BlackRock, Inc. (SPRB) reports 6.8% beneficial ownership in Spruce Biosciences

Rhea-AI Filing Summary

BlackRock, Inc. reports beneficial ownership of common stock of Spruce Biosciences Inc.. BlackRock and certain of its subsidiaries and affiliates collectively beneficially own 187,836 shares of Spruce Biosciences common stock, representing 6.8% of the outstanding class.

BlackRock has sole voting power over 185,907 shares and sole dispositive power over 187,836 shares, with no shared voting or dispositive power reported. Various underlying clients and accounts have rights to dividends or sale proceeds from these shares, but no single such person holds more than five percent of Spruce Biosciences’ outstanding common shares. The filing is made on a Schedule 13G basis as a large institutional holder.

Key Figures

Beneficial Ownership: 187,836 shares Percent of Class: 6.8% Sole Voting Power: 185,907 shares +1 more

4 metrics

Beneficial Ownership 187,836 shares Common stock of Spruce Biosciences Inc. beneficially owned by BlackRock business units

Percent of Class 6.8% Portion of Spruce Biosciences common stock class held by BlackRock

Sole Voting Power 185,907 shares Shares of Spruce Biosciences over which BlackRock has sole voting power

Sole Dispositive Power 187,836 shares Shares of Spruce Biosciences over which BlackRock has sole dispositive power

Key Terms

Schedule 13G, beneficially owned, sole voting power, sole dispositive power, +1 more

5 terms

Schedule 13G regulatory

"In accordance with SEC Release No. 34-39538 (January 12, 1998), this reflects the securities beneficially owned"

A Schedule 13G is a formal document that investors file with the government when they acquire a large ownership stake in a company, usually for investment purposes rather than control. It helps keep the public informed about who owns significant parts of a company's shares, which can influence how the company is managed and how investors make decisions. Filing this schedule is important for transparency and understanding the ownership landscape of publicly traded companies.

beneficially owned financial

"this reflects the securities beneficially owned, or deemed to be beneficially owned, by certain business units"

Beneficially owned describes securities or assets where a person has the economic rights and control—such as the right to receive dividends and to direct voting—even if legal title is held in another name. Think of it like having the keys and using a car that’s registered to someone else: you get the benefits and make decisions. Investors care because beneficial ownership reveals who truly controls value and voting power, affecting corporate decisions and takeover dynamics.

sole voting power financial

"Sole Voting Power 185,907.00"

Sole voting power is the exclusive right to cast votes attached to a shareholder’s stock without needing approval from anyone else. Like holding the only remote control for a TV, it lets that holder decide corporate matters such as board members, mergers, and policy changes, making it important to investors because it concentrates control and can strongly influence a company’s strategy and the value of its shares.

sole dispositive power financial

"Sole Dispositive Power 187,836.00"

Sole dispositive power is the exclusive legal authority to decide what happens to a security — for example, whether to sell, transfer, or retain shares — without needing anyone else’s permission. Investors care because it signals who truly controls the economic outcome of an investment: like holding the only key to a safe, the holder can realize gains or losses and may trigger regulatory reporting, insider rules, or influence over corporate ownership.

parent holding company regulatory

"Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company"

AI-generated analysis. How Rhea-AI works. Not financial advice.

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FAQ

What percentage of SPRB common stock does BlackRock, Inc. report owning?

BlackRock, Inc. reports beneficial ownership of 6.8% of Spruce Biosciences Inc. (SPRB) common stock. This stake is based on 187,836 shares beneficially owned by certain BlackRock business units, as disclosed in the Schedule 13G filing.

How many SPRB shares does BlackRock, Inc. beneficially own according to the Schedule 13G?

BlackRock, Inc. beneficially owns 187,836 shares of Spruce Biosciences Inc. (SPRB) common stock. These shares are attributed to certain BlackRock business units and represent a significant institutional position above the 5% reporting threshold.

What voting power does BlackRock, Inc. have over its SPRB shares?

BlackRock, Inc. has sole voting power over 185,907 shares of Spruce Biosciences Inc. (SPRB) and no shared voting power. This means decisions on how these shares are voted are controlled solely by the reporting BlackRock business units.

