STOCK TITAN

TG Therapeutics (NASDAQ: TGTX) lifts 2026 BRIUMVI sales and revenue guidance

Filing Impact
(High)
Filing Sentiment
(Neutral)
Form Type
8-K

Rhea-AI Filing Summary

TG Therapeutics reported sharply improved first quarter 2026 results, driven by strong uptake of BRIUMVI for multiple sclerosis. Total revenue reached $204.9 million, up from $120.9 million a year earlier, producing operating income of $34.8 million and net income of $19.8 million.

Product revenue, mainly from BRIUMVI, was $201.3 million, while cash, cash equivalents and investment securities grew to $572.8 million as of March 31, 2026. Despite higher research, selling, general and administrative expenses, profitability and cash balances increased.

Reflecting this momentum, the company raised its full-year 2026 total global revenue target to about $925 million and increased its BRIUMVI U.S. net product revenue guidance to $885–900 million, signaling confidence in ongoing demand and commercial execution.

Positive

  • Strong top-line growth and profitability: Q1 2026 total revenue rose to $204.9 million from $120.9 million, with operating income increasing to $34.8 million and net income to $19.8 million, indicating a meaningful earnings inflection.
  • Material 2026 revenue guidance increase: The company raised its full-year 2026 total global revenue target to about $925 million and lifted BRIUMVI U.S. net product revenue guidance to $885–900 million, reflecting confidence in sustained demand.

Negative

  • None.

Insights

Revenue and earnings inflect higher as BRIUMVI outperforms, prompting a sizable 2026 guidance raise.

TG Therapeutics delivered Q1 2026 revenue of $204.9M, up from $120.9M, with operating income rising to $34.8M. The business is now clearly leveraging BRIUMVI’s commercial ramp, moving from a small profit base in 2025 to more meaningful earnings power.

Management raised full-year 2026 total global revenue guidance to roughly $925M and BRIUMVI U.S. net product revenue guidance to $885–900M. That guidance reset, tied directly to stronger-than-expected demand and record new patient starts, suggests confidence in the durability of current trends.

Costs are also scaling: selling, general and administrative expense climbed to $88.2M, and there was a $9.2M loss on extinguishment of debt. However, with cash and investments of $572.8M as of March 31, 2026, the balance sheet appears stronger, providing flexibility as the company advances its subcutaneous BRIUMVI and broader pipeline programs.

Item 2.02 Results of Operations and Financial Condition Financial
Disclosure of earnings results, typically an earnings press release or preliminary financials.
Item 9.01 Financial Statements and Exhibits Exhibits
Financial statements, pro forma financial information, and exhibit attachments filed with this report.
Total revenue Q1 2026 $204.9M Three months ended March 31, 2026
Product revenue Q1 2026 $201.3M Net product revenue for three months ended March 31, 2026
Net income Q1 2026 $19.8M Three months ended March 31, 2026
Diluted EPS Q1 2026 $0.12/share Diluted net income per common share, quarter ended March 31, 2026
Cash and investments $572.8M Cash, cash equivalents and investment securities as of March 31, 2026
Total 2026 global revenue target $925M Raised full-year 2026 total global revenue guidance
2026 BRIUMVI U.S. guidance $885–900M Raised full-year 2026 BRIUMVI U.S. net product revenue target
Total costs and expenses Q1 2026 $170.1M Three months ended March 31, 2026
loss on extinguishment of debt financial
"Loss on extinguishment of debt | | | 9,153 | | | | — |"
Loss on extinguishment of debt is the accounting hit a company records when it retires or restructures a loan or bond for an amount that exceeds the debt’s recorded value—like paying more than the remaining balance to settle a loan early. It matters to investors because it reduces reported profit and can use cash, but may also cut future interest costs or signal financial stress; understanding it helps assess earnings quality and balance-sheet strength.
glycoengineering technical
"Removal of these sugar molecules, a process called glycoengineering, allows for efficient B-cell depletion"
Progressive Multifocal Leukoencephalopathy (PML) medical
"Progressive Multifocal Leukoencephalopathy (PML): PML is an opportunistic viral infection of the brain"
relapsing multiple sclerosis (RMS) medical
"BRIUMVI is indicated in the U.S. for the treatment of adults with RMS"
A chronic neurological condition in which the body's immune system periodically damages the protective coating around nerve fibers in the brain and spinal cord, causing episodes of symptoms that come and go (relapses) and sometimes gradually worsen. For investors, relapsing multiple sclerosis matters because it defines the market for therapies, clinical trial design and regulatory approval paths, and can drive demand for drugs or diagnostics much like recurring faults in an electrical system create ongoing need for repairs and upgrades.
stock-based compensation financial
"Stock-based compensation | | | 15,075 | | | | 11,640 |"
Stock-based compensation is when a company pays employees, directors or consultants with shares or the right to buy shares instead of or in addition to cash. It matters to investors because issuing stock or options spreads ownership thinner (like cutting a pie into more slices), which can reduce each existing share’s claim on profits and can also change reported earnings; investors watch it to assess true cost of running the business and how management is incentivized.
Total revenue $204.9M vs $120.9M in Q1 2025
Net income $19.8M vs $5.1M in Q1 2025
Diluted EPS $0.12 vs $0.03 in Q1 2025
Guidance

