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SYNLOGIC INC (SYBX) Financials

SYBX
FY2025 annual
Revenue $0 -100.0% YoY
Net Income -$1.0M +95.7% YoY
EPS (Diluted) -$0.08 +95.8% YoY
Free Cash Flow -$4.4M +86.2% YoY
Market Cap $13.5M as of Oct 8, 2026
Price / Sales n/m revenue is not positive, FY2025
Price / Earnings n/m net loss, so no earnings multiple, FY2025
Price / Book 1.1x on $12.0M equity, Q2 FY2026

A multiple compares the market's price with a filed figure; it says what the market pays, not how the business is doing. The market capitalization is the vendor's as of Oct 8, 2026; every other figure is from the SEC filings on this page. Not financial advice.

Source SEC Filings (10-K/10-Q) Latest period Q2 FY2026, ended Jun 30, 2026 Reported Currency USD FYE December

Newest figures come from the 10-Q for Q2 FY2026, filed Aug 11, 2026. Each column of the statement tables below links to the filing it was taken from, and every filing is listed on the SYBX SEC filings page.

SYNLOGIC INC (SYBX) reported $0 in revenue for fiscal year 2025, down 100.0% from the prior fiscal year. This page shows its income statement, balance sheet, cash flow statement, and key financial ratios. View 13 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).

Rhea AI SYBX FY2025

Synlogic’s reported numbers describe a development-stage business shrinking its research footprint, with losses and cash use falling as activity contracts.

R&D contraction took spending from $9.2M in FY2024 to $43K in FY2025, a sharper change than ordinary efficiency gains. Operating cash flow also improved from -$31.7M to -$4.4M; because the spending base shrank simultaneously, the narrower loss reflects reduced activity rather than demonstrated sales economics.

FY2025’s current ratio was 4.3x and debt-to-equity was 0.3x, indicating near-term assets materially exceeded reported obligations without heavy debt financing. The reported liquidity comparison was 40.4 months of annual outflow, reinforcing that the balance sheet—not sales—was the immediate source of financial capacity.

Total assets fell from $75.6M in FY2023 to $15.4M in FY2025, so the company’s contraction reached the balance sheet rather than appearing only in the income statement. That shrinking capital base, combined with reduced research spending, describes a materially smaller operation rather than a sales-led expansion.

[ NOT FINANCIAL ADVICE ]

Financial Health Signals

Financial health score not available

SYNLOGIC INC does not currently provide enough eligible data for a peer-relative financial health score, so none is published. The signals and metrics below are current.

Altman Z-Score Distress
-37.80

SYNLOGIC INC scores -37.80, below the 1.81 distress threshold. The score is driven primarily by a large market capitalization ($13.5M) relative to total liabilities ($3.6M). This indicates elevated financial distress risk and warrants close attention to liquidity and debt levels.

Distress-screening estimate for non-financial companies. Not computed for banks or insurers, where the Altman model does not apply.

Piotroski F-Score Partial
2/7

SYNLOGIC INC passes 2 of 7 computable financial strength tests (2 of the nine could not be computed from available data). 1 of 4 profitability signals pass, 1 of 2 leverage/liquidity signals pass, neither operating efficiency signal passes.

Earnings Quality No Cash Backing
N/A

SYNLOGIC INC reported a net loss of $1.0M while operations used $4.4M of cash. With neither figure positive, the ratio between the two carries no quality signal.

Key Financial Metrics

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Earnings & Revenue

Revenue
$0

SYNLOGIC INC generated $0 in revenue in Q2 2026.

Net Income
-$543K
YoY-2.6%
QoQ-179.7%

SYNLOGIC INC reported -$543K in net income in Q2 2026. This represents a decrease of 2.6% from the same quarter a year earlier. Against the prior quarter it is down 179.7%.

EPS (Diluted)
-$0.04
YoY0.0%
QoQ-180.0%

SYNLOGIC INC earned -$0.04 per diluted share (EPS) in Q2 2026. That is unchanged from the same quarter a year earlier. Against the prior quarter it is down 180.0%.

EBITDA

Not reported for Q2 2026.

