UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549
    FORM 6-K
    REPORT OF FOREIGN PRIVATE ISSUER
    PURSUANT TO RULE 13a-16 OR 15d-16
    OF THE SECURITIES EXCHANGE ACT OF 1934
    For the month of October 2025
    Commission File Number: 001-39152
    QUANTUM BIOPHARMA LTD.
    (Registrant)
    1 Adelaide Street East, Suite 801
    Toronto, Ontario M5C 2V9
    (Address of Principal Executive Offices)
    Indicate by check mark whether the Registrant files or will file annual reports under cover of Form 20-F or Form 40-F.
    Form 20-F  ☒            Form 40-F  ☐
    Indicate by check mark if the Registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):  ☐
    Indicate by check mark if the Registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):  ☐
    
    DOCUMENTS INCORPORATED BY REFERENCE
    Exhibits 99.3 through 99.11 of this Form 6-K are hereby incorporated by reference into the Registrant’s Registration Statement on Form F-3 (File No. 333-276264) and shall be deemed to be a part thereof from the date on which this report is furnished, to the extent not superseded by documents or reports subsequently filed or furnished.
    SIGNATURES
 
    Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
    
        
            |  | QUANTUM BIOPHARMA LTD. | 
        
            |  | (Registrant) | 
        
            |  |  |  | 
        
            | Date October 28, 2025 | By | /s/ Donal Carroll | 
        
            |  |  | Donal Carroll | 
        
            |  |  | Chief Financial Officer | 
    
    
    
    EXHIBIT INDEX
    
        
            | Exhibit |  | Description of Exhibit | 
        
            |  |  | 
        
            | 99.1 |  | Material Change Report dated February 6, 2024 | 
        
            |  |  |  | 
        
            | 99.2 |  | Material Change Report dated February 26, 2024 | 
        
            |  |  |  | 
        
            | 99.3 |  | Material Change Report dated July 3, 2024 | 
        
            |  |  |  | 
        
            | 99.4 |  | Material Change Report dated August 23, 2024 | 
        
            |  |  |  | 
        
            | 99.5 |  | Material Change Report dated August 29, 2024 | 
        
            |  |  |  | 
        
            | 99.6 |  | Material Change Report dated September 13, 2024 | 
        
            |  |  |  | 
        
            | 99.7 |  | Material Change Report dated September 19, 2024 | 
        
            |  |  |  | 
        
            | 99.8 |  | Material Change Report dated October 3, 2024 | 
        
            |  |  |  | 
        
            | 99.9 |  | Material Change Report dated March 17, 2025 | 
        
            |  |  |  | 
        
            | 99.10 |  | Material Change Report dated June 27, 2025 | 
        
            |  |  |  | 
        
            | 99.11 |  | Material Change Report dated September 30, 2025 |