Full-year 2026 total global revenue target about $925M; BRIUMVI U.S. net product revenue guidance $885–900M.

false 0001001316 0001001316 2026-05-06 2026-05-06
 ​​


 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
 

 
FORM 8-K
 

 
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934
 
Date of report (Date of earliest event reported): May 6, 2026
 
TG Therapeutics, Inc.
(Exact Name of Registrant as Specified in Charter)
 
Delaware
001-32639
36-3898269
(State or Other Jurisdiction
(Commission File Number)
(IRS Employer Identification No.)
of Incorporation)
 ​
3020 Carrington Mill Blvd, Suite 475
Morrisville, North Carolina 27560
(Address of Principal Executive Offices)
 
(212) 554-4484
(Registrant’s telephone number, including area code)
 
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
 
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
 
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
 
Pre-commencement communications pursuant to Rule 14d-2b under the Exchange Act (17 CFR 240.14d-2(b))
 
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))
 
Securities filed pursuant to Section 12(b) of the Act:
 
Title of Class
Trading Symbol(s)
Exchange Name
Common Stock
TGTX
Nasdaq Capital Market
 ​
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company
 
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
 

 
 
Item 2.02. Results of Operations and Financial Condition.
 ​
On May 6, 2026, the Company issued a press release announcing results of operations for the three months ended March 31, 2026. A copy of such press release is being furnished as Exhibit 99.1.
 
In accordance with General Instruction B.2 of Form 8-K, the information included in Item 2.02 of this Current Report on Form 8-K (including Exhibit 99.1 hereto), shall not be deemed “filed” for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference into any filing made by the Company under the Exchange Act or Securities Act of 1933, as amended, except as shall be expressly set forth by specific reference in such a filing.
 
Item 9.01. Financial Statements and Exhibits.
 
(d) Exhibits
 
Exhibit No.
 
Description
     
99.1
 
Press release issued by TG Therapeutics, Inc., dated May 6, 2026.
     
104
 
The cover page from this Current Report on Form 8-K formatted in Inline XBRL.
 ​
 

 
 
SIGNATURES
 
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
 
TG Therapeutics, Inc.
(Registrant)
Date: May 6, 2026
By:
/s/ Sean A. Power
Sean A. Power
Chief Financial Officer
 ​
 

Exhibit 99.1

 

TG Therapeutics Reports First Quarter 2026 Financial Results and Raises BRIUMVI Revenue Guidance

 

First quarter 2026 total global revenue of approximately $205 million, including BRIUMVI U.S. net revenue of approximately $195 million

 

Raises full year 2026 total global revenue target to approximately $925 million and raises full year 2026 BRIUMVI U.S. net product revenue target to $885-900 million

 

Conference call to be held today, Wednesday, May 6, 2026, at 8:30 AM ET

 

New York, NY, (May 6, 2026) – TG Therapeutics, Inc. (NASDAQ: TGTX) (the Company or TG Therapeutics) today announced its financial results for the first quarter of 2026, along with recent company developments and provided an update on 2026 financial guidance.

