STOCK TITAN

[Form 4] Rhythm Pharmaceuticals, Inc. Insider Trading Activity

Filing Impact
(High)
Filing Sentiment
(Negative)
Form Type
4
Rhea-AI Filing Summary

On 11 July 2025, I-MAB (Nasdaq: IMAB) submitted a Form 6-K to notify investors that it has amended its 15 May 2025 prospectus covering the offer and sale of up to US$21 million in American Depositary Shares (ADSs). Each block of ten ADSs represents twenty-three ordinary shares with a par value of US$0.0001. The prospectus is part of the company’s shelf Registration Statement on Form F-3 (File No. 333-286954).
The filing attaches a Cayman Islands legal opinion from Harney Westwood & Riegels (Exhibit 5.1) together with the corresponding consent (Exhibit 23.1), confirming the validity of the ADSs and underlying ordinary shares. The 6-K states that the information and exhibits are incorporated by reference into the existing Form F-3 and several Form S-8 registration statements covering share-based compensation plans.
No operating or financial results are disclosed. The amendment maintains regulatory compliance and keeps the shelf registration effective, giving I-MAB flexibility to raise up to US$21 million when market conditions permit. While this improves liquidity options, it may also lead to equity dilution for current shareholders if the full amount is issued.

Il 11 luglio 2025, I-MAB (Nasdaq: IMAB) ha presentato un Modulo 6-K per informare gli investitori di aver modificato il proprio prospetto del 15 maggio 2025 relativo all'offerta e vendita fino a 21 milioni di dollari in American Depositary Shares (ADS). Ogni blocco di dieci ADS rappresenta ventitré azioni ordinarie con un valore nominale di 0,0001 dollari. Il prospetto fa parte della dichiarazione di registrazione a scaglione della società sul Modulo F-3 (File No. 333-286954).
La documentazione allega un parere legale delle Isole Cayman di Harney Westwood & Riegels (Esibizione 5.1) insieme al relativo consenso (Esibizione 23.1), confermando la validità degli ADS e delle azioni ordinarie sottostanti. Il Modulo 6-K dichiara che le informazioni e le esibizioni sono incorporate per riferimento nel Modulo F-3 esistente e in diverse dichiarazioni di registrazione Form S-8 relative a piani di compensazione basati su azioni.
Non vengono divulgati risultati operativi o finanziari. La modifica garantisce la conformità normativa e mantiene efficace la registrazione a scaglione, offrendo a I-MAB la flessibilità di raccogliere fino a 21 milioni di dollari quando le condizioni di mercato lo permettono. Pur migliorando le opzioni di liquidità, ciò potrebbe comportare una diluizione azionaria per gli azionisti attuali se l'intero importo venisse emesso.

El 11 de julio de 2025, I-MAB (Nasdaq: IMAB) presentó un Formulario 6-K para notificar a los inversores que ha modificado su prospecto del 15 de mayo de 2025 que cubre la oferta y venta de hasta 21 millones de dólares en American Depositary Shares (ADS). Cada bloque de diez ADS representa veintitrés acciones ordinarias con un valor nominal de 0,0001 dólares. El prospecto forma parte de la declaración de registro en estantería de la compañía en el Formulario F-3 (Archivo No. 333-286954).
El documento adjunta una opinión legal de las Islas Caimán de Harney Westwood & Riegels (Exhibición 5.1) junto con el consentimiento correspondiente (Exhibición 23.1), confirmando la validez de los ADS y las acciones ordinarias subyacentes. El 6-K indica que la información y los anexos se incorporan por referencia al Formulario F-3 existente y a varias declaraciones de registro Form S-8 que cubren planes de compensación basados en acciones.
No se divulgan resultados operativos o financieros. La enmienda mantiene el cumplimiento normativo y mantiene la vigencia del registro en estantería, brindando a I-MAB la flexibilidad para recaudar hasta 21 millones de dólares cuando las condiciones del mercado lo permitan. Aunque mejora las opciones de liquidez, también podría causar dilución accionaria para los accionistas actuales si se emite el monto total.

