RTW reports 6% uniQure (QURE) stake in amended Schedule 13G

Rhea-AI Filing Summary

RTW Investments, LP and Roderick Wong, M.D. report a significant ownership stake in uniQure N.V. in this amended Schedule 13G filing. They disclose beneficial ownership of 3,711,462 ordinary shares, representing 6.0% of the class, based on 62,291,663 shares outstanding as of November 6, 2025.

The shares are held by RTW-managed funds, with RTW Investments and Dr. Wong sharing voting and dispositive power over the same 3,711,462 shares. They certify the position is held in the ordinary course of business and not for the purpose of changing or influencing control of uniQure.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 3)

uniQure N.V.

(Name of Issuer)

Ordinary Shares, par value 0.05 euro

(Title of Class of Securities)

N90064101

(CUSIP Number)

12/31/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. N90064101

1

Names of Reporting Persons

RTW Investments, LP

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 3,711,462.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 3,711,462.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

3,711,462.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.0 %

12

Type of Reporting Person (See Instructions)

IA, PN

SCHEDULE 13G

CUSIP No. N90064101

1

Names of Reporting Persons

Roderick Wong

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 3,711,462.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 3,711,462.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

3,711,462.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.0 %

12

Type of Reporting Person (See Instructions)

HC, IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: uniQure N.V.
(b)	Address of issuer's principal executive offices: Paasheuvelweg 25a, Amsterdam, P7, 1105 BP.
Item 2.
(a)	Name of person filing: This statement is filed by: (i) RTW Investments, LP ("RTW Investments"), a Delaware limited partnership and the investment adviser to certain funds (the "RTW Funds"), with respect to the Ordinary Shares, par value Euro 0.05 (the "Shares") of uniQure N.V. (the "Company") directly held by the RTW Funds; and (ii) Roderick Wong, M.D. ("Dr. Wong"), the Managing Partner and Chief Investment Officer of RTW Investments, with respect to the Shares directly held by the RTW Funds. The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, as amended, the beneficial owner of the Shares reported herein.
(b)	Address or principal business office or, if none, residence: The address of the business office of each of the Reporting Persons is 40 10th Avenue, Floor 7, New York, New York 10014.
(c)	Citizenship: RTW Investments is a Delaware limited partnership. Dr. Wong is a citizen of the United States.
(d)	Title of class of securities: Ordinary Shares, par value 0.05 euro
(e)	CUSIP No.: N90064101
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: The information required by Item 4(a) is set forth in Rows 5 - 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentages set forth in Row 11 of the cover pages are calculated based upon 62,291,663 Shares outstanding as of November 6, 2025 as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (the "SEC") on November 10, 2025.
(b)	Percent of class: RTW Investments: 6.0% Dr. Wong: 6.0%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: RTW Investments: 0 Dr. Wong: 0
	(ii) Shared power to vote or to direct the vote: RTW Investments: 3,711,462 Shares Dr. Wong: 3,711,462 Shares
	(iii) Sole power to dispose or to direct the disposition of: RTW Investments: 0 Dr. Wong: 0
	(iv) Shared power to dispose or to direct the disposition of: RTW Investments: 3,711,462 Shares Dr. Wong: 3,711,462 Shares
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. See Item 2. The RTW Funds have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Shares reported herein.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

RTW Investments, LP

Signature:	/s/ Roderick Wong, M.D.
Name/Title:	Roderick Wong, M.D., Managing Partner
Date:	02/17/2026

Roderick Wong

Signature:	s/ Roderick Wong, M.D.
Name/Title:	Roderick Wong, M.D.
Date:	02/17/2026

Exhibit Information

Exhibit 99.1 Joint Filing Agreement (incorporated by reference to Exhibit 99.1 to the Reporting Persons' Schedule 13G filed with the SEC on May 15, 2025).

FAQ

What ownership in uniQure (QURE) do RTW Investments and Roderick Wong report?

RTW Investments and Roderick Wong report beneficial ownership of 3,711,462 uniQure ordinary shares, equal to 6.0% of the outstanding class. This percentage is calculated using 62,291,663 shares outstanding as of November 6, 2025, as disclosed by uniQure.

Who are the reporting persons in this uniQure (QURE) Schedule 13G/A?

The reporting persons are RTW Investments, LP, a Delaware investment adviser to certain funds, and Roderick Wong, M.D., its Managing Partner and Chief Investment Officer. They collectively report beneficial ownership of the same 3,711,462 uniQure ordinary shares.

How much voting and dispositive power over uniQure (QURE) shares do the filers report?

RTW Investments and Roderick Wong each report shared voting power and shared dispositive power over 3,711,462 uniQure ordinary shares, and no sole voting or dispositive power. This means decisions are made jointly regarding those shares held by the RTW funds.

On what share count is the 6.0% uniQure (QURE) ownership based?

The reported 6.0% ownership is based on 62,291,663 uniQure ordinary shares outstanding as of November 6, 2025. That outstanding share figure comes from uniQure’s Quarterly Report on Form 10-Q filed with the SEC on November 10, 2025.

Are RTW Investments and Roderick Wong seeking control of uniQure (QURE)?

The filers certify the uniQure shares were acquired and are held in the ordinary course of business. They state the holdings are not for the purpose of changing or influencing control of uniQure and are not part of any control-seeking transaction.

Who has the right to dividends and sale proceeds from the uniQure (QURE) shares?

The filing states that the RTW Funds have the right to receive, or direct the receipt of, dividends and sale proceeds from the reported uniQure shares. RTW Investments advises these funds, and the shares are directly held by the RTW Funds.