Cash & Balance Sheet

Cash & Debt
$13.2M
YoY-22.6%
QoQ-6.5%
5Y CAGR-14.7%
10Y CAGR-8.1%

SYNLOGIC INC held $13.2M in cash as of Q2 2026; long-term debt is not reported for that period.

Shares Outstanding
12M
YoY+4.7%
QoQ+4.7%
5Y CAGR-25.2%
10Y CAGR-5.2%

SYNLOGIC INC had 12M shares outstanding in Q2 2026. This represents an increase of 4.7% from the same quarter a year earlier. Against the prior quarter it is up 4.7%.

Free Cash Flow

Not reported for Q2 2026.

Dividends Per Share

Not reported for Q2 2026.

Margins & Returns

Return on Equity
-4.5%
YoY-0.3pp
QoQ-9.9pp

SYNLOGIC INC's ROE was -4.5% in Q2 2026, measuring profit generated per dollar of shareholder equity. This is down 0.3 percentage points from the same quarter a year earlier. Against the prior quarter it is down 9.9 percentage points.

Gross Margin

Not reported for Q2 2026.

Operating Margin

Not reported for Q2 2026.

Net Margin

Not reported for Q2 2026.

Capital Allocation

None of these metrics is reported for Q2 2026.

SYBX Income Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

SYBX quarterly income statement
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
Revenue$0$0N/A$0$0$0-100.0%N/A$0-100.0%
R&D ExpensesN/A$49K+122.7%N/AN/AN/A$22K-99.7%N/AN/A
SG&A Expenses$828K+3.5%$1.1M+27.3%N/A$818K-29.8%$800K-32.1%$836K-71.0%N/A$1.2M-65.7%
Operating Income-$1.0M-30.2%-$1.3M-46.9%N/A-$991K-32.5%-$777K-285.4%-$898K+97.7%N/A-$748K+94.1%
EBITDAN/AN/AN/A-$991K-32.5%-$777K-285.4%-$898K+97.7%N/A-$748K+93.9%
Interest ExpenseN/AN/AN/AN/AN/AN/AN/A$0
Income TaxN/AN/AN/A$0$0-100.0%N/AN/A$0-100.0%
Net Income-$543K-2.6%$681K+114.8%N/A-$2.3M-1866.7%-$529K-117.2%$317K+101.2%N/A-$117K+99.0%
EPS (Basic)-$0.040.0%$0.05+66.7%$0.12+300.0%-$0.19-1800.0%-$0.04-116.0%$0.03+101.4%-$0.06+76.0%-$0.01+99.6%
EPS (Diluted)-$0.040.0%$0.05+66.7%$0.12+300.0%-$0.19-1800.0%-$0.04-116.0%$0.03+101.4%-$0.06+76.0%-$0.01
Diluted Shares (Avg)12M+0.8%12M+0.1%N/A12M+0.8%12M-0.6%12M+2.1%N/A12M

Not reported in any period shown, so not listed: Cost of Revenue, Gross Profit.

SYBX Balance Sheet

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

SYBX quarterly balance sheet
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
Total Assets$13.5M-22.4%$14.6M-18.7%$15.4M-22.1%$16.6M-20.2%$17.4M-19.7%$18.0M-50.2%$19.8M-73.8%$20.8M-68.7%
Current Assets$13.4M-22.5%$14.6M-18.7%$15.4M-22.1%$16.5M-20.3%$17.3M-19.7%$17.9M-48.7%$19.8M-60.4%$20.7M-45.2%
Cash & Equivalents$13.2M-22.6%$14.1M-18.3%$14.7M-22.2%$15.6M-19.6%$17.0M-14.7%$17.3M-30.4%$18.9M-21.3%$19.4M-21.0%
Short-Term Investments$0$0$0$0$0$0-100.0%$0-100.0%$0-100.0%
Long-Term Investments$0$0$0$0$0$0$0$0
Total Liabilities$1.5M-69.4%$2.1M-57.8%$3.6M-49.3%$6.2M-18.5%$4.8M-43.9%$4.9M-81.7%$7.1M-83.5%$7.6M-66.5%
Current Liabilities$1.5M-69.4%$2.1M-57.8%$3.6M-49.3%$6.2M-18.5%$4.8M-43.9%$4.9M-67.2%$7.1M-76.6%$7.6M-16.4%
Non-Current Liabilities$0$0$0$0$0$0-100.0%$0-100.0%$0-100.0%
Total Equity$12.0M-4.6%$12.6M-4.1%$11.9M-7.0%$10.3M-21.2%$12.6M-4.0%$13.1M+39.3%$12.8M-61.1%$13.1M-69.8%
Retained Earnings-$442.5M-0.1%-$442.0M-0.1%-$442.7M-0.2%-$444.2M-0.7%-$441.9M-0.2%-$441.3M+0.6%-$441.7M-5.6%-$440.9M-10.3%

Not reported in any period shown, so not listed: Inventory, Accounts Receivable, Goodwill, Long-Term Debt.

