Takeda H1 net profit rises 171.8% to JPY 305.6B

Operating profit rose 60.4% AER, while operating cash flow fell JPY 161.8 billion year over year.

Rhea-AI Filing Summary

Takeda Pharmaceutical Company Limited reported revenue of JPY 2,407.0 billion for the six months ended September 30, 2026, up 8.4% on an actual exchange rate (AER) basis but down 1.0% at constant exchange rates (CER); the reported increase was primarily attributable to depreciation of the yen. Operating profit rose 60.4% AER to JPY 406.7 billion, and net profit attributable to owners rose 171.8% AER to JPY 305.6 billion.

Core operating profit was JPY 710.6 billion, up 11.2% AER and 0.7% CER, while core net profit attributable to owners was JPY 489.6 billion, up 11.6% AER and down 0.2% CER. Net cash from operating activities declined JPY 161.8 billion year over year to JPY 431.9 billion, and cash and cash equivalents were JPY 418.5 billion as of September 30, 2026. Takeda also reported U.S. approval of ORZEYFUL for adults with narcolepsy type 1 and FDA approval of MIMRYLO for adults with polycythemia vera.

2 points · 0 major

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How the balance works

Positive

• Moderate pointOperating profit rose 60.4% AER to JPY 406.7 billion.
• Moderate pointNet profit attributable to owners rose 171.8% AER to JPY 305.6 billion.

Negative

• Moderate pointOperating cash flow fell JPY 161.8 billion year over year to JPY 431.9 billion.

Filing Explained

Takeda reports issuing 10,781 thousand new shares through a third-party allotment to 10,477 employees at JPY 5,050 per share; the issuance increases the share count and reduces existing holders’ percentage ownership, absent offsetting changes.

Key Figures

Revenue: JPY 2,407.0 billion Operating profit: JPY 406.7 billion Net profit attributable to owners: JPY 305.6 billion +3 more

6 metrics

Revenue JPY 2,407.0 billion Six months ended September 30, 2026; +8.4% AER and -1.0% CER year over year

Operating profit JPY 406.7 billion Six months ended September 30, 2026; +60.4% AER year over year

Net profit attributable to owners JPY 305.6 billion Six months ended September 30, 2026; +171.8% AER year over year

Core operating profit JPY 710.6 billion Six months ended September 30, 2026; +11.2% AER and +0.7% CER year over year

Net cash from operating activities JPY 431.9 billion Six months ended September 30, 2026; decreased JPY 161.8 billion year over year

Cash and cash equivalents JPY 418.5 billion As of September 30, 2026

Key Terms

AER, Constant Exchange Rate (CER) Change, Core Financial Measures, supplemental Biologics License Application (sBLA)

4 terms

AER financial

"percentage change based on Actual Exchange Rates"

Annual Equivalent Rate (AER) is a standardized way of showing the effective interest rate on savings that includes the effect of compounding over a year, so different accounts can be compared fairly. Think of it like the blended speedometer for your money—showing how fast your balance grows after interest is added repeatedly. Investors use AER to compare return on cash-like holdings and to estimate after-interest growth without needing to calculate compounding themselves.

Constant Exchange Rate (CER) Change financial

"percentage change based on Constant Exchange Rate"

Core Financial Measures financial

"Takeda’s Core Financial Measures, particularly Core Revenue"

supplemental Biologics License Application (sBLA) regulatory

"accepted for review its supplemental Biologics License Application (sBLA)"

A supplemental biologics license application (sBLA) is a formal request to a drug regulator to approve a change to a biologic product that already has a license, such as a new use, manufacturing process, dosage form, or labeling update. Investors care because approval can expand sales or reduce costs, while rejection or delay can create regulatory risk and affect revenue; think of it as asking permission to alter a proven recipe before selling the new version.

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

What was TAK's revenue for the six months ended September 30, 2026?

Revenue was JPY 2,407.0 billion, up 8.4% AER but down 1.0% CER year over year. The reported increase was primarily attributable to depreciation of the Japanese yen.

How much operating cash flow did TAK generate in the first half of fiscal 2026?

Net cash from operating activities was JPY 431.9 billion for the six months ended September 30, 2026, a decrease of JPY 161.8 billion from the same period of the prior fiscal year.

Which Takeda medicines received approvals during the six months ended September 30, 2026?

ORZEYFUL was approved in China for narcolepsy type 1 in adolescents aged 16 years and older and adults, and in the U.S. and Japan for adults. The FDA also approved MIMRYLO for erythrocytosis in adults with polycythemia vera.

AI-generated analysis. How Rhea-AI works. Not financial advice.

Form 6-K: How Foreign Companies Report to the SEC →

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Available on EDGAR 10/29/2026 - 06:49 AM EDT Accepted by SEC EDGAR 10/29/2026 - 06:49 AM EDT Learn about SEC filing dates

Table of Contents

FORM 6-K

________________________________________

U.S. SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

________________________________________

Report of Foreign Private Issuer

Pursuant to Rule 13a-16 or 15d-16 of

the Securities Exchange Act of 1934

Commission File Number: 001-38757

For the month of October 2026

________________________________________

TAKEDA PHARMACEUTICAL COMPANY LIMITED

(Translation of registrant’s name into English)

________________________________________

1-1, Nihonbashi-Honcho 2-Chome

Chuo-ku, Tokyo 103-8668

Japan

(Address of principal executive offices)

________________________________________

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form 20-F  ☒            Form 40-F  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):  ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7):  ☐

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Information furnished on this form:

Pursuant to the Financial Instruments and Exchange Act of Japan, Takeda Pharmaceutical Company Limited filed its Semi-annual Securities Report for The Six-month Period with the Director of the Kanto Local Finance Bureau in Japan on October 29, 2026. An English translation of such report is included as an exhibit hereto.

EXHIBIT

Exhibit Number
1.						(English Translation) Semi-annual Securities Report For The Six-month Period Ended September 30, 2026
99.1						Financial Appendix (incorporated by reference to Exhibit 99.1 to Form 6-K of the Registrant, filed on October 29, 2026)

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

			TAKEDA PHARMACEUTICAL COMPANY LIMITED
Date: October 29, 2026			By:			/s/ Norimasa Takeda
						Norimasa Takeda Chief Accounting Officer and Corporate Controller

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Translation for reference purpose only

Semi-annual Securities Report

(The semi-annual of 150th Business Term)

for The Six-month Period Ended September 30, 2026

TAKEDA PHARMACEUTICAL COMPANY LIMITED

AND ITS SUBSIDIARIES

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Translation for reference purpose only

Index

			Page
[Cover]			1
A. Company Information
I. Overview of Takeda			2
1. Key Consolidated Financial Data			2
2. Business Overview			2
II. Operating and Financial Review			3
1. Risk Factors			3
2. Analysis on Business Performance, Financial Position and Cash Flows			3
3. Material Contracts			17
III. Information on the Company			18
1. Information on the Company’s Shares			18
2. Members of the Board of Directors			20
IV. Financial Information			22
1. Condensed Interim Consolidated Financial Statements			23
2. Others			40
B. Information on Guarantors of the Company			41

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Translation for reference purpose only

[Cover]
[Document Filed]			Semi-annual Securities Report
[Applicable Law]			Item 1 of the table in Article 24-5, Paragraph 1 of the Financial Instruments and Exchange Act of Japan
[Filed with]			Director, Kanto Local Finance Bureau
[Filing Date]			October 29, 2026
[Fiscal period]			The semi-annual of 150th Business Term (from April 1, 2026 to September 30, 2026)
[Company Name]			Takeda Pharmaceutical Company Limited
[Title and Name of Representative]			Julie Kim, Representative Director, President & Chief Executive Officer
[Address of Head Office]			1-1, Doshomachi 4-chome, Chuo-ku, Osaka
			(The above address is the registered head office location and the ordinary business operations are conducted at the “Nearest Place of Contact”)
[Telephone Number]			Not applicable
[Name of Contact Person]			Not applicable
[Nearest Place of Contact]			1-1, Nihonbashi-Honcho 2-chome, Chuo-ku, Tokyo
			(Global Headquarters)
[Telephone Number]			+81-3-3278-2111 (Main telephone number)
[Name of Contact Person]			Norimasa Takeda, Chief Accounting Officer & Corporate Controller, Accounting & Controllership, Global Finance
[Place for public inspection]			Takeda Pharmaceutical Company Limited (Global Headquarters)
			(1-1, Nihonbashi Honcho 2-chome, Chuo-ku, Tokyo)
			Tokyo Stock Exchange, Inc.
			(2-1, Nihonbashi Kabutocho, Chuo-ku, Tokyo)
			Nagoya Stock Exchange, Inc.
			(8-20, Sakae 3-chome, Naka-ku, Nagoya)
			Fukuoka Stock Exchange
			(14-2, Tenjin 2-chome, Chuo-ku, Fukuoka)
			Sapporo Stock Exchange
			(14-1, Minamiichijonishi 5-chome, Chuo-ku, Sapporo)

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Translation for reference purpose only

A. Company Information

I. Overview of Takeda

1. Key Consolidated Financial Data

						JPY (millions), unless otherwise indicated
						Six-month period ended September 30,						Six-month period ended September 30,						For the year ended March 31,
Term						2025						2026						2026
Revenue						2,219,481						2,406,997						4,505,720
Profit (loss) before tax						178,804						318,688						(142,355)
Net profit (loss) for the period						112,550						305,716						(152,125)
Net profit (loss) attributable to owners of the Company						112,441						305,626						(152,390)
Total comprehensive income (loss) for the period						365,385						107,101						780,275
Total equity						7,131,690						7,417,176						7,430,649
Total assets						14,470,300						15,271,498						15,511,506
Basic earnings per share (loss) (JPY)						71.57						192.53						(96.75)
Diluted earnings per share (loss) (JPY)						70.45						189.52						(96.75)
Ratio of equity attributable to owners of the Company to total assets (%)						49.3						48.6						47.9
Net cash from operating activities						593,651						431,890						1,041,431
Net cash used in investing activities						(81,326)						(108,774)						(369,141)
Net cash used in financing activities						(226,881)						(491,370)						(496,820)
Cash and cash equivalents at the end of the period						681,486						418,533						595,054

*1 As the Company prepares Condensed Interim Consolidated Financial Statements, key unconsolidated financial data is not presented.

*2    All amounts shown are rounded to the nearest million JPY.

*3    The key consolidated financial data for the year ended March 31, 2026 is based on the consolidated financial statements prepared in accordance with International Financial Reporting Standards (IFRS). The key consolidated financial data for the six-month periods ended September 30, 2025 and 2026 are based on the condensed interim consolidated financial statements prepared in accordance with IAS 34.

2. Business Overview

There has been no significant change in our business for the six-month period ended September 30, 2026.

As of September 30, 2026, Takeda consisted of 157 entities comprised of 147 consolidated subsidiaries (including partnerships), 9 associates* accounted for using the equity method, and Takeda Pharmaceutical Company Limited. There has been no significant change in our group companies for the six-month period ended September 30, 2026.

* Associates include a joint venture.

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II. Operating and Financial Review

1. Risk Factors

There were no new risk factors identified for the six-month period ended September 30, 2026 as well as no significant changes in the risk factors compared to what we reported in our Annual Securities Report for the year ended March 31, 2026 which was filed in Japan.

2. Analysis on Business Performance, Financial Position and Cash Flows

(1) Consolidated Financial Results (April 1 to September 30, 2026)

						Billion JPY or percentage
						FY2025 H1						FY2026 H1						AER												CER
																		JPY Change						% Change						% Change
Revenue						2,219.5						2,407.0						187.5						8.4		%				(1.0)		%
Cost of sales						(764.7)						(798.8)						(34.0)						4.5		%				(4.6)		%
Selling, general and administrative expenses						(509.4)						(558.2)						(48.8)						9.6		%				0.3		%
Research and development expenses						(305.4)						(338.6)						(33.3)						10.9		%				2.1		%
Amortization and impairment losses on intangible assets associated with products						(336.8)						(218.5)						118.3						(35.1)		%				(40.7)		%
Other operating income						23.5						15.5						(8.1)						(34.3)		%				(37.7)		%
Other operating expenses						(73.1)						(101.6)						(28.5)						39.0		%				25.4		%
Operating profit						253.6						406.7						153.2						60.4		%				45.0		%
Finance income and (expenses), net						(72.1)						(88.0)						(15.9)						22.0		%				15.0		%
Share of loss of investments accounted for using the equity method						(2.6)						(0.0)						2.6						(99.8)		%				―
Profit before tax						178.8						318.7						139.9						78.2		%				59.3		%
Income tax expenses						(66.3)						(13.0)						53.3						(80.4)		%				(92.6)		%
Net profit for the period						112.5						305.7						193.2						171.6		%				148.7		%
Net profit for the period attributable to owners of the Company						112.4						305.6						193.2						171.8		%				148.9		%

In this section, the amount of change and percentage change based on Actual Exchange Rates are presented in “AER” (which is presented in accordance with IFRS) and percentage change based on Constant Exchange Rate (which is a non-IFRS measure) is presented in “CER”. For additional information on CER change, see “Definition and Explanation of Core Financial Measures and Constant Exchange Rate Change” in Core Results (April 1 to September 30, 2026).

