Synlogic (SYBX) investor reprices 2.64M-share warrant from $3.408 to $0.70

Rhea-AI Filing Summary

Synlogic, Inc. reported that New Enterprise Associates 14, L.P. and related reporting persons amended an existing warrant on Synlogic common stock. An outstanding warrant for 2,640,845 shares with a $3.408 exercise price was canceled and replaced with a new warrant for the same number of shares at a $0.70 exercise price, expiring on October 3, 2028. The warrant remains immediately exercisable but is subject to a 4.99% (or, at NEA 14’s election, 9.99%) beneficial ownership limitation, adjustable by NEA 14 with 61 days’ prior notice.

Insider Trade Summary

2 transactions reported

Mixed 2 txns

Insider New Enterprise Associates 14, L.P., NEA Partners 14, L.P., NEA 14 GP, LTD, Florence Anthony A. Jr., SANDELL SCOTT D, Makhzoumi Mohamad

Role Director, 10% Owner | Director, 10% Owner | Director, 10% Owner | Director, 10% Owner | Director, 10% Owner | Director, 10% Owner

Bought 2,640,845 shs

Type	Security	Shares	Price	Value
Derivative Expiration/Cancellation	Warrants (Right to Buy) F2, F1, F3	2,640,845	--	--
Purchase	Warrants (Right to Buy) F2, F1, F3	2,640,845	--	--

Holdings After Transaction: Warrants (Right to Buy) — 2,640,845 shares (Direct)

Footnotes (3)

1. F1. The warrants were immediately exercisable; provided, however, that the warrants carry a limitation on exercise preventing exercise if such exercise results in New Enterprise Associates 14, L.P. ("NEA 14") beneficially owning in excess of 4.99% (or, at the election of NEA 14, 9.99%) of the number of shares of the Issuer's Common Stock, which percentage can be increased or decreased at the option of NEA 14 upon 61 days' prior notice.
2. F2. The two transactions reported in Table II above involved the amendment of an outstanding warrant to reduce the exercise price from $3.408 a share to $0.70 a share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new one.
3. F3. The securities are directly held by NEA 14 and are indirectly held by NEA Partners 14, L.P. ("NEA Partners 14"), the sole general partner of NEA 14, NEA 14 GP, LTD ("NEA 14 LTD"), the sole general partner of NEA Partners 14, and the members of the Executive Committee (the "Executive Committee") of NEA Management Company, LLC (NEA Partners 14, NEA 14 LTD and the members of the Executive Committee together, the "Indirect Reporting Persons"). The members of the Executive Committee are Anthony A. Florence, Jr., Mohamad H. Makhzoumi, and Scott D. Sandell. The Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA 14 in which the Indirect Reporting Persons have no pecuniary interest.

Key Figures

Warrant shares amended: 2,640,845 shares Old exercise price: $3.408 per share New exercise price: $0.70 per share +2 more

5 metrics

Warrant shares amended 2,640,845 shares Underlying common shares for both canceled and new warrants

Old exercise price $3.408 per share Exercise price of canceled warrant on 2,640,845 shares

New exercise price $0.70 per share Exercise price of newly acquired warrant on 2,640,845 shares

Beneficial ownership cap 4.99% or 9.99% Maximum ownership allowed upon exercise, at NEA 14’s election

Warrant expiration October 3, 2028 Expiration date for both canceled and new warrants

Key Terms

beneficial ownership, warrants, exercise price, Executive Committee

4 terms

beneficial ownership regulatory

"preventing exercise if such exercise results in NEA 14 beneficially owning in excess of 4.99%"

Beneficial ownership means the person or entity that actually enjoys the benefits of owning shares or other assets — such as receiving dividends, voting rights, or price gains — even if the legal title is held in another name. For investors it matters because knowing who truly controls and profits from a company reveals who can influence decisions, exposes potential conflicts of interest or hidden concentration of power, and affects transparency and risk in the stock.

warrants financial

"The two transactions reported in Table II above involved the amendment of an outstanding warrant"

Warrants are special documents that give you the right to buy a company's stock at a set price before a certain date. They are often used as a way for companies to attract investors or raise money, and their value can increase if the company's stock price goes up.

exercise price financial

"amendment of an outstanding warrant to reduce the exercise price from $3.408 a share to $0.70 a share"

The exercise price is the fixed amount at which you can buy or sell an asset, like a stock, when using an options contract. It matters because it helps determine whether exercising the option will be profitable or not, depending on the current market price. Think of it as the set price you agree on today to buy or sell later.

Executive Committee regulatory

"The members of the Executive Committee are Anthony A. Florence, Jr., Mohamad H. Makhzoumi, and Scott D. Sandell."

An executive committee is a small group of top leaders within an organization responsible for making important decisions and setting strategic direction. Think of it as the company's steering team, guiding the overall course and ensuring management actions align with long-term goals. For investors, understanding the executive committee helps gauge how decisions are made at the highest level and how leadership might influence the company's future performance.

FAQ

What did Synlogic (SYBX) insider New Enterprise Associates 14, L.P. change in this Form 4?

New Enterprise Associates 14, L.P. amended a warrant on Synlogic common stock, canceling a warrant for 2,640,845 shares at $3.408 and acquiring a new warrant for the same number of shares at a reduced exercise price of $0.70, expiring October 3, 2028.

