Welcome to our dedicated page for Senti Biosciences Holdings SEC filings (Ticker: SNTI), a comprehensive resource for investors and traders seeking official regulatory documents including 10-K annual reports, 10-Q quarterly earnings, 8-K material events, and insider trading forms.
Senti Biosciences SEC filings document a clinical-stage biotechnology issuer built around the Gene Circuit platform and its cell-therapy pipeline. The company’s 8-K reports cover operating and financial results, corporate updates, clinical or regulatory disclosures, shareholder voting matters, governance items, capital-structure matters and material agreements, including research-and-development laboratory lease disclosures.
The filing record also includes a Form 15-12G for Senti Biosciences, Inc. after a completed Delaware holding company reorganization under which Senti became a subsidiary within Senti Biosciences Holdings. That filing addresses termination or suspension of Exchange Act registration and reporting duties for the covered Senti common stock, alongside the issuer’s corporate-status and security-class disclosures.
Senti Biosciences, Inc. reported 2025 results and highlighted key clinical progress, led by SENTI-202 in relapsed or refractory acute myeloid leukemia. The program generated updated positive preliminary Phase 1 data with encouraging response rates, durability and a favorable safety profile, and received U.S. FDA Regenerative Medicine Advanced Therapy (RMAT) designation.
As of December 31, 2025, Senti Bio held $16.4 million in cash and cash equivalents, with total assets of $51.2 million and total liabilities of $45.6 million. For full-year 2025, research and development expenses were $37.6 million and general and administrative expenses were $26.2 million. The company recorded a net loss of $61.4 million, or $2.73 per share, including a non-recurring $5.1 million impairment of long-lived assets and $5.7 million of non-cash stock-based compensation.
Senti Biosciences, Inc. entered into a series of agreements to restructure its facility lease and related sublease for its Alameda, California premises. Effective September 1, 2025, the company will reduce its leased space from approximately 91,910 to 45,955 rentable square feet, cutting its proportionate share of operating expenses and taxes to 50% while keeping responsibility for all utilities until the surrendered space is re-let.
The amended lease sets stepped monthly base rent for the remaining premises, starting at $188,311 from September 1, 2025 through July 31, 2026 and rising over time to $293,010 for August 2022. As consideration for this rent reduction, the landlord may draw $2.0 million on the company’s existing $2.76 million letter of credit, after which the required letter of credit amount drops to $760,000.
The company also amended its sublease with GeneFab, LLC so the subleased space and GeneFab’s payment obligations mirror the amended lease economics, and entered into a consent and letter agreement. GeneFab will pay a $1.0 million reduction fee to the landlord and has $1,374,005 of outstanding base rent that can be satisfied through a prepayment credit for future work or services, with any unpaid portion due by September 1, 2026. GeneFab’s failure to perform on these obligations constitutes an immediate event of default under the amended sublease.
Senti Biosciences executive Kanya Rajangam reported a routine tax-related share disposition. On this filing, 10,757 shares of common stock were withheld by the company to cover income tax obligations tied to vested restricted stock units, and not sold on the open market. After this withholding, Rajangam directly holds 74,843 common shares.
Senti Biosciences CEO Timothy K. Lu reported a tax-related share disposition. On the net settlement of time-based restricted stock units, 80,666 shares of common stock were withheld by the company to cover income tax obligations and remittance, which the filing states is not an open market sale. After this withholding, Lu directly holds 639,583 common shares, and the filing also notes 52,839 shares held indirectly, including through the Luminen Trust, where he disclaims beneficial ownership except for any pecuniary interest.
Senti Biosciences officer reports tax share withholding from RSU settlement. On 02/02/2026, Pres. & Chief Med. & Dev. Officer Kanya Rajangam had 1,384 shares of Senti Biosciences common stock withheld at a price of $0 per share to cover income tax obligations on vested restricted stock units.
These shares were withheld by the company and the transaction did not involve an open market sale. Following this tax-related withholding, Rajangam directly beneficially owns 85,600 shares of Senti Biosciences common stock.