2025년 7월 11일, I-MAB(Nasdaq: IMAB)는 투자자에게 2025년 5월 15일자 투자설명서를 수정하여 최대 2,100만 달러 규모의 미국예탁주식(ADS) 발행 및 판매를 알리는 Form 6-K를 제출했습니다. 10개의 ADS 블록은 액면가 0.0001달러인 보통주 23주를 나타냅니다. 해당 투자설명서는 회사의 선반등록신고서인 Form F-3(파일 번호 333-286954)의 일부입니다.
신고서에는 Harney Westwood & Riegels의 케이맨 제도 법률 의견서(증빙자료 5.1)와 이에 대한 동의서(증빙자료 23.1)가 첨부되어 ADS 및 기초 보통주의 유효성을 확인합니다. 6-K 문서는 정보와 증빙자료가 기존 Form F-3와 주식 기반 보상 계획을 다루는 여러 Form S-8 등록신고서에 참조로 포함된다고 명시합니다.
영업 실적이나 재무 결과는 공개하지 않았습니다. 이번 수정은 규제 준수를 유지하고 선반등록의 효력을 지속시켜 시장 상황이 허락할 때 최대 2,100만 달러를 조달할 수 있는 유연성을 I-MAB에 제공합니다. 이는 유동성 옵션을 개선하지만, 전액 발행 시 기존 주주에게 주식 희석을 초래할 수 있습니다.

Le 11 juillet 2025, I-MAB (Nasdaq : IMAB) a soumis un formulaire 6-K pour informer les investisseurs qu'elle a modifié son prospectus du 15 mai 2025 portant sur l'offre et la vente jusqu'à 21 millions de dollars américains en American Depositary Shares (ADS). Chaque bloc de dix ADS représente vingt-trois actions ordinaires d'une valeur nominale de 0,0001 dollar américain. Le prospectus fait partie de la déclaration d'enregistrement en étagère de la société sur le formulaire F-3 (dossier n° 333-286954).
Le dépôt comprend un avis juridique des îles Caïmans de Harney Westwood & Riegels (Exhibit 5.1) ainsi que le consentement correspondant (Exhibit 23.1), confirmant la validité des ADS et des actions ordinaires sous-jacentes. Le 6-K précise que les informations et annexes sont incorporées par référence dans le formulaire F-3 existant ainsi que dans plusieurs déclarations d'enregistrement Form S-8 couvrant des plans de rémunération en actions.
Aucun résultat opérationnel ou financier n'est divulgué. L'amendement maintient la conformité réglementaire et la validité de l'enregistrement en étagère, offrant à I-MAB la flexibilité de lever jusqu'à 21 millions de dollars lorsque les conditions du marché le permettent. Bien que cela améliore les options de liquidité, cela pourrait également entraîner une dilution des actions pour les actionnaires actuels si le montant total est émis.

Am 11. Juli 2025 reichte I-MAB (Nasdaq: IMAB) ein Formular 6-K ein, um Investoren mitzuteilen, dass es seinen Prospekt vom 15. Mai 2025 geändert hat, der das Angebot und den Verkauf von bis zu 21 Millionen US-Dollar in American Depositary Shares (ADS) abdeckt. Jeder Block von zehn ADS repräsentiert dreiundzwanzig Stammaktien mit einem Nennwert von 0,0001 US-Dollar. Der Prospekt ist Teil der Shelf-Registrierungserklärung des Unternehmens im Formular F-3 (Aktenzeichen 333-286954).
Der Einreichung liegt eine Rechtsgutachten der Kaiman-Inseln von Harney Westwood & Riegels (Anlage 5.1) sowie die entsprechende Zustimmung (Anlage 23.1) bei, die die Gültigkeit der ADS und der zugrunde liegenden Stammaktien bestätigt. Das 6-K gibt an, dass die Informationen und Anlagen durch Verweis in das bestehende Formular F-3 und mehrere Formulare S-8 zur Registrierung von aktienbasierten Vergütungsplänen aufgenommen werden.
Es werden keine operativen oder finanziellen Ergebnisse offengelegt. Die Änderung sichert die Einhaltung der Vorschriften und hält die Shelf-Registrierung wirksam, wodurch I-MAB die Flexibilität erhält, bis zu 21 Millionen US-Dollar zu beschaffen, wenn die Marktbedingungen dies zulassen. Dies verbessert zwar die Liquiditätsoptionen, kann aber auch zu einer Verwässerung der Aktien für bestehende Aktionäre führen, falls der volle Betrag ausgegeben wird.