SYBX Cash Flow Statement

Figures in USD, abbreviated K (thousand), M (million), B (billion), T (trillion). Negative values carry a minus sign and red type. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

SYBX quarterly cash flow statement
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
Operating Cash Flow-$922K-131.1%-$563K+64.8%-$923K-62.5%-$1.4M-121.6%-$399K+97.3%-$1.6M+89.6%-$568K+89.7%-$648K+95.0%
Depreciation & AmortizationN/AN/A$0$0$0$0-100.0%$0-100.0%$0-100.0%
Stock-Based Compensation$6K-79.3%$10K-60.0%N/A$33K-67.6%$29K-94.2%$25K-98.9%N/A$102K-84.1%
Capital ExpendituresN/AN/A$0$0$0-100.0%$0-100.0%$0-100.0%$0
Free Cash FlowN/AN/A-$923K-62.5%-$1.4M-121.6%-$399K+97.4%-$1.6M+89.9%-$568K+89.8%-$648K+95.0%
Investing Cash Flow$0-100.0%$0-100.0%$0-100.0%$0-100.0%$155K-98.3%$12K-99.9%$30K+100.2%$72K+100.8%
Financing Cash FlowN/AN/A$0-100.0%$0+100.0%$0-100.0%$0-100.0%$9K-100.0%-$1K-101.6%

Not reported in any period shown, so not listed: Dividends Paid, Share Buybacks.

SYBX Financial Ratios

Margins and returns are percentages; the remaining ratios are unitless multiples. Each change compares the year with the year before it, and each quarter with the same quarter a year earlier.

SYBX quarterly financial ratios
MetricQ2'2610-QQ1'2610-QQ4'2510-QQ3'2510-QQ2'2510-QQ1'2510-QQ4'2410-KQ3'2410-Q
Return on Equity-4.5%-0.3pp5.4%+3.0ppN/A-22.3%-21.4pp-4.2%-27.6pp2.4%+274.9ppN/A-0.9%+26.9pp
Return on Assets-4.0%-1.0pp4.7%+2.9ppN/A-13.9%-13.3pp-3.0%-17.3pp1.8%+72.8ppN/A-0.6%+17.7pp
Current Ratio9.19+5.6x7.08+3.4x4.30+1.5x2.65-0.1x3.63+1.1x3.68+1.3x2.80+1.1x2.71-1.4x
Debt-to-Equity0.12-0.3x0.16-0.2x0.30-0.3x0.600.0x0.38-0.3x0.37-2.5x0.55-0.8x0.58+0.1x
Asset Turnover0.000.0x0.000.0xN/A0.000.0x0.000.0x0.000.0xN/A0.000.0x

Not reported in any period shown, so not listed: Gross Margin, Operating Margin, Net Margin, FCF Margin.

Similar Companies

Newest fiscal year on record for each company. The health score is the peer-relative Financial Health Score for that year; a dash means no score is published for it.

Company Fiscal year Revenue Net income Net margin Market cap Health score
SYNLOGIC INC SYBX FY2025 $0 -$1.0M N/A $13.5M —
Pulmatrix, Inc. PULM FY2025 N/A -$5.2M N/A $5.6M —
Tharimmune, Inc. THAR FY2025 N/A -$35.9M N/A $187.4M —
MetaVia Inc. MTVA FY2025 N/A -$13.0M N/A $8.8M —
Lipocine Inc. LPCN FY2025 $2.0M -$9.6M N/A $15.9M 53/100
CARISMA THERAPEUTICS INC CARM FY2024 $19.6M -$60.5M N/A $6.4M —

Frequently Asked Questions

What is SYNLOGIC INC's annual revenue?