 

Michael S. Weiss, the Company’s Chairman and Chief Executive Officer, stated, “We are off to a strong start in 2026, with BRIUMVI performance exceeding expectations and momentum continuing to build. Growth is being driven by strong underlying demand, record new patient starts, and consistent commercial execution— reinforcing our belief that we remain early in the adoption curve for BRIUMVI. Based on this performance, we are significantly increasing our full-year U.S. BRIUMVI revenue guidance to $885-900 million and continue to see the brand as having a multi-billion-dollar potential before considering the impact of a subcutaneous BRIUMVI currently under development. With multiple near-term clinical catalysts and ongoing efforts to expand the franchise, we believe BRIUMVI is well-positioned to become a leading therapy in MS and a durable, long-term growth driver for TG.”

 

Recent Highlights & Developments

 

 

BRIUMVI® (ublituximab-xiiy) Commercialization

 

BRIUMVI U.S. net product revenue of $194.8 million for the first quarter 2026, representing approximately 63% quarterly growth over the same period last year

 

BRIUMVI Data Presentations & Publications

 

Published two articles in medical journals:

 

o

March 2026: “Efficacy of Ublituximab in People with Highly Active Relapsing Multiple Sclerosis”, published in Neurology and Therapy, highlighting data from a post hoc pooled analysis of the Phase 3 ULTIMATE I and II studies evaluating BRIUMVI in people with highly active RMS.

 

o

February 2026: “Five Years of Ublituximab in Multiple Sclerosis: ULTIMATE I and II Open-Label Extension (OLE) Study”, published in JAMA Neurology, highlighting five-year data from the OLE of the ULTIMATE I and II trials.

Pipeline

 

Completed patient enrollment into the randomized Phase 3 pivotal program evaluating subcutaneous BRIUMVI

 

Completed patient enrollment into the randomized Phase 3 pivotal program to evaluate a consolidated Day 1 and Day 15 dosing regimen for intravenous (IV) BRIUMVI in the ongoing ENHANCE trial

 

Continued enrollment for patients with progressive multiple sclerosis into the ongoing Phase 1 clinical trial evaluating azer-cel for the treatment of autoimmune diseases

 

Financial Update

 

Secured an additional $500 million in non-dilutive capital from Blue Owl Capital and expanded our second share repurchase program from $100 million to $300 million, of which $200 million is remaining

 

Since the inception of the first share repurchase program in 2024, and as of April 30, 2026, TG has repurchased a total of $200 million of common stock at an average price of $29.28 per share, of which $100 million was completed during the first quarter of 2026

 

 

 

2026 Financial Guidance

 

Raises full year 2026 target total global revenue to approximately $925 million

 

Raises full year 2026 target BRIUMVI U.S. net product revenue to approximately $885 - $900 million (prior guidance of $825-$850 million)

 

Provides second quarter 2026 target BRIUMVI U.S. net product revenue of approximately $220 million

 

Full year 2026 target operating expense, defined as R&D and SG&A, of approximately $350 million excluding non-cash compensation, in addition to approximately $100 million in expenses associated with the subcutaneous BRIUMVI manufacturing costs and secondary manufacturer start-up costs

 

2026 Development Pipeline Anticipated Milestones 

 

Announce topline Phase 3 data for ENHANCE trial combining Day 1 and Day 15 doses of IV BRIUMVI mid-year 2026

 

Present preliminary Phase 1 azer-cel data in Progressive MS in the second half of 2026

 

Announce topline Phase 3 data for subcutaneous BRIUMVI (ublituximab) year-end 2026/first quarter 2027

 

Commence a potentially registration-directed trial for BRIUMVI in Myasthenia Gravis (MG)

 

Commence additional exploratory studies for BRIUMVI and azer-cel in autoimmune disease (outside MS) 

 

Financial Results for First Quarter 2026

 

Product Revenue, net: Product revenue, net was $201.3 million for the three months ended March 31, 2026, compared to $119.7 million for the three months ended March 31, 2025. Product revenue, net consists primarily of net product sales of BRIUMVI in the United States, which totaled $194.8 million during the three months ended March 31, 2026. Also included in product revenue, net for the three months ended March 31, 2026 is sales of BRIUMVI to our ex-U.S. licensing partner, Neuraxpharm, of $6.5 million.

