Septerna director reports $5.23M share sale

Available on EDGAR 11/12/2026 - 07:56 AM EST Accepted by SEC EDGAR 11/12/2026 - 07:56 AM EST Learn about SEC filing dates

Rhea-AI Filing Summary

Septerna, Inc. director Alan Ezekowitz reported a sale of 100,000 common shares on November 11, 2026, with an aggregate market value of $5,234,000. The notice lists 47,549,223 common shares outstanding. Its remarks say the securities were acquired upon vesting of open-market purchases made from March 4, 2025, through March 7, 2025.

Key Figures

Common shares sold: 100,000 shares Aggregate market value: $5,234,000 Common shares outstanding: 47,549,223 shares

3 metrics

Common shares sold 100,000 shares Sale reported for November 11, 2026

Aggregate market value $5,234,000 Common shares reported for sale

Common shares outstanding 47,549,223 shares Listed in the notice

Key Terms

Aggregate Market Value, Open Market Purchase, Rule 10b5-1

3 terms

Aggregate Market Value financial

"Aggregate Market Value"

Aggregate market value is the combined price you would pay to buy all outstanding shares of a company or all companies in a group at current market prices — essentially the sum of each stock’s market capitalization. It matters to investors because it shows the overall size and weight of an investment or sector (like the total cost to buy every piece of a puzzle), helps compare scale across companies or markets, and influences index composition and risk exposure.

Open Market Purchase financial

"Nature of Acquisition Transaction: Open Market Purchase"

An open market purchase is when a company buys its own shares on public stock exchanges the same way any investor would, rather than through a private deal. Investors care because these purchases reduce the number of shares available, can boost earnings per share and share price, signal that management thinks the stock is undervalued, and use company cash that might otherwise go to reinvestment or dividends — like a business quietly buying back its own tickets at the box office.

Rule 10b5-1 regulatory

"If Relying on Rule 10b5-1"

Rule 10b5-1 is a regulation that allows company insiders to buy or sell their shares at predetermined times, even if they have access to non-public information. It acts like setting a schedule in advance for transactions, helping prevent accusations of unfair trading. This rule provides a way for insiders to plan trades transparently, giving investors confidence that these transactions are not based on hidden information.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many SEPN shares did Alan Ezekowitz sell, and what was their value?

Alan Ezekowitz reported a sale of 100,000 common shares with an aggregate market value of $5,234,000.

Which broker is listed for Alan Ezekowitz's SEPN share sale?

Morgan Stanley Smith Barney LLC is listed as the broker for the common shares.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001780209
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	Septerna, Inc.
SEC File Number	001-42382
Address of Issuer	250 East Grand Avenue South San Francisco CALIFORNIA 94080
Phone	6503383533
Name of Person for Whose Account the Securities are To Be Sold	ALAN EZEKOWITZ
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Director

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common	Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 8th Floor New York NY 10004	100000	5234000.00	47549223	11/11/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common	03/04/2025	Open Market Purchase	Issuer			100000	03/04/2025	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Nothing to Report

144: Remarks and Signature

Remarks	The securities to be sold were acquired upon the vesting of open market purchases during the period of 3/4/2025 through 3/7/2025. Sales that were executed on November 11, 2026 are being reported on this Form 144 filed on November 12, 2026 given the EDGAR system was not accepting filings on November 11, 2026 in observance of the federal holiday.
Date of Notice	11/11/2026
Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1	07/13/2026
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ Alan Ezekowitz
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)