such information is required to be disclosed in response to General Instruction C to Schedule 13D are set forth in Schedule A to this Statement and incorporated herein by this reference. |
| (c) | The principal business of the Reporting Persons is venture capital investments. |
| (d) | During the last five years, none of the Reporting Persons has been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors). |
| (e) | During the last five years, none of the Reporting Persons has been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree of final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws. |
| (f) | Row 6 of each Reporting Person's cover page to this Schedule 13D/A sets forth the place of organization of such Reporting Person and is incorporated by reference. |
| Item 5. | Interest in Securities of the Issuer |
| (a) | Rows 11 and 13 of each Reporting Person's cover page to this Schedule 13D/A set forth the aggregate number of shares of common stock and percentages of the shares of common stock beneficially owned by such Reporting Person and are incorporated by reference. The percentage set forth in each row 13 is based upon 104,721,098 shares of common stock outstanding as of April 29, 2026, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on May 7, 2026.
The Reporting Persons' beneficial ownership of the Issuer's securities includes (i) 2,084,240 shares of common stock directly held by Lightspeed Select IV; (ii) 1,958,726 shares of common stock directly held by Lightspeed Select; and (iii) 2,058,884 shares of common stock directly held by Lightspeed VIII. Collectively, the Reporting Persons beneficially own an aggregate of 6,101,850 shares of common stock, which represents 5.8% of the Issuer's outstanding common stock.
LUGP Select IV serves as the sole general partner of LGP Select IV, which serves as the sole general partner of Lightspeed Select IV.
LUGP Select serves as the sole general partner of LGP Select, which serves as the sole general partner of Lightspeed Select.
LUGP VIII serves as the sole general partner of LGP VIII, which serves as the sole general partner of Lightspeed VIII. The securities held by Lightspeed VIII are deemed to be held on behalf of, and for the benefit of, Lightspeed VIII Trust. Lightspeed VIII Trustee is the trustee of Lightspeed VIII Trust. |
| (b) | Rows 7 through 10 of each Reporting Person's cover page to this Schedule 13D/A set forth the number of shares of common stock as to which such Reporting Person has the sole or shared power to vote or direct the vote and sole or shared power to dispose or to direct the disposition and are incorporated by reference. |
| (c) | Except as set forth below, none of the Reporting Persons has effected any transactions with respect to the securities of the Issuer during the past sixty days.
On June 8, 2026, LSVP VIII Trust made a pro rata in-kind distribution for no additional consideration of 2,058,884 shares of common stock held by Lightspeed VIII to the beneficiaries of LSVP VIII Trust, which consist of LGP VIII and the limited partners of Lightspeed VIII. Of the shares distributed by LSVP VIII Trust, LGP VIII received 551,521 shares and subsequently made a pro rata in-kind distribution for no additional consideration of such shares of common stock to its members.
|
| (d) | No other person is known to have the right to receive or the power to direct the receipt of dividends from, or any proceeds from the sale of, the securities beneficially owned by any of the Reporting Persons. |
| (e) | Not applicable. |
| Item 7. | Material to be Filed as Exhibits. |
| | Exhibit 99.1 Joint Filing Agreement
Exhibit 99.2 Schedule A |
