Opaleye-affiliated holders report 6.3M shares in Rezolute (RZLT)

Rhea-AI Filing Summary

Rezolute, Inc. joint Schedule 13G/A amendment reports that Opaleye-related reporting persons beneficially own 6,300,000 shares of common stock, representing 6.58% of the class. The filing states the Adviser and Mr. Silverman have shared voting and dispositive power over those shares.

The filing also lists Opaleye, L.P. holding 6,165,000 shares (6.44%), citing 02/09/2026 outstanding share data of 95,697,685 common shares from a prior Form 10-Q. Signatures are dated 05/11/2026.

Insights

Corporate Governance Analyst

Joint filing documents a passive beneficial stake with shared authority.

The filing shows 6,300,000 shares (6.58%) reported jointly by Opaleye Management Inc., Opaleye, L.P., and James Silverman. It specifies shared voting and dispositive power over a managed account and fund positions.

The reported percentages use an 02/09/2026 outstanding share base of 95,697,685. Future filings may update ownership or power allocations; this filing is a snapshot of disclosed beneficial ownership as of the signatures dated 05/11/2026.

Key Figures

Reported beneficial ownership: 6,300,000 shares Percent of class: 6.58% Opaleye, L.P. holding: 6,165,000 shares +3 more

6 metrics

Reported beneficial ownership 6,300,000 shares Amount reported jointly by Opaleye-related reporting persons

Percent of class 6.58% Calculated using outstanding shares referenced in the filing

Opaleye, L.P. holding 6,165,000 shares Amount attributed to Opaleye, L.P. in the joint filing

Opaleye, L.P. percent 6.44% Opaleye, L.P. percent based on cited outstanding share count

Shares outstanding used 95,697,685 shares Outstanding common shares as of <date>02/09/2026</date> from Rezolute's Form 10-Q

Signature date 05/11/2026 Date the joint Schedule 13G/A amendment was signed

Key Terms

shared voting power, beneficially owned, managed account

3 terms

shared voting power regulatory

"Includes shares held in a managed account over which the Adviser has shared voting"

Shared voting power occurs when two or more parties jointly have the right to vote or decide how a block of company shares is cast, like co-owners who must agree before moving a piece of furniture. Investors care because who controls voting rights affects board elections, major corporate decisions and takeover outcomes, and shared control can alter regulatory disclosures and the practical influence any holder has over a company’s direction and value.

beneficially owned regulatory

"Amount beneficially owned: 6,300,000.00"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

managed account financial

"Includes shares held in a managed account over which the Adviser has shared voting"

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 2)

Rezolute, Inc.

(Name of Issuer)

Common Stock

(Title of Class of Securities)

76200L309

(CUSIP Number)

03/31/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 76200L309

1

Names of Reporting Persons

Opaleye Management Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

MASSACHUSETTS

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 6,300,000.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 6,300,000.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

6,300,000.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.58 %

12

Type of Reporting Person (See Instructions)

IA, CO

Comment for Type of Reporting Person: Includes shares held in a managed account over which the Adviser has shared voting and dispositive power.

SCHEDULE 13G

CUSIP Number(s): 76200L309

1

Names of Reporting Persons

Opaleye, L.P.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 6,165,000.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 6,165,000.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

6,165,000.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.44 %

12

Type of Reporting Person (See Instructions)

PN

Comment for Type of Reporting Person: Based on 95,697,685 Common Shares outstanding as of 02/09/2026 as reported by Rezolute, Inc. on 02/12/2026, in its Form 10-Q Quarterly Report.

SCHEDULE 13G

CUSIP Number(s): 76200L309

1

Names of Reporting Persons

James Silverman

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 6,300,000.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 6,300,000.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

6,300,000.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.58 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Rezolute, Inc.
(b)	Address of issuer's principal executive offices: 275 Shoreline Drive, Suite 500, Redwood City, CA 94065
Item 2.
(a)	Name of person filing: This statement is filed jointly by (i) Opaleye Management Inc. (the "Adviser"), (ii) Opaleye, L.P. (the "Fund"), and (iii) James Silverman (collectively, the "Reporting Persons") with respect to the shares of common stock held directly by the Fund and in a managed account advised by the Adviser. The Adviser serves as investment adviser to the Fund. Mr. Silverman is the controlling person of the Adviser. The filing of this statement should not be construed as an admission that any of the Reporting Persons is, for purposes of Section 13 of the Securities Exchange Act of 1934, as amended, the beneficial owner of any of the shares reported herein.
(b)	Address or principal business office or, if none, residence: One Boston Place, 26th Floor, Boston, MA 02108
(c)	Citizenship: Opaleye Management Inc. - Massachusetts, Opaleye, L.P. - Delaware, James Silverman - USA
(d)	Title of class of securities: Common Stock
(e)	CUSIP No.: 76200L309
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 6,300,000.00
(b)	Percent of class: 6.58 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 0
	(ii) Shared power to vote or to direct the vote: 6,300,000.00
	(iii) Sole power to dispose or to direct the disposition of: 0
	(iv) Shared power to dispose or to direct the disposition of: 6,300,000.00
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Opaleye Management Inc.

Signature:	/s/ James Silverman
Name/Title:	President
Date:	05/11/2026

Opaleye, L.P.

Signature:	/s/ James Silverman
Name/Title:	General Partner
Date:	05/11/2026

James Silverman

Signature:	/s/ James Silverman
Name/Title:	Individually
Date:	05/11/2026

Exhibit Information

Exhibit 99.1 Joint Filing Agreement by and among the reporting persons

FAQ

What ownership stake does Opaleye hold in Rezolute (RZLT)?

Opaleye-related reporting persons beneficially own 6,300,000 shares (6.58%). The filing attributes these shares to the Fund and a managed account with shared voting and dispositive power, and lists Opaleye, L.P. with 6,165,000 shares (6.44%).

Does James Silverman control the reported Rezolute shares?

Mr. Silverman is identified as the controlling person of the Adviser but the filing states shared voting and dispositive power. The statement disclaims that it should not be an admission of beneficial ownership under Section 13 definitions.

What outstanding share count does the filing use to calculate percentages for RZLT?

Percentages are based on 95,697,685 common shares outstanding as of 02/09/2026, cited from Rezolute's Form 10-Q filed on 02/12/2026. Those figures produce the reported 6.58% and 6.44% stakes.

When was the Schedule 13G/A amendment signed for Rezolute (RZLT)?

The joint filing is signed by the reporting persons with signature dates of 05/11/2026. The amendment identifies the reporting entities and their shared authority over the disclosed holdings.