STOCK TITAN

Spyre (SYRE) fund converts Series B preferred, then exits common stake

Filing Impact
(Very High)
Filing Sentiment
(Very Negative)
Form Type
4

Rhea-AI Filing Summary

Spyre Therapeutics, Inc. reported Form 4 activity for entities associated with Fairmount Funds Management LLC. Fairmount Healthcare Fund II L.P. converted 16,667 shares of Series B Preferred Stock into 666,680 shares of Common Stock for no cash consideration, based on a 40-to-1 conversion ratio subject to a 9.99% beneficial ownership limitation.

On the same date, Fairmount Healthcare Fund II L.P. sold 4,684,781 shares of Common Stock at $85.31 per share, leaving it with no directly held Common Stock after the transaction, while retaining indirect exposure through Series A Preferred Stock that is convertible into 13,841,800 shares of Common Stock. Fairmount, Peter Harwin, and Tomas Kiselak disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest.

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Insights

Fund converts preferred into common, then sells a large common position.

Entities associated with Fairmount Funds Management LLC converted 16,667 shares of Series B Preferred Stock into 666,680 shares of Common Stock, then sold 4,684,781 Common shares. This pattern combines derivative conversion with a sizeable disposition of Common Stock.

The filing also shows an indirect position in Series A Preferred Stock that is convertible into 13,841,800 Common shares, subject to a 9.99% beneficial ownership limitation. Fairmount and its managers disclaim beneficial ownership beyond their pecuniary interest, so the economic exposure runs primarily through the investment fund, not the individuals.

Insider Fairmount Funds Management LLC, Fairmount Healthcare Fund II L.P., Kiselak Tomas, Harwin Peter Evan
Role null | null | null | null
Sold 4,684,781 shs ($399.66M)
Type Security Shares Price Value
Conversion Series B Preferred Stock 16,667 $0.00 --
Conversion Common Stock 666,680 $0.00 --
Sale Common Stock 4,684,781 $85.31 $399.66M
holding Series A Preferred Stock -- -- --
holding Common Stock -- -- --
holding Common Stock -- -- --
Holdings After Transaction: Series B Preferred Stock — 0 shares (Indirect, Fairmount Healthcare Fund II LP); Common Stock — 4,684,781 shares (Indirect, By Fairmount Healthcare Fund II L.P.); Series A Preferred Stock — 13,841,800 shares (Indirect, Fairmount Healthcare Fund II LP)
Footnotes (1)
  1. Each share of Series B Preferred Stock is convertible at the option of the holder into 40 shares of Common Stock, subject to certain beneficial ownership limitations, including that a holder of Series B Preferred Stock is prohibited from converting shares of Series B Preferred Stock into shares of Common Stock if, as a result of such conversion, such holder, together with its affiliates, would beneficially own more than 9.99% of the total number of shares of Common Stock issued and outstanding immediately after giving effect to such conversion. On June 23, 2026, the Reporting Persons converted 16,667 shares of Series B Preferred Stock into 666,680 shares of Common Stock for no cash consideration, in accordance with the Certificate of Designations for the Series B Convertible Preferred Stock. Fairmount Funds Management LLC ("Fairmount") is the investment manager for Fairmount Healthcare Fund II L.P. The managers of Fairmount are Peter Harwin and Tomas Kiselak. Fairmount, Mr. Harwin, and Mr. Kiselak disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein. Each share of Series A Preferred Stock is convertible at the option of the holder into 40 shares of Common Stock, subject to certain beneficial ownership limitations, including that a holder of Series A Preferred Stock is prohibited from converting shares of Series A Preferred Stock into shares of Common Stock if, as a result of such conversion, such holder, together with its affiliates, would beneficially own more than 9.99% of the total number of shares of Common Stock issued and outstanding immediately after giving effect to such conversion.
Common shares sold 4,684,781 shares Open-market or private sale by Fairmount Healthcare Fund II L.P.
Sale price per share $85.31 per share Price for 4,684,781 Common shares sold
Series B converted 16,667 shares Series B Preferred Stock converted into Common Stock
Common from Series B 666,680 shares Common Stock received from converting Series B Preferred
Series B conversion ratio 40 Common per preferred share Stated Series B Preferred Stock conversion terms
Series A underlying common 13,841,800 shares Common Stock underlying Series A Preferred Stock position
Beneficial ownership cap 9.99% Maximum beneficial ownership after conversion for Series A and B
Series B Preferred Stock financial
"Each share of Series B Preferred Stock is convertible at the option of the holder into 40 shares of Common Stock"
Series B preferred stock is a type of ownership share issued by a company that offers certain advantages over common stock, such as priority in receiving dividends or assets if the company is sold or liquidated. It is typically issued after an initial round of funding, making it a way for investors to support a company's growth while gaining some protections and benefits. This stock matters to investors because it often provides a more secure investment position with potential for future growth.
beneficial ownership limitations regulatory
"subject to certain beneficial ownership limitations, including that a holder of Series B Preferred Stock is prohibited from converting"
Beneficial ownership limitations are rules or contractual caps that restrict how much of a company’s stock an individual or entity can be treated as owning or controlling for legal, regulatory or corporate-governance purposes. They matter to investors because such limits affect voting power, reporting obligations, takeover risk and the ability to increase a stake — like an elevator weight limit or a lane divider that prevents any one car from taking over the whole road.
derivative conversion financial
"transaction_action": "derivative conversion""
pecuniary interest financial
"disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein"
Series A Preferred Stock financial
"Each share of Series A Preferred Stock is convertible at the option of the holder into 40 shares of Common Stock"
Series A preferred stock is a type of ownership share in a company that gives investors certain advantages, such as priority in receiving profits or getting their money back if the company is sold or goes bankrupt. It is often issued during early funding stages to attract investors by offering more security than common shares. This stock matters to investors because it provides a safer way to invest while still holding potential for future gains.
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Learn about SEC filing dates
SEC Form 4
FORM 4UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number:3235-0287
Estimated average burden
hours per response:0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
1. Name and Address of Reporting Person*
Fairmount Funds Management LLC

