SYRE stock insider plans 30,000-share sale

SYRE insider Scott Burrows filed a notice to sell 30,000 shares of common stock through Morgan Stanley Smith Barney LLC Executive Financial Services on NASDAQ, related to an exercise of stock options for cash on 08/03/2026.

Rhea-AI Filing Summary

SYRE insider Scott Burrows filed a notice to sell 30,000 shares of common stock through Morgan Stanley Smith Barney LLC Executive Financial Services on NASDAQ, related to an exercise of stock options for cash on 08/03/2026. The filing also lists sales during the prior three months, including 7,500 shares for $658,043.00 on 07/01/2026 under a 10b5-1 plan, 15,000 shares for $1,307,000.00 on 06/25/2026, and 7,500 shares for $532,948.25 on 06/01/2026.

Key Figures

Planned shares to be sold: 30,000 shares Aggregate value of planned sale: $2,949,900.00 Planned transaction date: 08/03/2026 +3 more

6 metrics

Planned shares to be sold 30,000 shares Common stock to be sold through Morgan Stanley Smith Barney LLC Executive Financial Services

Aggregate value of planned sale $2,949,900.00 Total value associated with 30,000 shares of common stock

Planned transaction date 08/03/2026 Date tied to exercise of stock options and planned sale of 30,000 shares

10b5-1 sale on 07/01/2026 7,500 shares; $658,043.00 Common stock sold by Scott Burrows under a 10b5-1 plan

Sale on 06/25/2026 15,000 shares; $1,307,000.00 Common stock sale by Scott Burrows during prior three months

Sale on 06/01/2026 7,500 shares; $532,948.25 Common stock sale by Scott Burrows during prior three months

Key Terms

10b5-1 Sales, Exercise of Stock Options, Executive Financial Services

3 terms

10b5-1 Sales financial

"10b5-1 Sales for SCOTT BURROWS 221 Crescent Street"

10b5-1 sales are pre-arranged stock-trading plans that let company insiders automatically buy or sell shares according to a fixed schedule or formula, even if they later learn confidential information. Think of it as setting up an automatic thermostat for trades: it creates a clear, documented path that can protect insiders from insider-trading accusations and gives investors a signal about predictable insider activity—though it can also simply be a way for insiders to diversify or raise cash.

Exercise of Stock Options financial

"Common | 08/03/2026 | Exercise of Stock Options | Issuer"

Executive Financial Services financial

"Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza"

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What insider share sale is disclosed for SYRE in this Form 144 filing?

The filing discloses that Scott Burrows plans to sell 30,000 shares of SYRE common stock through Morgan Stanley Smith Barney LLC Executive Financial Services on or about 08/03/2026, related to an exercise of stock options for cash.

What is the aggregate value of the 30,000 SYRE shares planned for sale?

The planned sale of 30,000 SYRE common shares is listed with an aggregate value of $2,949,900.00. This reflects the total dollar amount associated with the shares indicated in the planned NASDAQ transaction.

Which broker is handling the planned SYRE stock sale for Scott Burrows?

The planned sale of 30,000 SYRE shares is to be handled by Morgan Stanley Smith Barney LLC Executive Financial Services, located at 1 New York Plaza, 8th Floor, New York, NY 10004, for execution on NASDAQ.

What prior 10b5-1 plan sales of SYRE stock are reported for Scott Burrows?

The filing reports 10b5-1 sales by Scott Burrows of 7,500 shares of SYRE common stock on 07/01/2026 for $658,043.00, in addition to other non-labeled plan sales in the preceding months.

What other SYRE share sales in the last three months are listed for Scott Burrows?

Beyond the 10b5-1 sale, the filing lists sales of 15,000 shares for $1,307,000.00 on 06/25/2026 and 7,500 shares for $532,948.25 on 06/01/2026, all in SYRE common stock.

How is the planned 30,000-share SYRE sale linked to stock options?

