STOCK TITAN

Revolution Medicines (RVMD) COO trades options, sells 93,575 shares under 10b5-1

Filing Impact
(Very High)
Filing Sentiment
(Very Negative)
Form Type
4

Rhea-AI Filing Summary

Revolution Medicines, Inc. Chief Operating Officer Margaret A. Horn reported a mix of option exercises and stock sales. On June 15 and June 17, 2026, she exercised stock options covering a total of 90,000 shares of common stock at exercise prices of $26.50, $29.80, and $40.74 per share.

Across June 15 and June 17, 2026 and June 16, 2025, she sold 93,575 shares of common stock in open-market transactions at weighted average prices around $156–$160 per share. Footnotes state that the 2026 transactions were effected under a Rule 10b5-1 trading plan and that an earlier Rule 10b5-1 instruction letter addressed tax withholding obligations on RSU vesting.

After these transactions, Horn continues to hold a significant direct equity position, including restricted stock units noted in the footnotes.

Positive

  • None.

Negative

  • None.

Insights

Routine option exercises and pre-planned sales by COO under 10b5-1 arrangements.

COO Margaret A. Horn exercised stock options for 90,000 shares of Revolution Medicines common stock at exercise prices of $26.50, $29.80, and $40.74. She then reported open-market sales totaling 93,575 shares at weighted average prices near $156–$160 per share.

Footnotes specify that the 2026 sales were made under a Rule 10b5-1 trading plan adopted on March 12, 2026. A separate Rule 10b5-1 instruction letter from May 31, 2023 addresses sales to satisfy tax withholding obligations upon RSU vesting after July 15, 2023, indicating some activity is driven by tax and pre-planned liquidity rather than discretionary market timing.

The filing shows continued direct ownership, including RSUs referenced in the footnotes, and an empty derivativeSummary, meaning the options covered in this report were fully exercised. As a result, these transactions appear to be routine equity compensation management rather than a thesis-changing signal for investors.

Insider Horn Margaret A
Role Chief Operating Officer
Sold 93,575 shs ($14.97M)
Type Security Shares Price Value
Exercise Stock Option (Right to Buy) 573 $0.00 --
Exercise Stock Option (Right to Buy) 3,302 $0.00 --
Exercise Stock Option (Right to Buy) 25,725 $0.00 --
Exercise Common Stock 573 $40.74 $23K
Exercise Common Stock 3,302 $29.80 $98K
Exercise Common Stock 25,725 $26.50 $682K
Sale Common Stock 29,600 $160.1243 $4.74M
Exercise Stock Option (Right to Buy) 15,546 $0.00 --
Exercise Stock Option (Right to Buy) 44,854 $0.00 --
Exercise Common Stock 15,546 $40.74 $633K
Exercise Common Stock 44,854 $29.80 $1.34M
Sale Common Stock 60,400 $160.1706 $9.67M
Sale Common Stock 3,575 $156.1193 $558K
Holdings After Transaction: Stock Option (Right to Buy) — 75,075 shares (Direct, null); Common Stock — 155,220 shares (Direct, null)
Footnotes (1)
  1. Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026. Includes 73,050 restricted stock units ("RSUs"). This transaction was executed in multiple trades in prices ranging from $160.00 to $160.3550, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of RSUs after July 15, 2023. This transaction was executed in multiple trades in prices ranging from $156.1105 to $156.8250, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Includes 66,201 RSUs. This transaction was executed in multiple trades in prices ranging from $160.00 to $160.48, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2025 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date. One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2024 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date. One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2023 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.
Shares sold June 17, 2026 29,600 shares at $160.1243 Open-market common stock sale
Shares sold June 15, 2026 60,400 shares at $160.1706 Open-market common stock sale
Shares sold June 16, 2025 3,575 shares at $156.1193 Open-market common stock sale
Total shares sold 93,575 shares Net reported sales across all S-code trades
Options exercised 90,000 shares Aggregate M-code derivative exercises
Option strike prices $26.50, $29.80, $40.74 Exercise prices for stock options converted to common
Shares held after 2025 sale 154,647 shares Direct common stock ownership following June 16, 2025 sale
RSUs included 73,050 RSUs Restricted stock units noted as part of holdings in footnote
Rule 10b5-1 trading plan regulatory
"Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026."
A Rule 10b5-1 trading plan is a pre-arranged schedule that allows company insiders to buy or sell stock at specific times, even if they have inside information. It helps prevent accusations of unfair trading by making these transactions look planned and transparent, rather than sneaky or illegal.
restricted stock units ("RSUs") financial
"Includes 73,050 restricted stock units ("RSUs")."
Restricted stock units (RSUs) are a company promise to give an employee shares of stock (or cash equivalent) in the future, but only after certain conditions—usually staying with the company for a set time or hitting performance goals—are met. Investors watch RSUs because when they vest they increase the number of shares outstanding and can lead insiders to sell shares, affecting share price, company dilution and the true cost of employee pay.
Stock Option (Right to Buy) financial
"security_title: "Stock Option (Right to Buy)""
vesting financial
"upon the vesting of RSUs after July 15, 2023."
Vesting is the process by which you earn full ownership of something, like company stock or a retirement benefit, over time. It’s like earning the right to keep a gift piece by piece the longer you stay with a company, making sure employees stay committed before they receive all the benefits.
exercise price financial
"conversion_or_exercise_price: "26.5000""
The exercise price is the fixed amount at which you can buy or sell an asset, like a stock, when using an options contract. It matters because it helps determine whether exercising the option will be profitable or not, depending on the current market price. Think of it as the set price you agree on today to buy or sell later.
Vesting Commencement Date financial
"measured from March 1, 2025 (the "Vesting Commencement Date"), so that 100% of the shares"
The vesting commencement date is the starting point when an employee begins earning ownership rights to their promised benefits, such as stock options or retirement contributions. Think of it like the day a savings account is opened—only after this date do the benefits start to grow and become fully available over time. It matters to investors because it marks when the clock begins ticking toward full ownership, affecting the timing and value of these benefits.
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SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Horn Margaret A

