STOCK TITAN

Skye Bioscience holders sell 33,892 shares

5AM-affiliated funds reported net sales of Skye Bioscience Common Stock while remaining significant indirect shareholders after the recent 1-for-8 reverse stock split.

(Neutral)
(Negative)
Form Type
4

Rhea-AI Filing Summary

Skye Bioscience, Inc. (SKYE) had affiliated investment funds managed by 5AM entities report open-market sales of its Common Stock on September 16, 2026. 5AM Ventures II, L.P. sold 32,607 shares and 5AM Co-Investors II, L.P. sold 1,285 shares at a weighted average price of $1.91 per share, leaving them with 142,463 and 5,616 shares, respectively, held indirectly. Another affiliated fund, 5AM Ventures VII, L.P., reported an indirect holding of 981,269 shares. A 1-for-8 reverse stock split effective August 24, 2026 is reflected in these amounts, and no Rule 10b5-1 trading plan is reported.

Positive

  • None.

Negative

  • None.
Insider 5AM Partners VII, LLC, 5AM Ventures VII, L.P., 5AM Partners II, LLC, 5AM Ventures II LP, 5AM CO-INVESTORS II LP, DIEKMAN JOHN D, PARMAR KUSH, ROCKLAGE SCOTT M
Role 10% Owner | 10% Owner | 10% Owner | 10% Owner | 10% Owner | 10% Owner | 10% Owner | 10% Owner
Sold 33,892 shs ($65K)
Type Security Shares Price Value
Sale Common Stock F1, F2 32,607 $1.91 $62K
Sale Common Stock F1, F3 1,285 $1.91 $2K
holding Common Stock F4 -- -- --
Holdings After Transaction: Common Stock — 142,463 shares (Indirect, By 5AM Ventures II, L.P.); Common Stock — 5,616 shares (Indirect, By 5AM Co-Investors II, L.P.); Common Stock — 981,269 shares (Indirect, By 5AM Ventures VII, L.P.)
Footnotes (4)
  1. F1. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.70 to $2.11 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
  2. F2. The securities are directly held by 5AM Ventures II, L.P. ("Ventures II"). 5AM Partners II, LLC ("Partners II") is the sole general partner of Ventures II. Dr. John Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are the managing members of Partners II and may be deemed to have shared voting and investment power over the securities beneficially owned by Ventures II. Each of Partners II, Dr. Diekman and Dr. Rocklage disclaims beneficial ownership of such securities except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.
  3. F3. The securities are directly held by 5AM Co-Investors II, L.P. ("Co-Investors II"). Partners II is the sole general partner of Co-Investors II. Dr. John Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are the managing members of Partners II and may be deemed to have shared voting and investment power over the securities beneficially owned by Co-Investors II. Each of Partners II, Dr. Diekman and Dr. Rocklage disclaims beneficial ownership of such shares except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.
  4. F4. The securities are directly held by 5AM Ventures VII, L.P. ("Ventures VII"). 5AM Partners VII, LLC ("Partners VII") is the sole general partner of Ventures VII. Dr. Kush Parmar and Andrew J. Schwab are the managing members of Partners VII and may be deemed to have shared voting and investment power over the securities beneficially owned by Ventures VII. Each of Partners VII and Dr. Parmar disclaims beneficial ownership of such securities except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.
Shares sold by 5AM Ventures II, L.P. 32,607 shares Open-market or private sale of Skye Bioscience Common Stock on September 16, 2026
Shares sold by 5AM Co-Investors II, L.P. 1,285 shares Open-market or private sale of Skye Bioscience Common Stock on September 16, 2026
Weighted average sale price $1.91 per share Sales on September 16, 2026; individual prices ranged from $1.70 to $2.11
Price range for reported sales $1.70–$2.11 per share Range of prices for multiple transactions included in the weighted average
Shares held after by 5AM Ventures II, L.P. 142,463 shares Indirect beneficial ownership of Skye Bioscience Common Stock after September 16, 2026 sale
Shares held after by 5AM Co-Investors II, L.P. 5,616 shares Indirect beneficial ownership of Skye Bioscience Common Stock after September 16, 2026 sale
Indirect holding by 5AM Ventures VII, L.P. 981,269 shares Reported beneficial ownership of Skye Bioscience Common Stock
Reverse stock split ratio 1-for-8 Reverse stock split of Skye Bioscience Common Stock effective August 24, 2026
reverse stock split financial
"On August 24, 2026, the Issuer effected a 1-for-8 reverse stock split"
A reverse stock split reduces a company's number of outstanding shares while raising the price per share proportionally, so the total value of each investor's holding is unchanged; a 1-for-10 split turns 100 shares worth $1 each into 10 shares worth $10 each. Companies often do this to regain compliance with an exchange's minimum price rule or to attract investors who avoid very low-priced stocks.
weighted average price financial
"The price reported in Column 4 is a weighted average price."
Weighted average price is the average price of a security where each trade or component is counted according to its size, so bigger trades pull the average more than smaller ones. Think of it like calculating the average cost of a grocery haul where items you bought more of have greater influence on the final per-item cost. Investors use it to understand the true average price paid or received, judge execution quality, and compare trading performance against market movement.
beneficial ownership financial
"may be deemed to have shared voting and investment power over the securities beneficially owned"
Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.
indirect ownership financial
"directly held by 5AM Ventures II, L.P. ... indirect beneficial ownership reported"
pecuniary interest financial
"disclaims beneficial ownership of such securities except to the extent of its or his respective pecuniary interest"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What did the 5AM-affiliated holders do in this Form 4 for SKYE?

