[Form 4] Septerna, Inc. Insider Trading Activity

Rhea-AI Filing Summary

Septerna, Inc. director Keith Michael Gottesdiener was granted a stock option to purchase 33,246 shares of common stock with an exercise price of $16.75. The option was issued on 09/25/2025, becomes exercisable in monthly installments equal to 1/36th of the shares beginning on that date (subject to continued service), and expires on 09/24/2035. Following the reported transaction, the reporting person beneficially owned 33,246 option shares, held directly. The Form 4 was signed via attorney-in-fact on 09/29/2025. No other securities or cash transactions are reported.

Insights

Financial Analyst

TL;DR: Routine equity compensation: a 10-year option with standard monthly vesting to align director incentives.

The grant of a 33,246-share option at $16.75 appears to be a standard director equity award intended to align long-term incentive with shareholder value. The 1/36th monthly vesting schedule over three years is typical for service-based vesting. The exercise price equals the stated grant price and the 10-year term is conventional. No cash purchase or sale was reported and the holding is direct. This disclosure is administrative and does not indicate other material corporate actions.

Corporate Governance Expert

TL;DR: Governance-standard option grant disclosed; vesting tied to continued service, filed under Section 16.

The filing records a service-vested option for a director, with explicit monthly vesting over 36 months commencing 09/25/2025, and a 2035 expiration. The Form 4 correctly reports the director relationship and direct ownership post-grant. The execution by attorney-in-fact and timely Form 4 submission indicate compliance with Section 16 reporting obligations. No departures from typical governance disclosure practices are evident in the text provided.

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

Gottesdiener Keith Michael

(Last) (First) (Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO CA 94080

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director		10% Owner
	Officer (give title below)		Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
09/25/2025

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Option (Right to Buy)	$16.75	09/25/2025		A		33,246		(1)	09/24/2035	Common Stock	33,246	$0	33,246	D

Explanation of Responses:

1. 1/36th of the shares subject to such option shall vest and become exercisable in substantially equal monthly installments on each monthly anniversary of September 25, 2025, subject to the Reporting Person's continuous service to the Issuer on each such date.

	/s/ Gil M. Labrucherie, Attorney-in-Fact	09/29/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What was reported on the Septerna (SEPN) Form 4 for Keith Michael Gottesdiener?

The report discloses a grant of a stock option for 33,246 shares at an exercise price of $16.75, dated 09/25/2025.

When does the option granted to the SEPN director become exercisable and when does it expire?

The option vests in monthly installments equal to 1/36th beginning 09/25/2025 (subject to continued service) and expires on 09/24/2035.

How many shares does the reporting person beneficially own after the reported transaction?

Following the transaction the reporting person beneficially owned 33,246 option shares, held directly.

Who filed and signed the Form 4 for SEPN and when was it signed?

The Form 4 was signed by an attorney-in-fact, Gil M. Labrucherie, on 09/29/2025.

Is the transaction an acquisition or disposition on SEPN Form 4?

The filing reports an acquisition (grant) of derivative securities — a stock option — on 09/25/2025.