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OrbiMed fund trims Sionna Therapeutics (SION) stake in 10b5-1 sale

Filing Impact
(Very High)
Filing Sentiment
(Very Negative)
Form Type
4

Rhea-AI Filing Summary

Sionna Therapeutics director-affiliated fund reports planned share sale. OrbiMed Private Investments VIII LP, an entity associated with director Peter A. Thompson, sold 115,844 shares of Sionna Therapeutics common stock in an open-market transaction at $45.50 per share under a Rule 10b5-1 trading plan. Following this sale, 2,555,877 shares of Sionna common stock are reported as indirectly held, with OrbiMed-related entities and the reporting person disclaiming beneficial ownership beyond any pecuniary interest.

Positive

  • None.

Negative

  • None.
Insider Thompson Peter A.
Role null
Sold 115,844 shs ($5.27M)
Type Security Shares Price Value
Sale Common Stock 115,844 $45.50 $5.27M
Holdings After Transaction: Common Stock — 2,555,877 shares (Indirect, See footnotes)
Footnotes (1)
  1. These securities were sold pursuant to a 10b5-1 plan. These securities are held of record by OrbiMed Private Investments VIII, LP ("OPI VIII"). OrbiMed Capital GP VIII LLC ("GP VIII") is the general partner of OPI VIII and OrbiMed Advisors LLC ("OrbiMed Advisors") is the managing member of GP VIII. By virtue of such relationships, GP VIII and OrbiMed Advisors may be deemed to have voting and investment power with respect to the shares held by OPI VIII and as a result may be deemed to have beneficial ownership of such shares. OrbiMed Advisors exercises investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares held by OPI VIII. The Reporting Person is a member of OrbiMed Advisors. Each of the Reporting Person, OrbiMed Advisors, and GP VIII disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any such entity or person is a beneficial owner of such securities for purposes of Section 16 of the Exchange Act, or for any other purpose.
Shares sold 115,844 shares Open-market sale of common stock on June 30, 2026
Sale price per share $45.50 per share Price for the 115,844 shares sold
Shares held after sale 2,555,877 shares Indirect holdings reported following the transaction
Net shares sold in filing 115,844 shares Net selling activity, as transactionSummary shows net-sell
Rule 10b5-1 plan regulatory
"These securities were sold pursuant to a 10b5-1 plan."
A Rule 10b5-1 plan is a prearranged, written schedule that lets corporate insiders buy or sell company stock at set times or amounts, even if they later learn material nonpublic information. Think of it like setting an automatic thermostat for trades: it creates a clear record that trades were planned in advance, reducing the risk of insider-trading accusations and helping investors trust that insider transactions are routine rather than based on secret information.
beneficial ownership regulatory
"may be deemed to have beneficial ownership of such shares."
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
pecuniary interest financial
"except to the extent of its pecuniary interest therein, if any."
Section 16 regulatory
"beneficial owner of such securities for purposes of Section 16 of the Exchange Act"
Section 16 is a U.S. securities law rule that governs the trading and disclosure obligations of company insiders — typically officers, directors and large shareholders — to promote transparency and deter unfair profit-taking. It requires insiders to publicly report their stock trades and allows companies or the issuer to reclaim quick, short-term profits from certain insider trades, like a scoreboard and a refund policy that help investors see and limit possible insider advantage.
voting and investment power financial
"may be deemed to have voting and investment power with respect to the shares"
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SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
X
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Thompson Peter A.

(Last)(First)(Middle)
C/O SIONNA THERAPEUTICS, INC.
21 HICKORY DRIVE, SUITE 500

(Street)
WALTHAM MASSACHUSETTS 02451

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Sionna Therapeutics, Inc. [ SION ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
06/30/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
XForm filed by One Reporting Person
Form filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock06/30/2026S115,844(1)D$45.52,555,877ISee footnotes(2)(3)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
1. These securities were sold pursuant to a 10b5-1 plan.
2. These securities are held of record by OrbiMed Private Investments VIII, LP ("OPI VIII"). OrbiMed Capital GP VIII LLC ("GP VIII") is the general partner of OPI VIII and OrbiMed Advisors LLC ("OrbiMed Advisors") is the managing member of GP VIII. By virtue of such relationships, GP VIII and OrbiMed Advisors may be deemed to have voting and investment power with respect to the shares held by OPI VIII and as a result may be deemed to have beneficial ownership of such shares. OrbiMed Advisors exercises investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the shares held by OPI VIII. The Reporting Person is a member of OrbiMed Advisors.
3. Each of the Reporting Person, OrbiMed Advisors, and GP VIII disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any such entity or person is a beneficial owner of such securities for purposes of Section 16 of the Exchange Act, or for any other purpose.
/s/ Peter A. Thompson07/02/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What insider transaction did Sionna Therapeutics (SION) report in this Form 4?

Sionna Therapeutics reported that OrbiMed Private Investments VIII LP, associated with director Peter A. Thompson, sold 115,844 shares of common stock. The sale was an open-market transaction at $45.50 per share executed under a Rule 10b5-1 trading plan.

Who actually sold the Sionna Therapeutics (SION) shares reported in this filing?

The shares were sold by OrbiMed Private Investments VIII LP, not directly by Peter A. Thompson. OrbiMed-related entities may be deemed to have voting and investment power, while Thompson is a member of OrbiMed Advisors and is indirectly associated with the holding entity.

How many Sionna Therapeutics (SION) shares were sold and at what price?

The filing shows a sale of 115,844 shares of Sionna Therapeutics common stock. These shares were sold in an open-market transaction at a price of $45.50 per share, as disclosed in the transaction details for June 30, 2026.

How many Sionna Therapeutics (SION) shares remain held after this transaction?

After the reported sale, 2,555,877 shares of Sionna Therapeutics common stock are reported as indirectly held. These shares are held of record by OrbiMed Private Investments VIII LP, with related OrbiMed entities potentially sharing voting and investment power over the position.

Was the Sionna Therapeutics (SION) insider sale made under a Rule 10b5-1 plan?

Yes. The filing notes that the securities were sold pursuant to a Rule 10b5-1 trading plan. Such plans are pre-arranged programs that allow insiders or affiliated entities to systematically sell shares according to predetermined instructions, reducing discretion over trade timing.

Does Peter A. Thompson fully own the Sionna Therapeutics (SION) shares reported here?

No. The filing states that Peter A. Thompson, OrbiMed Advisors, and GP VIII each disclaim beneficial ownership of the reported securities, except to the extent of any pecuniary interest. This means economic interests may exist, but full beneficial ownership is not asserted.