SYNLOGIC INC (SYBX) reported $0 in total revenue for fiscal year 2025. This represents a -100.0% change compared to the previous fiscal year. Revenue measures the total income earned from the company's primary business operations before any expenses are deducted.

How fast is SYNLOGIC INC's revenue growing?

SYNLOGIC INC (SYBX) revenue declined by 100.0% year-over-year, from $8K to $0 in fiscal year 2025.

Is SYNLOGIC INC profitable?

No, SYNLOGIC INC (SYBX) reported a net income of -$1.0M in fiscal year 2025.

SYNLOGIC INC (SYBX) reported diluted earnings per share of -$0.08 for fiscal year 2025. This represents a 95.8% change compared to the previous fiscal year. EPS represents the portion of a company's net income allocated to each outstanding share of common stock and is widely used to evaluate profitability on a per-share basis.

SYNLOGIC INC (SYBX) had EBITDA of -$4.0M in fiscal year 2025, measuring earnings before interest, taxes, depreciation, and amortization.

SYNLOGIC INC (SYBX) has a return on equity of -8.5% for fiscal year 2025, measuring how efficiently the company generates profit from shareholder equity.

SYNLOGIC INC (SYBX) recorded an outflow of $4.4M in free cash flow during fiscal year 2025. This represents a 86.2% change compared to the previous fiscal year. Free cash flow represents the cash a company generates after accounting for capital expenditures, and is widely used to assess financial flexibility and shareholder value.

SYNLOGIC INC (SYBX) recorded an outflow of $4.4M in operating cash flow during fiscal year 2025, representing cash used by core business activities.

SYNLOGIC INC (SYBX) had $15.4M in total assets as of fiscal year 2025, including both current and long-term assets.

SYNLOGIC INC (SYBX) reported no capital expenditure during fiscal year 2025.

SYNLOGIC INC (SYBX) invested $43K in research and development during fiscal year 2025.

SYNLOGIC INC (SYBX) had 12M shares outstanding as of fiscal year 2025.

SYNLOGIC INC (SYBX) had a current ratio of 4.30 as of fiscal year 2025, which is generally considered healthy.

SYNLOGIC INC (SYBX) had a debt-to-equity ratio of 0.30 as of fiscal year 2025, measuring the company's financial leverage by comparing total debt to shareholder equity.

SYNLOGIC INC (SYBX) had a return on assets of -6.5% for fiscal year 2025, measuring how efficiently the company uses its assets to generate profit.

SYNLOGIC INC (SYBX) has no price-to-earnings ratio at the moment: net loss, so no earnings multiple (FY2025). The market capitalization is $13.5M as of Oct 8, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.

SYNLOGIC INC (SYBX) has no price-to-sales ratio at the moment: revenue is not positive (FY2025). The market capitalization is $13.5M as of Oct 8, 2026; a multiple compares that price with a filed figure and says nothing about the quality of the business.

At the end of fiscal year 2025, SYNLOGIC INC (SYBX) held $14.7M in cash, cash equivalents and investments, and reported an operating cash outflow of $4.4M over that year. Dividing the one by the other, the reported balance equals about 40 months of the outflow reported that year. This is arithmetic over figures already filed, not a projection: it assumes nothing about future spending, financing or operations.

SYNLOGIC INC (SYBX) has an Altman Z-Score of -37.80, placing it in the Distress Zone (elevated bankruptcy risk). The Z-Score combines five financial ratios (working capital, retained earnings, EBIT, market capitalization, and revenue relative to total assets) to predict the likelihood of bankruptcy. Scores above 2.99 indicate financial safety while scores below 1.81 suggest financial distress. Learn more in our complete guide to financial health indicators.

SYNLOGIC INC (SYBX) has a Piotroski F-Score of 2 out of 7 computable signals; 2 of the nine could not be computed from available data, so the full-scale strength rating is not shown. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7 to 9 indicate strong and improving fundamentals. Learn more in our complete guide to financial health indicators.

SYNLOGIC INC (SYBX) reported a net loss of $1.0M while operations used $4.4M of cash. With neither figure positive, the ratio between the two carries no quality signal. This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation. Learn more in our complete guide to financial health indicators.

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