 

License, milestone, royalty and other revenue: License, milestone, royalty and other revenue was approximately $3.6 million for the three months ended March 31, 2026 compared to approximately $1.2 million for the three months ended March 31, 2025. License, milestone, royalty and other revenue for the three months ended March 31, 2026 is predominantly comprised of $2.7 million of royalty revenue recognized under the Commercialization Agreement with Neuraxpharm and $0.9 million of consideration received for development and regulatory activities performed on behalf of Neuraxpharm in accordance with the Commercialization Agreement.

 

R&D Expenses: Total research and development (R&D) expense was approximately $48.4 million for the three months ended March 31, 2026, compared to $46.4 million for the three months ended March 31, 2025. The increase in R&D expense during the three months ended March 31, 2026 was primarily attributable to license and milestone expense pertaining to our license agreement with Precision BioSciences, Inc., as well as increased clinical trial related expenses and increased personnel costs during the period ended March 31, 2026. These increases were partially offset by lower manufacturing and development costs in connection with our subcutaneous ublituximab development work incurred during the period ended March 31, 2026.

 

SG&A Expenses: Total selling, general and administrative (SG&A) expense was approximately $88.2 million for the three months ended March 31, 2026, compared to $50.3 million for the three months ended March 31, 2025. The increase in selling, general and administrative costs during the three months ended March 31, 2026 was primarily due to an increase in marketing and media spend, and personnel and external costs associated with the commercialization of BRIUMVI.

 

Net income: Net income was $19.8 million for the three months ended March 31, 2026, compared to net income of $5.1 million for the three months ended March 31, 2025.

 

Cash Position and Financial Guidance: Cash, cash equivalents and investment securities were $572.8 million as of March 31, 2026. We anticipate that our cash, cash equivalents and investment securities as of March 31, 2026, combined with the projected revenues from BRIUMVI, will be sufficient to fund our business based on our current operating plan.

 

 

 

CONFERENCE CALL INFORMATION
The Company will host a conference call today, May 6, 2026, at 8:30 AM ET, to discuss the Company’s financial results from first quarter of 2026.

 

To participate in the conference call, please call 1-877-407-8029 (U.S.), 1-201-689-8029 (outside the U.S.), Conference Title: TG Therapeutics. A live audio webcast will be available on the Events page, located within the Investors & Media section, of the Company's website at http://ir.tgtherapeutics.com/events. An audio recording of the conference call will also be available for a period of 30 days after the call.

 

ABOUT BRIUMVI® (ublituximab-xiiy) 150 mg/6 mL Injection for IV
BRIUMVI is a novel monoclonal antibody that targets a unique epitope on CD20-expressing B-cells. Targeting CD20 using monoclonal antibodies has proven to be an important therapeutic approach for the management of autoimmune disorders, such as RMS. BRIUMVI is uniquely designed to lack certain sugar molecules normally expressed on the antibody. Removal of these sugar molecules, a process called glycoengineering, allows for efficient B-cell depletion at low doses.

BRIUMVI is indicated in the U.S. for the treatment of adults with RMS, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease and in several countries outside of the U.S. for the treatment of adult patients with RMS with active disease defined by clinical or imaging features.

 

A list of authorized specialty distributors can be found at www.briumvi.com.

 

IMPORTANT SAFETY INFORMATION

 

Contraindications: BRIUMVI is contraindicated in patients with:

 

Active Hepatitis B Virus infection

 

A history of life-threatening infusion reaction to BRIUMVI

 

WARNINGS AND PRECAUTIONS

 

Infusion Reactions: BRIUMVI can cause infusion reactions, which can include pyrexia, chills, headache, influenza-like illness, tachycardia, nausea, throat irritation, erythema, and an anaphylactic reaction. In MS clinical trials, the incidence of infusion reactions in BRIUMVI-treated patients who received infusion reaction-limiting premedication prior to each infusion was 48%, with the highest incidence within 24 hours of the first infusion. 0.6% of BRIUMVI-treated patients experienced infusion reactions that were serious, some requiring hospitalization.

 

Observe treated patients for infusion reactions during the infusion and for at least one hour after the completion of the first two infusions unless infusion reaction and/or hypersensitivity has been observed in association with the current or any prior infusion. Inform patients that infusion reactions can occur up to 24 hours after the infusion. Administer the recommended pre-medication to reduce the frequency and severity of infusion reactions. If life-threatening, stop the infusion immediately, permanently discontinue BRIUMVI, and administer appropriate supportive treatment. Less severe infusion reactions may involve temporarily stopping the infusion, reducing the infusion rate, and/or administering symptomatic treatment.

