uniQure N.V. filed an Amendment No. 4 to a Schedule 13G/A reporting shared beneficial ownership of 2,586,356 Ordinary Shares. The filing states this represents 4.1% of the class based on 62,529,408 Shares outstanding as of February 26, 2026. The reporting persons are RTW Investments, LP and Roderick Wong, M.D., reporting shared voting and dispositive power over the same 2,586,356 shares. The statement notes the RTW Funds have the right to receive dividends or proceeds from these Shares.
Positive
None.
Negative
None.
Insights
RTW and Dr. Wong report shared beneficial ownership of 2,586,356 shares (4.1%).
The filing lists 2,586,356 shares under shared voting and shared dispositive power for both RTW Investments and Dr. Wong, calculated against February 26, 2026 outstanding shares of 62,529,408. This is a passive disclosure under Schedule 13G/A classification.
Cash‑flow treatment is not stated; subsequent filings could disclose transactions but none are shown here.
The amendment clarifies ownership and confirms the RTW Funds' entitlement to dividends/proceeds.
The statement reiterates that the RTW Funds "have the right to receive or the power to direct the receipt of dividends" from the reported Shares. The text preserves standard Schedule 13G/A language about beneficial ownership and the reporting persons' roles.
Filing signatures and a joint filing agreement are referenced by exhibit.
Key Figures
Reported shares:2,586,356 sharesPercent of class:4.1%Shares outstanding:62,529,408 shares
3 metrics
Reported shares2,586,356 sharesshared voting and dispositive power reported by RTW and Dr. Wong
Percent of class4.1%calculated on <date>February 26, 2026</date> outstanding shares
Shares outstanding62,529,408 sharesas of <date>February 26, 2026</date> per company 10-K
"Amendment No. 4 to a Schedule 13G/A reporting beneficial ownership"
A Schedule 13G/A is an amended public filing with the U.S. securities regulator that updates a previous Schedule 13G, disclosing when an individual or group holds a substantial (typically over 5%) stake in a company and is claiming a passive, non‑controlling intent. Investors monitor these updates because rising or falling holdings can signal changing confidence, potential future moves, or shifts in voting power — like watching a public ledger where large shareholders quietly adjust their positions.
Shared Dispositive Powerregulatory
"Shared Dispositive Power 2,586,356.00"
Beneficially ownedregulatory
"Amount beneficially owned: The information required by Item 4(a)"
Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.
What stake does RTW Investments report in uniQure (QURE)?
RTW Investments reports shared beneficial ownership of 2,586,356 shares, equal to 4.1% of the class based on 62,529,408 shares outstanding as of February 26, 2026. The shares are reported as shared voting and dispositive power.
Does Roderick Wong directly control the uniQure shares reported?
The filing shows Dr. Wong reports the same 2,586,356 shares with shared voting and shared dispositive power. It attributes holdings to RTW Funds and states the filing should not be construed as admission of individual beneficial ownership.
Are the uniQure shares reported by RTW subject to dividend or sale proceeds rights?
Yes. The filing explicitly states the RTW Funds "have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of," the reported Shares, per the Schedule 13G/A language included in Item 6.
What outstanding share base does the Schedule 13G/A use for its percentage calculation?
The percentage calculation uses 62,529,408 Shares outstanding as of February 26, 2026, a figure disclosed from the company’s Annual Report on Form 10‑K referenced in the filing.
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 4)
uniQure N.V.
