Plus Therapeutics, Inc. reporting persons CVI Investments, Inc. and Heights Capital Management, Inc. disclosed beneficial ownership of 9,009,978 shares, representing 4.9% of the outstanding common stock. The filing states there were 171,550,698 Shares outstanding as of March 18, 2026.
The reported shares consist of shares issuable upon exercise of warrants, and exercise is limited so that beneficial ownership would not exceed 4.99%. Heights Capital Management, Inc. serves as investment manager and may exercise shared voting and dispositive power over the reported shares.
Positive
None.
Negative
None.
Insights
Large holder reports a sub-5% position via warrants managed by an investment manager.
The filing lists 9,009,978 shares as beneficially owned by CVI Investments, Inc. and Heights Capital Management, Inc., equal to 4.9% of 171,550,698 shares outstanding as of March 18, 2026. The reported holdings "consist of Shares issuable upon the exercise of warrants".
Because the warrants include a 4.99% beneficial ownership cap, actual exercisability depends on other aggregated holdings; subsequent disclosures would show any exercises or transfers.
Filing clarifies voting/dispositive authority and limited beneficial ownership disclosure.
The reporting persons state shared voting and dispositive power of 9,009,978 shares and include a note that Heights Capital Management, Inc. is investment manager to CVI Investments, Inc. Signatures show authorization via a previously filed Limited Power of Attorney.
Disclosure labels and the 4.99% exercisability cap are governance-relevant; further filings will reflect any change in exercised warrants or aggregated holdings.
Key Figures
Beneficial ownership:9,009,978 sharesPercent of class:4.9%Shares outstanding:171,550,698 shares+2 more
5 metrics
Beneficial ownership9,009,978 sharesreported beneficially owned by CVI Investments/Heights Capital
Percent of class4.9%percent of common stock based on shares outstanding
Shares outstanding171,550,698 sharesas of <date>March 18, 2026</date>
Beneficial ownership cap4.99%warrants not exercisable to the extent that ownership would exceed 4.99%
Filing signature date05/13/2026signature by Sarah Travis
Key Terms
warrants, Schedule 13G/A, Limited Power of Attorney
3 terms
warrantsfinancial
"The number of Shares reported as beneficially owned consists of Shares issuable upon the exercise of warrants"
Warrants are special documents that give you the right to buy a company's stock at a set price before a certain date. They are often used as a way for companies to attract investors or raise money, and their value can increase if the company's stock price goes up.
Schedule 13G/Aregulatory
"This statement is filed by the entities listed below"
A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.
Limited Power of Attorneylegal
"Heights Capital Management, Inc. serves as authorized agent ... pursuant to a Limited Power of Attorney"
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 1)
Plus Therapeutics, Inc.
(Name of Issuer)
Common Stock, $0.001 par value per share
(Title of Class of Securities)
72941H509
(CUSIP Number)
03/31/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
72941H509
1
Names of Reporting Persons
CVI Investments, Inc.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
CAYMAN ISLANDS
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
9,009,978.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
9,009,978.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
9,009,978.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
4.9 %
12
Type of Reporting Person (See Instructions)
CO
Comment for Type of Reporting Person: With respect to Row 6 and Row 8 above, Heights Capital Management, Inc. is the investment manager to CVI Investments, Inc. and as such may exercise voting and dispositive power over the shares reported as beneficially owned by CVI Investments, Inc. herein.
SCHEDULE 13G
CUSIP Number(s):
72941H509
1
Names of Reporting Persons
Heights Capital Management, Inc.
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
9,009,978.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
9,009,978.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
9,009,978.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
4.9 %
12
Type of Reporting Person (See Instructions)
CO
Comment for Type of Reporting Person: With respect to Row 6 and Row 8 above, Heights Capital Management, Inc. is the investment manager to CVI Investments, Inc. and as such may exercise voting and dispositive power over the shares reported as beneficially owned by CVI Investments, Inc. herein.
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
Plus Therapeutics, Inc.
(b)
Address of issuer's principal executive offices:
6420 Levit Green Boulevard, Suite 310, Houston, TX 77021
Item 2.
(a)
Name of person filing:
This statement is filed by the entities listed below, who are collectively referred to herein as "Reporting Persons," with respect to the shares of common stock of Plus Therapeutics, Inc. (the "Company"), $0.001 par value per share (the "Shares").
(i) CVI Investments, Inc.