Positive
  • Shelf registration remains effective, giving the company flexibility to raise up to US$21 million when opportune.
  • Legal opinion and consent filed, reducing execution risk and demonstrating regulatory compliance.
Negative
  • Potential equity dilution if the full US$21 million ADS offering is executed.
  • Filing offers no operational or earnings information, leaving investors without insight into current performance or cash runway.

Insights

TL;DR – Neutral: keeps capital window open, modest dilution risk.

The 6-K merely updates legal documentation for an existing Form F-3. Because the maximum raise is capped at US$21 million, the potential dilution is limited relative to large biotech financings, yet meaningful for smaller-cap companies. The attached legal opinion removes an execution hurdle, signalling readiness to issue shares quickly if funding is needed. Absent earnings data, credit metrics or pipeline updates, the filing is administratively important but not fundamentally transformative. Overall impact on valuation is neutral unless or until the company actually sells ADSs.

TL;DR – Slight downside due to dilution overhang.

Investors must now factor in issuance of up to US$21 million in new ADSs—effectively expanding the free float and exerting downward pressure on share price until the offering clears. As no partnership cash or milestone revenue is disclosed, the raise appears intended for general corporate purposes, hinting at ongoing cash burn typical of clinical-stage biotech. Still, the modest size limits balance-sheet transformation. The filing is therefore modestly negative but not catastrophic.

Il 11 luglio 2025, I-MAB (Nasdaq: IMAB) ha presentato un Modulo 6-K per informare gli investitori di aver modificato il proprio prospetto del 15 maggio 2025 relativo all'offerta e vendita fino a 21 milioni di dollari in American Depositary Shares (ADS). Ogni blocco di dieci ADS rappresenta ventitré azioni ordinarie con un valore nominale di 0,0001 dollari. Il prospetto fa parte della dichiarazione di registrazione a scaglione della società sul Modulo F-3 (File No. 333-286954).
La documentazione allega un parere legale delle Isole Cayman di Harney Westwood & Riegels (Esibizione 5.1) insieme al relativo consenso (Esibizione 23.1), confermando la validità degli ADS e delle azioni ordinarie sottostanti. Il Modulo 6-K dichiara che le informazioni e le esibizioni sono incorporate per riferimento nel Modulo F-3 esistente e in diverse dichiarazioni di registrazione Form S-8 relative a piani di compensazione basati su azioni.
Non vengono divulgati risultati operativi o finanziari. La modifica garantisce la conformità normativa e mantiene efficace la registrazione a scaglione, offrendo a I-MAB la flessibilità di raccogliere fino a 21 milioni di dollari quando le condizioni di mercato lo permettono. Pur migliorando le opzioni di liquidità, ciò potrebbe comportare una diluizione azionaria per gli azionisti attuali se l'intero importo venisse emesso.