How many Synlogic (SYBX) shares are covered by the amended warrant?

The amended warrant covers 2,640,845 shares of Synlogic common stock. Both the canceled warrant and the newly issued warrant relate to this same number of underlying shares, maintaining the overall warrant share count while changing the exercise price.

What is the new exercise price for the Synlogic (SYBX) warrant reported in this Form 4?

The new warrant has an exercise price of $0.70 per share. It replaces a prior warrant with a $3.408 exercise price, with both warrants covering 2,640,845 underlying shares of Synlogic common stock and sharing an expiration date of October 3, 2028.

What beneficial ownership limits apply to the Synlogic (SYBX) warrant held by NEA 14?

The warrant is immediately exercisable but subject to a 4.99% beneficial ownership cap, or 9.99% at NEA 14’s election. NEA 14 can increase or decrease this percentage by providing 61 days’ prior notice, limiting how many shares can be acquired at once.

Who are the indirect reporting persons in the Synlogic (SYBX) Form 4 related to this warrant?

The securities are directly held by New Enterprise Associates 14, L.P. and indirectly by NEA Partners 14, L.P., NEA 14 GP, LTD, and members of the Executive Committee: Anthony A. Florence, Jr., Mohamad H. Makhzoumi, and Scott D. Sandell, who disclaim certain beneficial ownership.

Were the Synlogic (SYBX) warrant transactions made under a Rule 10b5-1 trading plan?

The filing indicates the transactions were not made pursuant to a Rule 10b5-1 trading plan. The document-level 10b5-1 checkbox is not affirmatively marked, and no footnote describes these transactions as executed under a pre-arranged trading plan.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Form 4 Insider Transactions: What Each Field Means →

Available on EDGAR 08/14/2026 - 04:18 PM Accepted by SEC EDGAR 08/14/2026 - 04:09 PM Learn about SEC filing dates

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

New Enterprise Associates 14, L.P.

(Last) (First) (Middle)

1954 GREENSPRING DRIVE

SUITE 600

(Street)

TIMONIUM MARYLAND 21093

(City) (State) (Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
SYNLOGIC, INC. [ SYBX ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
07/27/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

	Form filed by One Reporting Person
X	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Warrants (Right to Buy)	$3.408	07/27/2026		H			2,640,845	(1)	10/03/2028	Common Stock	2,640,845	(2)	0	D(3)
Warrants (Right to Buy)	$0.7	07/27/2026		P		2,640,845		(1)	10/03/2028	Common Stock	2,640,845	(2)	2,640,845	D(3)

1. Name and Address of Reporting Person^*

New Enterprise Associates 14, L.P.

(Last) (First) (Middle)

1954 GREENSPRING DRIVE

SUITE 600

(Street)

TIMONIUM MARYLAND 21093

(City) (State) (Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

NEA Partners 14, L.P.

(Last) (First) (Middle)

1954 GREENSPRING DRIVE

SUITE 600

(Street)

TIMONIUM MARYLAND 21093

(City) (State) (Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

NEA 14 GP, LTD

(Last) (First) (Middle)

1954 GREENSPRING DRIVE

SUITE 600

(Street)

TIMONIUM MARYLAND 21093

(City) (State) (Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Florence Anthony A. Jr.

(Last) (First) (Middle)

104 5TH AVE

19TH FLOOR

(Street)

NEW YORK NEW YORK 10011

(City) (State) (Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

SANDELL SCOTT D

(Last) (First) (Middle)

1954 GREENSPRING DRIVE

SUITE 600

(Street)

TIMONIUM MARYLAND 21093

(City) (State) (Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

1. Name and Address of Reporting Person^*

Makhzoumi Mohamad

(Last) (First) (Middle)

2855 SAND HILL ROAD

(Street)

MENLO PARK CALIFORNIA 94025

(City) (State) (Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer

X	Director	X	10% Owner
	Officer (give title below)		Other (specify below)

Explanation of Responses:

1. The warrants were immediately exercisable; provided, however, that the warrants carry a limitation on exercise preventing exercise if such exercise results in New Enterprise Associates 14, L.P. ("NEA 14") beneficially owning in excess of 4.99% (or, at the election of NEA 14, 9.99%) of the number of shares of the Issuer's Common Stock, which percentage can be increased or decreased at the option of NEA 14 upon 61 days' prior notice.

2. The two transactions reported in Table II above involved the amendment of an outstanding warrant to reduce the exercise price from $3.408 a share to $0.70 a share. The amendment is reported above as the cancellation of the old warrant and the acquisition of a new one.

3. The securities are directly held by NEA 14 and are indirectly held by NEA Partners 14, L.P. ("NEA Partners 14"), the sole general partner of NEA 14, NEA 14 GP, LTD ("NEA 14 LTD"), the sole general partner of NEA Partners 14, and the members of the Executive Committee (the "Executive Committee") of NEA Management Company, LLC (NEA Partners 14, NEA 14 LTD and the members of the Executive Committee together, the "Indirect Reporting Persons"). The members of the Executive Committee are Anthony A. Florence, Jr., Mohamad H. Makhzoumi, and Scott D. Sandell. The Indirect Reporting Persons disclaim beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the securities held by NEA 14 in which the Indirect Reporting Persons have no pecuniary interest.

	/s/ Zachary Bambach, attorney-in-fact	08/14/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)