STOCK TITAN

Spruce Biosciences (NASDAQ: SPRB) names Adrian Quartel as chief medical officer

(Moderate)
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

Spruce Biosciences, Inc. appointed Adrian Quartel, M.D., FFPM as Chief Medical Officer on July 27, 2026, replacing Interim Chief Medical Officer Dr. Kirk Ways, who remains on the Board of Directors. Quartel has more than 25 years of international pharmaceutical experience across clinical development, pharmacovigilance, and medical affairs.

He previously served as Chief Medical Officer at Zevra Therapeutics, Acer Therapeutics, and Adamas Pharmaceuticals. Earlier, at BioMarin Pharmaceutical, he led global medical affairs and helped launch six treatments for rare diseases and genetic disorders, including the enzyme replacement therapies NAGLAZYME and Brineura. Quartel holds an M.D. from Erasmus University Medical School and a postgraduate specialization in pharmaceutical medicine, and is board certified by the UK General Medical Council in pharmaceutical medicine.

Positive

  • None.

Negative

  • None.
Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers Governance
Key personnel changes including departures, elections, or appointments of directors and executive officers.
Appointment date July 27, 2026 Date Adrian Quartel was appointed Chief Medical Officer
Industry experience More than 25 years Quartel’s experience in the international pharmaceutical industry
Rare disease treatments launched Six treatments Number of rare disease and genetic disorder treatments launched at BioMarin
Chief Medical Officer financial
"appointed Adrian Quartel, M.D., FFPM, as the Company’s Chief Medical Officer"
A chief medical officer is a senior executive responsible for overseeing the health and medical strategies within an organization, often in the healthcare or pharmaceutical sectors. They play a key role in guiding decisions related to medical research, product safety, and healthcare policies, which can impact a company's reputation and success. For investors, understanding the chief medical officer's role helps gauge how well a company manages medical risks and advances its healthcare goals.
pharmacovigilance medical
"senior roles spanning clinical development, pharmacovigilance, and medical affairs"
Pharmacovigilance is the process of monitoring and assessing the safety of medicines after they are on the market, ensuring that any side effects or risks are identified and managed. For investors, it matters because it helps ensure that pharmaceutical companies maintain safe products, which can influence a company’s reputation, regulatory approval, and financial stability over time.
enzyme replacement therapies medical
"a track record of advancing and launching enzyme replacement therapies for rare diseases"
Enzyme replacement therapies are medical treatments that supply patients with missing or malfunctioning enzymes by administering lab-made versions, often through regular infusions. Like replacing a broken part in a machine to restore normal function, these therapies can transform chronic, debilitating conditions into manageable ones; for investors they matter because they often command high prices, face strict regulatory and manufacturing hurdles, and can drive predictable long-term revenue if widely adopted.
rare diseases medical
"launch of six treatments for rare diseases and genetic disorders"
Medical conditions that affect a very small percentage of the population, often chronic, serious, and with limited or no approved treatments. For investors, rare diseases are like niche markets: patient groups are small but demand can be intense, allowing higher prices, quicker regulatory pathways, and exclusive rights that can drive significant returns—while also carrying development, reimbursement, and commercial risks tied to that small customer base.
board certified medical
"is board certified by the General Medical Council (GMC) in pharmaceutical medicine"
Board certified means a professional has been formally approved by an independent governing board after meeting specific education, experience and testing requirements for a specialty area. For investors, this is a signal of verified expertise and lower operational or reputational risk when that person holds a key clinical, regulatory or technical role—think of it like a specialized license or endorsement that increases confidence in the person’s qualifications, though it is not a guarantee of performance.

AI-generated analysis. How Rhea-AI works. Not financial advice.

See more from StockTitan in Google Search and AI answers. Adds StockTitan as a preferred source · opens Google
Add on Google
Learn about SEC filing dates

FAQ

Who was appointed Chief Medical Officer at Spruce Biosciences (SPRB)?

Spruce Biosciences appointed Adrian Quartel, M.D., FFPM as Chief Medical Officer on July 27, 2026. He succeeds Dr. Kirk Ways, who had served as Interim Chief Medical Officer and continues to serve as a member of the Board of Directors.

What experience does Adrian Quartel bring to Spruce Biosciences (SPRB)?

Adrian Quartel brings more than 25 years of international pharmaceutical experience, spanning clinical development, pharmacovigilance, and medical affairs, including leadership roles at Zevra Therapeutics, Acer Therapeutics, Adamas Pharmaceuticals, and BioMarin Pharmaceutical in rare disease and neurological treatment development.

