[Form 3] Septerna, Inc. Initial Statement of Beneficial Ownership

Rhea-AI Filing Summary

Septerna, Inc. (SEPN) director Keith Michael Gottesdiener filed an initial Form 3 disclosing his relationship to the issuer and stating no securities are beneficially owned. The filing lists his address at Septerna, Inc., identifies him as a director, and is signed by an attorney-in-fact on his behalf. The form reports the event date as 09/25/2025.

Insights

Financial Analyst

TL;DR: A director filed an initial ownership statement and reported no beneficial holdings, which is a neutral compliance disclosure.

The Form 3 confirms the company correctly recorded an initial Section 16 filing for a director with no reportable equity positions. This has no direct financial impact on SEPterna's capitalization or dilution. The filing satisfies disclosure requirements but provides no new operational or financial information for valuation.

Corporate Governance Expert

TL;DR: Governance disclosure completed; absence of holdings limits immediate insider-alignment insights.

The submission documents the director relationship and completes required Section 16 reporting. Because the reporting person disclosed no securities beneficially owned, investors cannot infer insider alignment through ownership. The filing is procedural and does not indicate any governance action or change in control.

SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

Gottesdiener Keith Michael

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
09/25/2025

3. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

Remarks:

Exhibit 24 - Power of Attorney

No securities are beneficially owned.

	/s/ Gil M. Labrucherie, Attorney-in-Fact	09/29/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did the Form 3 filed by Keith Michael Gottesdiener for SEPN disclose?

It disclosed that he is a director of Septerna, Inc. and stated no securities are beneficially owned.

When is the event date reported on the SEPN Form 3?

The Date of Event Requiring Statement is 09/25/2025.

Who signed the Form 3 for Keith Michael Gottesdiener?

The form was signed by Gil M. Labrucherie, Attorney-in-Fact, on 09/29/2025.

What relationship to Septerna, Inc. does the reporting person have?

The filing lists the reporting person as a Director of Septerna, Inc.

Does the Form 3 list any securities or derivative holdings for the reporting person?

No. The form explicitly states: No securities are beneficially owned.