Revenue

Revenue for the six-month period ended September 30, 2026 was JPY 2,407.0 billion (JPY +187.5 billion and +8.4% AER, -1.0% CER). The increase compared to the same period of the previous fiscal year was primarily attributable to foreign exchange impacts from the depreciation of the Japanese yen.

Revenue of our key business areas, which comprise Gastroenterology (“GI”), Rare Diseases, Plasma-Derived Therapies (“PDT”), Oncology, Vaccines, and Neuroscience, was JPY 2,308.2 billion (JPY +191.8 billion and +9.1% AER, -0.5% CER). Revenue outside of our key business areas was JPY 98.8 billion (JPY -4.3 billion and -4.2% AER, -12.7% CER).

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Revenue by Geographic Region

The following shows revenue by geographic region:

						Billion JPY or percentage
						FY2025 H1						FY2026 H1						AER												CER
Revenue:																		JPY Change						% Change						% Change
Japan						219.1						213.9						(5.2)						(2.4)		%				(2.7)		%
United States						1,091.9						1,130.7						38.8						3.6		%				(5.4)		%
Europe*2						482.1						559.8						77.7						16.1		%				4.8		%
Latin America						118.5						144.5						26.0						22.0		%				5.6		%
China						92.7						106.2						13.6						14.6		%				(0.9)		%
Asia (excluding Japan & China)						47.8						54.6						6.8						14.1		%				7.7		%
Russia/CIS						43.2						52.8						9.6						22.2		%				7.8		%
Other*1, 2						124.3						144.5						20.3						16.3		%				4.5		%
Total						2,219.5						2,407.0						187.5						8.4		%				(1.0)		%

*1 Other includes Canada, the Middle East, Oceania and Africa.

*2 Following the implementation of a new organizational structure, the geographical classification previously presented as “Europe and Canada” through the prior fiscal year has been revised to “Europe” from the current fiscal year, and revenue attributable to Canada is now included in “Other“. Accordingly, revenue for FY2025 H1 in the above has been reclassified to conform to the FY2026 H1 presentation.  Revenue by geographic region for FY2025 H1 previously presented under “Europe and Canada” and “Other” amounted to JPY 535.2 billion and JPY 71.2 billion, respectively.

Revenue by Business Area

The following shows revenue by business area:

						Billion JPY or percentage
						FY2025 H1						FY2026 H1						AER												CER
Revenue:																		JPY Change						% Change						% Change
GI						692.8						776.8						84.0						12.1		%				2.5		%
Rare Diseases						380.5						395.7						15.2						4.0		%				(5.6)		%
PDT						517.4						561.2						43.7						8.5		%				(1.5)		%
Oncology						287.8						317.0						29.2						10.1		%				0.9		%
Vaccines						31.7						36.6						5.0						15.7		%				7.7		%
Neuroscience						206.1						220.9						14.8						7.2		%				(1.6)		%
Other						103.1						98.8						(4.3)						(4.2)		%				(12.7)		%
Total						2,219.5						2,407.0						187.5						8.4		%				(1.0)		%

Year-on-year change in revenue for this six-month period in each of our business areas was primarily attributable to the following products:

GI

In GI, revenue was JPY 776.8 billion (JPY +84.0 billion and +12.1% AER, +2.5% CER).

Sales of ENTYVIO (for ulcerative colitis and Crohn’s disease) were JPY 541.7 billion (JPY +62.4 billion and +13.0% AER, +2.7% CER). Sales in the U.S. were JPY 351.8 billion (JPY +32.8 billion and +10.3% AER). The increase was driven by favorable foreign exchange rates against the U.S. dollar, accompanied by growth of the subcutaneous formulation. Sales in Europe were JPY 124.9 billion (JPY +16.4 billion and +15.1% AER). The increase was due to favorable foreign exchange rates against the Euro, complemented by continued growth in patient numbers, supported by increased use of the subcutaneous formulation.

Sales of GATTEX/REVESTIVE (for short bowel syndrome) were JPY 79.9 billion (JPY +8.3 billion and +11.5% AER, +2.1% CER). The increase was primarily due to favorable foreign exchange rates, accompanied by a sales increase in the U.S. driven by stable demand.

Sales of TAKECAB/VOCINTI (for acid-related diseases) were JPY 76.0 billion (JPY +7.1 billion and +10.3% AER, +6.2% CER). The increase was primarily due to a sales increase in China and Japan driven by stable demand, accompanied by favorable foreign exchange rates.

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Rare Diseases

In Rare Diseases, revenue was JPY 395.7 billion (JPY +15.2 billion and +4.0% AER, -5.6% CER).

Sales of LIVTENCITY (for post-transplant cytomegalovirus infection/disease) were JPY 28.8 billion (JPY +6.7 billion and +30.2% AER, +18.6% CER). The increase was primarily attributable to continued performance in the U.S. market reflecting strong market penetration, accompanied by favorable foreign exchange rates.

Sales of VONVENDI (for von Willebrand Disease) were JPY 15.9 billion (JPY +4.5 billion and +39.3% AER, +27.0% CER). The increase was due to the expanded indication of VONVENDI, enabling prophylactic use for adult populations, complemented by favorable foreign exchange rates.

Sales of ADZYNMA (for congenital thrombotic thrombocytopenic purpura) were JPY 8.8 billion (JPY +4.0 billion and +82.2% AER, +65.5% CER). The increase was primarily due to post-launch growth in Europe, reflecting an unmet need for treatment of an ultra-rare patient population.

PDT

In PDT, revenue was JPY 561.2 billion (JPY +43.7 billion and +8.5% AER, -1.5% CER).

Aggregate sales of immunoglobulin products, mainly used for the treatment of primary immunodeficiency, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy, were JPY 423.8 billion (JPY +36.7 billion and +9.5% AER, -0.3% CER). Sales of CUVITRU and HYQVIA, which are subcutaneous immunoglobulin therapies, experienced double digit percentage sales growth, due to continued strong demand globally, accompanied by favorable foreign exchange rates. Sales of GAMMAGARD LIQUID/KIOVIG, which are intravenous immunoglobulin therapies, slightly increased, primarily due to favorable foreign exchange rates.

Aggregate sales of albumin products including HUMAN ALBUMIN and FLEXBUMIN (both primarily used for hypovolemia and hypoalbuminemia) were JPY 69.1 billion (JPY +3.0 billion and +4.5% AER, -6.9% CER). The increase was primarily attributable to favorable foreign exchange rates, which was partially offset by a sales decline in the U.S.

Oncology

In Oncology, revenue was JPY 317.0 billion (JPY +29.2 billion and +10.1% AER, +0.9% CER).

Sales of ADCETRIS (for malignant lymphomas) were JPY 85.5 billion (JPY +10.9 billion and +14.7% AER, +2.5% CER). The increase was primarily due to favorable foreign exchange rates, accompanied by a sales increase in Latin America driven by stable demand.

Sales of FRUZAQLA (for colorectal cancer) were JPY 33.4 billion (JPY +6.1 billion and +22.4% AER, +12.6% CER). The increase was primarily attributable to continued performance in Europe, as FRUZAQLA is addressing a need for new treatment options in metastatic colorectal cancer, and favorable foreign exchange rates.

Sales of LEUPLIN/ENANTONE (for endometriosis, uterine fibroids, premenopausal breast cancer, prostate cancer, and other certain indications) were JPY 63.9 billion (JPY +5.2 billion and +8.9% AER, +1.9% CER). The increase was due to favorable foreign exchange rates, accompanied by a sales increase in China, driven by volume growth following the implementation of provincial volume-based procurement.

Sales of NINLARO (for multiple myeloma) were JPY 44.1 billion (JPY +2.7 billion and +6.5% AER, -4.0% CER). The increase was primarily attributable to favorable foreign exchange rates, which was partially offset by a sales decline in the U.S.

Sales of ICLUSIG (for leukemia) were JPY 37.1 billion (JPY +2.7 billion and +7.8% AER, -2.0% CER). The increase was primarily attributable to favorable foreign exchange rates.

Vaccines

In Vaccines, revenue was JPY 36.6 billion (JPY +5.0 billion and +15.7% AER, +7.7% CER).

Sales of QDENGA (for prevention of dengue) were JPY 26.6 billion (JPY +5.6 billion and +26.4% AER, +14.4% CER). The increase was due to post-launch growth in Latin America, as well as favorable foreign exchange rates.

Neuroscience

In Neuroscience, revenue was JPY 220.9 billion (JPY +14.8 billion and +7.2% AER, -1.6% CER).

Sales of TRINTELLIX (for major depressive disorder) were JPY 71.3 billion (JPY +14.3 billion and +25.2% AER, +15.6% CER). The increase was due to pricing favorability in the U.S. including a price increase and shifts in payer mix, lower sales in the same period of the previous year following changes in the distribution model of a major customer and favorable foreign exchange rates.

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Cost of Sales

Cost of Sales was JPY 798.8 billion (JPY +34.0 billion and +4.5% AER, -4.6% CER). The increase was primarily due to foreign exchange impacts from the depreciation of the Japanese yen partially offset by a lower cost ratio resulting from changes in product mix.

Selling, General and Administrative (SG&A) Expenses

SG&A Expenses were JPY 558.2 billion (JPY +48.8 billion and +9.6% AER, +0.3% CER). The increase was mainly due to foreign exchange impacts from the depreciation of the Japanese yen.

Research and Development (R&D) Expenses

R&D Expenses were JPY 338.6 billion (JPY +33.3 billion and +10.9% AER, +2.1% CER). The increase was mainly attributable to foreign exchange impacts from the depreciation of the Japanese yen and increased expenses related to late-stage pipeline programs, including arcotatug tavatecan (TAK-921), elritercept (TAK-226) and TAK-928.

Amortization and Impairment Losses on Intangible Assets Associated with Products

Amortization and Impairment Losses on Intangible Assets Associated with Products were JPY 218.5 billion (JPY -118.3 billion and -35.1% AER, -40.7% CER). The decrease reflected lower amortization expenses (JPY -48.4 billion) and impairment losses (JPY -69.8 billion). The decrease in amortization expenses mainly reflected the completion of amortization of intangible assets related to VYVANSE/ELVANSE, partially offset by foreign exchange impacts from the depreciation of the Japanese yen. The decrease in impairment losses was primarily attributable to impairment charges recognized in the six-month period ended September 30, 2025, including JPY 58.2 billion related to the gamma delta T-cell therapy platform and associated oncology programs following the decision to discontinue the cell therapy research.

Other Operating Income

Other Operating Income was JPY 15.5 billion (JPY -8.1 billion and -34.3% AER, -37.7% CER). The decrease was mainly due to lower gains on the divestiture of non-core products recorded in the six-month period ended September 30, 2026.

Other Operating Expenses

Other Operating Expenses were JPY 101.6 billion (JPY +28.5 billion and +39.0% AER, +25.4% CER). The increase was primarily attributable to a JPY 52.4 billion increase in restructuring expenses, reflecting ongoing implementation of the transformation program in the six-month period ended September 30, 2026. This increase was partially offset by a decrease in expenses related to pre-launch inventories compared to the six-month period ended September 30, 2025.

Operating Profit

As a result of the above factors, Operating Profit was JPY 406.7 billion (JPY +153.2 billion and +60.4% AER, +45.0% CER).

Net Finance Expenses

Net Finance Expenses were JPY 88.0 billion (JPY +15.9 billion and +22.0% AER, +15.0% CER). The increase was mainly attributable to higher interest expense relating to the unsecured U.S. dollar-denominated senior guaranteed notes issued on July 2, 2025, and the lease liability associated with the building lease in Cambridge, Massachusetts, as well as losses on the investments in convertible notes in the six-month period ended September 30, 2026.

Share of Loss of Investments Accounted for Using the Equity Method

Share of Loss of Investments Accounted for Using the Equity Method was JPY 0.0 billion (JPY -2.6 billion and -99.8% AER).

Profit Before Tax

As a result of the above factors, Profit Before Tax was JPY 318.7 billion (JPY +139.9 billion and +78.2% AER, +59.3% CER).