What dispositive power does BlackRock, Inc. report over SPRB shares?

BlackRock, Inc. reports sole dispositive power over 187,836 shares of Spruce Biosciences Inc. (SPRB) and no shared dispositive power. Sole dispositive power covers the authority to sell or otherwise dispose of these shares.

Do any BlackRock clients individually own more than 5% of SPRB shares?

No. The filing states that various persons have rights to dividends or sale proceeds from SPRB shares, but no one person’s interest exceeds five percent of Spruce Biosciences Inc.’s total outstanding common shares.

Who signed the Schedule 13G for BlackRock, Inc. regarding SPRB?

The Schedule 13G for BlackRock, Inc. regarding Spruce Biosciences Inc. (SPRB) was signed by Spencer Fleming, identified as a Managing Director. A Power of Attorney is referenced as Exhibit 24 in support of the signing authority.

SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

SPRUCE BIOSCIENCES INC

(Name of Issuer)

Common Stock

(Title of Class of Securities)

85209E208

(CUSIP Number)

06/30/2026

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

schemaVersion:

SCHEDULE 13G

CUSIP Number(s): 85209E208

1

Names of Reporting Persons

BlackRock, Inc.

2

Check the appropriate box if a member of a Group (see instructions)

(a)
(b)

3

Sec Use Only

4

Citizenship or Place of Organization

DELAWARE

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 185,907.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 187,836.00
8	Shared Dispositive Power 0.00

9

Aggregate Amount Beneficially Owned by Each Reporting Person

187,836.00

10

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

11

Percent of class represented by amount in row (9)

6.8 %

12

Type of Reporting Person (See Instructions)

HC

SCHEDULE 13G

Item 1.
(a)	Name of issuer: SPRUCE BIOSCIENCES INC
(b)	Address of issuer's principal executive offices: 611 Gateway Boulevard, Suite 740 South San Francisco CA 94080
Item 2.
(a)	Name of person filing: BlackRock, Inc. In accordance with SEC Release No. 34-39538 (January 12, 1998), this Schedule 13G reflects the securities beneficially owned, or deemed to be beneficially owned, by certain business units (collectively, the "Reporting Business Units") of BlackRock, Inc. and its subsidiaries and affiliates. It does not include securities, if any, beneficially owned by other business units whose beneficial ownership of securities are disaggregated from that of the Reporting Business Units in accordance with such release.
(b)	Address or principal business office or, if none, residence: BlackRock, Inc., 50 Hudson Yards New York, NY 10001
(c)	Citizenship: See Item 4 of Cover Page
(d)	Title of class of securities: Common Stock
(e)	CUSIP Number(s): 85209E208
Item 3.	If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)	Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);
(b)	Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);
(c)	Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);
(d)	Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);
(e)	An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);
(f)	An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);
(g)	A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)	A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)	A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)	A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J), please specify the type of institution:
(k)	Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).
Item 4.	Ownership
(a)	Amount beneficially owned: 187836
(b)	Percent of class: 6.8 %
(c)	Number of shares as to which the person has:
	(i) Sole power to vote or to direct the vote: 185907
	(ii) Shared power to vote or to direct the vote: 0
	(iii) Sole power to dispose or to direct the disposition of: 187836
	(iv) Shared power to dispose or to direct the disposition of: 0
Item 5.	Ownership of 5 Percent or Less of a Class.
	Not Applicable
Item 6.	Ownership of more than 5 Percent on Behalf of Another Person.
	If any other person is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required. Various persons have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of the common stock of SPRUCE BIOSCIENCES INC. No one person's interest in the common stock of SPRUCE BIOSCIENCES INC is more than five percent of the total outstanding common shares.
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.
	If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary. See Exhibit 99
Item 8.	Identification and Classification of Members of the Group.
	Not Applicable
Item 9.	Notice of Dissolution of Group.
	Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

BlackRock, Inc.

Signature:	Spencer Fleming
Name/Title:	Managing Director
Date:	07/30/2026

Exhibit Information

Exhibit 24: Power of Attorney Exhibit 99: Item 7