They sold 33,892 shares of Skye Bioscience Common Stock on September 16, 2026 in open-market or private transactions, through 5AM Ventures II, L.P. and 5AM Co-Investors II, L.P., and reported updated indirect holdings after these sales.

How many SKYE shares did 5AM Ventures II, L.P. sell and what does it hold now?

5AM Ventures II, L.P. sold 32,607 shares of Skye Bioscience Common Stock at a weighted average price of $1.91 per share, with prices ranging from $1.70 to $2.11, and reported 142,463 shares indirectly held afterward.

How many SKYE shares did 5AM Co-Investors II, L.P. sell and what is its new position?

5AM Co-Investors II, L.P. sold 1,285 shares of Skye Bioscience Common Stock at a weighted average price of $1.91 per share and reported an indirect holding of 5,616 shares following the transaction.

What SKYE stake does 5AM Ventures VII, L.P. report in this filing?

5AM Ventures VII, L.P. reports an indirect holding of 981,269 shares of Skye Bioscience Common Stock. These securities are directly held by 5AM Ventures VII, L.P., with 5AM Partners VII, LLC as its sole general partner.

Was there a recent stock split affecting SKYE share counts in this Form 4?

Yes. On August 24, 2026, Skye Bioscience effected a 1-for-8 reverse stock split of its Common Stock, and the numbers of securities beneficially owned reported by the 5AM-affiliated reporting persons already reflect this reverse split.

Were the SKYE share sales made under a Rule 10b5-1 trading plan?

No. The filing indicates that the Rule 10b5-1 checkbox is not marked, and there is no footnote stating that these transactions were made pursuant to a Rule 10b5-1 or other pre-arranged trading plan.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Learn about SEC filing dates
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
5AM Partners VII, LLC

(Last)(First)(Middle)
4 EMBARCADERO CENTER, SUITE 3110

(Street)
SAN FRANCISCO CALIFORNIA 94111

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Skye Bioscience, Inc. [ SKYE ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
DirectorX10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
09/16/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
XForm filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock09/16/2026S32,607D$1.91(1)142,463IBy 5AM Ventures II, L.P.(2)
Common Stock09/16/2026S1,285D$1.91(1)5,616IBy 5AM Co-Investors II, L.P.(3)
Common Stock981,269IBy 5AM Ventures VII, L.P.(4)
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
1. Name and Address of Reporting Person*
5AM Partners VII, LLC

(Last)(First)(Middle)
4 EMBARCADERO CENTER, SUITE 3110

(Street)
SAN FRANCISCO CALIFORNIA 94111

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
DirectorX10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
5AM Ventures VII, L.P.