 

Infections: Serious, life-threatening or fatal, bacterial and viral infections have been reported in BRIUMVI-treated patients. In MS clinical trials, the overall rate of infections in BRIUMVI-treated patients was 56% compared to 54% in teriflunomide-treated patients. The rate of serious infections was 5% compared to 3% respectively. There were 3 infection-related deaths in BRIUMVI-treated patients. The most common infections in BRIUMVI-treated patients included upper respiratory tract infection (45%) and urinary tract infection (10%). Delay BRIUMVI administration in patients with an active infection until the infection is resolved.

 

Consider the potential for increased immunosuppressive effects when initiating BRIUMVI after immunosuppressive therapy or initiating an immunosuppressive therapy after BRIUMVI.

 

Hepatitis B Virus (HBV) Reactivation: HBV reactivation occurred in an MS patient treated with BRIUMVI in clinical trials. Fulminant hepatitis, hepatic failure, and death caused by HBV reactivation have occurred in patients treated with anti-CD20 antibodies. Perform HBV screening in all patients before initiation of treatment with BRIUMVI. Do not start treatment with BRIUMVI in patients with active HBV confirmed by positive results for HB surface antigen (HBsAg) and anti-HB tests. For patients who are negative for HBsAg and positive for HB core antibody [HBcAb+] or are carriers of HBV [HBsAg+], consult a liver disease expert before starting and during treatment.

 

Progressive Multifocal Leukoencephalopathy (PML): PML is an opportunistic viral infection of the brain caused by the JC virus (JCV) that typically only occurs in patients who are immunocompromised, and that usually leads to death or severe disability. JCV infection resulting in PML has been observed in patients treated with anti-CD20 antibodies, including BRIUMVI, and other MS therapies.

 

If PML is suspected, withhold BRIUMVI and perform an appropriate diagnostic evaluation. Typical symptoms associated with PML are diverse, progress over days to weeks, and include progressive weakness on one side of the body or clumsiness of limbs, disturbance of vision, and changes in thinking, memory, and orientation leading to confusion and personality changes.

 

MRI findings may be apparent before clinical signs or symptoms; monitoring for signs consistent with PML may be useful. Further investigate suspicious findings to allow for an early diagnosis of PML, if present. Following discontinuation of another MS medication associated with PML, lower PML-related mortality and morbidity have been reported in patients who were initially asymptomatic at diagnosis compared to patients who had characteristic clinical signs and symptoms at diagnosis.

 

If PML is confirmed, treatment with BRIUMVI should be discontinued.

 

 

 

Vaccinations: Administer all immunizations according to immunization guidelines: for live or live-attenuated vaccines, at least 4 weeks and, whenever possible, at least 2 weeks prior to initiation of BRIUMVI for non-live vaccines. BRIUMVI may interfere with the effectiveness of non-live vaccines. The safety of immunization with live or live-attenuated vaccines during or following administration of BRIUMVI has not been studied. Vaccination with live virus vaccines is not recommended during treatment and until B-cell repletion.

 

Vaccination of Infants Born to Mothers Treated with BRIUMVI During Pregnancy: In infants of mothers exposed to BRIUMVI during pregnancy, assess B-cell counts prior to administration of live or live-attenuated vaccines as measured by CD19+ B-cells. Depletion of B-cells in these infants may increase the risks from live or live-attenuated vaccines. Inactivated or non-live vaccines may be administered prior to B-cell recovery. Assessment of vaccine immune responses, including consultation with a qualified specialist, should be considered to determine whether a protective immune response was mounted.

 

Fetal Risk: Based on data from animal studies, BRIUMVI may cause fetal harm when administered to a pregnant woman. Transient peripheral B-cell depletion and lymphocytopenia have been reported in infants born to mothers exposed to other anti-CD20 B-cell depleting antibodies during pregnancy. Advise females of reproductive potential to use effective contraception during BRIUMVI treatment and for 6 months after the last dose.

