[SCHEDULE 13G] Syndax Pharmaceuticals, Inc. SEC Filing

Rhea-AI Filing Summary

Point72 entities and Steven A. Cohen report a 5.0% stake in Syndax Pharmaceuticals (SNDX). As of the close of business on August 15, 2025, Point72 Asset Management, L.P., Point72 Capital Advisors, Inc. and Steven A. Cohen each report beneficial ownership of 4,327,952 shares of Syndax common stock, representing 5.0% of the class. The filing shows no sole voting or dispositive power and reports shared voting and shared dispositive power of 4,327,952 shares. The statement is filed jointly pursuant to a Joint Filing Agreement (Exhibit 99.1). The issuer's principal executive office is listed at 730 Third Avenue, 9th Floor, New York, NY 10017.

Positive

• Institutional ownership disclosed: Point72 and affiliates report a clear 5.0% stake, improving transparency for investors
• Joint filing and Exhibit 99.1: Formal joint disclosure clarifies reporting responsibilities among related parties

Negative

• No sole voting or dispositive power: The reporting persons claim only shared control, limiting their unilateral influence
• Position size limited to 5.0%: Stake is material but not large enough alone to indicate control or immediate governance changes

Insights

Financial Analyst

TL;DR: A 5.0% shared stake by Point72 and Mr. Cohen is material but not a controlling position; it signals meaningful ownership without sole control.

The filing documents a 4,327,952-share position representing exactly 5.0% of Syndax's common stock held through Point72-managed vehicles as of August 15, 2025. Reported rights are exclusively shared voting and shared dispositive power, with no sole voting or dispositive authority claimed. The joint filing and Exhibit 99.1 indicate coordinated disclosure rather than an acquisition intended to change control. For investors, this is a visible institutional stake that could increase monitoring and engagement but, based solely on this filing, does not indicate shifts in board control or governance.

Corporate Governance Expert

TL;DR: Joint filing and shared powers point to coordinated ownership; not a standalone controlling block.

The Schedule 13G shows Point72 Asset Management, Point72 Capital Advisors and Steven A. Cohen jointly reporting beneficial ownership of 4,327,952 shares (5.0%). The registrants explicitly report shared voting and dispositive power and disclaim sole control. The inclusion of a Joint Filing Agreement as Exhibit 99.1 formalizes joint reporting responsibilities. From a governance perspective, a 5.0% passive/common reporting stake can prompt engagement but, per the filing language, is not presented as an effort to influence or change issuer control.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

Syndax Pharmaceuticals Inc

(Name of Issuer)

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

87164F105

(CUSIP Number)

08/15/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No. 87164F105

1

Names of Reporting Persons

Point72 Asset Management, L.P.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 4,327,952.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 4,327,952.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,327,952.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.0 %

12

Type of Reporting Person (See Instructions)

PN

SCHEDULE 13G

CUSIP No. 87164F105

1

Names of Reporting Persons

Point72 Capital Advisors, Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 4,327,952.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 4,327,952.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,327,952.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.0 %

12

Type of Reporting Person (See Instructions)

CO

SCHEDULE 13G

CUSIP No. 87164F105

1

Names of Reporting Persons

Steven A. Cohen

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 4,327,952.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 4,327,952.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

4,327,952.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

5.0 %

12

Type of Reporting Person (See Instructions)

IN

SCHEDULE 13G

Item 1.
(a)	Name of issuer: Syndax Pharmaceuticals Inc
(b)	Address of issuer's principal executive offices: 730 Third Avenue, 9th Floor, New York, NY 10017
Item 2.
(a)	Name of person filing: This statement is filed by: (i) Point72 Asset Management, L.P. ("Point72 Asset Management") with respect to the shares of common stock, par value $0.0001 per share ("Shares"), of Syndax Pharmaceuticals Inc. held by Point72 Associates, LLC, an investment fund it manages ("Point72 Associates"); (ii) Point72 Capital Advisors, Inc. ("Point72 Capital Advisors Inc.") with respect to the Shares held by Point72 Associates; and (iii) Steven A. Cohen ("Mr. Cohen") with respect to the Shares beneficially owned by Point72 Asset Management and Point72 Capital Advisors Inc. Each of Cubist Systematic Strategies, LLC, Point72 Asia (Singapore) Pte. Ltd. and Point72 (DIFC) Limited are advisors under common control with Point72 Asset Management, and each acts as a sub-advisor with respect to a portion of the Shares reported herein. Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen have entered into a Joint Filing Agreement, a copy of which is filed with this Schedule 13G as Exhibit 99.1, pursuant to which they have agreed to file this Schedule 13G jointly in accordance with the provisions of Rule 13d-1(k) of the Securities Exchange Act of 1934 (the "Act").
(b)	Address or principal business office or, if none, residence: The address of the principal business office of Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road, Stamford, CT 06902.
(c)	Citizenship: Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a Delaware corporation. Mr. Cohen is a United States citizen.
(d)	Title of class of securities: Common Stock, par value $0.0001 per share
(e)	CUSIP No.: 87164F105
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on August 15, 2025. Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen own directly no Shares. Pursuant to an investment management agreement, Point72 Asset Management maintains investment and voting power with respect to the securities held by Point72 Associates. Point72 Capital Advisors Inc. is the general partner of Point72 Asset Management. Mr. Cohen controls each of Point72 Asset Management and Point72 Capital Advisors Inc. The filing of this statement should not be construed as an admission that any of the foregoing persons or any Reporting Person is, for the purposes of Section 13 of the Act, the beneficial owner of the Shares reported herein.
(b)	Percent of class: 5.0%
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on August 15, 2025.
	(ii) Shared power to vote or to direct the vote: The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on August 15, 2025.
	(iii) Sole power to dispose or to direct the disposition of: The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on August 15, 2025.
	(iv) Shared power to dispose or to direct the disposition of: The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on August 15, 2025.
Item 5.	Ownership of 5 Percent or Less of a Class.
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. See Item 2(a). Point72 Associates has the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, more than 5 percent of the outstanding Shares.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	Not Applicable
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Point72 Asset Management, L.P.

Signature:	/s/ Jason M. Colombo
Name/Title:	Jason M. Colombo, Authorized Person
Date:	08/18/2025

Point72 Capital Advisors, Inc.

Signature:	/s/ Jason M. Colombo
Name/Title:	Jason M. Colombo, Authorized Person
Date:	08/18/2025

Steven A. Cohen

Signature:	/s/ Jason M. Colombo
Name/Title:	Jason M. Colombo, Authorized Person
Date:	08/18/2025

Exhibit Information

Exhibit 99.1: Joint Filing Agreement

FAQ

How many Syndax (SNDX) shares does Point72 report owning?

Point72 entities and Steven A. Cohen report beneficial ownership of 4,327,952 shares of Syndax common stock.

What percentage of Syndax does the reported position represent?

The reported shares represent 5.0% of the outstanding common stock as of the close of business on August 15, 2025.

Does Point72 or Steven A. Cohen have sole voting or dispositive power over the shares?

No. The filing reports 0 sole voting power and 0 sole dispositive power, and 4,327,952 shares of shared voting and shared dispositive power.

Is this filing a Schedule 13G or 13D and what does that imply?

This document is a Schedule 13G, indicating a passive or qualifying institutional reporting stance rather than an acquisition seeking to change control.

Where can I find the Joint Filing Agreement referenced in the filing?

The Joint Filing Agreement is included as Exhibit 99.1 to this Schedule 13G.