Septerna CPO exercises options, sells 6,250 shares

Septerna, Inc. Chief People Officer Samira Shaikhly reported an exercise-and-sale transaction in company stock.

Rhea-AI Filing Summary

Septerna, Inc. Chief People Officer Samira Shaikhly reported an exercise-and-sale transaction in company stock. On June 12, 2026, she exercised options to acquire 6,250 shares of common stock at $11.70 per share, then sold 6,250 shares in an open-market transaction at a weighted average price of $35.0759 per share, with individual sale prices ranging from $35.00 to $35.19. These trades were executed under a pre-arranged Rule 10b5-1 sales plan. Following the transactions, she directly holds 793 shares of common stock and 23,750 stock options that remain outstanding and are scheduled to expire on August 6, 2035, continuing to give her equity exposure to Septerna’s future performance.

Insider Trade Summary 10b5-1

Exercise and Sale: 6,250 shares ($146K approx. pre-tax spread)

Exercise and Sale 3 txns

Insider Shaikhly Samira

Role Chief People Officer

Sold 6,250 shs ($219K)

Approx. gross sale proceeds $219K

Approx. exercise cost $73K

Approx. pre-tax spread $146K

Type	Security	Shares	Price	Value
Exercise	Stock Option (Right to Buy)	6,250	$0.00	$0.00
Exercise	Common Stock	6,250	$11.70	$73K
Sale	Common Stock	6,250	$35.0759	$219K

Holdings After Transaction: Stock Option (Right to Buy) — 23,750 contracts (Direct); Common Stock — 793 shares (Direct)

Footnotes (3)

1. F1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.
2. F2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.00 to $35.19. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
3. F3. 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

Key Figures

Shares sold: 6,250 shares Weighted average sale price: $35.0759 per share Options exercised: 6,250 shares +5 more

8 metrics

Shares sold 6,250 shares Open-market sale on June 12, 2026

Weighted average sale price $35.0759 per share Sale prices ranged from $35.00 to $35.19

Options exercised 6,250 shares Stock options exercised at $11.70 per share

Exercise price $11.70 per share Stock Option (Right to Buy) for Septerna common stock

Shares held after transaction 793 shares Direct common stock holding after June 12, 2026 trades

Remaining options 23,750 options Stock options outstanding after reported exercise

Option expiration August 6, 2035 Expiration date of the stock option grant

Vesting schedule 1/48th monthly Options vest on each monthly anniversary of August 1, 2025

Key Terms

Rule 10b5-1 sales plan, weighted average price, Stock Option (Right to Buy), Exercise or conversion of derivative security, +1 more

5 terms

Rule 10b5-1 sales plan regulatory

"This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025."

weighted average price financial

"The price reported in Column 4 is a weighted average price."

Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.

Stock Option (Right to Buy) financial

"security_title: Stock Option (Right to Buy)"

Exercise or conversion of derivative security financial

"transaction_code_description: Exercise or conversion of derivative security"

open-market sale financial

"transaction_action: open-market sale"

An open-market sale is when a shareholder sells existing shares directly on a public exchange to any willing buyer, rather than through a private deal. Think of it like putting goods on a busy market stall where price is set by supply and demand; for investors it matters because such sales increase available supply, can put short-term downward pressure on the stock price, and signal changes in liquidity or investor confidence.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider transaction did Septerna (SEPN) disclose for Samira Shaikhly?

Septerna reported that Chief People Officer Samira Shaikhly exercised 6,250 stock options and sold 6,250 common shares. The sale was an open-market transaction executed under a Rule 10b5-1 plan, indicating the trades were pre-scheduled rather than discretionary.

How many Septerna (SEPN) shares did Samira Shaikhly sell and at what price?

Samira Shaikhly sold 6,250 Septerna common shares at a weighted average price of $35.0759. Individual sale prices ranged from $35.00 to $35.19 per share across multiple trades executed on June 12, 2026.

What stock options did Samira Shaikhly exercise in Septerna (SEPN)?

She exercised stock options covering 6,250 Septerna common shares at an exercise price of $11.70 per share. These options are part of a larger grant that vests in monthly installments, reflecting ongoing equity-based compensation tied to continued service.

How many Septerna (SEPN) shares does Samira Shaikhly hold after this Form 4?

After the reported transactions, Samira Shaikhly directly owns 793 Septerna common shares. This figure reflects her position following the exercise of 6,250 options and the sale of 6,250 shares in the open market on June 12, 2026.

What is the status of Samira Shaikhly’s remaining Septerna (SEPN) stock options?

Following the June 12, 2026 activity, she holds 23,750 Septerna stock options. These options relate to a grant scheduled to vest monthly starting August 1, 2025, and are set to expire on August 6, 2035 if not fully exercised earlier.

Was Samira Shaikhly’s Septerna (SEPN) stock sale under a Rule 10b5-1 plan?

Yes. The Form 4 notes the sale was executed under a Rule 10b5-1 sales plan adopted on October 31, 2025. Such pre-arranged plans allow insiders to systematically sell shares according to preset instructions, reducing timing concerns.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 06/16/2026 - 08:31 PM EDT Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Shaikhly Samira

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CALIFORNIA 94080

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	Chief People Officer

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
06/12/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	06/12/2026		M		6,250	A	$11.7	7,043	D
Common Stock	06/12/2026		S(1)		6,250	D	$35.0759(2)	793	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$11.7	06/12/2026		M			6,250	(3)	08/06/2035	Common Stock	6,250	$0	23,750	D

Explanation of Responses:

1. This transaction was effected pursuant to a Rule 10b5-1 sales plan adopted by the Reporting Person on October 31, 2025.

2. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.00 to $35.19. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

3. 1/48th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of August 1, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

	/s/ Mark A. Wilson, Attorney-in-Fact	06/16/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)