Filed by Strive, Inc.
(Commission File No.: 001-41612)
Pursuant to Rule 425 of the Securities Act of 1933
and deemed filed pursuant to Rule 14a-12
under the Securities Exchange Act of 1934
Subject Company: Semler Scientific, Inc.
(Commission File No.: 001-36305)
The following communication was posted on X.com by Matthew Cole,
Chief Executive Officer of Strive, Inc. (“Strive”), on November 14, 2025, in connection with Strive’s proposed business
combination with Semler Scientific, Inc. (“Semler Scientific”).

Cautionary Statement Regarding Forward-Looking Statements
Certain statements herein
and the documents incorporated herein by reference may constitute "forward-looking statements" within the meaning of the Private
Securities Litigation Reform Act of 1995, Section 27A of the Securities Act of 1933, as amended (the "Securities Act"), and
Rule 175 promulgated thereunder, and Section 21E of the Securities Exchange Act of 1934, as amended (the "Exchange Act") and
Rule 3b-6 promulgated thereunder, which statements involve inherent risks and uncertainties. Examples of forward-looking
statements include, but are not limited to, statements regarding the outlook and expectations of Strive and Semler Scientific, respectively,
with respect to the proposed transaction (the “proposed transaction”), the strategic benefits and financial benefits of the
proposed transaction, including the expected impact of the proposed transaction on the combined company's future financial performance,
the timing of the closing of the proposed transaction, and the ability to successfully integrate the combined businesses. Such
statements are often characterized by the use of qualified words (and their derivatives) such as "may," "will," "anticipate,"
"could," "should," "would," "believe," "contemplate," "expect," "estimate,"
"continue," "plan," "project," "predict," "potential," "assume," "forecast,"
"target," "budget," "outlook," "trend," "guidance," "objective," "goal,"
"strategy," "opportunity," and "intend," as well as words of similar meaning or other statements concerning
opinions or judgments of Strive, Semler Scientific and/or their respective management about future events. Forward-looking
statements are based on assumptions as of the time they are made and are subject to risks, uncertainties and other factors that are difficult
to predict with regard to timing, extent, likelihood and degree of occurrence, which could cause actual results to differ materially from
anticipated results expressed or implied by such forward-looking statements. Other risks, uncertainties and assumptions, including, among
others, the following:
| · | the occurrence of any event, change or other circumstances that could give rise to the right of one or both of Strive and Semler Scientific
to terminate the merger agreement between Strive and Semler Scientific; |
| · | the possibility that the proposed transaction does not close when expected or at all because the conditions to closing are not received
or satisfied on a timely basis or at all; |
| · | the outcome of any legal proceedings that may be instituted against Strive or Semler Scientific or the combined company; |
| · | the possibility that the anticipated benefits of the proposed transaction, including anticipated cost savings and strategic gains,
are not realized when expected or at all, including as a result of changes in, or problems arising from, implementation of Bitcoin treasury
strategies and risks associated with Bitcoin and other digital assets, general economic and market conditions, interest and exchange rates,
monetary policy, and laws and regulations and their enforcement; |
| · | the possibility that the integration of the two companies may be more difficult, time-consuming or costly than expected; |
| · | the possibility that the proposed transaction may be more expensive or take longer to complete than anticipated, including as a result
of unexpected factors or events; |
| · | the diversion of management's attention from ongoing business operations and opportunities; |
| · | dilution caused by Strive’s issuance of additional shares of its Class A common stock in connection with the proposed transaction; |
| · | potential adverse reactions of Strive’s or Semler Scientific’s customers or changes to business or employee relationships,
including those resulting from the announcement or completion of the proposed transaction; |
| · | changes in Strive’s or Semler Scientific’s share price before closing; and |
| · | other factors that may affect future results of Strive, Semler Scientific or the combined company. |
These factors are not necessarily all of the factors
that could cause Strive’s, Semler Scientific’s or the combined company's actual results, performance or achievements to differ
materially from those expressed in or implied by any of the forward-looking statements. Other factors, including unknown or
unpredictable factors, also could harm Strive, Semler Scientific or the combined company's results.
Although each of Strive and Semler Scientific
believes that its expectations with respect to forward-looking statements are based upon reasonable assumptions within the bounds of its
existing knowledge of its business and operations, there can be no assurance that the actual results of Strive or Semler Scientific will
not differ materially from any projected future results expressed or implied by such forward-looking statements. Additional factors that
could cause results to differ materially from those described above can be found in Strive’s Quarterly Report on Form 10-Q filed
on November 14, 2025 and Strive’s Form S-4 filed on October 10, 2025, Semler Scientific’s Quarterly Report on Form 10-Q filed
on November 12, 2025, and other documents subsequently filed by Strive and Semler Scientific with the SEC.