What is Dr. Kirk Ways’ role at Spruce Biosciences (SPRB) after the CMO change?

After Adrian Quartel’s appointment as Chief Medical Officer, Dr. Kirk Ways remains on the Board of Spruce Biosciences. He previously served as Interim Chief Medical Officer and continues his involvement as a member of the company’s Board of Directors.

Which prior CMO positions has Adrian Quartel held before joining Spruce Biosciences (SPRB)?

Before joining Spruce Biosciences, Adrian Quartel served as Chief Medical Officer at Zevra Therapeutics, and previously as Chief Medical Officer of Acer Therapeutics and Adamas Pharmaceuticals, overseeing clinical development, medical affairs, and regulatory strategy in rare and neurological diseases.

What rare disease experience does the new CMO of Spruce Biosciences (SPRB) have?

At BioMarin Pharmaceutical, Adrian Quartel helped launch six treatments for rare diseases and genetic disorders, including the enzyme replacement therapies NAGLAZYME and Brineura. This background aligns with Spruce Biosciences’ focus on complex and underserved medical conditions.

What are Adrian Quartel’s medical qualifications relevant to Spruce Biosciences (SPRB)?

Adrian Quartel holds an M.D. from Erasmus University Medical School and a postgraduate specialization in pharmaceutical medicine. He is board certified by the UK General Medical Council in pharmaceutical medicine, underscoring his formal training in drug development and medical leadership.
false000168355300016835532026-07-272026-07-27

 

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

 

FORM 8-K

 

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): July 27, 2026

 

 

Spruce Biosciences, Inc.

(Exact name of Registrant as Specified in Its Charter)

 

 

Delaware

001-39594

81-2154263

(State or Other Jurisdiction
of Incorporation)

(Commission File Number)

(IRS Employer
Identification No.)

 

 

 

 

 

611 Gateway Boulevard, Suite 740

 

South San Francisco, California

 

94080

(Address of Principal Executive Offices)

 

(Zip Code)

 

Registrant’s Telephone Number, Including Area Code: 415-343-5986

 

Not Applicable

(Former Name or Former Address, if Changed Since Last Report)

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

 

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

Securities registered pursuant to Section 12(b) of the Act:


Title of each class

 

Trading
Symbol(s)

 


Name of each exchange on which registered

Common Stock, par value $0.0001 per share

 

SPRB

 

Nasdaq Capital Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

 


Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

 

On July 27, 2026, Spruce Biosciences, Inc. (the “Company”) appointed Adrian Quartel, M.D., FFPM, as the Company’s Chief Medical Officer, replacing Dr. Kirk Ways, who had been serving as the Company’s Interim Chief Medical Officer. Dr. Ways will continue to serve as a member of the Company’s Board of Directors.

 

Dr. Quartel brings more than 25 years of experience in the international pharmaceutical industry, with senior roles spanning clinical development, pharmacovigilance, and medical affairs, and a track record of advancing and launching enzyme replacement therapies for rare diseases. Dr. Quartel most recently served as Chief Medical Officer of Zevra Therapeutics, where he helped guide the clinical development, medical affairs, and regulatory strategy for the company’s rare disease portfolio. Prior to Zevra, he served as Chief Medical Officer of Acer Therapeutics and Chief Medical Officer of Adamas Pharmaceuticals, a company focused on drug development for neurological diseases. Earlier, as Group Vice President of Global Medical Affairs at BioMarin Pharmaceutical, Dr. Quartel spearheaded the launch of six treatments for rare diseases and genetic disorders, including the enzyme replacement therapies NAGLAZYME®, VIMIZIM®, and Brineura®. Before BioMarin, Dr. Quartel oversaw clinical development and held senior medical leadership positions at Astellas, Chiltern, and ICON Clinical Research. Dr. Quartel holds an M.D. from Erasmus University Medical School, Rotterdam, and a postgraduate specialization in pharmaceutical medicine from the Faculty of Pharmaceutical Medicine, in London, and is board certified by the General Medical Council (GMC) in pharmaceutical medicine in the United Kingdom.


SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

Spruce Biosciences, Inc.

Date: July 27, 2026

By:

 /s/ Samir Gharib

Samir Gharib

President and Chief Financial Officer

 


Filing Exhibits & Attachments

1 document