SYRE executive files to sell 27,500 shares

Company reporting a Form 144 filing that lists 27,500 shares of Common Stock proposed for sale.

Rhea-AI Filing Summary

Company reporting a Form 144 filing that lists 27,500 shares of Common Stock proposed for sale. The filing ties the sale to an exercise of stock options on 05/01/2026 with cash indicated as the method. The filing also discloses recent 10b5-1 sales: 7,500 shares sold on 04/01/2026 for $370,066.25 and 2,500 shares sold on 03/03/2026 for $101,620.50.

Insights

Equity Compensation Analyst

Form 144 lists an option exercise and proposed resale of 27,500 shares.

The filing states the 27,500 shares are linked to an exercise of stock options on 05/01/2026, with cash shown as the method. This indicates a securities disposition filing under Rule 144 procedures rather than a corporate issuance.

Recent executed transactions under a 10b5-1 plan are disclosed: 7,500 shares on 04/01/2026 for $370,066.25 and 2,500 shares on 03/03/2026 for $101,620.50. Timing and execution method for the 27,500-share sale are not described in the excerpt.

Key Figures

Proposed shares to sell: 27,500 shares 10b5-1 sale on 04/01/2026: 7,500 shares 10b5-1 sale on 03/03/2026: 2,500 shares

3 metrics

Proposed shares to sell 27,500 shares listed as tied to an exercise of stock options on 05/01/2026

10b5-1 sale on 04/01/2026 7,500 shares sold for <money>$370,066.25</money>

10b5-1 sale on 03/03/2026 2,500 shares sold for <money>$101,620.50</money>

Key Terms

Form 144, 10b5-1 Sales, Exercise of Stock Options

3 terms

Form 144 regulatory

"Form 144 filing listing securities to be sold"

Form 144 is a document that investors must file with the government when they plan to sell a large number of shares of a company's stock. It helps ensure transparency so everyone knows how many shares are being sold and when, which can impact the stock's price.

10b5-1 Sales regulatory

"10b5-1 Sales for SCOTT BURROWS listed with dates and amounts"

10b5-1 sales are pre-arranged stock-trading plans that let company insiders automatically buy or sell shares according to a fixed schedule or formula, even if they later learn confidential information. Think of it as setting up an automatic thermostat for trades: it creates a clear, documented path that can protect insiders from insider-trading accusations and gives investors a signal about predictable insider activity—though it can also simply be a way for insiders to diversify or raise cash.

Exercise of Stock Options financial

"Securities To Be Sold: Exercise of Stock Options on 05/01/2026"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What does SYRE's Form 144 disclose about the 27,500 shares?

It discloses a proposed sale of 27,500 shares tied to an exercise of stock options on 05/01/2026. The filing shows cash as the method; execution timing and sale mechanics are not detailed in the excerpt.

What recent insider sales does the SYRE excerpt report?

It reports 10b5-1 sales of 7,500 shares on 04/01/2026 for $370,066.25 and 2,500 shares on 03/03/2026 for $101,620.50. These are presented as completed transactions in the past three months.

Are the 27,500 shares being sold by the issuer or a selling holder?

The excerpt ties the 27,500-share line to an Exercise of Stock Options with the role labeled Issuer. The filing text links the amount to option exercise on 05/01/2026 and lists cash as the method.

Does the Form 144 show proceeds or price per share for the proposed sales?

The excerpt shows proceeds for past 10b5-1 sales ($370,066.25 and $101,620.50) but does not state a price or aggregate proceeds for the 27,500-share item in the provided text.

What is a 10b5-1 sale as referenced in SYRE's filing?

A 10b5-1 sale is a prearranged trading plan permitting scheduled sales by insiders. The filing lists such executed sales of 7,500 and 2,500 shares on the stated dates under that designation.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Accepted by SEC EDGAR 05/01/2026 - 04:44 PM EDT Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001853327
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	SPYRE THERAPEUTICS, INC.
SEC File Number	001-37722
Address of Issuer	221 Crescent Street Building 23 Suite 105 Waltham MASSACHUSETTS 02453
Phone	617-651-5940
Name of Person for Whose Account the Securities are To Be Sold	SCOTT BURROWS
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Officer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common	Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 8th Floor New York NY 10004	27500	2047375.00	78540164	05/01/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common	05/01/2026	Exercise of Stock Options	Issuer			27500	05/01/2026	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
10b5-1 Sales for SCOTT BURROWS 221 Crescent Street Building 23 Suite 105 Waltham MA 02453	Common	04/01/2026	7500	370066.25
10b5-1 Sales for SCOTT BURROWS 221 Crescent Street Building 23 Suite 105 Waltham MA 02453	Common	03/03/2026	2500	101620.50

144: Remarks and Signature

Remarks	The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
Date of Notice	05/01/2026
Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1	11/10/2025
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ Scott Burrows
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)