(Last)(First)(Middle)
4 EMBARCADERO CENTER, SUITE 3110

(Street)
SAN FRANCISCO CALIFORNIA 94111

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
DirectorX10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
5AM Partners II, LLC

(Last)(First)(Middle)
4 EMBARCADERO CENTER, SUITE 3110

(Street)
SAN FRANCISCO CALIFORNIA 94111

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
DirectorX10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
5AM Ventures II LP

(Last)(First)(Middle)
4 EMBARCADERO CENTER, SUITE 3110

(Street)
SAN FRANCISCO CALIFORNIA 94111

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
DirectorX10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
5AM CO-INVESTORS II LP

(Last)(First)(Middle)
4 EMBARCADERO CENTER, SUITE 3110

(Street)
SAN FRANCISCO CALIFORNIA 94111

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
DirectorX10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
DIEKMAN JOHN D

(Last)(First)(Middle)
4 EMBARCADERO CENTER, SUITE 3110

(Street)
SAN FRANCISCO CALIFORNIA 94111

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
DirectorX10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
PARMAR KUSH

(Last)(First)(Middle)
4 EMBARCADERO CENTER, SUITE 3110

(Street)
SAN FRANCISCO CALIFORNIA 94111

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
DirectorX10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
ROCKLAGE SCOTT M

(Last)(First)(Middle)
4 EMBARCADERO CENTER, SUITE 3110

(Street)
SAN FRANCISCO CALIFORNIA 94111

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
DirectorX10% Owner
Officer (give title below)Other (specify below)
Explanation of Responses:
1. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $1.70 to $2.11 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.
2. The securities are directly held by 5AM Ventures II, L.P. ("Ventures II"). 5AM Partners II, LLC ("Partners II") is the sole general partner of Ventures II. Dr. John Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are the managing members of Partners II and may be deemed to have shared voting and investment power over the securities beneficially owned by Ventures II. Each of Partners II, Dr. Diekman and Dr. Rocklage disclaims beneficial ownership of such securities except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.
3. The securities are directly held by 5AM Co-Investors II, L.P. ("Co-Investors II"). Partners II is the sole general partner of Co-Investors II. Dr. John Diekman, Andrew J. Schwab and Dr. Scott M. Rocklage are the managing members of Partners II and may be deemed to have shared voting and investment power over the securities beneficially owned by Co-Investors II. Each of Partners II, Dr. Diekman and Dr. Rocklage disclaims beneficial ownership of such shares except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.
4. The securities are directly held by 5AM Ventures VII, L.P. ("Ventures VII"). 5AM Partners VII, LLC ("Partners VII") is the sole general partner of Ventures VII. Dr. Kush Parmar and Andrew J. Schwab are the managing members of Partners VII and may be deemed to have shared voting and investment power over the securities beneficially owned by Ventures VII. Each of Partners VII and Dr. Parmar disclaims beneficial ownership of such securities except to the extent of its or his respective pecuniary interest therein. Mr. Schwab is a director of the Issuer and files separate Section 16 reports.
Remarks:
On August 24, 2026, the Issuer effected a 1-for-8 reverse stock split of its Common Stock, which is reflected in the Reporting Persons' number of securities beneficially owned reported in this filing.
5AM Partners VII, LLC, By /s/ Andrew J. Schwab, Managing Member09/18/2026
5AM Ventures VII, L.P., By: 5AM Partners VII, LLC, its General Partner, By /s/ Andrew J. Schwab, Managing Member09/18/2026
5AM Partners II, LLC, By /s/ Andrew J. Schwab, Managing Member09/18/2026
5AM Ventures II, L.P., By: 5AM Partners II, LLC, its General Partner, By /s/ Andrew J. Schwab, Managing Member09/18/2026
5AM Co-Investors II, L.P., By: 5AM Partners II, LLC, its General Partner, By /s/ Andrew J. Schwab, Managing Member09/18/2026
/s/ John Diekman09/18/2026
/s/ Kush Parmar09/18/2026
/s/ Scott M. Rocklage09/18/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

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