Senti Biosciences CEO Timothy K. Lu reported a routine tax-related share withholding. On February 2, 2026, the company withheld 4,191 shares of common stock to cover income tax obligations tied to vested restricted stock units, which was not an open market sale.
After this withholding, Lu directly beneficially owned 720,249 shares of common stock. The filing also lists 52,839 shares held indirectly by his spouse and another 52,839 shares held by Luminen Services, LLC as trustee of the Luminen Trust, for which Lu disclaims beneficial ownership except for any pecuniary interest.
Celadon Partners SPV 24 and Celadon Partners, LLC report a 45% beneficial stake in Senti Biosciences, Inc. common stock, including warrant shares subject to a 45% cap. They report beneficial ownership of 13,511,322 shares, which includes 3,734,322 shares issuable upon exercise of warrants, calculated against 26,290,838 shares outstanding as of October 31, 2025.
The investors state they are in preliminary discussions with Senti about a potential financing of at least $10.0 million through convertible bonds issued by a new Senti subsidiary. These bonds would be convertible into equity of the subsidiary or exchangeable for Senti common stock, with proceeds intended to advance CMC and clinical trials for v2.0 process development and GMP manufacturing. They are also exploring possible restructuring or merger and acquisition transactions with Senti that could involve changes to the company’s capital structure. The investors report no Senti stock transactions in the past 60 days.
Senti Biosciences (SNTI) filed its Q3 2025 10‑Q, reporting a net loss of $18.1 million for the quarter and $47.0 million for the nine months. Cash and cash equivalents were $12.2 million at September 30, 2025, down from $48.3 million at year‑end, and management concluded that substantial doubt exists about the company’s ability to continue as a going concern without additional financing.
Operating expenses were $16.9 million in Q3, driven by R&D $10.5 million and G&A $6.4 million. Net cash used in operating activities was $36.6 million for the nine months. The company also recorded a $3.3 million reversal of previously recognized sublease income tied to related‑party GeneFab after determining collectibility was not probable. As of quarter‑end, GeneFab owed $4.7 million in past‑due sublease rent; $1.0 million was received in October.
Senti received a default notice on its Alameda lease for ~$0.4 million of unpaid rent; discussions to cure are ongoing and the lease remains in place. The company converted 21,157 shares of Series A preferred into 21,157,000 common shares in March 2025. Shares outstanding were 26,290,838 as of October 31, 2025. CIRM grant receipts totaled $7.4 million to date, supporting the SENTI‑202 program.
Senti Biosciences (SNTI) furnished a press release announcing its financial results for the quarter ended September 30, 2025. The company reported this via an Item 2.02 Form 8-K dated November 13, 2025, with the press release attached as Exhibit 99.1.
Consistent with General Instruction B.2., the information in Item 2.02 and Exhibit 99.1 is furnished and not deemed filed under Section 18 of the Exchange Act, and it is not incorporated by reference into Securities Act filings.
Celadon Partners disclosed a 45.0% beneficial ownership stake in Senti Biosciences, Inc. (SNTI), reporting ownership of 13,404,441 shares, which includes 3,627,441 shares issuable upon exercise of warrants subject to a 45% ownership cap. The percentage is calculated using 26,160,206 shares outstanding as of July 31, 2025. The filing (Amendment No. 2 to Schedule 13D) states Celadon intends to continue preliminary discussions with Senti about a potential financing and may seek changes to capital structure and Board composition, including potential additional Board representation. Celadon also reserves the right to buy or sell securities or pursue hedging or other actions as circumstances evolve.
Celadon Partners disclosed a 45.0% beneficial ownership stake in Senti Biosciences, Inc. (SNTI), reporting ownership of 13,404,441 shares, which includes 3,627,441 shares issuable upon exercise of warrants subject to a 45% ownership cap. The percentage is calculated using 26,160,206 shares outstanding as of July 31, 2025. The filing (Amendment No. 2 to Schedule 13D) states Celadon intends to continue preliminary discussions with Senti about a potential financing and may seek changes to capital structure and Board composition, including potential additional Board representation. Celadon also reserves the right to buy or sell securities or pursue hedging or other actions as circumstances evolve.