Income Tax Expenses

Income Tax Expenses were JPY 13.0 billion (JPY -53.3 billion and -80.4% AER, -92.6% CER). The decrease was primarily attributable to deferred tax benefits recognized in the six-month period ended September 30, 2026, reflecting a reassessment of the recoverability of deferred tax assets related to deductible temporary differences, as well as deferred tax benefits arising from capital losses generated through the restructuring of a subsidiary. This decrease was partially offset by increased tax expense due to higher pretax earnings.

Net Profit for the Period

As a result of the above factors, Net Profit for the Period was JPY 305.7 billion (JPY +193.2 billion and +171.6% AER, +148.7% CER) and Net Profit for the Period attributable to owners of the Company was JPY 305.6 billion (JPY +193.2 billion and +171.8% AER, +148.9% CER).

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Core Results (April 1 to September 30, 2026)

Definition and Explanation of Core Financial Measures and Constant Exchange Rate Change

Core Financial Measures

Takeda’s Core Financial Measures, particularly Core Revenue, Core Operating Profit, Core Net Profit for the Year attributable to owners of the Company and Core EPS, exclude revenue from divestments, amortization and impairment losses on intangible assets associated with products (including in-process R&D) and other impacts unrelated to the underlying trends and business performance of Takeda’s core operations, such as non-recurring items, purchase accounting effects and transaction related costs. Core Revenue represents revenue adjusted to exclude revenue items unrelated to the underlying trends and business performance of Takeda’s core operations (primarily revenue or related adjustments associated with divestments and liquidations). Core Operating Profit represents operating profit adjusted to exclude other operating expenses and income, amortization and impairment losses on intangible assets associated with products (including in-process R&D) and non-cash items or items unrelated to the underlying trends and business performance of Takeda’s core operations. Core Net Profit for the Year attributable to owners of the Company represents net profit for the year attributable to owners of the Company, adjusted to eliminate the impact of items excluded in the calculation of Core Operating Profit, other non-operating items (e.g. amongst other items, fair value adjustments and the imputed financial charge related to contingent consideration) that are unusual, non-recurring in nature or unrelated to the underlying trends and business performance of Takeda’s ongoing operations and foreign exchange gains and losses arising directly from, or economically attributable to items excluded from the Core Financial Measures. Core Net Profit for the Year attributable to owners of the Company is also adjusted to eliminate the tax effect associated with each of these adjustments. Core EPS is calculated by dividing Core Net Profit for the Year attributable to owners of the Company by the average outstanding shares (excluding treasury shares) of the reporting periods presented.

Takeda presents its Core Financial Measures because Takeda believes that these measures are useful to understanding its business without the effect of items that Takeda considers to be unrelated to the underlying trends and business performance of its core operations, including items (i) which may vary significantly from year-to-year or may not occur in each year or (ii) whose recognition Takeda believes is largely uncorrelated to trends in the underlying performance of our core business. Takeda believes that similar measures are frequently used by other companies in its industry and that providing these measures helps investors evaluate Takeda’s performance against not only its performance in prior years but on a similar basis as its competitors. Takeda also presents Core Financial Measures because these measures are used by Takeda for budgetary planning and compensation purposes (i.e., certain targets for the purposes of Takeda’s Short-Term Incentive and Long-Term Incentive compensation programs, including incentive compensation of the CEO and CFO, are set in relation to the results of Takeda’s Core Financial Measures).

Constant Exchange Rate (“CER”) Change

CER Change eliminates the effect of foreign exchange rates from year-over-year comparisons by translating financial results in accordance with IFRS or Core (non-IFRS) financial measures for the current period using corresponding exchange rates in the same period of the previous fiscal year, provided, however, that the results of operations of subsidiaries in countries experiencing hyperinflation, and for which IAS 29, Financial Reporting in Hyperinflationary Economies, is applied, are not adjusted for CER Change, and instead are calculated in accordance with IAS 29.

Takeda presents CER change because we believe that this measure is useful to investors to better understand the effect of exchange rates on our business and to understand how our results of operations might have changed from year to year without the effect of fluctuations in exchange rates. These are the primary ways in which our management uses these measures to evaluate our results of operations. We also believe that this is a useful measure for investors as similar performance measures are frequently used by securities analysts, investors and other interested parties in the evaluation of the results of operations of other companies in our industry (many of whom similarly present measures that adjust for the effect of exchange rates).

The usefulness of this presentation has significant limitations including but not limited to, that while CER change is calculated using the same exchange rates used to calculate financial results as presented under IFRS for the previous fiscal year, this does not necessarily mean that the transactions entered into during the relevant fiscal year could have been entered into or would have been recorded at the same exchange rates. Moreover, other companies in our industry using similarly titled measures may define and calculate those measures differently than we do and therefore such measures may not be directly comparable. Accordingly, CER change should not be considered in isolation and is not, and should not be viewed as, a substitute for change in financial results as prepared and presented in accordance with IFRS.

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Results of Core Operations

						Billion JPY or percentage
						FY2025 H1						FY2026 H1						AER												CER
																		JPY Change						% Change						% Change
Core revenue						2,219.5						2,407.0						187.5						8.4		%				(1.0)		%
Core operating profit						639.2						710.6						71.4						11.2		%				0.7		%
Core net profit for the period						438.7						489.7						51.0						11.6		%				(0.2)		%
Core net profit for the period attributable to owners of the Company						438.6						489.6						51.0						11.6		%				(0.2)		%
Core EPS (yen)						279						308						29						10.5		%				(1.2)		%

Core Revenue

Core Revenue for the six-month period ended September 30, 2026 was JPY 2,407.0 billion (JPY +187.5 billion and +8.4% AER, -1.0% CER). The increase compared to the same period of the previous fiscal year was primarily attributable to foreign exchange impacts from the depreciation of the Japanese yen.

Excluding the foreign exchange impacts, Core Revenue slightly declined, as broadly flat Core In-line Brands*1 and steady growth of New Launches*2 were more than offset by a decline in revenue from loss of exclusivity-impacted and mature products.

*1 Core In-line Brands refers to select products launched 6 or more years ago that generate over JPY 100.0 billion in annual revenue and are actively promoted (ENTYVIO, GATTEX/REVESTIVE, TAKECAB/VOCINTI, TAKHZYRO, immunoglobulin products, albumin products, ADCETRIS). In the six-month period ended September 30, 2026, these products represented 58% of Core Revenue and grew by 0.5% at CER.

*2 New Launches refers to select products launched within past 5 years (EOHILIA, LIVTENCITY, ADZYNMA, FRUZAQLA, QDENGA) and recently approved products ORZEYFUL and MIMRYLO. In the six-month period ended September 30, 2026, these products represented 4% of Core Revenue and grew by 17.3% at CER.

Core Operating Profit

Core Operating Profit was JPY 710.6 billion (JPY +71.4 billion and +11.2% AER, +0.7% CER). The components of Core Operating Profit are as follows:

						Billion JPY or percentage
						FY2025 H1						FY2026 H1						AER												CER
																		JPY Change						% Change						% Change
Core revenue						2,219.5						2,407.0						187.5						8.4		%				(1.0)		%
Core cost of sales						(765.2)						(799.4)						(34.3)						4.5		%				(4.6)		%
Core selling, general and administrative (SG&A) expenses						(509.7)						(558.4)						(48.7)						9.6		%				0.2		%
Core research and development (R&D) expenses						(305.5)						(338.6)						(33.2)						10.9		%				2.1		%
Core operating profit						639.2						710.6						71.4						11.2		%				0.7		%

During the periods presented, these items fluctuated as follows:

Core Cost of Sales

Core Cost of Sales was JPY 799.4 billion (JPY +34.3 billion and +4.5% AER, -4.6% CER). The increase was primarily due to foreign exchange impacts from the depreciation of the Japanese yen partially offset by a lower cost ratio resulting from changes in product mix.

Core Selling, General and Administrative (SG&A) Expenses

Core SG&A Expenses were JPY 558.4 billion (JPY +48.7 billion and +9.6% AER, +0.2% CER). The increase was mainly due to foreign exchange impacts from the depreciation of the Japanese yen.

Core Research and Development (R&D) Expenses

Core R&D Expenses were JPY 338.6 billion (JPY +33.2 billion and +10.9% AER, +2.1% CER). The increase was mainly attributable to foreign exchange impacts from the depreciation of the Japanese yen and increased expenses related to late-stage pipeline programs, including arcotatug tavatecan (TAK-921), elritercept (TAK-226) and TAK-928.

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Core Net Profit for the Period

Core Net Profit for the Period was JPY 489.7 billion (JPY +51.0 billion and +11.6% AER, -0.2% CER) and Core Net Profit for the Period attributable to owners of the Company was JPY 489.6 billion (JPY +51.0 billion and +11.6% AER, -0.2% CER). Core Net Profit for the Period is calculated from Core Operating Profit as follows:

						Billion JPY or percentage
						FY2025 H1						FY2026 H1						AER												CER
																		JPY Change						% Change						% Change
Core operating profit						639.2						710.6						71.4						11.2		%				0.7		%
Core finance income and (expenses), net						(67.1)						(79.8)						(12.6)						18.8		%				12.1		%
Core share of profit (loss) of investments accounted for using the equity method						(0.6)						(0.0)						0.6						(99.2)		%				―
Core profit before tax						571.5						630.8						59.3						10.4		%				(0.5)		%
Core income tax expenses						(132.8)						(141.1)						(8.3)						6.3		%				(1.5)		%
Core net profit for the period						438.7						489.7						51.0						11.6		%				(0.2)		%
Core net profit for the period attributable to owners of the Company						438.6						489.6						51.0						11.6		%				(0.2)		%

During the periods presented, these items fluctuated as follows:

Core Net Finance Expenses

Core Net Finance Expenses were JPY 79.8 billion (JPY +12.6 billion and +18.8% AER, +12.1% CER). The increase was mainly attributable to higher interest expense relating to the unsecured U.S. dollar-denominated senior guaranteed notes issued on July 2, 2025, and the lease liability recognized in August 2026 associated with the building lease in Cambridge, Massachusetts.

Core Share of Loss of Investments Accounted for Using the Equity Method

Core Share of Loss of Investments Accounted for Using the Equity Method was JPY 0.0 billion (JPY -0.6 billion and -99.2% AER).

Core Profit Before Tax

Core Profit Before Tax was JPY 630.8 billion (JPY +59.3 billion and +10.4% AER, -0.5% CER).

Core Income Tax Expenses

Core Income Tax Expenses were JPY 141.1 billion (JPY +8.3 billion and +6.3% AER, -1.5% CER). The increase was primarily attributable to higher Core pretax earnings in the six-month period ended September 30, 2026.

Core EPS

Core EPS was JPY 308 (JPY +29 and +10.5% AER, -1.2% CER).

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(2) Consolidated Financial Position

						Billion JPY
						As of												Change
						March 31, 2026						September 30, 2026
Total Assets						15,511.5						15,271.5						(240.0)
Total Liabilities						8,080.9						7,854.3						(226.5)
Total Equity						7,430.6						7,417.2						(13.5)

Assets

Total Assets as of September 30, 2026 were JPY 15,271.5 billion (JPY -240.0 billion). Intangible Assets decreased (JPY -201.3 billion), mainly due to amortization, accompanied by the effect of foreign currency translation. Goodwill decreased (JPY -124.5 billion), primarily due to the effect of foreign currency translation. In addition, Cash and Cash Equivalents decreased (JPY -176.5 billion). These decreases were partially offset by the increase of Property, Plant and Equipment (JPY +161.3 billion), mainly due to an increase in right-of-use assets associated with the building lease in Cambridge, Massachusetts.

Liabilities

Total Liabilities as of September 30, 2026 were JPY 7,854.3 billion (JPY -226.5 billion). Total Bonds and Loans were JPY 4,575.6 billion*, which decreased (JPY -306.2 billion), mainly due to the redemption of USD 1,500 million unsecured U.S. dollar-denominated senior notes during the six-month period ended September 30, 2026. The decrease was partially offset by the increase of total Other Financial Liabilities (JPY +193.0 billion), mainly due to an increase in the lease liability associated with the building lease in Cambridge, Massachusetts.

