| UNITED STATES |
| SECURITIES AND EXCHANGE COMMISSION |
| Washington, D.C. 20549 |
| Notice of Effectiveness |
| Effectiveness Date: |
March 4,
2026 |
| Accession Number: |
0001628280-26-012785 |
| Submission Type: |
POS AM |
| CIK: |
0001636282 |
| Company Name: |
Spyre Therapeutics, Inc. |
| File Number: |
333-285341 |
|
