Revolution Medicines, Inc. filings document a late-stage clinical oncology company focused on RAS-addicted cancers and RAS(ON) inhibitors. Its Form 8-K reports include financial results, clinical-program updates for daraxonrasib and other pipeline candidates, regulatory-related disclosures and material events tied to corporate progress.
The company’s SEC record also covers proxy governance, annual meeting matters, executive compensation, registered securities and capital-structure changes. Disclosures identify Nasdaq-listed common stock and warrants, and material-agreement filings describe convertible senior notes due 2033, related indenture terms and other financing arrangements used to support research and development, administrative expenses and potential commercialization activities.
Revolution Medicines reported strong topline results from its global Phase 3 RASolute 302 trial of oral daraxonrasib in previously treated metastatic pancreatic ductal adenocarcinoma. Daraxonrasib improved median overall survival to 13.2 months versus 6.7 months with standard intravenous chemotherapy, with a hazard ratio of 0.40 (p < 0.0001). The therapy also showed statistically significant, clinically meaningful gains in progression-free survival and was generally well tolerated, with a manageable safety profile and no new safety signals. Based on this first interim analysis, all progression-free and overall survival endpoints are considered final, and the company plans to submit these data to global regulators, including a future U.S. New Drug Application under a Commissioner’s National Priority Voucher.
The Vanguard Group filed Amendment No. 4 to a Schedule 13G/A reporting 0 shares (0%) of Revolution Medicines Inc common stock (CUSIP 76155X100). The filing states an internal realignment effective January 12, 2026 under SEC Release No. 34-39538 that disaggregated certain subsidiaries' holdings from The Vanguard Group, Inc. The Schedule lists the filing address as 100 Vanguard Blvd., Malvern, PA and is signed by Ashley Grim, Head of Global Fund Administration, dated 03/27/2026.
The filing declares no sole or shared voting or dispositive power over any Revolution Medicines shares and confirms ownership of 5% or less of the class.
Revolution Medicines, Inc. officer Anthony Mancini exercised options and sold shares of common stock. He exercised options for 37,450 shares of common stock at an exercise price of $33.6200 per share and received 37,450 shares.
On the same date, he sold a total of 37,450 shares in multiple open-market transactions at prices ranging from $93.2230 to $97.2071, pursuant to a Rule 10b5-1 trading plan adopted on December 24, 2025. After these transactions, he directly holds 54,800 shares of common stock, which the footnotes state includes 54,400 restricted stock units.
Revolution Medicines, Inc. officer Anthony Mancini filed an initial statement of beneficial ownership, detailing his existing equity position rather than reporting new trades. He directly holds 54,400 shares of Common Stock as Restricted Stock Units.
He also holds stock options over 149,800 shares of Common Stock at an exercise price of $33.62 per share, expiring on March 31, 2035. Twenty-five percent of these option shares vest on the first anniversary of the April 1, 2025 vesting commencement date, with the remainder vesting monthly over four years.
A separate stock option covers 26,200 shares of Common Stock at an exercise price of $102.02 per share, expiring on February 28, 2036. One forty-eighth of these shares vests on each monthly anniversary of the March 1, 2026 vesting commencement date, so they become fully vested after four years of continued service.
Revolution Medicines, Inc. Chief Development Officer Alan B. Sandler filed an initial beneficial ownership report. He directly holds 53,000 shares of Common Stock, which include 53,000 Restricted Stock Units. He also holds stock options over 167,300 shares at an exercise price of $58.84 per share expiring on October 31, 2035, and options over 11,700 shares at $102.02 per share expiring on February 28, 2036. These options vest monthly over four years starting from vesting commencement dates on November 1, 2025 and March 1, 2026, subject to his continued service.
Revolution Medicines, Inc. Chief Medical Officer Wei Lin reported an open-market sale of 2,073 shares of common stock on March 17, 2026 at an average price of $99.4804 per share. The transaction was made under a pre-arranged Rule 10b5-1 instruction letter adopted on December 23, 2024 to satisfy tax withholding obligations upon the vesting of restricted stock units after March 15, 2025. Following this sale, Lin holds 101,366 shares directly, which the disclosure states includes 62,050 restricted stock units.
Revolution Medicines, Inc. officer Stephen Michael Kelsey reported an open-market sale of 4,302 shares of Common Stock at 99.4804 per share. The transaction was made pursuant to a Rule 10b5-1 instruction letter adopted on May 31, 2023 to satisfy tax withholding obligations upon vesting of restricted stock units. After this sale, he directly owns 295,398 shares, which includes 84,250 restricted stock units.
Revolution Medicines director Mark A. Goldsmith sold 12,871 shares of common stock in an open-market transaction at an average price of $99.4804 per share on March 17, 2026. The sale was made under a Rule 10b5-1 instruction letter to satisfy tax withholding obligations from vesting restricted stock units.
After the sale, he holds 276,698 shares directly, including 201,150 RSUs. He also has indirect holdings through trusts, with reported positions of 594,060, 64,424, and 64,424 shares of common stock held in separate revocable trusts.
Revolution Medicines, Inc. Chief Operating Officer Margaret A. Horn reported an open-market sale of 4,583 shares of common stock at an average price of $99.4804 per share. After this transaction, she directly holds 157,570 shares. A footnote states the sale was executed under a Rule 10b5-1 instruction letter to satisfy tax withholding obligations related to vesting restricted stock units.