(Last)(First)(Middle)
200 BARR HARBOR DRIVE
SUITE 400

(Street)
WEST CONSHOHOCKEN PENNSYLVANIA 19428

(City)(State)(Zip)

UNITED STATES

(Country)
2. Issuer Name and Ticker or Trading Symbol
Spyre Therapeutics, Inc. [ SYRE ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
XDirector10% Owner
Officer (give title below)Other (specify below)
2a. Foreign Trading Symbol
3. Date of Earliest Transaction (Month/Day/Year)
06/23/2026
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
XForm filed by More than One Reporting Person
4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year)2A. Deemed Execution Date, if any (Month/Day/Year)3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeVAmount(A) or (D)Price
Common Stock06/23/2026C666,680A(1)4,684,781IBy Fairmount Healthcare Fund II L.P.(2)
Common Stock06/23/2026S4,684,781D$85.310IBy Fairmount Healthcare Fund II L.P.(2)
Common Stock406,038IBy Tomas Kiselak
Common Stock406,038IBy Peter Harwin
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year)3A. Deemed Execution Date, if any (Month/Day/Year)4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year)7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Series B Preferred Stock(1)06/23/2026C16,667 (1) (1)Common Stock666,680$0.000IFairmount Healthcare Fund II LP(2)
Series A Preferred Stock(3) (3) (3)Common Stock13,841,800346,045IFairmount Healthcare Fund II LP(2)
1. Name and Address of Reporting Person*
Fairmount Funds Management LLC

(Last)(First)(Middle)
200 BARR HARBOR DRIVE
SUITE 400

(Street)
WEST CONSHOHOCKEN PENNSYLVANIA 19428

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
XDirector10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
Fairmount Healthcare Fund II L.P.