El 11 de julio de 2025, I-MAB (Nasdaq: IMAB) presentó un Formulario 6-K para notificar a los inversores que ha modificado su prospecto del 15 de mayo de 2025 que cubre la oferta y venta de hasta 21 millones de dólares en American Depositary Shares (ADS). Cada bloque de diez ADS representa veintitrés acciones ordinarias con un valor nominal de 0,0001 dólares. El prospecto forma parte de la declaración de registro en estantería de la compañía en el Formulario F-3 (Archivo No. 333-286954).
El documento adjunta una opinión legal de las Islas Caimán de Harney Westwood & Riegels (Exhibición 5.1) junto con el consentimiento correspondiente (Exhibición 23.1), confirmando la validez de los ADS y las acciones ordinarias subyacentes. El 6-K indica que la información y los anexos se incorporan por referencia al Formulario F-3 existente y a varias declaraciones de registro Form S-8 que cubren planes de compensación basados en acciones.
No se divulgan resultados operativos o financieros. La enmienda mantiene el cumplimiento normativo y mantiene la vigencia del registro en estantería, brindando a I-MAB la flexibilidad para recaudar hasta 21 millones de dólares cuando las condiciones del mercado lo permitan. Aunque mejora las opciones de liquidez, también podría causar dilución accionaria para los accionistas actuales si se emite el monto total.

2025년 7월 11일, I-MAB(Nasdaq: IMAB)는 투자자에게 2025년 5월 15일자 투자설명서를 수정하여 최대 2,100만 달러 규모의 미국예탁주식(ADS) 발행 및 판매를 알리는 Form 6-K를 제출했습니다. 10개의 ADS 블록은 액면가 0.0001달러인 보통주 23주를 나타냅니다. 해당 투자설명서는 회사의 선반등록신고서인 Form F-3(파일 번호 333-286954)의 일부입니다.
신고서에는 Harney Westwood & Riegels의 케이맨 제도 법률 의견서(증빙자료 5.1)와 이에 대한 동의서(증빙자료 23.1)가 첨부되어 ADS 및 기초 보통주의 유효성을 확인합니다. 6-K 문서는 정보와 증빙자료가 기존 Form F-3와 주식 기반 보상 계획을 다루는 여러 Form S-8 등록신고서에 참조로 포함된다고 명시합니다.
영업 실적이나 재무 결과는 공개하지 않았습니다. 이번 수정은 규제 준수를 유지하고 선반등록의 효력을 지속시켜 시장 상황이 허락할 때 최대 2,100만 달러를 조달할 수 있는 유연성을 I-MAB에 제공합니다. 이는 유동성 옵션을 개선하지만, 전액 발행 시 기존 주주에게 주식 희석을 초래할 수 있습니다.

Le 11 juillet 2025, I-MAB (Nasdaq : IMAB) a soumis un formulaire 6-K pour informer les investisseurs qu'elle a modifié son prospectus du 15 mai 2025 portant sur l'offre et la vente jusqu'à 21 millions de dollars américains en American Depositary Shares (ADS). Chaque bloc de dix ADS représente vingt-trois actions ordinaires d'une valeur nominale de 0,0001 dollar américain. Le prospectus fait partie de la déclaration d'enregistrement en étagère de la société sur le formulaire F-3 (dossier n° 333-286954).
Le dépôt comprend un avis juridique des îles Caïmans de Harney Westwood & Riegels (Exhibit 5.1) ainsi que le consentement correspondant (Exhibit 23.1), confirmant la validité des ADS et des actions ordinaires sous-jacentes. Le 6-K précise que les informations et annexes sont incorporées par référence dans le formulaire F-3 existant ainsi que dans plusieurs déclarations d'enregistrement Form S-8 couvrant des plans de rémunération en actions.
Aucun résultat opérationnel ou financier n'est divulgué. L'amendement maintient la conformité réglementaire et la validité de l'enregistrement en étagère, offrant à I-MAB la flexibilité de lever jusqu'à 21 millions de dollars lorsque les conditions du marché le permettent. Bien que cela améliore les options de liquidité, cela pourrait également entraîner une dilution des actions pour les actionnaires actuels si le montant total est émis.

