Avidity Biosciences (RNA) CMO sells 2,373 shares to cover taxes on RSUs

Rhea-AI Filing Summary

Avidity Biosciences, Inc. Chief Medical Officer Steven George Hughes reported a mandatory sale of company stock. On January 7, 2026, he sold 2,373 shares of common stock at $72.23 per share, leaving him with 36,494 shares held directly.

According to the disclosure, the sale was required to cover tax withholding tied to the vesting of restricted stock units (RSUs) on January 6, 2026. The company’s equity incentive plans mandate a “sell-to-cover” transaction for these tax obligations, and the filing notes this was an automatic, non-discretionary sale executed under an instruction letter intended to satisfy the affirmative defense conditions of Rule 10b5-1.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
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hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Hughes Steven George

(Last) (First) (Middle)

C/O AVIDITY BIOSCIENCES, INC.

3020 CALLAN RD.

(Street)

SAN DIEGO CA 92121

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Avidity Biosciences, Inc. [ RNA ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief Medical Officer

3. Date of Earliest Transaction (Month/Day/Year)
01/07/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	01/07/2026		S		2,373(1)	D	$72.23	36,494	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Represents the number of shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of RSUs on January 6, 2026 and the sale of the resulting shares of common stock on January 7, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell-to-cover" transaction and does not represent a discretionary trade by the Reporting Person. The Reporting Person has executed an instruction letter for the automatic sale of such "sell-to-cover" shares, intended to satisfy the affirmative defense conditions of Rule 10b5-1.

Remarks:

	/s/ John B. Moriarty, Jr., J.D., Attorney-in-Fact	01/09/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What insider transaction did Avidity Biosciences (RNA) report in this Form 4?

The Form 4 reports that Chief Medical Officer Steven George Hughes sold 2,373 shares of Avidity Biosciences common stock on January 7, 2026 at $72.23 per share, leaving him with 36,494 directly held shares.

Why did the Avidity Biosciences (RNA) CMO sell 2,373 shares?

The filing states the 2,373 shares were sold to cover tax withholding obligations arising from the vesting of RSUs on January 6, 2026. The sale was mandated by the company’s equity incentive plans as a “sell-to-cover” transaction.

Was the Avidity Biosciences (RNA) insider trade discretionary?

No. The document explains that the sale “does not represent a discretionary trade” by the reporting person. It was an automatic sell-to-cover transaction required under Avidity’s equity incentive plans.

Is the Avidity Biosciences (RNA) CMO’s sale part of a Rule 10b5-1 plan?

Yes. The disclosure notes that the reporting person executed an instruction letter for the automatic sale of the sell-to-cover shares, intended to satisfy the affirmative defense conditions of Rule 10b5-1.

How many Avidity Biosciences (RNA) shares does the CMO own after this transaction?

After the tax-related sale, Steven George Hughes is reported to beneficially own 36,494 shares of Avidity Biosciences common stock, held directly.

What role does the reporting person hold at Avidity Biosciences (RNA)?

The reporting person, Steven George Hughes, is identified as an officer of Avidity Biosciences, serving as the company’s Chief Medical Officer.