* The carrying amount of Bonds was JPY 4,350.6 billion and that of Loans was JPY 225.0 billion as of September 30, 2026. The breakdown of Bonds and Loans' carrying amount is as follows:

Bonds:

Name of Bond  (Face Value if Denominated in Foreign Currency)

Issuance

Maturity

Carrying Amount (Billion JPY)

Unsecured US Dollar Denominated Senior Notes (USD 500 million)

June 2015

June 2045

80.0

Unsecured Euro Denominated Senior Notes (EUR 3,000 million)

November 2018

November 2026 ~ November 2030

533.5

Unsecured US Dollar Denominated Senior Notes (USD 1,750 million)

November 2018

November 2028

274.0

Unsecured US Dollar Denominated Senior Notes (USD 7,000 million)

July 2020

March 2030 ~ July 2060

1,093.0

Unsecured Euro Denominated Senior Notes (EUR 3,600 million)

July 2020

July 2027 ~ July 2040

638.9

Unsecured JPY Denominated Senior Bonds

October 2021

October 2031

249.7

Hybrid Bonds (Subordinated Bonds)

June 2024

June 2084

458.7

Unsecured US Dollar Denominated Senior Notes (USD 3,000 million)

July 2024

July 2034 ~ July 2064

466.0

Unsecured JPY Denominated Senior Bonds

June 2025

June 2030 ~ June 2035

183.6

Unsecured US Dollar Denominated Senior Notes (USD 2,400 million)

July 2025

July 2035 ~ July 2055

373.3

Total

4,350.6

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Loans:

Name of Loan

Execution

Maturity

Carrying Amount (Billion JPY)

Bilateral Loans

March 2023 ~ March 2026

March 2029 ~ March 2034

185.0

Syndicated Hybrid Loans (Subordinated Loans)

October 2024

October 2084

40.0

Total

225.0

On September 23, 2026, Takeda redeemed USD 1,500 million of unsecured U.S. dollar-denominated senior notes issued in September 2016 on their maturity date.

*Amounts presented in the above explanation for Bonds are based on the principal amount.

Equity

Total Equity as of September 30, 2026 was JPY 7,417.2 billion (JPY -13.5 billion). The decrease of Other Components of Equity (JPY -197.6 billion) was mainly due to a change in currency translation adjustments reflecting the appreciation of the Japanese yen. This decrease was partially offset by the increase in Retained Earnings (JPY +146.9 billion), driven by the increase of JPY 305.6 billion from Net Profit for the Period, offset by the decrease of JPY 158.2 billion related to dividend payments.

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(3) Consolidated Cash Flows

						Billion JPY
						FY2025 H1						FY2026 H1						Change
Net cash from operating activities						593.7						431.9						(161.8)
Net cash used in investing activities						(81.3)						(108.8)						(27.4)
Net cash used in financing activities						(226.9)						(491.4)						(264.5)
Net increase (decrease) in cash and cash equivalents						285.4						(168.3)						(453.7)
Cash and cash equivalents at the beginning of the year						385.1						595.1						209.9
Effects of exchange rate changes on cash and cash equivalents						10.9						(8.3)						(19.2)
Cash and cash equivalents at the end of the period						681.5						418.5						(263.0)

Net Cash from Operating Activities

Net Cash from Operating Activities was JPY 431.9 billion (JPY -161.8 billion). The decrease was mainly due to changes in working capital primarily resulting from an increase in Trade and Other Receivables, and net cash outflows from Settlement of Forward Exchange Contracts, Net during the six-month period ended September 30, 2026. The decrease was partially offset by favorable impacts resulting from Net Profit for the Period adjusted for non-cash items and other adjustments.

Net Cash used in Investing Activities

Net Cash used in Investing Activities was JPY 108.8 billion (JPY +27.4 billion). The increase was mainly due to an increase in cash used in Acquisition of Intangible Assets and Acquisition of Property, Plant and Equipment. The increase was partially offset by an increase in Proceeds from Sales and Redemption of Investments.

Net Cash used in Financing Activities

Net Cash used in Financing Activities was JPY 491.4 billion (JPY +264.5 billion). The increase was mainly due to cash outflows from Repayment of Bonds and Long-term Loans during the six-month period ended September 30, 2026, compared with net cash inflows from the issuance and repayments of bonds and loans during the six-month period ended September 30, 2025.

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(4) Research & Development Activities and Results

Research and development expenses for the six-month period ended September 30, 2026 were JPY 338.6 billion. Takeda does not report disaggregated R&D expenses, including by therapeutic area or clinical trial stage, as our R&D budget is determined on a company-wide basis and specific expenditures may be subject to re-allocation depending on development results and priorities.

Takeda’s R&D engine is focused on translating science into highly innovative, life-transforming medicines that make a critical difference to patients. Our R&D efforts focus on three core therapeutic areas: Gastrointestinal and Inflammation, Neuroscience, and Oncology. We also make targeted R&D investments in Plasma Derived Therapies (PDT). The R&D engine for our three core therapeutic areas is the largest component of our R&D investment and has produced exciting new molecular entities (“NMEs”) that represent potential best-in-class and/or first-in-class medicines in areas of high unmet medical need across our core therapeutic areas (Gastrointestinal and Inflammation, Neuroscience, and Oncology). Takeda is committed to developing therapies for both rare and more prevalent diseases, and many of the life-transforming medicines we are pursuing will treat rare diseases in our core therapeutic areas as well as in PDT. We are embracing data and digital technologies with the aim of improving the quality of innovation and accelerating execution. We seek to achieve a foundational shift that embeds AI into every stage of drug discovery, redesigning workflows to include automated, data-driven, predictive processes that accelerate innovation.

Takeda’s pipeline is positioned to support both the near-term and long-term sustained growth of the company. Once first approval of a product is achieved, Takeda R&D is equipped to support geographic expansions of such approval and approvals in additional indications, as well as post-marketing commitment and potential additional formulation work. Takeda’s R&D team works closely with the commercial functions to maximize the value of marketed products and reflect commercial insights in its R&D strategies and portfolio.

Major progress on R&D events since April 2026 are listed as follows:

R&D pipeline

Gastrointestinal and Inflammation

In Gastrointestinal and Inflammation, Takeda focuses on delivering innovative, life-changing therapeutics for patients with gastrointestinal diseases (including those of the liver) as well as immune-mediated inflammatory diseases. Takeda is maximizing the potential of our inflammatory bowel disease (IBD) franchise around ENTYVIO, including the introduction of a subcutaneous formulation and running real-world evidence generation studies that demonstrate ENTYVIO’s place as a backbone therapy in the IBD treatment paradigm and further our understanding of how to improve outcomes for patients. Zasocitinib (TAK-279) is a next generation oral tyrosine kinase 2 (TYK2) inhibitor with potential to treat multiple immune-mediated inflammatory diseases. Fazirsiran (TAK-999) is a potential first-in-class RNAi treatment for alpha-1 antitrypsin-deficiency associated liver disease in late-stage development. Mezagitamab (TAK-079) is a potential best-in-class anti-CD38 antibody with disease modifying potential for multiple immune-mediated diseases like immune thrombocytopenia (ITP) and IgA nephropathy (IgAN). Furthermore, Takeda is making progress on its pipeline built through in-house discovery, partnerships and business development, which explores opportunities in inflammatory diseases (specifically in gastric, dermatological and rheumatic disorders), along with select rare hematological and renal disorders (ADZYNMA, mezagitamab (TAK-079)), liver diseases, and neurogastric disorders.

ENTYVIO / Generic name: vedolizumab

–In June 2026, Takeda announced that the U.S. Food and Drug Administration (FDA) accepted for review its supplemental Biologics License Application (sBLA) for intravenous (IV) ENTYVIO for the treatment of moderately to severely active ulcerative colitis (UC) and Crohn’s disease in pediatric patients ages 2 years and older. The FDA has set a Prescription Drug User Fee Act (PDUFA) goal date in the first quarter of calendar year 2027. Takeda also submitted a marketing authorization application (MAA) to the European Medicines Agency for ENTYVIO IV for the treatment of moderately to severely active UC and Crohn’s disease in pediatric patients ages 2 years and older. The sBLA and MAA are supported by data from two Phase 3 pediatric trials, the KEPLER study in UC and the ongoing WEBB study in Crohn’s disease.

–In July 2026, Takeda announced that it submitted an application to the Japanese Ministry of Health, Labour and Welfare (MHLW) for a partial change to the manufacturing and marketing approval of ENTYVIO IV. The application seeks approval for an additional dosing regimen allowing a shortened dosing interval from every eight weeks to every four weeks in adult patients who have experienced a decrease in their response during maintenance therapy, and an expansion of the dosage and administration for pediatric patients with moderate to severe UC and active Crohn’s disease. Vedolizumab received Orphan Drug Designation in Japan in June 2026, for pediatric patients with ulcerative colitis and Crohn’s disease. The application for every-four-week dosing in adult patients is based on data from the Phase 3 Vedolizumab-3039 study

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conducted in Japan. The pediatric indication expansion is supported by data from the global Phase 3 KEPLER study in UC and WEBB study in Crohn’s disease.

–In October 2026, Takeda announced new data from the VERDICT trial, showing that treating adults with intravenous ENTYVIO to achieve corticosteroid-free (CSF) disease clearance versus CSF symptomatic remission alone, resulted in a significantly longer time to first ulcerative colitis (UC)-related complication, reducing UC complication risk by nearly 70 percent. VERDICT, a Phase 4 ENTYVIO clinical trial, provides the first prospective, randomized evidence that disease clearance is an achievable and clinically relevant target in the treatment of moderate to severe UC. Results were presented during late-breaker and poster sessions at United European Gastroenterology (UEG) Week 2026 and published in the United European Gastroenterology Journal.

Development code: TAK-279 / Generic name: zasocitinib

–In July 2026, Takeda announced new data from the two pivotal Phase 3 studies (LATITUDE PsO 3001 and 3002 studies) of zasocitinib in adults with moderate-to-severe psoriasis (PsO). Presented at the 2026 American Academy of Dermatology (AAD) Innovation Academy, these secondary endpoint data show that zasocitinib demonstrated consistent and high rates of skin clearance across hard-to-treat, high-impact sites, including the scalp, nails, palms and soles, compared with placebo.

–In September 2026, Takeda announced that the U.S. Food and Drug Administration (FDA) accepted its New Drug Application (NDA) under Priority Review for zasocitinib for the treatment of adults with moderate-to-severe plaque psoriasis. The NDA filing is supported by a comprehensive data package including the pivotal global Phase 3 LATITUDE PsO 3001 and 3002 studies. The European Medicines Agency (EMA) also accepted Takeda’s new marketing authorization application (MAA) for zasocitinib, initiating the review process for the treatment of moderate-to-severe plaque psoriasis.

–In September 2026, Takeda announced new data from Phase 3 LATITUDE psoriasis studies of zasocitinib, presented during late-breaking and oral sessions at the European Academy of Dermatology & Venereology (EADV) Congress 2026. In the Phase 3 LATITUDE Atlas (TAK-279 PsO 3004) head-to-head study, zasocitinib demonstrated statistical superiority over deucravacitinib across the primary and all key secondary efficacy endpoints with higher rates of complete skin clearance (PASI 100) observed as early as week 8. At week 16, 36.5% of patients treated with zasocitinib achieved PASI 100 which was more than 2.5 times compared to deucravacitinib. New long-term data from the pivotal Phase 3 LATITUDE PsO 3001 and 3002 studies demonstrated durable skin clearance with zasocitinib through week 52. Among patients who achieved a response at week 24, up to 93% maintained their skin clearance results through week 52 in LATITUDE PsO 3001 (post-hoc analysis) and week 40 in LATITUDE PsO 3002. Additional data from the pivotal Phase 3 LATITUDE PsO 3001 and 3002 studies demonstrated that zasocitinib-treated patients reported improvements in itch and quality of life as early as week 2 with continued improvements through week 24. The safety and tolerability profile of zasocitinib remained consistent across psoriasis studies.

Neuroscience

In Neuroscience, Takeda is focusing its R&D investments on potentially transformative treatments for neurological and neuromuscular diseases of high unmet need building its innovative pipeline by leveraging internal expertise and external collaborations. Takeda Neuroscience’s core focus is orexin biology, rare neurology and neurodegeneration diseases. We are advancing a portfolio of tailored therapies designed to unlock the full power of orexin (i.e., ORZEYFUL (oveporexton), TAK-360, TAK-495) to redefine the standard of care for people living with rare sleep-wake disorders and other conditions where orexin biology is implicated. Across our portfolio, we are harnessing advances in disease biology understanding, translational tools, innovative modalities and digital innovation to accelerate development and patient access.

VYVANSE / Generic name: lisdexamfetamine

–In June 2026, Takeda announced that it received notification from the Japanese Ministry of Health, Labour and Welfare (MHLW) regarding the partial lifting of certain approval conditions applied to VYVANSE. The partial lifting of the approval conditions is based on the MHLW’s assessment that the necessary measures associated with the relevant approval condition have been appropriately implemented, based on data submitted by Takeda, including results from post-marketing surveillance studies and initiatives to ensure appropriate use.

Lifted approval condition: “Measures ensuring that VYVANSE would be used only in cases where other attention-deficit/hyperactivity disorder (ADHD) treatments are insufficient, until evaluation of abuse and dependence under actual use conditions has been completed.”