Am 11. Juli 2025 reichte I-MAB (Nasdaq: IMAB) ein Formular 6-K ein, um Investoren mitzuteilen, dass es seinen Prospekt vom 15. Mai 2025 geändert hat, der das Angebot und den Verkauf von bis zu 21 Millionen US-Dollar in American Depositary Shares (ADS) abdeckt. Jeder Block von zehn ADS repräsentiert dreiundzwanzig Stammaktien mit einem Nennwert von 0,0001 US-Dollar. Der Prospekt ist Teil der Shelf-Registrierungserklärung des Unternehmens im Formular F-3 (Aktenzeichen 333-286954).
Der Einreichung liegt eine Rechtsgutachten der Kaiman-Inseln von Harney Westwood & Riegels (Anlage 5.1) sowie die entsprechende Zustimmung (Anlage 23.1) bei, die die Gültigkeit der ADS und der zugrunde liegenden Stammaktien bestätigt. Das 6-K gibt an, dass die Informationen und Anlagen durch Verweis in das bestehende Formular F-3 und mehrere Formulare S-8 zur Registrierung von aktienbasierten Vergütungsplänen aufgenommen werden.
Es werden keine operativen oder finanziellen Ergebnisse offengelegt. Die Änderung sichert die Einhaltung der Vorschriften und hält die Shelf-Registrierung wirksam, wodurch I-MAB die Flexibilität erhält, bis zu 21 Millionen US-Dollar zu beschaffen, wenn die Marktbedingungen dies zulassen. Dies verbessert zwar die Liquiditätsoptionen, kann aber auch zu einer Verwässerung der Aktien für bestehende Aktionäre führen, falls der volle Betrag ausgegeben wird.

SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Cramer Pamela J.

(Last) (First) (Middle)
C/O RHYTHM PHARMACEUTICALS, INC.
222 BERKELEY STREET, 12TH FLOOR

(Street)
BOSTON MA 02116

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
RHYTHM PHARMACEUTICALS, INC. [ RYTM ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
Chief Human Resources Officer
3. Date of Earliest Transaction (Month/Day/Year)
07/09/2025
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 07/09/2025 M 10,547 A $6.8 29,756 D
Common Stock 07/09/2025 M 5,025 A $27.35 34,781 D
Common Stock 07/09/2025 S(1) 4,225 D $75.5544(2) 30,556 D
Common Stock 07/09/2025 S(1) 7,831 D $76.6907(3) 22,725 D
Common Stock 07/09/2025 S(1) 3,516 D $80 19,209 D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Options (Right to Buy) $6.8 07/09/2025 M 10,547 (4) 02/08/2032 Common Stock 10,547 $0 17,581 D
Stock Options (Right to Buy) $27.35 07/09/2025 M 5,025 (5) 01/31/2033 Common Stock 5,025 $0 15,075 D
Explanation of Responses:
1. The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.
2. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $75.08 to $75.98 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
3. The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $76.17 to $76.75 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
4. The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.
5. The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.
/s/ Stephen Vander Stoep, attorney-in-fact for Pamela J. Cramer 07/11/2025
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

How much capital can I-MAB (IMAB) raise under the amended prospectus?

The prospectus amendment covers the sale of up to US$21 million in ADSs.

What does each I-MAB ADS represent?

Each 10 ADSs represent 23 ordinary shares with a par value of US$0.0001 per share.

Which registration statement does the amended prospectus belong to?

It is part of I-MAB’s Form F-3 shelf registration (File No. 333-286954).

What legal documents were filed with the Form 6-K?

Exhibit 5.1 is the opinion of Harney Westwood & Riegels; Exhibit 23.1 is their consent, included within Exhibit 5.1.

Will the amended prospectus information affect other I-MAB filings?

Yes. The 6-K states the information is incorporated by reference into the existing Form F-3 and several Form S-8 filings.
Rhythm Pharmaceu

NASDAQ:RYTM

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4.22B
61.50M
0.54%
107.82%
8.14%
Biotechnology
Pharmaceutical Preparations
Link
United States
BOSTON