(ii) Heights Capital Management, Inc.
(b)
Address or principal business office or, if none, residence:
The address of the principal business office of CVI Investments, Inc. is:
P.O. Box 309GT
Ugland House
South Church Street
George Town
Grand Cayman
KY1-1104
Cayman Islands
The address of the principal business office of Heights Capital Management, Inc. is:
101 California Street, Suite 3250
San Francisco, California 94111
(c)
Citizenship:
Citizenship is set forth in Row 4 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person.
(d)
Title of class of securities:
Common Stock, $0.001 par value per share
(e)
CUSIP No.:
72941H509
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
The information required by this Item 4(a) is set forth in Row 9 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person.
The number of Shares reported as beneficially owned consists of Shares issuable upon the exercise of warrants to purchase Shares (the "Warrants"). The Warrants are not exercisable to the extent that the total number of Shares then beneficially owned by a Reporting Person and its affiliates and any other persons whose beneficial ownership of Shares would be aggregated with such Reporting Person for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended, would exceed 4.99%.
The Company's Definitive Proxy Statement on Schedule 14A, filed on March 31, 2026, indicates there were 171,550,698 Shares outstanding as of March 18, 2026.
(b)
Percent of class:
4.9 %
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
The information required by this Item 4(c)(i) is set forth in Row 5 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person.
(ii) Shared power to vote or to direct the vote:
The information required by this Item 4(c)(ii) is set forth in Row 6 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person.
Heights Capital Management, Inc., which serves as the investment manager to CVI Investments, Inc., may be deemed to be the beneficial owner of all Shares owned by CVI Investments, Inc. Each of the Reporting Persons hereby disclaims any beneficial ownership of any such Shares, except for their pecuniary interest therein.
(iii) Sole power to dispose or to direct the disposition of:
The information required by this Item 4(c)(iii) is set forth in Row 7 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person.
(iv) Shared power to dispose or to direct the disposition of:
The information required by this Item 4(c)(iv) is set forth in Row 8 of the cover page for each Reporting Person hereto and is incorporated herein by reference for each such Reporting Person.
Heights Capital Management, Inc., which serves as the investment manager to CVI Investments, Inc., may be deemed to be the beneficial owner of all Shares owned by CVI Investments, Inc. Each of the Reporting Persons hereby disclaims any beneficial ownership of any such Shares, except for their pecuniary interest therein.
Item 5.
Ownership of 5 Percent or Less of a Class.
Ownership of 5 percent or less of a class
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
Not Applicable
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
Not Applicable
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
CVI Investments, Inc.
Signature:
/s/ Sarah Travis
Name/Title:
Sarah Travis, Assistant General Counsel and Assistant Secretary of Heights Capital Management, Inc.
Date:
05/13/2026
Heights Capital Management, Inc.
Signature:
/s/ Sarah Travis
Name/Title:
Sarah Travis, Assistant General Counsel and Assistant Secretary
Date:
05/13/2026
Comments accompanying signature: Heights Capital Management, Inc. serves as authorized agent of CVI Investments, Inc. pursuant to a Limited Power of Attorney, a copy of which was previously filed.
Exhibit Information
EXHIBIT INDEX
EXHIBIT DESCRIPTION
24 Limited Power of Attorney*
99 Joint Filing Agreement*
* Previously filed
What stake does CVI Investments / Heights Capital hold in PSTV?
They report beneficial ownership of 9,009,978 shares, equal to 4.9% of common stock. The filing states 171,550,698 Shares outstanding as of March 18, 2026, and the reported shares consist of shares issuable upon exercise of warrants.
Are the reported PSTV shares immediately exercisable?
The filing states the reported shares "consist of Shares issuable upon the exercise of warrants." It also states exercises are limited so that ownership would not exceed 4.99%. Timing and exercisability conditions are not detailed in the excerpt.
Who holds voting and dispositive power over the reported PSTV shares?
Heights Capital Management, Inc. serves as investment manager to CVI Investments, Inc. and may exercise shared voting and dispositive power over the 9,009,978 shares reported. Both entities disclaim beneficial ownership except for pecuniary interest.
Does this filing trigger Schedule 13G/A reporting thresholds for PSTV?
Yes; the filing is a Schedule 13G/A reporting ownership of less than 5%. It is titled an amendment and classifies the position as ownership of 5 percent or less of a class under applicable rules.