(Name of Issuer)
Ordinary Shares, par value 0.05 euro
(Title of Class of Securities)
N90064101
(CUSIP Number)
03/31/2026
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
Rule 13d-1(b)
Rule 13d-1(c)
Rule 13d-1(d)
schemaVersion:
SCHEDULE 13G
CUSIP Number(s):
N90064101
1
Names of Reporting Persons
RTW Investments, LP
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
DELAWARE
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
2,586,356.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
2,586,356.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
2,586,356.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
4.1 %
12
Type of Reporting Person (See Instructions)
IA, PN
SCHEDULE 13G
CUSIP Number(s):
N90064101
1
Names of Reporting Persons
Roderick Wong
2
Check the appropriate box if a member of a Group (see instructions)
(a)
(b)
3
Sec Use Only
4
Citizenship or Place of Organization
UNITED STATES
Number of Shares Beneficially Owned by Each Reporting Person With:
5
Sole Voting Power
0.00
6
Shared Voting Power
2,586,356.00
7
Sole Dispositive Power
0.00
8
Shared Dispositive Power
2,586,356.00
9
Aggregate Amount Beneficially Owned by Each Reporting Person
2,586,356.00
10
Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)
11
Percent of class represented by amount in row (9)
4.1 %
12
Type of Reporting Person (See Instructions)
HC, IN
SCHEDULE 13G
Item 1.
(a)
Name of issuer:
uniQure N.V.
(b)
Address of issuer's principal executive offices:
Paasheuvelweg 25a, Amsterdam, P7, 1105 BP.
Item 2.
(a)
Name of person filing:
This statement is filed by:
(i) RTW Investments, LP ("RTW Investments"), a Delaware limited partnership and the investment adviser to certain funds (the "RTW Funds"), with respect to the Ordinary Shares, par value Euro 0.05 (the "Shares") of uniQure N.V. (the "Company") directly held by the RTW Funds; and
(ii) Roderick Wong, M.D. ("Dr. Wong"), the Managing Partner and Chief Investment Officer of RTW Investments, with respect to the Shares directly held by the RTW Funds.
The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons."
The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, as amended, the beneficial owner of the Shares reported herein.
(b)
Address or principal business office or, if none, residence:
The address of the business office of each of the Reporting Persons is 40 10th Avenue, Floor 7, New York, New York 10014.
(c)
Citizenship:
RTW Investments is a Delaware limited partnership. Dr. Wong is a citizen of the United States.
(d)
Title of class of securities:
Ordinary Shares, par value 0.05 euro
(e)
CUSIP No.:
N90064101
Item 3.
If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)
Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)
An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)
An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:
(k)
Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.
Ownership
(a)
Amount beneficially owned:
The information required by Item 4(a) is set forth in Rows 5 - 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentages set forth in Row 11 of the cover pages are calculated based upon 62,529,408 Shares outstanding as of February 26, 2026 as reported in the Company's Annual Report on Form 10-K filed with the Securities and Exchange Commission (the "SEC") on March 2, 2026.
(b)
Percent of class:
RTW Investments: 4.1%
Dr. Wong: 4.1%
(c)
Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
RTW Investments: 0
Dr. Wong: 0
(ii) Shared power to vote or to direct the vote:
RTW Investments: 2,586,356 Shares
Dr. Wong: 2,586,356 Shares
(iii) Sole power to dispose or to direct the disposition of:
RTW Investments: 0
Dr. Wong: 0
(iv) Shared power to dispose or to direct the disposition of:
RTW Investments: 2,586,356 Shares
Dr. Wong: 2,586,356 Shares
Item 5.
Ownership of 5 Percent or Less of a Class.
Ownership of 5 percent or less of a class
Item 6.
Ownership of more than 5 Percent on Behalf of Another Person.
If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
See Item 2. The RTW Funds have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Shares reported herein.
Item 7.
Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
Not Applicable
Item 8.
Identification and Classification of Members of the Group.
Not Applicable
Item 9.
Notice of Dissolution of Group.
Not Applicable
Item 10.
Certifications:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
RTW Investments, LP
Signature:
/s/ Roderick Wong, M.D.
Name/Title:
Roderick Wong, M.D., Managing Partner
Date:
05/15/2026
Roderick Wong
Signature:
s/ Roderick Wong, M.D.
Name/Title:
Roderick Wong, M.D.
Date:
05/15/2026
Exhibit Information
Exhibit 99.1 Joint Filing Agreement (incorporated by reference to Exhibit 99.1 to the Reporting Persons' Schedule 13G filed with the SEC on May 15, 2025).
