Septerna director Alan Ezekowitz sells 81,820 shares

Available on EDGAR 11/13/2026 - 07:02 PM EST Accepted by SEC EDGAR 11/13/2026 - 07:02 PM EST

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Rhea-AI Filing Summary

Septerna, Inc. (SEPN) director Alan Ezekowitz reported selling 81,820 shares of common stock on November 11, 2026, in seven transactions pursuant to a Rule 10b5-1 sales plan adopted July 13, 2026. The reported weighted-average prices ranged from $46.0050 to $51.9000 per share.

Insider Trade Summary 10b5-1

Net Seller: 81,820 shares

Net Sell 7 txns

Insider Ezekowitz Alan

Role Director

Sold 81,820 shs ($3.93M)

Type	Security	Shares	Price	Value
Sale	Common Stock ^{F1, F2}	6,939	$46.005	$319K
Sale	Common Stock ^{F1, F3}	13,201	$47.0116	$621K
Sale	Common Stock ^{F1, F4}	22,865	$47.7799	$1.09M
Sale	Common Stock ^{F1, F5}	31,572	$48.7002	$1.54M
Sale	Common Stock ^{F1, F6}	4,175	$49.6465	$207K
Sale	Common Stock ^{F1, F7}	2,013	$50.897	$102K
Sale	Common Stock ^F1	1,055	$51.90	$55K

Holdings After Transaction: Common Stock — 35,600 shares (Direct)

Footnotes (7)

F1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on July 13, 2026.
F2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $45.36 to $46.35. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
F3. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $46.37 to $47.36. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
F4. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $47.37 to $48.35. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
F5. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $48.37 to $49.33. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
F6. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $49.38 to $50.31. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
F7. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $50.47 to $51.32. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

Key Figures

Shares sold: 81,820 shares Weighted-average price: $46.0050 per share Weighted-average price: $47.0116 per share +5 more

8 metrics

Shares sold 81,820 shares Seven reported sales on November 11, 2026.

Weighted-average price $46.0050 per share Price for 6,939 shares sold November 11, 2026.

Weighted-average price $47.0116 per share Price for 13,201 shares sold November 11, 2026.

Weighted-average price $47.7799 per share Price for 22,865 shares sold November 11, 2026.

Weighted-average price $48.7002 per share Price for 31,572 shares sold November 11, 2026.

Weighted-average price $49.6465 per share Price for 4,175 shares sold November 11, 2026.

Weighted-average price $50.8970 per share Price for 2,013 shares sold November 11, 2026.

Reported price $51.9000 per share Price for 1,055 shares sold November 11, 2026.

Key Terms

Rule 10b5-1 sales plan, weighted average price

2 terms

Rule 10b5-1 sales plan regulatory

"Rule 10b5-1 sales plan adopted on July 13, 2026"

weighted average price financial

"The price reported in Column 4 is a weighted average price."

Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many SEPN shares did Alan Ezekowitz sell, and at what prices?

Alan Ezekowitz reported selling 81,820 SEPN common shares on November 11, 2026, at reported weighted-average prices ranging from $46.0050 to $51.9000 per share. The lots were: 6,939 shares at $46.0050; 13,201 at $47.0116; 22,865 at $47.7799; 31,572 at $48.7002; 4,175 at $49.6465; 2,013 at $50.8970; and 1,055 at $51.9000 per share.

Were Alan Ezekowitz's SEPN sales made under a Rule 10b5-1 plan?

Yes. The sales were made pursuant to a Rule 10b5-1 sales plan adopted July 13, 2026.

AI-generated analysis. How Rhea-AI works. Not financial advice.

Form 4 Insider Transactions: What Each Field Means →

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SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Ezekowitz Alan

(Last)

(First)

(Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO

CALIFORNIA

94080

(City)

(State)

(Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	10% Owner
	Officer (give title below)	Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
11/11/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	11/11/2026		S⁽¹⁾		6,939	D	$46.005⁽²⁾	110,481	D
Common Stock	11/11/2026		S⁽¹⁾		13,201	D	$47.0116⁽³⁾	97,280	D
Common Stock	11/11/2026		S⁽¹⁾		22,865	D	$47.7799⁽⁴⁾	74,415	D
Common Stock	11/11/2026		S⁽¹⁾		31,572	D	$48.7002⁽⁵⁾	42,843	D
Common Stock	11/11/2026		S⁽¹⁾		4,175	D	$49.6465⁽⁶⁾	38,668	D
Common Stock	11/11/2026		S⁽¹⁾		2,013	D	$50.897⁽⁷⁾	36,655	D
Common Stock	11/11/2026		S⁽¹⁾		1,055	D	$51.9	35,600	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)

Explanation of Responses:

1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on July 13, 2026.

2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $45.36 to $46.35. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

3. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $46.37 to $47.36. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

4. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $47.37 to $48.35. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

5. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $48.37 to $49.33. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

6. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $49.38 to $50.31. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

7. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $50.47 to $51.32. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

	/s/ Mark A. Wilson, Attorney-in-Fact	11/13/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

Source: View Original Filing on SEC EDGAR