State Street reports 3.6% stake in Uniqure

State Street Corporation reports shared beneficial ownership of 2,260,512 shares of Uniqure N.V. common stock, representing 3.6% of the class as reported on 03/31/2026.

Rhea-AI Filing Summary

State Street Corporation reports shared beneficial ownership of 2,260,512 shares of Uniqure N.V. common stock, representing 3.6% of the class as reported on 03/31/2026. The filing lists shared voting power of 2,230,049 and identifies affiliated investment adviser entities.

The filing is a Schedule 13G disclosure showing passive/beneficial ownership by institutional holders and names SSGA Funds Management, State Street Global Advisors Europe Limited, State Street Global Advisors Limited, State Street Global Advisors Trust Company and State Street Global Advisors, Ltd. as related entities.

Insights

Institutional Ownership Analyst

Large passive stake disclosed by State Street affiliates; no active control asserted.

State Street Corporation reports beneficial ownership of 2,260,512 shares of Uniqure common stock, equal to 3.6% of the class as of 03/31/2026. The filing attributes voting and dispositive powers as shared, indicating custody/agency arrangements.

The excerpt names multiple State Street investment adviser entities; cash‑flow treatment is not specified in the excerpt. Subsequent filings would show changes in holdings if any affiliate adjusts positions.

Corporate Governance Specialist

Disclosure clarifies institutional ownership and group affiliations; no governance change.

The Schedule 13G lists affiliated managers (SSGA Funds Management; State Street Global Advisors entities) consistent with institutional reporting. The filing assigns shared voting power 2,230,049 and shared dispositive power 2,260,512.

This is a passive ownership disclosure under the applicable rules and does not assert control or propose board actions; monitoring future Section 13 filings will show any material shifts.

Key Figures

Beneficial ownership: 2,260,512 shares Percent of class: 3.6% Shared voting power: 2,230,049 shares +3 more

6 metrics

Beneficial ownership 2,260,512 shares Amount beneficially owned as of 03/31/2026

Percent of class 3.6% Percent of Uniqure common stock as of 03/31/2026

Shared voting power 2,230,049 shares Shared power to vote reported in Item 4

Shared dispositive power 2,260,512 shares Shared power to dispose reported in Item 4

CUSIP N90064101 Identifier for Uniqure common stock

Filing type Schedule 13G Passive beneficial ownership disclosure

Key Terms

Schedule 13G, Shared dispositive power, Investment adviser (IA)

3 terms

Schedule 13G regulatory

"The filing is a Schedule 13G disclosure showing passive/beneficial ownership"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

Shared dispositive power financial

"Shared power to dispose or to direct the disposition of: 2,260,512"

Investment adviser (IA) regulatory

"SSGA FUNDS MANAGEMENT, INC. (IA);STATE STREET GLOBAL ADVISORS EUROPE LIMITED (IA)"

An investment adviser (IA) is a person or firm that provides personalized guidance on buying, selling, or holding investments and often manages client portfolios for a fee. Investors should care because an IA has a legal duty to act in the client's best interest—think of them as a navigator who plans and steers your financial journey—so their advice, fee structure and potential conflicts can directly affect returns and financial risk.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What stake does State Street hold in Uniqure (QURE)?

State Street reports beneficial ownership of 2,260,512 shares, equal to 3.6% of Uniqure common stock as of 03/31/2026. The filing attributes this stake to affiliated State Street investment adviser entities.

Does the Schedule 13G indicate State Street controls Uniqure?

No. The filing shows shared voting power of 2,230,049 and lists adviser affiliates, which indicates institutional reporting of beneficial ownership rather than an assertion of control over Uniqure.

Which State Street entities are identified in the filing?

The filing names SSGA Funds Management, Inc., State Street Global Advisors Europe Limited, State Street Global Advisors Limited, State Street Global Advisors Trust Company, and State Street Global Advisors, Ltd. as related affiliates.

When was this beneficial ownership reported?

The reported ownership figure of 2,260,512 shares and the 3.6% stake are tied to the reference date 03/31/2026, with the Schedule 13G signed on 05/12/2026.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 05/12/2026 - 12:13 PM EDT Learn about SEC filing dates

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

UNIQURE NV

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

N90064101

(CUSIP Number)

03/31/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): N90064101

1

Names of Reporting Persons

STATE STREET CORPORATION

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

MASSACHUSETTS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 2,230,049.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 2,260,512.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

2,260,512.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

3.6 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

Item 1.
(a)	Name of issuer: UNIQURE NV
(b)	Address of issuer's principal executive offices: PAASHEUVELWEG 25A, AMSTERDAM, NETHERLANDS, 1105BP
Item 2.
(a)	Name of person filing: STATE STREET CORPORATION;
(b)	Address or principal business office or, if none, residence: ONE CONGRESS STREET, SUITE 1, BOSTON MA 02114, UNITED STATES
(c)	Citizenship: MA
(d)	Title of class of securities: COMMON STOCK
(e)	CUSIP Number(s): N90064101
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 2260512.00
(b)	Percent of class: 3.6 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 2,230,049
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 2,260,512
Item 5.	Ownership of 5 Percent or Less of a Class.
	Ownership of 5 percent or less of a class
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. NOT APPLICABLE
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. SSGA FUNDS MANAGEMENT, INC. (IA);STATE STREET GLOBAL ADVISORS EUROPE LIMITED (IA);STATE STREET GLOBAL ADVISORS LIMITED (IA);STATE STREET GLOBAL ADVISORS TRUST COMPANY (IA);STATE STREET GLOBAL ADVISORS, LTD. (IA);
Item 8.	Identification and Classification of Members of the Group.
	If a group has filed this schedule pursuant to §240.13d-1(b)(1)(ii)(K), so indicate under Item 3(k) and attach an exhibit stating the identity and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to §240.13d-1(c) or §240.13d-1(d), attach an exhibit stating the identity of each member of the group. NOT APPLICABLE
Item 9.	Notice of Dissolution of Group.
	Notice of dissolution of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5. NOT APPLICABLE

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

STATE STREET CORPORATION

Signature:	ELIZABETH SCHAEFER
Name/Title:	SENIOR VICE PRESIDENT, CHIEF ACCOUNTING OFFICER
Date:	05/12/2026