 

Reduction in Immunoglobulins: As expected with any B-cell depleting therapy, decreased immunoglobulin levels were observed. Decrease in immunoglobulin M (IgM) was reported in 0.6% of BRIUMVI-treated patients compared to none of the patients treated with teriflunomide in RMS clinical trials. Monitor the levels of quantitative serum immunoglobulins during treatment, especially in patients with opportunistic or recurrent infections, and after discontinuation of therapy, until B-cell repletion. Consider discontinuing BRIUMVI therapy if a patient with low immunoglobulins develops a serious opportunistic infection or recurrent infections, or if prolonged hypogammaglobulinemia requires treatment with intravenous immunoglobulins.

 

Liver Injury: Clinically significant liver injury, without findings of viral hepatitis, has been reported in the postmarketing setting in patients treated with anti-CD20 B-cell depleting therapies approved for the treatment of MS, including BRIUMVI. Signs of liver injury, including markedly elevated serum hepatic enzymes with elevated total bilirubin, have occurred from weeks to months after administration.

 

Patients treated with BRIUMVI found to have an alanine aminotransaminase (ALT) or aspartate aminotransferase (AST) greater than 3x the upper limit of normal (ULN) with serum total bilirubin greater than 2x ULN are potentially at risk for severe drug-induced liver injury.

 

Obtain liver function tests prior to initiating treatment with BRIUMVI, and monitor for signs and symptoms of any hepatic injury during treatment. Measure serum aminotransferases, alkaline phosphatase, and bilirubin levels promptly in patients who report symptoms that may indicate liver injury, including new or worsening fatigue, anorexia, nausea, vomiting, right upper abdominal discomfort, dark urine, or jaundice. If liver injury is present and an alternative etiology is not identified, discontinue BRIUMVI.

 

Most Common Adverse Reactions: The most common adverse reactions in RMS trials (incidence of at least 10%) were infusion reactions and upper respiratory tract infections.

 

Physicians, pharmacists, or other healthcare professionals with questions about BRIUMVI should visit www.briumvi.com.

 

ABOUT BRIUMVI PATIENT SUPPORT in the U.S.
BRIUMVI Patient Support is a flexible program designed by TG Therapeutics to support U.S. patients through their treatment journey in a way that works best for them. More information about the BRIUMVI Patient Support program can be accessed at www.briumvipatientsupport.com.

 

ABOUT MULTIPLE SCLEROSIS
Relapsing multiple sclerosis (RMS) is a chronic demyelinating disease of the central nervous system (CNS) and includes people with relapsing-remitting multiple sclerosis (RRMS) and people with secondary progressive multiple sclerosis (SPMS) who continue to experience relapses. RRMS is the most common form of multiple sclerosis (MS) and is characterized by episodes of new or worsening signs or symptoms (relapses) followed by periods of recovery. It is estimated that nearly 1 million people are living with MS in the United States and approximately 85% are initially diagnosed with RRMS.1,2 The majority of people who are diagnosed with RRMS will eventually transition to SPMS, in which they experience steadily worsening disability over time. Worldwide, more than 2.3 million people have a diagnosis of MS.1

 

ABOUT TG THERAPEUTICS

TG Therapeutics is a fully integrated, commercial stage, biotechnology company focused on the acquisition, development and commercialization of novel treatments for B-cell diseases. In addition to a research pipeline, TG Therapeutics has received approval from the U.S. Food and Drug Administration (FDA) for BRIUMVI® (ublituximab-xiiy) to treat adult patients with relapsing forms of multiple sclerosis (RMS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, as well as approval from several regulatory agencies outside of the U.S. for BRIUMVI to treat adult patients with RMS who have active disease defined by clinical or imaging features. For more information, visit www.tgtherapeutics.com, and follow us on X (formerly Twitter) @TGTherapeutics and on LinkedIn.

BRIUMVI® is a registered trademark of TG Therapeutics, Inc.

Cautionary Statement

 

This press release contains forward-looking statements that involve a number of risks and uncertainties. All statements contained in this press release other than statements of historical facts, including statements regarding our future results of operations and financial position, our strategic and financial initiatives, our business strategy, and objectives for future operations may constitute forward-looking statements. For those statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995.

 

 

 

Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release. In addition to the risk factors identified from time to time in our reports filed with the U.S. Securities and Exchange Commission (SEC), factors that could cause our actual results to differ materially include the below.