The actual results anticipated may not be realized
or, even if substantially realized, they may not have the expected consequences to or effects on Strive, Semler Scientific or their respective
businesses or operations. Investors are cautioned not to rely too heavily on any such forward-looking statements. Forward-looking
statements contained herein speak only as of the date they are made and Strive and Semler Scientific undertake no obligation to update
or clarify these forward-looking statements, whether as a result of new information, future events or otherwise, except to the extent
required by applicable law.
Additional Information
and Where to Find It
In connection with the
proposed transaction, Strive has filed with the SEC a Registration Statement on Form S-4 (the "Registration Statement") to register
the Class A common stock to be issued by Strive in connection with the proposed transaction and that will include an information statement
of Strive, proxy statement of Semler Scientific and a prospectus of Strive (the "Information Statement/Proxy Statement/Prospectus"),
and each of Strive and Semler Scientific may file with the SEC any other relevant documents concerning the proposed transaction. A
definitive Information Statement/Proxy Statement/Prospectus will be sent to the stockholders of Semler Scientific to seek their approval
of the proposed transaction. BEFORE MAKING ANY VOTING OR INVESTMENT DECISION, INVESTORS AND STOCKHOLDERS OF SEMLER SCIENTIFIC
ARE URGED TO READ THE REGISTRATION STATEMENT AND INFORMATION STATEMENT/PROXY STATEMENT/PROSPECTUS REGARDING THE PROPOSED TRANSACTION WHEN
THEY BECOME AVAILABLE AND ANY OTHER RELEVANT DOCUMENTS FILED WITH THE SEC, AS WELL AS ANY AMENDMENTS OR SUPPLEMENTS TO THOSE DOCUMENTS,
BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION ABOUT STRIVE, SEMLER SCIENTIFIC AND THE PROPOSED TRANSACTION AND RELATED MATTERS.
A copy of the Registration
Statement, Information Statement/Proxy Statement/Prospectus, as well as other filings containing information about Strive and Semler Scientific,
may be obtained, free of charge, at the SEC's website (http://www.sec.gov). You will
also be able to obtain these documents, when they are filed, free of charge, from Strive by accessing Strive’s website at https://investors.strive.com/.
Copies of the Registration Statement, the Information Statement/Proxy Statement/Prospectus and the filings with the SEC that will be incorporated
by reference therein can also be obtained, without charge, by directing a request to Strive’s Investor Relations department at 200
Crescent Court, Suite 1400, Dallas, Texas 75201 or by calling (855) 427-7360 or by submitting an inquiry at https://investors.strive.com/ir-resources/contact-ir. Copies
of the documents filed with the SEC by Semler Scientific will be available free of charge on Semler Scientific’s website at https://ir.semlerscientific.com/.
The information on Strive’s or Semler Scientific’s respective websites is not, and shall not be deemed to be, a part of this
communication or incorporated into other filings either company makes with the SEC.
Participants in the
Solicitation
Strive, Semler Scientific
and certain of their respective directors, executive officers and employees may be deemed to be participants in the solicitation of proxies
from the stockholders of Semler Scientific in connection with the proposed transaction. Information about the interests of
the directors and executive officers of Strive and Semler Scientific and other persons who may be deemed to be participants in the solicitation
of stockholders of Semler Scientific in connection with the proposed transaction and a description of their direct and indirect interests,
by security holdings or otherwise, will be included in the Information Statement/Proxy Statement/Prospectus related to the proposed transaction,
which will be filed with the SEC. Information about the current directors and executive officers of Semler Scientific, and
their ownership of Semler Scientific common stock is set forth in the section entitled "THE MERGERS" and "SECURITY OWNERSHIP
OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT" included in Strive’s Form
S-4 filed with the SEC on October 10, 2025 and Semler Scientific’s Current Report on Form 8-K filed with the SEC on October
17, 2025. Additional information regarding ownership of Semler Scientific’s securities by its directors and executive officers is
included in such persons’ SEC filings on Forms 3 or 4, which are available at https://www.sec.gov/cgi-bin/own-disp?action=getissuer&CIK=0001554859.
Information about the current directors and executive officers of Strive is contained in Strive’s Current Report on Form
8-K filed with the SEC on September 12, 2025, Strive’s Current Report on Form
8-K filed with the SEC on September 15, 2025, Strive’s Current Report on Form
8-K filed with the SEC on October 6, 2025 and under “Meet the Leadership Team” accessed through the “About Us”
link on Strive’s website at https://strive.com/team. Additional information regarding
ownership of Strive’s securities by its directors and executive officers is included in such persons’ SEC filings
on Forms 3 or 4 which are available at https://www.sec.gov/cgi-bin/own-disp?action=getissuer&CIK=1920406. These documents
and the other SEC filings described in this paragraph may be obtained free of charge as described above under the heading “Additional
Information and Where to Find It.”
No Offer or Solicitation
This communication is not intended to and shall
not constitute an offer to sell or the solicitation of an offer to sell or the solicitation of an offer to buy any securities or the solicitation
of any vote of approval, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would
be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No offer of securities shall be
made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act, or pursuant to an exemption from, or
in a transaction not subject to, such registration requirements.