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ORZEYFUL / Generic name: oveporexton

–In June 2026, Takeda presented additional results from two pivotal studies at SLEEP 2026 showing oveporexton improved daily functioning as well as cognitive and sleep-related symptoms associated with narcolepsy type 1 (NT1). The presentations highlighted results from secondary and exploratory endpoints from the FirstLight and the RadiantLight studies including functioning, cognition, and nighttime sleep. At all doses, oveporexton significantly improved daily functioning at week 12 compared to placebo (p<0.001) across the six domains of the Functional Impacts of Narcolepsy Instrument (FINI). Oveporexton improved cognitive symptoms associated with NT1 compared to placebo, as measured using objective neuropsychological tests of attention, executive function and memory along with patient-reported measures. Exploratory endpoints demonstrated that oveporexton improved quality of sleep across both studies.

–In July 2026, Takeda announced that the National Medical Products Administration (NMPA) of China approved the use of ORZEYFUL (oveporexton) for the treatment of NT1 in adolescents aged 16 years and older and adults. ORZEYFUL is the first oral orexin receptor 2 (OX2R)-selective agonist approved in China and is the only approved medicine to treat NT1. The approval is based on the comprehensive clinical program including the global Phase 3 FirstLight and RadiantLight studies.

–In August 2026, Takeda announced that the U.S. Food and Drug Administration (FDA) approved ORZEYFUL for the treatment of NT1 in adult patients. As a first-in-class orexin treatment, ORZEYFUL is the only medicine indicated in the U.S. to treat the disease holistically rather than individual symptoms. The approval is based on a comprehensive clinical program including the global Phase 3 FirstLight and RadiantLight studies. The controlled substance classification for ORZEYFUL is currently under review by the Drug Enforcement Administration (DEA) and is expected within 90 days post approval. After the controlled substance classification is determined, Takeda expects ORZEYFUL will be made available through a specialty pharmacy to U.S. healthcare providers and adults living with NT1.

–In August 2026, Takeda announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) approved the use of ORZEYFUL for the treatment of NT1 in adults. ORZEYFUL is a first-in-class oral OX2R agonist and the only medicine indicated in Japan to treat the disease holistically rather than individual symptoms. The discovery of this new class of medicine originated in Takeda's laboratories in Japan. The approval is based on a comprehensive clinical program including the global Phase 3 FirstLight and RadiantLight studies.

Oncology

In Oncology, we are advancing a pipeline of potential therapies across thoracic, gastrointestinal, and hematologic malignancies. In thoracic and gastrointestinal cancers, TAK‑928 (IBI363) and arcotatug tavatecan (TAK‑921/IBI343) are being evaluated across multiple indications. In hematologic cancers, we are growing a portfolio focused on myeloid malignancies, including MIMRYLO (rusfertide) and elritercept (TAK‑226). Our deep internal expertise, global footprint and strong network of strategic collaborators underpin our ability to drive innovation and long‑term value creation. We aspire to cure cancer, with inspiration from patients and innovation from everywhere.

MIMRYLO / Generic name: rusfertide

–In August 2026, Takeda announced U.S. Food and Drug Administration (FDA) approval of the New Drug Application (NDA) for MIMRYLO for the treatment of erythrocytosis in adults with polycythemia vera (PV). MIMRYLO is a first-in-class hepcidin mimetic designed to regulate iron distribution in the body and red blood cell overproduction to control hematocrit levels, which is the ratio of red blood cells to the total amount of blood in the body. The approval is supported by data from the global randomized Phase 3 VERIFY study.

–In September 2026, Takeda announced that MIMRYLO is the only treatment to be recommended as a Category 1 option across both low- and high-risk PV in the latest National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Myeloproliferative Neoplasms (Version 3.2026), updated on September 18, 2026. NCCN Guidelines inclusion was based on two late-stage pivotal studies, including the Phase 3 VERIFY study as well as the Phase 2 REVIVE study.

ELAHERE / Generic name: mirvetuximab soravtansine

–In September 2026, Takeda announced that it received manufacturing and marketing approval from the Japanese Ministry of Health, Labour and Welfare (MHLW) for ELAHERE, an antibody-drug conjugate (ADC) that binds to folate receptor alpha (FRα), for the treatment of FRα-positive, platinum-resistant recurrent ovarian cancer (PROC). The approval is based on results from the studies in patients with FRα-positive PROC, global Phase 3 MIRASOL and SORAYA trials, and TAK-853-1501 trial, a Phase 1/2 study conducted exclusively in Japan.

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Development code: TAK-921/IBI343 / Generic name: arcotatug tavatecan

–In October 2026, Takeda announced positive results from the Phase 3 G-HOPE-001 study of arcotatug tavatecan in patients with Claudin (CLDN) 18.2-positive, previously treated, advanced gastric or gastroesophageal junction adenocarcinoma (G/GEJA). Results from two prespecified interim analyses were shared in a late-breaking oral presentation at the 2026 European Society for Medical Oncology (ESMO) Congress. The G-HOPE-001 study met both prespecified primary endpoints of overall survival (OS) and progression-free survival (PFS), with arcotatug tavatecan demonstrating statistically significant improvements compared with treatment of physician’s choice (TPC) (irinotecan, paclitaxel or trifluridine/tipiracil). The second prespecified interim analysis (IA2) evaluated OS. Results from IA2 showed statistically significant and clinically meaningful improvement in OS, clinically meaningful improvement in PFS, higher objective response rate (ORR), and generally manageable overall safety profile of arcotatug tavatecan. The first prespecified interim analysis (IA1) included the final analysis of PFS and an assessment of OS futility. Results from IA1 showed statistically significant and clinically meaningful improvement in PFS.

Other Rare Diseases programs

Takeda’s R&D engine is focused on areas of high unmet medical need, both in rare and more prevalent conditions, across three core therapeutic areas (Gastrointestinal and Inflammation, Neuroscience, and Oncology). In other Rare Diseases programs, Takeda focuses on several areas of high unmet medical need, on top of marketed products such as TAKHZYRO in hereditary angioedema. In rare hematology, Takeda focuses on addressing today’s needs in the treatment of bleeding disorders, including through ADVATE and ADYNOVATE/ADYNOVI. In addition, Takeda aims to redefine the management of post-transplant cytomegalovirus (CMV) infection/disease with LIVTENCITY. Takeda commits to fulfilling our vision to deliver life-transforming medicines to patients with rare diseases. Takeda will continue to explore late-stage business development that may leverage our rare diseases capabilities as well as bolster our commitment and leadership in rare diseases.

Plasma-Derived Therapies (PDT)

Takeda has created a dedicated PDT business unit with a focus on managing the business end-to-end, from plasma donation to manufacturing, R&D, and commercialization. In PDT, we aspire to develop life-saving plasma-derived therapies, which are essential for patients with a variety of rare and complex chronic diseases. The dedicated R&D organization within PDT is charged with maximizing the value of existing therapies, identifying new targeted therapies, and optimizing efficiencies across the PDT value chain, from plasma donation to product manufacturing. Near-term, our priority is focused on delivering value from our broad immunoglobulin portfolio (HYQVIA, CUVITRU, GAMMAGARD LIQUID and GAMMAGARD LIQUID ERC) through the pursuit of new indications, geographic expansions, and enhanced patient experience through integrated healthcare technologies. Additionally, we are developing next generation immunoglobulin product with 20% facilitated SCIG (TAK-881) and are pursuing other early-stage opportunities (e.g. TAK-411: hypersialylated Immunoglobulin (hsIgG)) that would add to our diversified commercial portfolio of more than 20 therapeutic products distributed worldwide.

KENKETU GLOVENIN-I/GLOVENIN-I / Generic name: Immunoglobulin (IG) Infusion (Human) for intravenous administration

–In June 2026, Takeda announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) approved a partial change to the manufacturing and marketing authorization for an additional indication of KENKETU GLOVENIN-I 10% Intravenous Injection, derived from plasma collected in Japan, and GLOVENIN-I 10% Intravenous Injection, derived from plasma collected outside of Japan, for the treatment of autoimmune encephalitis (AE). Both products received Orphan Drug Designation for AE in August 2025.

Development code: TAK-881 / Generic name: Immunoglobulin (IG) Infusion 20% (Human) w/ Recombinant Human Hyaluronidase for subcutaneous administration

–In October 2026, Takeda announced detailed results from the pivotal Phase 2/3 IgGNITE clinical trial evaluating investigational TAK-881 which, if approved, has the potential to become the first facilitated SCIG 20% therapy for patients with Primary Immunodeficiency Disease (PID) administered up to once-monthly (every 3 to 4 weeks) in the U.S. Data in participants aged 16 years and older are featured in two late-breaking posters at the 22nd Biennial Meeting of the European Society for Immunodeficiencies (ESID 2026). The newly presented data showed TAK-881 delivered the same IG dose in 50% less volume with median infusion times shortened by 56.2 minutes (42.6%) for one infusion site versus HYQVIA, while maintaining up to once-monthly dosing. TAK-881 was well tolerated with no new safety signals or TAK-881-related serious adverse events identified as compared to HYQVIA.

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Vaccines

In Vaccines, Takeda is applying innovation to tackle infectious diseases such as dengue (QDENGA), and COVID-19 (NUVAXOVID). To support the expansion of our pipeline and the development of our programs, we have entered into partnerships with government organizations in Japan, and leading global institutions including WHO (World Health Organization), PAHO (Pan American Health Organization) and Gavi (Global Alliance for Vaccines and Immunization), among others. These partnerships have been essential in building the critical capabilities that will be necessary to deliver on our programs and realize their full potential.

NUVAXOVID Intramuscular Injection / Generic name: Recombinant coronavirus (SARS-CoV-2) vaccine

–In August 2026, Takeda announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) approved a partial change to the manufacturing and marketing authorization for NUVAXOVID formulated to target Omicron XFG lineage for which the application was submitted in June 2026. The approval is based on quality data related to the change of antigen strain, as well as non-clinical data in which NUVAXOVID was shown to induce neutralizing antibodies against SARS-CoV-2 antigens (XFG, JN.1, LP.8.1, NB.1.8.1 and XFG.3.4.1).

Building a sustainable research platform / Enhancing R&D collaboration

In addition to our concentrated efforts to increase our in-house R&D capabilities, external partnerships with third-party partners are a key component of our strategy for enhancing our R&D pipeline. Our strategy to expand and diversify our external partnerships allows us to take part in research of a wide variety of new products and increases the chances that we will be able to take part in a major research-related breakthrough.

3. Material Contracts

There were no decisions or agreements reached on important management matters, nor any material contracts executed, during the six-month period ended September 30, 2026.

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III. Information on the Company

1. Information on the Company’s Shares

(1) Total number of shares and other related information

1) Total number of shares

Class						Total number of shares authorized to be issued (Shares)
Common stock						3,500,000,000
Total						3,500,000,000

2) Number of shares issued

Class						Number of shares issued as of September 30, 2026						Number of shares issued as of the filing date (October 29, 2026)						Names of stock exchanges on which the Company is listed or names of authorized financial instruments firms association with which the Company is registered						Description
Common stock						1,602,218,559						1,602,218,559						Tokyo (Prime Market), Nagoya (Premier Market), Fukuoka, Sapporo, and New York						The number of shares per one unit of shares is 100 shares.
Total						1,602,218,559						1,602,218,559						—						—

*1    The Company's American Depositary Shares (ADSs) are listed on the New York Stock Exchange.

*2    The number of shares outstanding as of the filing date does not include shares issued upon exercise of stock acquisition rights from October 1, 2026 to the filing date of Semi-annual Securities Report (October 29, 2026).

(2) Status of stock acquisition rights

1) Contents of stock option plans

Not applicable.

2) Status of other stock acquisition rights

Not applicable.

(3) Exercise status of bonds with stock acquisition rights containing a clause for exercise price adjustments

Not applicable.

(4) Changes in the total number of issued shares and the amount of share capital and capital reserve

Date						Increase/decrease in number of shares issued (Thousands of shares)						Balance of shares issued  (Thousands of shares)						Increase/decrease in share capital JPY (millions)						Balance of share capital JPY (millions)						Increase/decrease in legal capital surplus  JPY (millions)						Balance of legal capital surplus JPY (millions)
From April 1, 2026 to September 30, 2026						10,989						1,602,219						27,669						1,722,947						27,669						1,714,960

*    The increase of 10,781 thousand shares in the total number of issued shares was due to the issuance of new shares through third party allotment.