 

Such forward looking statements include but are not limited to statements regarding our plans, business strategies and operations related to the commercialization of BRIUMVI® (ublituximab-xiiy) for RMS in the United States, or any jurisdictions outside of the United States; anticipated healthcare professional (HCP) and patient acceptance and use of BRIUMVI for the approved indications; expectations of future revenue for BRIUMVI, or TG expenses or profit estimates or targets; our ability to execute our share repurchase program; expectations and timing for our clinical trials of subcutaneous ublituximab (the active ingredient in BRIUMVI), and sometimes referred to as subcutaneous BRIUMVI; expectations and timing for our ENHANCE Phase 3 pivotal program to evaluate a consolidated day 1 and day 15 dosing regimen for IV BRIUMVI; and expectations and timing for any of our pipeline products or programs, including Azer-cel or BRIUMVI in MG.

 

Additional factors that could cause our actual results to differ materially include the following: the Company’s ability to continue to commercialize BRIUMVI; the risk that trends in prescriptions are not maintained or that prescriptions are not filled; the failure to obtain and maintain payor coverage; the risk that HCP interest in BRIUMVI will not be sustained; the risk that momentum in sales for BRIUMVI will not be sustained during the course of the year; the risk that the commercialization of BRIUMVI does not continue to exceed expectations; the risk that our BRIUMVI revenue targets will not be achieved; the failure to obtain and maintain requisite regulatory approvals, including the risk that the Company fails to satisfy post-approval regulatory requirements, the potential for variations from the Company’s projections and estimates about the potential market for BRIUMVI due to a number of factors, including, further limitations that regulators may impose on the required labeling for BRIUMVI (such as modifications, resulting from safety signals that arise in the post-marketing setting or in the long-term extension study from the ULTIMATE I and II clinical trials); the Company’s ability to meet post-approval compliance obligations (on topics including but not limited to product quality, product distribution and supply chain, pharmacovigilance, and sales and marketing); the Company’s reliance on third parties for manufacturing, distribution and supply, and other support functions for our clinical and commercial products, including BRIUMVI, and the ability of the Company and its manufacturers and suppliers to produce and deliver BRIUMVI to meet the market demand for BRIUMVI; the risk that any individual patient’s clinical experience in the post-marketing setting, or the aggregate patient experience in the post-marketing setting, may differ from that demonstrated in controlled clinical trials such as ULTIMATE I and II; the risk that the Company does not achieve its 2026 development pipeline anticipated milestones or goals in the timeframe projected or at all, including (i) completing a pivotal program for subcutaneous ublituximab, (ii) completing a pivotal program based on data from the ENHANCE trial to consolidate day 1 and day 15 dosing, (iii) enrolling patients into a trial evaluating BRIUMVI in MG, or (iv) enrolling patients into a trial evaluating azer-cel; the risk that clinical trial data readouts may be delayed due to a number of factors including enrollment, data collection, data maturity or other factors; the risk that the subcutaneous Phase 3 program will not be successful or if successful still will not be approved by the FDA or achieve commercial acceptance; the risk that, if subcutaneous BRIUMV is approved, the anticipated expansion of the addressable market will not be realized; the risk that the ENHANCE Phase 3 trial will not be successful or if successful will not be approved by the FDA or achieve commercial acceptance; the risk that we will not move forward with the development of BRIUMVI in MG or schizophrenia and azer-cel in progressive MS following preliminary studies; the uncertainties generally inherent in research and development and early stage exploratory programs; the risk that the collaboration with Christina Applegate is not able to be implemented or does not go as planned for regulatory or other reasons; the risk that the www.nextinms.com platform does not gain traction or ceases to exist; regulatory developments, legislative actions, executive orders, including the imposition of tariffs and policy changes in the U.S. and other jurisdictions; and general political, economic and business conditions. Further discussion about these and other risks and uncertainties can be found in our Annual Report on Form 10-K for the fiscal year ended December 31, 2025 and in our other filings with the SEC.

 

Any forward-looking statements set forth in this press release speak only as of the date of this press release. We do not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof. This press release and prior releases are available at www.tgtherapeutics.com. The information found on our website is not incorporated by reference into this press release and is included for reference purposes only.


