Septerna officer proposes $493K common share sale

Morgan Stanley Smith Barney LLC is listed as the broker for the proposed sale.

Rhea-AI Filing Summary

Septerna, Inc. officer Samira Shaikhly reported a proposed sale of 12,592 common shares with an aggregate market value of $492,724.96 and an approximate sale date of October 1, 2026. The notice reports that the shares were acquired from the issuer on October 1, 2026, through exercise of stock options for cash; it lists 46,676,947 shares outstanding.

Key Figures

Proposed sale: 12,592 common shares Aggregate market value: $492,724.96 Shares outstanding: 46,676,947 shares +1 more

4 metrics

Proposed sale 12,592 common shares Approximate sale date October 1, 2026

Aggregate market value $492,724.96 Proposed sale

Shares outstanding 46,676,947 shares Reported in the notice

Approximate sale date October 1, 2026 Proposed sale

Key Terms

Rule 144, Exercise of Stock Options, Securities To Be Sold

3 terms

Rule 144 regulatory

"See the definition of "person" in paragraph (a) of Rule 144"

Rule 144 is a U.S. securities regulation that sets conditions under which restricted or insider-held shares can be legally resold to the public, such as required holding periods, availability of public information, limits on how much can be sold at once, and certain filing requirements. For investors it matters because it determines when previously locked-up shares can enter the market — like a release valve that can increase supply, affect share price, and signal insider intent.

Exercise of Stock Options financial

"Exercise of Stock Options"

Securities To Be Sold regulatory

"144: Securities To Be Sold"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many SEPN shares does Samira Shaikhly propose to sell?

Samira Shaikhly's notice lists a proposed sale of 12,592 common shares with an aggregate market value of $492,724.96.

When is Samira Shaikhly's SEPN share sale expected?

The approximate sale date is October 1, 2026.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 10/01/2026 - 04:25 PM Accepted by SEC EDGAR 10/01/2026 - 04:24 PM Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0002040363
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	Septerna, Inc.
SEC File Number	001-42382
Address of Issuer	250 East Grand Avenue South San Francisco CALIFORNIA 94080
Phone	650-338-3533
Name of Person for Whose Account the Securities are To Be Sold	SAMIRA SHAIKHLY
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Officer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common	Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 8th Floor New York NY 10004	12592	492724.96	46676947	10/01/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common	10/01/2026	Exercise of Stock Options	Issuer			12592	10/01/2026	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Nothing to Report

144: Remarks and Signature

Remarks
Date of Notice	10/01/2026
Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1	10/31/2025
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ Samira Shaikhly
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)