Issue price: JPY 5,050     Amount included in share capital per share: JPY 2,525

Allottee: 10,477 employees of the Company and certain subsidiaries of the Company

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(5) Major shareholders

												As of September 30, 2026
Name						Address						Number of Shares Held (Thousands of Shares)						Percentage of Total Number of Shares Issued (Excluding Treasury Stocks) (%)
The Master Trust Bank of Japan, Ltd. (Trust account)						8-1, Akasaka 1-chome, Minato-ku, Tokyo						265,712						16.59
The Bank of New York Mellon as depositary bank for depositary receipt holders (Standing proxy: Sumitomo Mitsui Banking Corporation)						240 Greenwich Street, 8th Floor West, New York, NY 10286, U.S.A. (1-2, Marunouchi 1-chome, Chiyoda-ku, Tokyo)						97,237						6.07
Custody Bank of Japan, Ltd. (Trust account)						8-12, Harumi 1-chome, Chuo-ku, Tokyo						82,105						5.13
The Chase Manhattan Bank, N.A. London Secs Lending Omnibus Account (Standing proxy: Settlement & Clearing Services Department, Mizuho Bank, Ltd.)						Woolgate House, Coleman Street, London EC2P 2HD, England (2-15-1, Konan, Minato-ku, Tokyo)						44,587						2.78
State Street Bank and Trust Company 505001 (Standing proxy: Settlement & Clearing Services Department, Mizuho Bank, Ltd.)						One Congress Street, Suite 1, Boston, Massachusetts, U.S.A. (15-1, Konan 2-chome, Minato-ku, Tokyo)						42,787						2.67
SMBC Nikko Securities Inc.						3-1, Marunouchi 3-chome, Chiyoda-ku, Tokyo						24,052						1.50
JP Morgan Chase Bank 385781 (Standing proxy: Settlement & Clearing Services Department, Mizuho Bank, Ltd.)						25 Bank Street, Canary Wharf, London, E14 5JP, United Kingdom (15-1, Konan 2-chome, Minato-ku, Tokyo)						23,982						1.50
Takeda Science Foundation						3-6, Doshomachi 2-chome, Chuo-ku, Osaka						17,912						1.12
BNYM as AGT/CLTS 10 Percent (Standing proxy: MUFG Bank, Ltd.)						240 Greenwich Street, New York, New York 10286, U.S.A. (1-4-5, Marunouchi, Chiyoda-ku, Tokyo)						17,834						1.11
JP Morgan Securities Japan Co., Ltd.						7-3, Marunouchi 2-chome, Chiyoda-ku, Tokyo						17,607						1.10
Total						—						633,815						39.56

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(6) Information on voting rights

1) Total number of shares

						As of September 30, 2026
Classification						Number of shares (Shares)									Number of voting rights (Units)						Description
Shares without voting rights									—						—						—
Shares with restricted voting rights (Treasury stock and other)									—						—						—
Shares with restricted voting rights (Others)									—						—						—
Shares with full voting rights (Treasury stock and other)						(Treasury stock)   Common stock			195,300						—						—
Shares with full voting rights (Others)						Common stock			1,599,895,000						15,998,950						—
Shares less than one unit						Common stock			2,128,259						—						Shares less than one unit (100 shares)
Number of shares issued									1,602,218,559						—						—
Total number of voting rights									—						15,998,950						—

*1 On July 8, 2026, Takeda conducted the disposal of 6,096,159 treasury shares based on the resolution made on June 9, 2026 by Christophe Weber, the Company's Representative Director, President and Chief Executive Officer as of the date of the resolution, for the purpose of providing the Company's ADS to group employees outside of Japan under the long-term incentive plan. The disposed shares of the Company's common stock were converted into the Company's ADSs and settled with employees.

*2 "Shares with full voting rights (Others)" includes 2,664,000 (voting rights: 26,640) and 1,910,100 (voting rights: 19,101) of the shares held by the ESOP and BIP trust, respectively.

*3 "Shares less than one unit" includes 51 shares of treasury stock, and 94 and 117 of the shares held by the ESOP and BIP trust, respectively.

2) Treasury stock and other

						As of September 30, 2026
Name of shareholders						Address						Number of shares held under own name (Shares)						Number of shares held under the name of others (Shares)						Total shares held (Shares)						Percentage of total shares issued (%)
(Treasury stock)
Takeda Pharmaceutical Company Limited						1-1, Doshomachi 4-chome, Chuo-ku, Osaka						195,300						—						195,300						0.01
Total						—						195,300						—						195,300						0.01

*    In addition to the treasury shares shown above and 51 shares of treasury stock constituting less than one unit, 2,664,094 of the shares held by the ESOP trust and 1,910,217 of the shares held by the BIP trust are included in treasury stock on the condensed interim consolidated financial statements.

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2. Members of the Board of Directors

Subsequent to the filing date of the Annual Securities Report for the fiscal year ended March 31, 2026, the proposals entitled "Election of Eight (8) Directors who are not Audit and Supervisory Committee Members" and "Election of Three (3) Directors who are Audit and Supervisory Committee Members" were approved and adopted as proposed at the 150th Annual General Meeting of Shareholders held on June 24, 2026. As a result, as of the filing date of this Semi-annual Securities Report, the Company has 11 Directors (8 male Directors and 3 female Directors).

At meetings of the Board of Directors and the Audit and Supervisory Committee held after the General Meeting of Shareholders, the titles and other roles of the Directors were determined. The member composition of the Audit and Supervisory Committee, the Nomination Committee and the Compensation Committee is as follows:

Audit and Supervisory Committee: Mr. Koichiro Kimura (Head), Mr. Bruce Broussard and Ms. Kimberly A. Reed

Nomination Committee: Mr. Masami Iijima (Chairperson), Dr. Steven Gillis and Mr. Koichiro Kimura (Ms. Julie Kim as an observer)

Compensation Committee: Dr. John Maraganore (Chairperson), Mr. Masami Iijima, Ms. Kimberly A. Reed and Ms. Miki Tsusaka

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IV. Financial Information

Basis of Preparation of the Condensed Interim Consolidated Financial Statements

Takeda has prepared the condensed interim consolidated financial statements in accordance with IAS 34 “Interim Financial Reporting” pursuant to Article 312 of "Ordinance on the Terminology, Forms and Preparation Methods of Consolidated Financial Statements" (Ordinance of the Ministry of Finance No. 28, 1976) (hereinafter “Ordinance on Consolidated Financial Statements”).

Takeda falls under the category listed in the upper column of item 1 of the table in Article 24-5, Paragraph 1 of the Financial Instruments and Exchange Act of Japan, and prepares Type 1 Interim Consolidated Financial Statements in accordance with the provisions of Part 1 and Part 5 of Ordinance on Consolidated Financial Statements.

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1. Condensed Interim Consolidated Financial Statements

(1) Condensed Interim Consolidated Statements of Profit or Loss

																											JPY (millions, except per share data)
																					Six-month Period Ended September 30,
			Note																								2025						2026
Revenue			4																								2,219,481						2,406,997
Cost of sales																											(764,736)						(798,769)
Selling, general and administrative expenses																											(509,436)						(558,227)
Research and development expenses																											(305,373)						(338,624)
Amortization and impairment losses on intangible assets associated with products			5																								(336,793)						(218,516)
Other operating income																											23,519						15,463
Other operating expenses			6																								(73,101)						(101,585)
Operating profit																											253,561						406,739
Finance income																											118,154						39,177
Finance expenses																											(190,296)						(127,224)
Share of loss of investments accounted for using the equity method																											(2,615)						(4)
Profit before tax																											178,804						318,688
Income tax expenses			7																								(66,254)						(12,972)
Net profit for the period																											112,550						305,716
Attributable to:
Owners of the Company																											112,441						305,626
Non-controlling interests																											108						89
Net profit for the period																											112,550						305,716
Earnings per share (JPY)
Basic earnings per share			8																								71.57						192.53
Diluted earnings per share			8																								70.45						189.52

See accompanying notes to condensed interim consolidated financial statements.

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(2) Condensed Interim Consolidated Statements of Comprehensive Income

									JPY (millions)
									Six-month Period Ended September 30,
									2025						2026
Net profit for the period									112,550						305,716
Other comprehensive income (loss)
Items that will not be reclassified to profit or loss:
Changes in fair value of financial assets measured at fair value through other comprehensive income									27,311						(8,867)
Remeasurement of defined benefit pension plans									757						3,140
									28,067						(5,727)
Items that may be reclassified subsequently to profit or loss:
Exchange differences on translation of foreign operations									204,959						(189,760)
Cash flow hedges									16,611						(6,937)
Hedging cost									3,458						3,919
Share of other comprehensive loss of investments accounted for using the equity method									(260)						(110)
									224,768						(192,888)
Other comprehensive income (loss) for the period, net of tax									252,835						(198,615)
Total comprehensive income for the period									365,385						107,101
Attributable to:
Owners of the Company									365,288						107,076
Non-controlling interests									97						25
Total comprehensive income for the period									365,385						107,101

See accompanying notes to condensed interim consolidated financial statements.

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(3) Condensed Interim Consolidated Statements of Financial Position

									JPY (millions)
			Note						As of March 31, 2026						As of September 30, 2026
ASSETS
Non-current assets:
Property, plant and equipment									2,120,639						2,281,914
Goodwill									5,809,010						5,684,518
Intangible assets									3,419,348						3,218,033
Investments accounted for using the equity method									8,796						8,617
Other financial assets									439,941						399,638
Other non-current assets									77,010						74,100
Deferred tax assets									546,260						607,522
Total non-current assets									12,421,004						12,274,342
Current assets:
Inventories									1,396,620						1,441,087
Trade and other receivables									844,312						872,682
Other financial assets									41,888						35,868
Income taxes receivable									32,036						37,563
Other current assets									162,638						178,077
Cash and cash equivalents									595,054						418,533
Assets held for sale									17,955						13,346
Total current assets									3,090,503						2,997,156
Total assets									15,511,506						15,271,498

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									JPY (millions)
			Note						As of March 31, 2026						As of September 30, 2026
LIABILITIES AND EQUITY
LIABILITIES
Non-current liabilities:
Bonds and loans			9						4,369,681						4,174,676
Other financial liabilities									571,248						781,767
Net defined benefit liabilities									143,683						132,188
Provisions									37,550						34,378
Other non-current liabilities									99,818						103,476
Deferred tax liabilities									26,804						24,287
Total non-current liabilities									5,248,784						5,250,773
Current liabilities:
Bonds and loans			9						512,157						400,974
Trade and other payables									491,345						486,196
Other financial liabilities									141,220						123,713
Income taxes payable									97,880						117,080
Provisions									998,501						962,143
Other current liabilities									590,152						512,675
Liabilities held for sale									818						769
Total current liabilities									2,832,074						2,603,549
Total liabilities									8,080,858						7,854,322
EQUITY
Share capital									1,695,277						1,722,947
Share premium									1,776,352						1,758,304
Treasury shares									(49,128)						(20,913)
Retained earnings									712,381						859,247
Other components of equity									3,297,407						3,099,816
Other comprehensive income associated with assets held for sale									(2,848)						(3,216)
Equity attributable to owners of the Company									7,429,441						7,416,185
Non-controlling interests									1,208						991
Total equity									7,430,649						7,417,176
Total liabilities and equity									15,511,506						15,271,498

See accompanying notes to condensed interim consolidated financial statements.