The planned transaction on 08/03/2026 for 30,000 SYRE shares is described as arising from an exercise of stock options, with the consideration listed as cash for the shares to be sold.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Available on EDGAR 08/03/2026 - 04:52 PM Accepted by SEC EDGAR 08/03/2026 - 04:51 PM Learn about SEC filing dates

Form 144 Filer Information	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 144 NOTICE OF PROPOSED SALE OF SECURITIES PURSUANT TO RULE 144 UNDER THE SECURITIES ACT OF 1933
FORM 144

144: Filer Information

Filer CIK	0001853327
Filer CCC	XXXXXXXX
Is this a LIVE or TEST Filing?	LIVE TEST
Submission Contact Information
Name
Phone
E-Mail Address

144: Issuer Information

Name of Issuer	SPYRE THERAPEUTICS INC
SEC File Number	001-37722
Address of Issuer	221 Crescent Street Building 23 Waltham MASSACHUSETTS 02453
Phone	6176515940
Name of Person for Whose Account the Securities are To Be Sold	SCOTT BURROWS
See the definition of "person" in paragraph (a) of Rule 144. Information is to be given not only as to the person for whose account the securities are to be sold but also as to all other persons included in that definition. In addition, information shall be given as to sales by all persons whose sales are required by paragraph (e) of Rule 144 to be aggregated with sales for the account of the person filing this notice.
Relationship to Issuer	Officer

144: Securities Information

Title of the Class of Securities To Be Sold	Name and Address of the Broker	Number of Shares or Other Units To Be Sold	Aggregate Market Value	Number of Shares or Other Units Outstanding	Approximate Date of Sale	Name the Securities Exchange
Common	Morgan Stanley Smith Barney LLC Executive Financial Services 1 New York Plaza 8th Floor New York NY 10004	30000	2949900.00	86841253	08/03/2026	NASDAQ

Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:

144: Securities To Be Sold

Title of the Class	Date you Acquired	Nature of Acquisition Transaction	Name of Person from Whom Acquired	Is this a Gift?	Date Donor Acquired	Amount of Securities Acquired	Date of Payment	Nature of Payment *
Common	08/03/2026	Exercise of Stock Options	Issuer			30000	08/03/2026	Cash

* If the securities were purchased and full payment therefor was not made in cash at the time of purchase, explain in the table or in a note thereto the nature of the consideration given. If the consideration consisted of any note or other obligation, or if payment was made in installments describe the arrangement and state when the note or other obligation was discharged in full or the last installment paid.

Furnish the following information as to all securities of the issuer sold during the past 3 months by the person for whose account the securities are to be sold.

144: Securities Sold During The Past 3 Months

Name and Address of Seller	Title of Securities Sold	Date of Sale	Amount of Securities Sold	Gross Proceeds
10b5-1 Sales for SCOTT BURROWS 221 Crescent Street Building 23 Waltham MA 02453	Common	07/01/2026	7500	658043.00
SCOTT BURROWS 221 Crescent Street Building 23 Waltham MA 02453	Common	06/25/2026	15000	1307000.00
10b5-1 Sales for SCOTT BURROWS 221 Crescent Street Building 23 Waltham MA 02453	Common	06/01/2026	7500	532948.25

144: Remarks and Signature

Remarks	The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale.
Date of Notice	08/03/2026
Date of Plan Adoption or Giving of Instruction, If Relying on Rule 10b5-1	11/10/2025
ATTENTION:
The person for whose account the securities to which this notice relates are to be sold hereby represents by signing this notice that he does not know any material adverse information in regard to the current and prospective operations of the Issuer of the securities to be sold which has not been publicly disclosed. If such person has adopted a written trading plan or given trading instructions to satisfy Rule 10b5-1 under the Exchange Act, by signing the form and indicating the date that the plan was adopted or the instruction given, that person makes such representation as of the plan adoption or instruction date.
Signature	/s/ Scott Burrows
ATTENTION: Intentional misstatements or omission of facts constitute Federal Criminal Violations (See 18 U.S.C. 1001)