CONTACT:

 

Investor Relations

Email: ir@tgtxinc.com

Telephone: 1.877.575.TGTX (8489), Option 4

 

Media Relations:

Email: media@tgtxinc.com

Telephone: 1.877.575.TGTX (8489), Option 6

 

1. MS Prevalence. National Multiple Sclerosis Society website. https://www.nationalmssociety.org/About-the-Society/MS-Prevalence. Accessed October 26, 2020. 2. Multiple Sclerosis International Federation, 2013 via Data monitor p. 236.

 

 

 

 

TG Therapeutics, Inc.

Selected Condensed Consolidated Financial Data

  

Statements of Operations Information (in thousands, except share and per share amounts; unaudited): 

 

   

Three months ended March 31,

 
                 
   

2026

   

2025

 

Revenue:

               

Product revenue, net

  $ 201,308     $ 119,655  

License, milestone, royalty and other revenue

    3,610       1,201  

Total revenue

  $ 204,918     $ 120,856  
                 

Costs and expenses:

               

Cost of revenue

    33,510       15,541  

Research and development:

               

Stock-based compensation

    4,875       3,331  

Other research and development

    43,521       43,031  

Total research and development

    48,396       46,362  
                 

Selling, general and administrative:

               

Stock-based compensation

    15,075       11,640  

Other selling, general and administrative

    73,142       38,691  

Total selling, general and administrative

    88,217       50,331  
                 

Total costs and expenses

    170,123       112,234  
                 

Operating income

    34,795       8,622  
                 

Other expense (income):

               

Interest expense

    7,666       6,757  

Loss on extinguishment of debt

    9,153        

Other income

    (2,387 )     (3,603 )

Total other expense, net

    14,432       3,154  
                 

Net income before taxes

  $ 20,363     $ 5,468  

Income tax expense

    (586 )     (408 )

Net income

  $ 19,777     $ 5,060  
                 

Net income per common share:

               

Basic

  $ 0.14     $ 0.03  

Diluted

  $ 0.12     $ 0.03  
                 

Weighted-average shares of common stock outstanding

               

Basic

    144,439,370       146,677,783  

Diluted

    160,062,326       162,769,202  

 

 

Condensed Balance Sheet Information (in thousands): 

  

   

March 31, 2026

(Unaudited)

   

December 31,

2025*

 

Cash, cash equivalents and investment securities

    572,835       199,511  

Total assets

    1,528,837       1,063,253  

Total equity

    583,131       648,020  

  

* Condensed from audited financial statements 

 

 

FAQ

How much revenue did TG Therapeutics (TGTX) report for Q1 2026?

TG Therapeutics reported total Q1 2026 revenue of $204.9 million. This included $201.3 million of product revenue and $3.6 million from license, milestone, royalty and other revenue, showing significant growth versus the prior-year quarter.

How profitable was TG Therapeutics (TGTX) in the first quarter of 2026?

TG Therapeutics generated $34.8 million in operating income and $19.8 million in net income in Q1 2026. Basic earnings per share were $0.14 and diluted earnings per share were $0.12, compared with $0.03 in the prior-year period.

What 2026 revenue guidance did TG Therapeutics (TGTX) provide?

TG Therapeutics raised its full-year 2026 total global revenue target to approximately $925 million. It also increased its 2026 BRIUMVI U.S. net product revenue guidance to a range of $885–900 million, reflecting stronger-than-expected early-year performance.

How important is BRIUMVI to TG Therapeutics’ (TGTX) results?

BRIUMVI is central to TG Therapeutics’ performance, contributing $201.3 million of Q1 2026 product revenue and driving overall growth. Management highlighted strong demand, record new patient starts and believes BRIUMVI can be a long-term growth driver for the company.

What is TG Therapeutics’ (TGTX) cash position after Q1 2026?

As of March 31, 2026, TG Therapeutics held $572.8 million in cash, cash equivalents and investment securities. Total assets were $1.53 billion, and total equity was $583.1 million, providing resources to support commercialization and pipeline development.

How did TG Therapeutics’ operating expenses change in Q1 2026?

Total costs and expenses rose to $170.1 million in Q1 2026 from $112.2 million a year earlier. Research and development totaled $48.4 million, while selling, general and administrative expenses increased to $88.2 million as the company expanded its commercial and corporate activities.

Filing Exhibits & Attachments

5 documents