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(4) Condensed Interim Consolidated Statements of Changes in Equity

Six-month period ended September 30, 2025 (From April 1 to September 30, 2025)

									JPY (millions)
									Equity attributable to owners of the Company
									Share capital						Share premium						Treasury shares						Retained earnings						Other components of equity
			Note																														Exchange differences on translation of foreign operations						Changes in fair value of financial assets measured at fair value through other comprehensive income
As of April 1, 2025									1,694,685						1,775,713						(74,815)						1,187,586						2,419,978						4,757
Net profit for the period																											112,441
Other comprehensive income (loss)																																	204,710						27,311
Comprehensive income (loss) for the period									—						—						—						112,441						204,710						27,311
Transactions with owners:
Issuance of new shares									74						74
Acquisition of treasury shares															(20)						(51,610)
Dividends			10																								(154,411)
Transfers from other components of equity																											3,042												(2,285)
Share-based compensation															36,219
Exercise of share-based awards			10												(77,301)						77,301
Transfer to other comprehensive income associated with assets held for sale																																	3,595
Total transactions with owners									74						(41,028)						25,691						(151,369)						3,595						(2,285)
As of September 30, 2025									1,694,759						1,734,685						(49,124)						1,148,658						2,628,283						29,782

									Equity attributable to owners of the Company
									Other components of equity																								Other comprehensive income related to assets held for sale						Total equity attributable to owners of the Company
			Note						Cash flow hedges						Hedging cost						Remeasurements of defined benefit pension plans						Total other components of equity																		Non- controlling interests						Total equity
As of April 1, 2025									(64,852)						(7,967)						—						2,351,915						—						6,935,084						895						6,935,979
Net profit for the period																											—												112,441						108						112,550
Other comprehensive income (loss)									16,611						3,458						757						252,847												252,847						(11)						252,835
Comprehensive income (loss) for the period									16,611						3,458						757						252,847						—						365,288						97						365,385
Transactions with owners:
Issuance of new shares																											—												148												148
Acquisition of treasury shares																											—												(51,630)												(51,630)
Dividends			10																								—												(154,411)												(154,411)
Transfers from other components of equity																					(757)						(3,042)												—												—
Share-based compensation																											—												36,219												36,219
Exercise of share-based awards			10																								—												—												—
Transfer to other comprehensive income associated with assets held for sale																											3,595						(3,595)						—												—
Total transactions with owners									—						—						(757)						553						(3,595)						(169,674)						—						(169,674)
As of September 30, 2025									(48,241)						(4,509)						—						2,605,315						(3,595)						7,130,697						992						7,131,690

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Six-month period ended September 30, 2026 (From April 1 to September 30, 2026)

									JPY (millions)
									Equity attributable to owners of the Company
									Share capital						Share premium						Treasury shares						Retained earnings						Other components of equity
			Note																														Exchange differences on translation of foreign operations						Changes in fair value of financial assets measured at fair value through other comprehensive income
As of April 1, 2026									1,695,277						1,776,352						(49,128)						712,381						3,326,132						11,986
Net profit for the period																											305,626
Other comprehensive income (loss)																																	(198,399)						(8,867)
Comprehensive income (loss) for the period									—						—						—						305,626						(198,399)						(8,867)
Transactions with owners:
Issuance of new shares			10						27,669						27,669
Acquisition of treasury shares																					(1,014)
Dividends			10																								(158,169)
Transfers from other components of equity																											(591)												3,731
Share-based compensation															37,956
Exercise of share-based awards			10												(83,673)						29,229
Transfer to other comprehensive income associated with assets held for sale																																	8,961
Total transactions with owners									27,669						(18,047)						28,215						(158,760)						8,961						3,731
As of September 30, 2026									1,722,947						1,758,304						(20,913)						859,247						3,136,695						6,851

									Equity attributable to owners of the Company
									Other components of equity																								Other comprehensive income related to assets held for sale						Total equity attributable to owners of the Company
			Note						Cash flow hedges						Hedging cost						Remeasurements of defined benefit pension plans						Total other components of equity																		Non- controlling interests						Total equity
As of April 1, 2026									(35,903)						(4,808)						—						3,297,407						(2,848)						7,429,441						1,208						7,430,649
Net profit for the period																											—												305,626						89						305,716
Other comprehensive income (loss)									(6,937)						3,919						3,140						(207,143)						8,593						(198,550)						(64)						(198,615)
Comprehensive income (loss) for the period									(6,937)						3,919						3,140						(207,143)						8,593						107,076						25						107,101
Transactions with owners:
Issuance of new shares			10																								—												55,339												55,339
Acquisition of treasury shares																											—												(1,014)												(1,014)
Dividends			10																								—												(158,169)						(242)						(158,411)
Transfers from other components of equity																					(3,140)						591												—												—
Share-based compensation																											—												37,956												37,956
Exercise of share-based awards			10																								—												(54,444)												(54,444)
Transfer to other comprehensive income associated with assets held for sale																											8,961						(8,961)						—												—
Total transactions with owners									—						—						(3,140)						9,553						(8,961)						(120,332)						(242)						(120,574)
As of September 30, 2026									(42,840)						(889)						—						3,099,816						(3,216)						7,416,185						991						7,417,176

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(5) Condensed Interim Consolidated Statements of Cash Flows

									JPY (millions)
									Six-month Period Ended September 30,
			Notes						2025						2026
Cash flows from operating activities:
Net profit for the period									112,550						305,716
Depreciation and amortization									366,618						327,473
Impairment losses									87,143						30,855
Equity-settled share-based compensation									35,262						37,593
Loss on sales and disposal of property, plant and equipment									916						759
Loss (gain) on divestment of business and subsidiaries									(17,929)						2,074
Change in fair value of financial assets and liabilities associated with contingent consideration arrangements, net									989						30
Finance (income) and expenses, net									72,142						88,047
Share of loss of investments accounted for using the equity method									2,615						4
Income tax expenses									66,254						12,972
Changes in assets and liabilities:
Decrease (increase) in trade and other receivables									38,286						(30,320)
Increase in inventories									(42,031)						(75,653)
Decrease in trade and other payables									(11,242)						(13,636)
Increase (decrease) in provisions									8,533						(21,707)
Decrease in other financial liabilities									(5,309)						(28,569)
Settlement of forward exchange contracts, net									75,364						(16,126)
Other, net									(110,154)						(114,298)
Cash generated from operations									680,006						505,215
Income taxes paid									(91,891)						(77,247)
Tax refunds and interest on tax refunds received									5,535						3,923
Net cash from operating activities									593,651						431,890
Cash flows from investing activities:
Interest received									7,726						9,222
Dividends received									584						233
Acquisition of property, plant and equipment									(88,008)						(98,501)
Proceeds from sales of property, plant and equipment									6,385						1,459
Acquisition of intangible assets									(39,885)						(60,457)
Acquisition of investments									(229)						(1,122)
Proceeds from sales and redemption of investments									4,010						17,402
Acquisition of shares in associates									(623)						(200)
Proceeds from sales of shares in associates									686						—
Proceeds from sales of business, net of cash and cash equivalents divested									29,645						22,736
Settlement of forward exchange contracts designated as net investment hedges, net									(1,536)						—
Other, net									(82)						453
Net cash used in investing activities									(81,326)						(108,774)

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									JPY (millions)
									Six-month Period Ended September 30,
			Notes						2025						2026
Cash flows from financing activities:
Net decrease in short-term loans and commercial papers									(341,780)						—
Proceeds from issuance of bonds and long-term loans									526,060						—
Repayments of bonds and long-term loans									(125,385)						(239,624)
Acquisition of treasury shares									(51,603)						(1,007)
Interest paid									(52,296)						(66,447)
Dividends paid									(154,082)						(157,865)
Repayments of lease liabilities									(22,318)						(21,685)
Other, net									(5,476)						(4,742)
Net cash used in financing activities									(226,881)						(491,370)
Net increase (decrease) in cash and cash equivalents									285,444						(168,254)
Cash and cash equivalents at the beginning of the year									385,113						595,054
Effects of exchange rate changes on cash and cash equivalents									10,929						(8,267)
Cash and cash equivalents at the end of the period									681,486						418,533

See accompanying notes to condensed interim consolidated financial statements.

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Notes to Condensed Interim Consolidated Financial Statements

1.    Reporting Entity

Takeda Pharmaceutical Company Limited (the “Company”) is a public company incorporated in Japan. The Company and its subsidiaries (collectively, “Takeda”) has a diverse portfolio, engaged primarily in the research, development, production and global commercialization of pharmaceutical products. Takeda is a global R&D-driven biopharmaceutical company focused on discovering and delivering life-transforming treatments in our core therapeutic areas of gastrointestinal and inflammation, neuroscience and oncology, and through our plasma-derived therapies and vaccine business. Takeda’s principal pharmaceutical products are grouped into the following categories: Gastroenterology (“GI”), Rare Diseases, Plasma-Derived Therapies (“PDT”), Oncology, Vaccines and Neuroscience.

2.    Basis of Preparation

(1) Compliance with Interim Financial Reporting Standards

Takeda has prepared the condensed interim consolidated financial statements in accordance with IAS 34 “Interim Financial Reporting” as issued by the International Accounting Standards Board (“IASB”).

The condensed interim consolidated financial statements do not contain all the information required in consolidated financial statements as of the end of a fiscal year. Therefore, the condensed interim consolidated financial statements should be used with the consolidated financial statements as of and for the fiscal year ended March 31, 2026.

(2) Approval of Financial Statements

Takeda’s condensed interim consolidated financial statements as of and for the six-month period ended September 30, 2026 were approved on October 29, 2026 by Representative Director, President & Chief Executive Officer (“CEO”) Julie Kim and Director & Chief Financial Officer (“CFO”) Milano Furuta.

(3) Functional and Presentation Currency

The condensed interim consolidated financial statements are presented in Japanese Yen (“JPY”), which is the functional currency of the Company. All financial information presented in JPY has been rounded to the nearest million JPY, except when otherwise indicated. In tables with rounded figures, sums may not add up due to rounding.

(4) Use of Judgments, Estimates and Assumptions

The preparation of the condensed interim consolidated financial statements requires management to make certain judgments, estimates and assumptions that affect the application of accounting policies and the reported amounts of assets, liabilities, revenues and expenses, and the disclosure of contingent assets and liabilities. Actual results could differ from these estimates.

These estimates and underlying assumptions are reviewed on a continuous basis. Changes in these accounting estimates are recognized in the period in which the estimates are revised and in any future periods affected.

The condensed interim consolidated financial statements are prepared based on the same judgments and estimations as well as the accounting estimates and assumptions applied and described in Takeda’s consolidated financial statements as of and for the fiscal year ended March 31, 2026.

As of September 30, 2026 and through the issuance date of this report, Takeda concluded there was no indication of goodwill impairment.

3.    Material Accounting Policies

Material accounting policies adopted for the condensed interim consolidated financial statements are the same as those adopted for the consolidated financial statements as of and for the fiscal year ended March 31, 2026.

Takeda calculated income tax expenses for the six-month period ended September 30, 2026, based on the estimated average annual effective tax rate.

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4.    Operating Segment and Revenue Information

Takeda comprises a single operating segment and is engaged in the research, development, manufacturing, marketing and out-licensing of pharmaceutical products. This is consistent with how the financial information is viewed in allocating resources, measuring performance, and forecasting future periods by the CEO who is Takeda’s Chief Operating Decision Maker.

(1) Disaggregation of Revenue Information

Takeda’s revenue from contracts with customers is comprised of the following:

Revenue by Type of Good or Service

			JPY (millions)
			Six-month Period Ended September 30,
			2025						2026
Sales of pharmaceutical products			2,183,456						2,359,670
Out-licensing and service income			36,025						47,327
Total			2,219,481						2,406,997

Revenue by Business Area and Product

			JPY (millions)
			Six-month Period Ended September 30,
			2025						2026
Gastroenterology:
ENTYVIO			479,235						541,656
GATTEX/REVESTIVE			71,641						79,895
TAKECAB/VOCINTI *			68,948						76,041
DEXILANT			16,374						18,347
EOHILIA			4,250						4,372
Others			52,339						56,447
Total Gastroenterology			692,788						776,759
Rare Diseases:
TAKHZYRO			113,298						115,552
ELAPRASE			49,067						50,969
ADVATE			53,571						50,625
REPLAGAL			38,686						41,167
LIVTENCITY			22,111						28,786
ADYNOVATE/ADYNOVI			28,806						26,800
VONVENDI			11,399						15,874
ADZYNMA			4,850						8,836
Others			58,735						57,091
Total Rare Diseases			380,523						395,699
PDT:
Immunoglobulin			387,069						423,760
Albumin			66,127						69,123
Others			64,233						68,286
Total PDT			517,429						561,169
Oncology:
ADCETRIS			74,536						85,481
LEUPLIN/ENANTONE			58,634						63,874
NINLARO			41,432						44,136

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			JPY (millions)
			Six-month Period Ended September 30,
			2025						2026
ICLUSIG			34,471						37,148
FRUZAQLA			27,262						33,357
ALUNBRIG			17,773						19,622
Others			33,725						33,396
Total Oncology			287,834						317,014
Vaccines:
QDENGA			21,064						26,631
Others			10,593						10,011
Total Vaccines			31,657						36,643
Neuroscience:
VYVANSE/ELVANSE			106,551						105,590
TRINTELLIX			56,951						71,300
ADDERALL XR			10,587						10,346
Others			32,060						33,695
Total Neuroscience			206,149						220,932
Other:
FOSRENOL			4,803						3,653
AZILVA *			2,505						1,665
Others			95,794						93,463
Total Other			103,102						98,781
Total			2,219,481						2,406,997

* The figures include the amounts of fixed dose combinations and blister packs.

(2) Geographic Information

Takeda’s revenue from contracts with customers is based on the following geographic locations:

			JPY (millions)
			Six-month Period Ended September 30,
			2025						2026
Japan			219,060						213,869
U.S.			1,091,867						1,130,653
Europe*2			482,103						559,841
Latin America			118,518						144,543
China			92,653						106,206
Asia (excluding Japan & China)			47,799						54,552
Russia/CIS			43,190						52,785
Other*1, 2			124,290						144,546
Total			2,219,481						2,406,997

*1 Other includes Canada, the Middle East, Oceania and Africa. This disaggregation provides revenue attributable to countries and regions based on the customer location.

