Spyre Therapeutics: Turtle proposes $4.01M share sale

The listed shares were obtained through previously exercised stock options dated June 15, 2023, and the notice includes two recent sales marked 10b5-1.

Rhea-AI Filing Summary

Spyre Therapeutics, Inc. (SYRE) is named as issuer in Cameron Turtle’s Form 144 notice of a proposed sale of 45,000 common shares, with an aggregate market value of $4,006,350.00 through Morgan Stanley Smith Barney LLC. The shares are identified as previously exercised stock options dated June 15, 2023, and October 1, 2026 is listed as the approximate sale date. The notice also lists two prior sales marked 10b5-1: 15,000 shares on August 3, 2026, for $1,432,669.50 and 15,000 shares on September 1, 2026, for $1,309,413.00.

Key Figures

Common shares proposed for sale: 45,000 shares Aggregate market value: $4,006,350.00 Shares outstanding: 88,173,762 shares +4 more

7 metrics

Common shares proposed for sale 45,000 shares Proposed sale

Aggregate market value $4,006,350.00 Proposed sale

Shares outstanding 88,173,762 shares Securities information

Shares sold 15,000 shares August 3, 2026 sale marked 10b5-1

Reported sale amount $1,432,669.50 August 3, 2026 sale marked 10b5-1

Shares sold 15,000 shares September 1, 2026 sale marked 10b5-1

Reported sale amount $1,309,413.00 September 1, 2026 sale marked 10b5-1

Key Terms

10b5-1 Sales, Previously Exercised Stock Options, aggregate market value

3 terms

10b5-1 Sales regulatory

"10b5-1 Sales for CAMERON W TURTLE"

10b5-1 sales are pre-arranged stock-trading plans that let company insiders automatically buy or sell shares according to a fixed schedule or formula, even if they later learn confidential information. Think of it as setting up an automatic thermostat for trades: it creates a clear, documented path that can protect insiders from insider-trading accusations and gives investors a signal about predictable insider activity—though it can also simply be a way for insiders to diversify or raise cash.

Previously Exercised Stock Options financial

"Previously Exercised Stock Options"

aggregate market value financial

"Aggregate market value"

Aggregate market value is the combined price you would pay to buy all outstanding shares of a company or all companies in a group at current market prices — essentially the sum of each stock’s market capitalization. It matters to investors because it shows the overall size and weight of an investment or sector (like the total cost to buy every piece of a puzzle), helps compare scale across companies or markets, and influences index composition and risk exposure.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

How many SYRE shares does Cameron Turtle propose to sell?

Cameron Turtle’s notice lists a proposed sale of 45,000 common shares with an aggregate market value of $4,006,350.00 through Morgan Stanley Smith Barney LLC. October 1, 2026 is listed as the approximate sale date.

What recent SYRE sales does Cameron Turtle’s notice list?

The notice lists two sales marked 10b5-1: 15,000 shares on August 3, 2026, for $1,432,669.50, and 15,000 shares on September 1, 2026, for $1,309,413.00.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 10/01/2026 - 04:37 PM Accepted by SEC EDGAR 10/01/2026 - 04:36 PM Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001758363
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	SPYRE THERAPEUTICS INC
SEC File Number	001-37722
Address of Issuer	221 Crescent Street Building 23 Waltham MASSACHUSETTS 02453
Phone	6176515940
Name of Person for Whose Account the Securities are To Be Sold	CAMERON TURTLE
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Director
Relationship to Issuer	Officer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common	Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 8th Floor New York NY 10004	45000	4006350.00	88173762	10/01/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common	06/15/2023	Previously Exercised Stock Options	Issuer			45000	06/15/2023	N/A

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
10b5-1 Sales for CAMERON W TURTLE 221 Crescent Street Building 23 Waltham MA 02453	Common	09/01/2026	15000	1309413.00
10b5-1 Sales for CAMERON W TURTLE 221 Crescent Street Building 23 Waltham MA 02453	Common	08/03/2026	15000	1432669.50

144: Remarks and Signature

Remarks
Date of Notice	10/01/2026
Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1	06/20/2025
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ Cameron Turtle
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)