STOCK TITAN

Septerna (SEPN) CPO sells 5,935 shares under Rule 10b5-1 plan

Filing Impact
(Neutral)
Filing Sentiment
(Neutral)
Form Type
4

Rhea-AI Filing Summary

Septerna, Inc.’s Chief People Officer Samira Shaikhly reported an exercise-and-sell sequence in company stock. She exercised options to acquire 5,935 shares of common stock at exercise prices of $1.55 and $2.76 per share, then sold 5,935 shares in open-market transactions at weighted average prices of $27.78, $28.79 and $29.66 per share, within ranges from $27.24 to $30.08. The sales were carried out under a pre-arranged Rule 10b5-1 sales plan adopted on October 31, 2025.

Positive

  • None.

Negative

  • None.
Insider Shaikhly Samira
Role Chief People Officer
Sold 5,935 shs ($172K)
Type Security Shares Price Value
Exercise Stock Option (Right to Buy) 4,355 $0.00 --
Exercise Stock Option (Right to Buy) 943 $0.00 --
Exercise Stock Option (Right to Buy) 637 $0.00 --
Exercise Common Stock 4,355 $1.55 $7K
Exercise Common Stock 943 $2.76 $3K
Exercise Common Stock 637 $2.76 $2K
Sale Common Stock 1,700 $27.7831 $47K
Sale Common Stock 1,346 $28.7928 $39K
Sale Common Stock 2,889 $29.6629 $86K
Holdings After Transaction: Stock Option (Right to Buy) — 11,614 shares (Direct, null); Common Stock — 5,148 shares (Direct, null)
Footnotes (1)
  1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.24 to $28.23. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.25 to $29.15. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.29 to $30.08. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. 25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such date. 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.
Shares sold 5,935 shares Net common stock sold by insider on June 1, 2026
Sale price tranche 1 $27.7831/share Weighted average price for 1,700 common shares sold
Sale price tranche 2 $28.7928/share Weighted average price for 1,346 common shares sold
Sale price tranche 3 $29.6629/share Weighted average price for 2,889 common shares sold
Exercise price 1 $1.55/share Stock options exercised into 4,355 common shares
Exercise price 2 $2.76/share Stock options exercised into 1,580 common shares (637 + 943)
Sale price range $27.24–$30.08/share Intraday ranges across reported sale transactions
Rule 10b5-1 sales plan financial
"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."
weighted average price financial
"The price reported in Column 4 is a weighted average price."
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
Stock Option (Right to Buy) financial
"security_title: Stock Option (Right to Buy)"
derivative security financial
"transaction_code_description: Exercise or conversion of derivative security"
A derivative security is a financial contract whose value comes from the price or performance of something else, such as a stock, bond, commodity, or market index. For investors it acts like an insurance policy or a wager: it can be used to protect against losses, lock in prices, or amplify gains and losses, so it can change a portfolio’s risk and potential return without owning the underlying asset directly.
open-market sale financial
"transaction_action: open-market sale"
An open-market sale is when a shareholder sells existing shares directly on a public exchange to any willing buyer, rather than through a private deal. Think of it like putting goods on a busy market stall where price is set by supply and demand; for investors it matters because such sales increase available supply, can put short-term downward pressure on the stock price, and signal changes in liquidity or investor confidence.
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SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Shaikhly Samira

(Last)(First)(Middle)
C/O SEPTERNA, INC.
250 EAST GRAND AVENUE

(Street)
SOUTH SAN FRANCISCO CALIFORNIA 94080

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director10% Owner
XOfficer (give title below)Other (specify below)
Chief People Officer
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
06/01/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock06/01/2026M4,355A$1.555,148D
Common Stock06/01/2026M943A$2.766,091D
Common Stock06/01/2026M637A$2.766,728D
Common Stock06/01/2026S(1)1,700D$27.7831(2)5,028D
Common Stock06/01/2026S(1)1,346D$28.7928(3)3,682D
Common Stock06/01/2026S(1)2,889D$29.6629(4)793D
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Stock Option (Right to Buy)$1.5506/01/2026M4,355 (5)03/30/2033Common Stock4,355$011,614D
Stock Option (Right to Buy)$2.7606/01/2026M943 (5)11/11/2033Common Stock943$02,517D
Stock Option (Right to Buy)$2.7606/01/2026M637 (6)03/19/2034Common Stock637$04,464D
Explanation of Responses:
1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.
2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $27.24 to $28.23. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
3. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.25 to $29.15. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
4. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.29 to $30.08. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
5. 25% of the shares underlying this option vested on February 1, 2024, with the remainder vesting in thirty-six substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service the Issuer on each such date.
6. 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of March 1, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.
/s/ Mark A. Wilson, Attorney-in-Fact06/03/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What insider transactions did Septerna (SEPN) report for Samira Shaikhly?

Septerna’s Chief People Officer Samira Shaikhly exercised options for 5,935 shares of common stock and sold 5,935 shares in open-market transactions. These trades occurred on June 1, 2026 and were disclosed in a Form 4 insider filing.

At what prices did Septerna (SEPN) insider Samira Shaikhly sell shares?

Samira Shaikhly sold Septerna common shares at weighted average prices of $27.78, $28.79 and $29.66 per share. Footnotes state individual trades occurred in ranges from $27.24 up to $30.08 per share across multiple transactions.

Were Septerna (SEPN) insider sales by Samira Shaikhly made under a Rule 10b5-1 plan?

Yes. The filing states the sales were effected under a Rule 10b5-1 sales plan adopted on October 31, 2025. Such pre-arranged plans schedule trades in advance, making transaction timing more routine rather than discretionary.

What options did Septerna (SEPN) insider Samira Shaikhly exercise?

Samira Shaikhly exercised stock options covering 5,935 shares of Septerna common stock at exercise prices of $1.55 and $2.76 per share. These exercises converted derivative securities into common shares as part of the reported activity.

How many Septerna (SEPN) shares did Samira Shaikhly sell in this Form 4?

The transaction summary shows net sales of 5,935 Septerna common shares by Samira Shaikhly. These were reported as three open-market sale transactions, each with its own weighted average sale price and detailed intraday price ranges.