[SCHEDULE 13G/A] uniQure N.V. SEC Filing

Rhea-AI Filing Summary

RTW Investments, LP and Roderick Wong report a passive 9.4% stake in uniQure (QURE), holding 5,158,231 ordinary shares. The holdings are held directly by the RTW Funds and RTW Investments and Dr. Wong report shared voting and dispositive power over all 5,158,231 shares and report no sole voting or dispositive power. The percentage is calculated using 54,865,673 shares outstanding as reported for the period cited in the filing. The statement is made on a Schedule 13G basis and includes a certification that the shares were acquired and are held in the ordinary course of business and not to change or influence control of the issuer.

Positive

• RTW Investments and Dr. Roderick Wong report ownership of 5,158,231 shares, representing a material 9.4% stake
• Holdings are reported as held on behalf of the RTW Funds with shared voting and dispositive power
• Filing is on Schedule 13G with a certification that shares were acquired in the ordinary course and not to change control

Negative

• None.

Insights

Financial Analyst

RTW holds a materially large passive position (9.4%) in uniQure, signaling notable institutional exposure without activist intent.

RTW Investments and Dr. Roderick Wong report ownership of 5,158,231 shares, representing 9.4% of the 54.9 million shares outstanding referenced in the filing. The filing is a Schedule 13G, and Item 10 contains the standard certification that the position was acquired and is held in the ordinary course of business and not for the purpose of changing control. The reported shared voting and dispositive power (and zero sole power) indicates influence through pooled fund holdings rather than individual control. For investors, this documents significant institutional interest but does not signal an imminent activist campaign.

Corporate Governance Expert

Schedule 13G classification confirms passive intent; 9.4% stake gives material voice in shareholder matters but no sole control.

The reporting persons are RTW Investments (an investment adviser to the RTW Funds) and Dr. Roderick Wong (Managing Partner/Chief Investment Officer). Both report shared voting and dispositive power over 5,158,231 shares and no sole powers. The filing identifies the shares as held on behalf of the RTW Funds and uses 54,865,673 shares outstanding as the denominator. From a governance perspective, a near-10% stake is material to votes and proposals, but the Schedule 13G framework here documents a non-control posture under the representations in Item 10.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 1)

uniQure N.V.

(Name of Issuer)

Ordinary Shares, par value 0.05 euro

(Title of Class of Securities)

N90064101

(CUSIP Number)

06/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. N90064101

1

Names of Reporting Persons

RTW Investments, LP

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 5,158,231.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 5,158,231.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

5,158,231.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

9.4 %

12

Type of Reporting Person (See Instructions)

IA, PN

SCHEDULE 13G

CUSIP No. N90064101

1

Names of Reporting Persons

Roderick Wong

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 5,158,231.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 5,158,231.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

5,158,231.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

9.4 %

12

Type of Reporting Person (See Instructions)

HC, IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: uniQure N.V.
(b)	Address of issuer's principal executive offices: Paasheuvelweg 25a, Amsterdam, P7, 1105 BP.
Item 2.
(a)	Name of person filing: This statement is filed by: (i) RTW Investments, LP ("RTW Investments"), a Delaware limited partnership and the investment adviser to certain funds (the "RTW Funds"), with respect to the Ordinary Shares, par value Euro 0.05 (the "Shares") of uniQure N.V. (the "Company") directly held by the RTW Funds; and (ii) Roderick Wong, M.D. ("Dr. Wong"), the Managing Partner and Chief Investment Officer of RTW Investments, with respect to the Shares directly held by the RTW Funds. The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Securities Exchange Act of 1934, as amended, the beneficial owner of the Shares reported herein.
(b)	Address or principal business office or, if none, residence: The address of the business office of each of the Reporting Persons is 40 10th Avenue, Floor 7, New York, New York 10014.
(c)	Citizenship: RTW Investments is a Delaware limited partnership. Dr. Wong is a citizen of the United States.
(d)	Title of class of securities: Ordinary Shares, par value 0.05 euro
(e)	CUSIP No.: N90064101
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: The information required by Item 4(a) is set forth in Rows 5 - 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentages set forth in Row 11 of the cover pages are calculated based upon 54,865,673 Shares outstanding as of June 30, 2025 as reported in the Company's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on July 29, 2025.
(b)	Percent of class: RTW Investments: 9.4% Dr. Wong: 9.4%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: RTW Investments: 0 Dr. Wong: 0
	(ii) Shared power to vote or to direct the vote: RTW Investments: 5,158,231 Shares Dr. Wong: 5,158,231 Shares
	(iii) Sole power to dispose or to direct the disposition of: RTW Investments: 0 Dr. Wong: 0
	(iv) Shared power to dispose or to direct the disposition of: RTW Investments: 5,158,231 Shares Dr. Wong: 5,158,231 Shares
Item 5.	Ownership of 5 Percent or Less of a Class.
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. See Item 2. The RTW Funds have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, the Shares reported herein.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

RTW Investments, LP

Signature:	/s/ Roderick Wong, M.D.
Name/Title:	Roderick Wong, M.D., Managing Partner
Date:	08/14/2025

Roderick Wong

Signature:	s/ Roderick Wong, M.D.
Name/Title:	Roderick Wong, M.D.
Date:	08/14/2025

FAQ

How many uniQure (QURE) shares does RTW Investments report owning?

The filing reports 5,158,231 shares beneficially owned by RTW Investments and Roderick Wong.

What percentage of uniQure does the reported stake represent?

The reported position represents 9.4% of the outstanding shares based on 54,865,673 shares used in the filing's calculation.

Is this a Schedule 13G or 13D filing for QURE?

This is a Schedule 13G (Amendment No. 1) filed by RTW Investments and Roderick Wong, indicating a passive investor filing under the applicable rule.

Do the reporting persons have sole voting or dispositive power over the shares?

No. The filing shows 0 sole voting power and 0 sole dispositive power and 5,158,231 shared voting and dispositive power.

On whose behalf are the shares held?

The shares are held directly by the RTW Funds, for which RTW Investments serves as investment adviser.