*2 Following the implementation of a new organizational structure, the geographical classification previously presented as “Europe and Canada” through the prior fiscal year has been revised to “Europe” from the current fiscal year, and revenue attributable to Canada is now included in “Other“. Accordingly, revenue for the six-month period ended September 30, 2025 in the above has been reclassified to conform to the presentation for the six-month period ended September 30, 2026.  Revenue by geographic region for the six-month period ended September 30, 2025 previously presented under “Europe and Canada” and “Other” amounted to JPY 535,202 million and JPY 71,191 million, respectively.

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5.    Amortization and impairment losses on intangible assets associated with products

The impairment losses recorded for the six-month period ended September 30, 2025 were JPY 76,042 million, which primarily included JPY 58,173 million of impairment charges related to the gamma delta T-cell therapy platform and associated Oncology program, and impairment charges for certain other in-process R&D assets, all of which were recorded following the decision to discontinue the related research and development activities.

The impairment losses recorded for the six-month period ended September 30, 2026 were immaterial.

6.    Other Operating Expenses

Other operating expenses for the six-month period ended September 30, 2025 included JPY 27,428 million of restructuring expenses, which mainly consisted of the costs related to the enterprise-wide efficiency program, and JPY 23,959 million of expenses recognized for the valuation reserve on pre-launch inventories.

Other operating expenses for the six-month period ended September 30, 2026 included JPY 79,822 million of restructuring expenses, which mainly consisted of the costs related to the transformation program.

7.    Income Tax Expenses

The effective tax rate for the six-month period ended September 30, 2026 was 4.1% compared to 37.1% for the six-month period ended September 30, 2025. The decrease in effective tax rate was primarily attributable to deferred tax benefits recognized in the six-month period ended September 30, 2026, reflecting a reassessment of the recoverability of deferred tax assets related to deductible temporary differences, as well as deferred tax benefits arising from capital losses generated through the restructuring of a subsidiary.

8.    Earnings per Share

The basis for calculating basic and diluted earnings per share (attributable to owners of the Company) is as follows:

			Six-month Period Ended September 30,
			2025						2026
Net profit for the period attributable to owners of the Company
Net profit for the period attributable to owners of the Company (million JPY)			112,441						305,626
Net profit used for calculation of earnings per share (million JPY)			112,441						305,626
Weighted average number of ordinary shares outstanding during the period (thousands of shares) [basic]			1,571,098						1,587,407
Dilutive effect (thousands of shares)			24,834						25,202
Weighted average number of ordinary shares outstanding during the period (thousands of shares) [diluted]			1,595,932						1,612,609
Earnings per share
Basic earnings per share (JPY)			71.57						192.53
Diluted earnings per share (JPY)			70.45						189.52

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9.    Bonds and Loans

During the six-month period ended September 30, 2026, Takeda had the following movements in the bonds and loans.

Bonds

Redemption

Instrument

Issuance Date

Redemption Date

Principal Amount in Contractual Currency

Unsecured US Dollar Denominated Senior Notes Assumed in Shire Acquisition

September 2016

September 23, 2026

USD 1,500 million

10.    Equity and Other Equity Items

(1) Issuance of shares and disposal of treasury shares

During the six-month period ended September 30, 2025, the Company disposed of 17,271 thousand treasury shares under the Long-Term Incentive Plan for Company Group Employees residing outside of Japan (“LTIP”). The disposal of treasury shares resulted in a decrease in treasury shares of JPY 73,760 million.

During the six-month period ended September 30, 2026, the Company issued 10,781 thousand shares of common stock and disposed of 6,096 thousand treasury shares under the LTIP. The issuance of these shares resulted in an increase in share capital of JPY 27,222 million and share premium of JPY 27,222 million. The disposal of treasury shares resulted in a decrease in treasury shares of JPY 26,037 million.

The shares of common stock issued and treasury shares disposed of were converted into the Company’s American Depositary Shares (ADSs) and delivered to employees.

(2) Dividends

Dividends declared and paid

Total dividends declared and paid JPY (millions)

Dividends per share (JPY)

Record date

Effective date

Six-month period ended September 30, 2025 (April 1, 2025 to September 30, 2025)

154,763

98.00

March 31, 2025

June 26, 2025

Six-month period ended September 30, 2026 (April 1, 2026 to September 30, 2026)

158,494

100.00

March 31, 2026

June 25, 2026

Dividends declared for which the effective date falls after September 30, 2026 are as follows:

Dividends declared

Total dividends declared  JPY (millions)

Dividends per share (JPY)

Record date

Effective date

For the fiscal year ending March 31, 2027 (April 1, 2026 to March 31, 2027)

163,406

102.00

September 30, 2026

December 1, 2026

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11.    Financial Instruments

(1) Fair Value Measurements

Derivative and non-derivative financial instruments measured at fair value are categorized in the following three-tier fair value hierarchy that reflects the significance of the inputs in making the measurements. Level 1 is defined as observable inputs, such as quoted prices in active markets for an identical asset or liability. Level 2 is defined as inputs other than quoted prices in active markets within Level 1 that are directly or indirectly observable. Level 3 is defined as unobservable inputs.

			JPY (millions)
As of September 30, 2026			Level 1						Level 2						Level 3						Total
Assets:
Financial assets measured at fair value through profit or loss
Derivatives			—						5,582						8,716						14,298
Investments in convertible notes			—						—						5,752						5,752
Investments in debt instruments			—						—						19,196						19,196
Financial assets associated with contingent consideration arrangements			—						—						10,006						10,006
Derivatives for which hedge accounting is applied			—						136,316						—						136,316
Financial assets measured at fair value through OCI
Trade and other receivables			—						102,579						—						102,579
Equity instruments			104,929						—						63,358						168,287
Investments in debt instruments			66,965						—						—						66,965
Total			171,894						244,478						107,026						523,398
Liabilities:
Financial liabilities measured at fair value through profit or loss
Derivatives			—						20,381						10,816						31,197
Financial liabilities associated with contingent consideration arrangements			—						—						4,083						4,083
Total			—						20,381						14,899						35,279

(2) Valuation Techniques

The fair value of derivatives classified as Level 2 is measured based on Treasury management system valuation models or the Black-Scholes model, whose significant inputs are based on observable market data.

Derivatives classified as Level 3 include those recognized in connection with settlements of cash flows arising from differences between the fixed prices and floating market prices of renewable energy in a virtual power purchase agreement and those recognized in an agreement to offset the volatility of such cash flows. The fair value of derivatives in Level 3 is measured using the discounted cash flow method. The key assumptions taken into account include forecasted renewable energy prices and the expected generation of the renewable energy generating facility.

The fair value of the investment in convertible notes is measured using techniques such as the discounted cash flow and option pricing models.

The fair value of trade and other receivables, which are due from customers that Takeda has the option to factor, are measured based on the invoiced amount.

Equity instruments and investments in debt instruments are not held for trading. If equity instruments or investments in debt instruments are quoted in an active market, the fair value is based on price quotations at the period-end-date. If equity instruments or investments in debt instruments are not quoted in an active market, the fair value is calculated utilizing an adjusted book value per share method or EBITDA multiples approach based on available information as of each period-end-date and comparable companies. The principal input that is not observable and utilized for the calculation of the fair value of equity instruments and investments in debt instruments classified as Level 3 is the EBITDA multiple used for the EBITDA multiples approach, which ranges from 5.3 times to 9.4 times.

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Financial assets and liabilities associated with contingent consideration arrangements are measured at fair value at the time of the divestiture or the acquisition date of business combination. When the contingent consideration arrangement meets the definition of a financial asset or liability, it is subsequently re-measured at fair value at each closing date. The determination of the fair value is based on models such as scenario-based methods and discounted cash flows. The key assumptions take into consideration the probability of meeting each performance target, forecasted revenue projections, and the discount factor. The financial assets associated with contingent consideration arrangements are recognized mainly in relation to the divestiture of XIIDRA. The financial liabilities associated with contingent consideration arrangements are discussed in Note (5) Financial liabilities associated with contingent consideration arrangements.

The fair value of the other financial liabilities is measured using the discounted cash flow model.

(3) Transfers between levels

There were no significant transfers between levels of the fair value hierarchy during the six-month period ended September 30, 2026.

(4) Level 3 fair values

Takeda invests in equity instruments mainly for research collaboration. The following table shows a reconciliation from the opening balances to the closing balances for Level 3 financial asset fair values for the six-month period ended September 30, 2026. The disclosure related to Level 3 financial liabilities which are financial liabilities associated with contingent consideration arrangements is included in (5) Financial liabilities associated with contingent consideration arrangements. There were no significant changes in the fair values of Level 3 financial assets resulting from changes in key assumptions used in their fair value measurements.

			JPY (millions)
			Six-month Period Ended September 30, 2026
			Financial assets associated with contingent consideration arrangements						Equity instruments
As of the beginning of the period			10,488						66,306
Changes recognized as finance income or finance expenses			(313)						—
Changes in fair value of financial assets measured at fair value through OCI and exchange differences on translation of foreign operations			(169)						(4,303)
Purchases			—						1,359
Sales			—						(4)
As of the end of the period			10,006						63,358

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(5) Financial liabilities associated with contingent consideration arrangements

Financial liabilities associated with contingent consideration arrangements represent consideration related to business combinations or license agreements that are payable only upon future events such as the achievement of development milestones and sales targets, including pre-existing contingent consideration arrangements of the companies that are acquired by Takeda. At each reporting date, the fair value of financial liabilities associated with contingent consideration arrangements is re-measured based on risk-adjusted future cash flows discounted using an appropriate discount rate.

As of September 30, 2026, the balance primarily relates to pre-existing contingent consideration arrangements from historical acquisitions.

The fair value of financial liabilities associated with contingent consideration arrangements could increase or decrease due to changes in certain assumptions which underpin the fair value measurements. The assumptions include probability of milestones being achieved.

The fair value of financial liabilities associated with contingent consideration arrangements is classified as Level 3 in the fair value hierarchy. The following table shows a reconciliation from the opening balances to the closing balances for financial liabilities associated with contingent consideration arrangements for the six-month period ended September 30, 2026. There were no significant changes in the fair values of financial liabilities associated with contingent consideration arrangements resulting from changes in the key assumptions used in their fair value measurements.

			JPY (millions)
			Six-month Period Ended September 30, 2026
As of the beginning of the period			3,185
Changes in the fair value during the period			34
Settled during the period			(26)
Foreign currency translation differences			889
As of the end of the period			4,083

(6) Financial instruments not measured at fair value

The carrying amount and fair value of financial instruments that are not measured at fair value in the condensed interim consolidated statements of financial position are as follows. Fair value information is not provided for financial instruments, if the carrying amount is a reasonable estimate of fair value due to the relatively short period of maturity of these instruments.

			JPY (millions)
			As of September 30, 2026
			Carrying amount						Fair value
Bonds			4,350,650						3,834,918
Long-term loans			225,000						213,978

Long-term financial liabilities are recognized at their carrying amount. The fair value of bonds is measured at quotes whose significant inputs to the valuation model used are based on observable market data. The fair value of loans is measured at the present value of future cash flows discounted using the applicable market rate on the loans in consideration of the credit risk by each group classified in a specified period. The fair value of bonds and long-term loans are classified as Level 2 in the fair value hierarchy.

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12.    Commitments and Contingent Liabilities

Litigation

Takeda is involved in various legal and administrative proceedings. There were no significant updates during the six-month period ended September 30, 2026, except for the matter below.

Intellectual property

ENTYVIO Patent Revocation and Infringement Actions

Since February 2026, third parties have brought patent revocation proceedings in several countries in Europe against certain patents owned by Takeda relating to ENTYVIO, including patents covering aspects of intravenous (“IV”) and subcutaneous (“SC”) dosing and certain IV and SC formulations. These proceedings are ongoing and still at an early stage.

Separately, beginning in August 2026, Takeda has filed patent infringement actions in the United States and Canada relating to proposed biosimilar products for the IV and SC formulations of ENTYVIO. These proceedings are ongoing and still at an early stage.

13.    Subsequent Events

Not applicable.

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2. Others

Interim Dividend

In accordance with the provision of Article 29 of the Articles of Incorporation of the Company, Takeda made the following resolution on an interim dividend for the 150th fiscal year (from April 1, 2026 to March 31, 2027) at the meeting of the Board of Directors held on October 29, 2026.

(a)			Total amount of interim dividends			JPY 163,406,367,216
(b)			Interim dividend per share			JPY 102.00
(c)			Effective date/ Payment start date			December 1, 2026

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B. Information on Guarantors of the Company

Not applicable.

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