(Last)(First)(Middle)
C/O REVOLUTION MEDICINES, INC.
700 SAGINAW DRIVE

(Street)
REDWOOD CITY CALIFORNIA 94063

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Revolution Medicines, Inc. [ RVMD ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
Chief Operating Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
06/15/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock06/15/2026M(1)15,546A$40.74173,768(2)D
Common Stock06/15/2026M(1)44,854A$29.8218,622(2)D
Common Stock06/15/2026S(1)60,400D$160.1706(3)158,222(2)D
Common Stock06/16/2025S(4)3,575D$156.1193(5)154,647(6)D
Common Stock06/17/2026M(1)573A$40.74155,220(6)D
Common Stock06/17/2026M(1)3,302A$29.8158,522(6)D
Common Stock06/17/2026M(1)25,725A$26.5184,247(6)D
Common Stock06/17/2026S(1)29,600D$160.1243(7)154,647(6)D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)$40.7406/15/2026M(1)15,546 (8)02/28/2035Common Stock15,546$075,648D
Stock Option (Right to Buy)$29.806/15/2026M(1)44,854 (9)02/28/2034Common Stock44,854$075,052D
Stock Option (Right to Buy)$40.7406/17/2026M(1)573 (8)02/28/2035Common Stock573$075,075D
Stock Option (Right to Buy)$29.806/17/2026M(1)3,302 (9)02/28/2034Common Stock3,302$071,750D
Stock Option (Right to Buy)$26.506/17/2026M(1)25,725 (10)02/28/2033Common Stock25,725$0114,275D
Explanation of Responses:
1. Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on March 12, 2026.
2. Includes 73,050 restricted stock units ("RSUs").
3. This transaction was executed in multiple trades in prices ranging from $160.00 to $160.3550, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
4. Transaction made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy the Reporting Person's tax withholding obligation upon the vesting of RSUs after July 15, 2023.
5. This transaction was executed in multiple trades in prices ranging from $156.1105 to $156.8250, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
6. Includes 66,201 RSUs.
7. This transaction was executed in multiple trades in prices ranging from $160.00 to $160.48, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.
8. One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2025 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.
9. One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2024 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.
10. One forty-eighth (1/48th) of the shares initially subject to the option will vest on each monthly anniversary measured from March 1, 2023 (the "Vesting Commencement Date"), so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date.
/s/ Jack Anders, as Attorney-in-fact for Margaret Horn06/17/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What insider transactions did RVMD COO Margaret Horn report in this Form 4?

Margaret Horn reported exercising stock options for 90,000 shares and selling 93,575 shares of Revolution Medicines common stock. The sales occurred at weighted average prices around $156–$160 per share, reflecting equity compensation activity combined with liquidity and tax-related transactions.

On what dates did RVMD COO Margaret Horn trade Revolution Medicines stock?

The Form 4 shows transactions on June 15, 2026, June 17, 2026, and June 16, 2025. These include both option exercises and open-market sales of common stock, providing a multi-year view of Horn’s reported equity compensation and related liquidity events.

How many Revolution Medicines shares did RVMD COO Margaret Horn sell?

Horn sold a total of 93,575 shares of Revolution Medicines common stock. This includes 60,400 shares sold on June 15, 2026, 29,600 shares sold on June 17, 2026, and 3,575 shares sold on June 16, 2025, all reported as open-market transactions.

Were Margaret Horn’s RVMD stock sales under a Rule 10b5-1 trading plan?

Yes. A footnote states that the 2026 transactions were executed pursuant to a Rule 10b5-1 trading plan adopted on March 12, 2026. Another footnote references a 10b5-1 instruction letter from May 31, 2023, used to address RSU-related tax withholding obligations.

What option exercises by RVMD COO Margaret Horn are disclosed in this Form 4?

The filing shows Horn exercised stock options for 90,000 shares of Revolution Medicines common stock. The options had exercise prices of $26.50, $29.80, and $40.74 per share, with expirations extending to 2033, 2034, and 2035 as disclosed in the derivative entries.

Does the RVMD Form 4 say anything about Margaret Horn’s restricted stock units (RSUs)?

Yes. A footnote notes that her holdings include 73,050 restricted stock units, while another states 66,201 RSUs at a different time. These RSUs represent share-based awards that vest over time, contributing to her ongoing equity stake in Revolution Medicines.