(Last)(First)(Middle)
200 BARR HARBOR DRIVE
SUITE 400

(Street)
WEST CONSHOHOCKEN PENNSYLVANIA 19428

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
XDirector10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
Kiselak Tomas

(Last)(First)(Middle)
200 BARR HARBOR DRIVE
SUITE 400

(Street)
WEST CONSHOHOCKEN PENNSYLVANIA 19428

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
XDirector10% Owner
Officer (give title below)Other (specify below)
1. Name and Address of Reporting Person*
Harwin Peter Evan

(Last)(First)(Middle)
200 BARR HARBOR DRIVE
SUITE 400

(Street)
WEST CONSHOHOCKEN PENNSYLVANIA 19428

(City)(State)(Zip)

UNITED STATES

(Country)

Relationship of Reporting Person(s) to Issuer
XDirector10% Owner
Officer (give title below)Other (specify below)
Explanation of Responses:
1. Each share of Series B Preferred Stock is convertible at the option of the holder into 40 shares of Common Stock, subject to certain beneficial ownership limitations, including that a holder of Series B Preferred Stock is prohibited from converting shares of Series B Preferred Stock into shares of Common Stock if, as a result of such conversion, such holder, together with its affiliates, would beneficially own more than 9.99% of the total number of shares of Common Stock issued and outstanding immediately after giving effect to such conversion. On June 23, 2026, the Reporting Persons converted 16,667 shares of Series B Preferred Stock into 666,680 shares of Common Stock for no cash consideration, in accordance with the Certificate of Designations for the Series B Convertible Preferred Stock.
2. Fairmount Funds Management LLC ("Fairmount") is the investment manager for Fairmount Healthcare Fund II L.P. The managers of Fairmount are Peter Harwin and Tomas Kiselak. Fairmount, Mr. Harwin, and Mr. Kiselak disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.
3. Each share of Series A Preferred Stock is convertible at the option of the holder into 40 shares of Common Stock, subject to certain beneficial ownership limitations, including that a holder of Series A Preferred Stock is prohibited from converting shares of Series A Preferred Stock into shares of Common Stock if, as a result of such conversion, such holder, together with its affiliates, would beneficially own more than 9.99% of the total number of shares of Common Stock issued and outstanding immediately after giving effect to such conversion.
Remarks:
The Reporting Persons may each be deemed a director by deputization of Issuer by virtue of the fact that Tomas Kiselak serves on the board of directors of Issuer and is also a Managing Member of Fairmount Funds Management LLC.
/s/ Tomas Kiselak, Managing Member of Fairmount Funds Management LLC06/23/2026
/s/ Tomas Kiselak, Managing Member of Fairmount Healthcare Fund II, L.P.06/23/2026
/s/ Tomas Kiselak06/23/2026
s/ Peter Harwin06/23/2026
** Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)

FAQ

What insider transactions did Spyre Therapeutics (SYRE) disclose in this Form 4?

Spyre Therapeutics disclosed that Fairmount Healthcare Fund II L.P. converted 16,667 Series B Preferred shares into 666,680 Common shares and sold 4,684,781 Common shares. The fund reported no remaining directly held Common Stock after these transactions.

Who carried out the Spyre Therapeutics (SYRE) transactions reported in this filing?

The transactions were carried out by Fairmount Healthcare Fund II L.P., an investment fund managed by Fairmount Funds Management LLC. Fairmount, Peter Harwin, and Tomas Kiselak are managers and disclaim beneficial ownership except to the extent of their pecuniary interest.

What were the terms of the Series B Preferred Stock conversion for Spyre Therapeutics (SYRE)?

Each share of Spyre’s Series B Preferred Stock is convertible into 40 Common shares, subject to a 9.99% beneficial ownership cap. On June 23, 2026, 16,667 Series B shares were converted into 666,680 Common shares for no cash consideration under these terms.

At what price were Spyre Therapeutics (SYRE) Common shares sold in this Form 4?

Fairmount Healthcare Fund II L.P. sold 4,684,781 shares of Spyre Therapeutics Common Stock at $85.31 per share. Following this sale, the fund reported holding zero shares of Common Stock directly, while maintaining exposure through convertible preferred shares.

What ongoing exposure to Spyre Therapeutics (SYRE) does the reporting fund retain?

The filing shows indirect holdings of Series A Preferred Stock that are convertible into 13,841,800 shares of Common Stock. These Series A shares are convertible at the holder’s option, subject to a 9.99% beneficial ownership limitation after giving effect to any conversion.

What do the beneficial ownership limitations mean for Spyre Therapeutics (SYRE) preferred conversions?

Both Series A and Series B Preferred Stock include a 9.99% beneficial ownership limitation. A holder, together with affiliates, cannot convert preferred shares if that conversion would result in beneficial ownership exceeding 9.99% of Spyre’s outstanding Common Stock immediately after conversion.