Septerna CPO sells 2,178 shares after option exercise

Septerna, Inc.’s Chief People Officer Samira Shaikhly reported a combined option exercise and share sale.

Rhea-AI Filing Summary

Septerna, Inc.’s Chief People Officer Samira Shaikhly reported a combined option exercise and share sale. She exercised stock options to acquire 2,178 shares of Common Stock at $6.81 per share, then sold 2,178 shares at $35.18 per share in an open-market transaction.

The filing notes the sale was made under a pre-arranged Rule 10b5-1 sales plan adopted on October 31, 2025. Following these transactions, she holds 793 Common Stock shares and 20,865 stock options directly.

Insider Trade Summary 10b5-1

Exercise and Sale: 2,178 shares ($62K approx. pre-tax spread)

Exercise and Sale 3 txns

Insider Shaikhly Samira

Role Chief People Officer

Sold 2,178 shs ($77K)

Approx. gross sale proceeds $77K

Approx. exercise cost $15K

Approx. pre-tax spread $62K

Type	Security	Shares	Price	Value
Exercise	Stock Option (Right to Buy)	2,178	$0.00	$0.00
Exercise	Common Stock	2,178	$6.81	$15K
Sale	Common Stock	2,178	$35.18	$77K

Holdings After Transaction: Stock Option (Right to Buy) — 20,865 contracts (Direct); Common Stock — 793 shares (Direct)

Footnotes (2)

1. F1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.
2. F2. 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

Key Figures

Shares sold: 2,178 shares Sale price: $35.18 per share Options exercised: 2,178 shares +5 more

8 metrics

Shares sold 2,178 shares Open-market sale of common stock

Sale price $35.18 per share Price for 2,178 common shares sold

Options exercised 2,178 shares Stock options converted into common stock

Option strike price $6.81 per share Exercise price of stock options

Shares held after 793 shares Common stock directly owned post-transaction

Options held after 20,865 options Stock options remaining after exercise

10b5-1 plan adoption date October 31, 2025 Rule 10b5-1 sales plan referenced in footnote

Option expiration September 22, 2034 Expiration date of stock option grant

Key Terms

Rule 10b5-1 sales plan, Stock Option (Right to Buy), open-market sale, derivative exercise/conversion

4 terms

Rule 10b5-1 sales plan financial

"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person..."

Stock Option (Right to Buy) financial

"Stock Option (Right to Buy) with an expiration date of 2034-09-22..."

open-market sale financial

"transaction_action: open-market sale with transaction_code S for Common Stock..."

An open-market sale is when a shareholder sells existing shares directly on a public exchange to any willing buyer, rather than through a private deal. Think of it like putting goods on a busy market stall where price is set by supply and demand; for investors it matters because such sales increase available supply, can put short-term downward pressure on the stock price, and signal changes in liquidity or investor confidence.

derivative exercise/conversion financial

"transaction_action: derivative exercise/conversion for 2,178 shares related to stock options..."

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider transactions did Septerna (SEPN) report for Samira Shaikhly?

Samira Shaikhly reported an option exercise and matching share sale. She exercised options for 2,178 Septerna shares at $6.81 each and sold 2,178 shares at $35.18 in an open-market trade executed under a Rule 10b5-1 plan.

How many Septerna (SEPN) shares did the CPO sell and at what price?

Samira Shaikhly sold 2,178 Septerna common shares at $35.18 each. The transaction was classified as an open-market sale and was carried out on June 29, 2026, pursuant to a pre-arranged Rule 10b5-1 sales plan adopted in October 2025.

What stock options did Samira Shaikhly exercise in Septerna (SEPN)?

She exercised stock options for 2,178 Septerna common shares at a $6.81 strike price. These options are part of a grant vesting monthly over 48 installments starting October 28, 2024, with the option expiring on September 22, 2034, according to the filing details.

How many Septerna (SEPN) shares and options does the CPO hold after the transactions?

After the transactions, Samira Shaikhly holds 793 Septerna common shares directly. She also retains 20,865 stock options, each representing the right to buy one share of common stock, reflecting her remaining equity-based compensation position with the company.

Was the Septerna (SEPN) insider sale by the CPO pre-planned?

Yes, the sale was executed under a Rule 10b5-1 sales plan. The filing states the plan was adopted on October 31, 2025, which means the June 29, 2026 open-market sale followed a pre-arranged trading schedule rather than a discretionary, same-day decision.

AI-generated analysis. How Rhea-AI works. Not financial advice.

Form 4 Insider Transactions: What Each Field Means →

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google

Add on Google Not now

Accepted by SEC EDGAR 06/30/2026 - 07:01 PM EDT Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Shaikhly Samira

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CALIFORNIA 94080

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief People Officer

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
06/29/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	06/29/2026		M		2,178	A	$6.81	2,971	D
Common Stock	06/29/2026		S(1)		2,178	D	$35.18	793	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$6.81	06/29/2026		M			2,178	(2)	09/22/2034	Common Stock	2,178	$0	20,865	D

Explanation of Responses:

1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

2. 1/48th of the shares subject to such option vest and become exercisable in substantially equal monthly installments on each monthly anniversary of October 28, 2024, subject to the Reporting Person's continuous service to the Issuer on each such date.

	/s/ Mark A. Wilson, Attorney-in-Fact	06/30/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)